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1. Full Text Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
by Koivunen, Peppi and Lee, Sungwoo and Duncan, Christopher G and Lopez, Giselle and Lu, Gang and Ramkissoon, Shakti and Losman, Julie A and Joensuu, Päivi and Bergmann, Ulrich and Gross, Stefan and Travins, Jeremy and Weiss, Samuel and Looper, Ryan and Ligon, Keith L and Verhaak, Roel G. W and Yan, Hai and Kaelin Jr, William G
Nature (London), ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 484 - 488
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Dioxygenases - metabolism | Humans | Hypoxia-Inducible Factor 1 - metabolism | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | Glioma - genetics | Cell Transformation, Neoplastic - genetics | Glioma - pathology | Glutarates - chemistry | Nuclear Proteins - genetics | Oncogenes | Astrocytes - cytology | Astrocytes - drug effects | Cell Line | Glioma - enzymology | Isocitrate Dehydrogenase - genetics | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Enzyme Activation - drug effects | Cell Transformation, Neoplastic - metabolism | Dioxygenases - genetics | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Glutarates - pharmacology | Astrocytes - metabolism | Genetic aspects | Gene mutations | Enantiomers | Properties | Identification and classification | Cancer cells | Hypoxia | Polypeptides | Mutation | Microbiology | Gene expression | Brain cancer | Index Medicus
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2. Full Text The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
by Moasser, M.M
Oncogene, ISSN 0950-9232, 10/2007, Volume 26, Issue 45, pp. 6469 - 6487
ErbB-2 | HER2/Neu | ErbB2 | HER2 | HER-2 | Neu | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Receptor, ErbB-2 - physiology | Animals | Neoplasms - genetics | Signal Transduction | Cell Transformation, Neoplastic | Models, Biological | Humans | Gene Expression Regulation, Neoplastic | Genes, erbB-2 - physiology | Mice | Mutation | Genetic aspects | Cellular signal transduction | Research | Carcinogenesis | Risk factors | Signal transduction | Cellular biology | Molecular biology | Index Medicus
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3. Full Text Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
by Cicalese, Angelo and Schurra, Catherine and Maestro, Roberta and Di Micco, Raffaella and Giovanni Nuciforo, Paolo and Piccinin, Sara and d'Adda di Fagagna, Fabrizio and Fumagalli, Marzia and Garre', Massimiliano and Gasparini, Patrizia and Luise, Chiara and Bensimon, Aaron and Giuseppe Pelicci, Pier
Nature (London), ISSN 0028-0836, 11/2006, Volume 444, Issue 7119, pp. 638 - 642
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Cellular Senescence - genetics | Animals | Cell Proliferation | Cell Transformation, Neoplastic - genetics | Humans | Cells, Cultured | DNA Replication | Mice | Genetic Markers | Genes, ras | Aging | Genetic aspects | Research | Cell transformation | Oncogenes | Cellular biology | Gene expression | DNA damage | Rodents | Tumors | Index Medicus
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4. Full Text SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
by Barber, Matthew F and Barber, Matthew F and Michishita-Kioi, Eriko and Michishita-Kioi, Eriko and Xi, Yuanxin and Xi, Yuanxin and Tasselli, Luisa and Tasselli, Luisa and Kioi, Mitomu and Moqtaderi, Zarmik and Tennen, Ruth I and Tennen, Ruth I and Paredes, Silvana and Paredes, Silvana and Young, Nicolas L and Chen, Kaifu and Chen, Kaifu and Struhl, Kevin and Garcia, Benjamin A and Gozani1, Or and Gozani, Or and Li, Wei and Li, Wei and Chua, Katrin F and Chua, Katrin F
Nature (London), ISSN 0028-0836, 2012, Volume 486, Issue 7405, pp. 114 - 118
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Chromatin - metabolism | Neoplasm Transplantation | Cell Proliferation | Humans | Transplantation, Heterologous | Sirtuins - deficiency | ets-Domain Protein Elk-4 - metabolism | Nucleotide Motifs | Adenovirus E1A Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Base Sequence | Transcription, Genetic | Lysine - metabolism | Acetylation | Sirtuins - genetics | Binding Sites | Repressor Proteins - metabolism | Promoter Regions, Genetic | Histone Deacetylases - metabolism | Cell Transformation, Neoplastic - metabolism | Disease Progression | Contact Inhibition | Phenotype | Animals | Adenovirus E1A Proteins - genetics | Cell Line, Tumor | Mice | Histones - metabolism | Cell Transformation, Neoplastic - pathology | Sirtuins - metabolism | Genetic transformation | Research | Properties | Oncogenes | Proteins | Epigenetics | Genetics | Gene expression | Mass spectrometry | Cancer | Index Medicus
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5. Full Text SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
by Lin, Lin and Komisarof, Justin and Kim, So Young and Minna, John D and Brose, Marcia S and Regev, Aviv and Zhu, Chang Qi and Beer, David G and Getz, Gad and Woo, Michele S and Wardwell, Leslie and Watanabe, Hideo and Verhaak, Roel G and Stairs, Douglas B and Rao, Shilpa and O'Kelly, Michael and Ramos, Alex H and Wong, Kwok K and Nakagawa, Hiroshi and Hahn, William C and Scheble, Veit and Yu, Soyoung and Chirieac, Lucian R and Rustgi, Anil K and Weir, Barbara A and Tamayo, Pablo and Dutt, Amit and Rozenblatt-Rosen, Orit and Rubin, Mark A and Mermel, Craig H and Tsao, Ming-Sound and Gat-Viks, Irit and Wilbertz, Theresia and Gazdar, Adi F and Jr, Ulysses Ribeiro and LaFargue, Christopher J and Giordano, Thomas J and Dziunycz, Piotr and Wagner, Patrick and Cecconello, Ivan and Marie, Suely K and Meyerson, Matthew and Beroukhim, Rameen and Dahl, Olav and Shivdasani, Ramesh A and Ma, Changqing and Bass, Adam J and Perner, Sven
Nature Genetics, ISSN 1061-4036, 11/2009, Volume 41, Issue 11, pp. 1238 - 1242
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Esophagus | Tumors | Lung Neoplasms - genetics | Oncogenes - genetics | Cell Survival | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - pathology | Esophageal Neoplasms - pathology | Cell Lineage | Gene Amplification | Esophageal Neoplasms - genetics | RNA Interference | SOXB1 Transcription Factors - genetics | Cell Differentiation | Genome, Human | Gene mutations | Lung cancer | Genetic aspects | Research | Health aspects | Risk factors | Esophageal cancer | Proteins | Medical research | Genetic testing | Molecular biology | Fluorescence in situ hybridization | Index Medicus
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6. Full Text Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
by Locasale, Jason W and Grassian, Alexandra R and Melman, Tamar and Lyssiotis, Costas A and Mattaini, Katherine R and Bass, Adam J and Heffron, Gregory and Metallo, Christian M and Muranen, Taru and Sharfi, Hadar and Sasaki, Atsuo T and Anastasiou, Dimitrios and Mullarky, Edouard and Vokes, Natalie I and Sasaki, Mika and Beroukhim, Rameen and Stephanopoulos, Gregory and Ligon, Azra H and Meyerson, Matthew and Richardson, Andrea L and Chin, Lynda and Wagner, Gerhard and Asara, John M and Brugge, Joan S and Cantley, Lewis C and Vander Heiden, Matthew G
Nature genetics, ISSN 1061-4036, 09/2011, Volume 43, Issue 9, pp. 869 - 874
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Neoplasms - metabolism | Cell Proliferation | Neoplasms - genetics | Phosphoglycerate Dehydrogenase - metabolism | Cell Transformation, Neoplastic - genetics | Humans | Glucose - metabolism | Glycolysis | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Cell Transformation, Neoplastic - metabolism