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Cell, ISSN 0092-8674, 2007, Volume 129, Issue 1, pp. 45 - 56
Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In , a paradigm for caspase regulation exists in which... 
CELLBIO | CELLIMMUNO
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 53, Issue 5, pp. 703 - 717
Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we... 
CELLBIO | MOLNEURO
Journal Article
Developmental Cell, ISSN 1534-5807, 10/2007, Volume 13, Issue 4, pp. 496 - 510
Here, we report a direct interaction between the β1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis.... 
CELLBIO
Journal Article
Developmental Cell, ISSN 1534-5807, 07/2010, Volume 19, Issue 1, pp. 148 - 159
Cell migration requires endocytosis and recycling of integrins, but it is not known whether degradation of these membrane proteins is involved. Here we... 
CELLBIO | Cellbio
Journal Article
Cell, ISSN 0092-8674, 04/2008, Volume 133, Issue 1, pp. 78 - 89
Characteristics of transformed and tumor cells include increased levels of protein synthesis and elevated expression of RNA polymerase (pol) III products, such... 
CELLBIO | PROTEINS | CELLCYCLE
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 58, Issue 5, pp. 749 - 762
At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating signaling events across the synaptic cleft. Among synaptic CAMs,... 
CELLBIO | MOLNEURO
Journal Article
Neuron, ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 755 - 770
Ca signaling plays a central role in activity-dependent regulation of dendritic arborization, but key molecular mechanisms downstream of calcium elevation... 
CELLBIO | DEVBIO | MOLNEURO
Journal Article
Current Biology, ISSN 0960-9822, 2010, Volume 20, Issue 8, pp. 703 - 709
Intracellular Ca signals constitute key elements in signal transduction. Of the three major Ca mobilizing messengers described, the most potent, nicotinic acid... 
CELLBIO | SIGNALING
Journal Article
Developmental Cell, ISSN 1534-5807, 06/2006, Volume 10, Issue 6, pp. 707 - 718
Heterotrimeric G proteins are critical cellular signal transducers. They are known to directly relay signals from seven-transmembrane G protein-coupled... 
CELLBIO | SIGNALING
Journal Article
Developmental Cell, ISSN 1534-5807, 2006, Volume 10, Issue 3, pp. 329 - 342
Clathrin-associated sorting proteins (CLASPs) expand the repertoire of endocytic cargo sorted into clathrin-coated vesicles beyond the transmembrane proteins... 
CELLBIO | SIGNALING | Signaling | Cell bio
Journal Article
ISSN 0969-2126, 2009
ABCG2 is a multidrug efflux pump associated with resistance of cancer cells to a plethora of unrelated drugs. ABCG2 is a "half-transporter," and previous... 
Cellcycle | Cellbio
Journal Article
Developmental Cell, ISSN 1534-5807, 2007, Volume 13, Issue 5, pp. 635 - 645
The COPII vesicular coat forms on the endoplasmic reticulum from Sar1-GTP, Sec23/24 and Sec13/31 protein subunits. Here, we define the interaction between... 
CELLBIO
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 59, Issue 1, pp. 43 - 55
As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets β-amyloid (Aß) reactions with synaptic Zn and Cu yet promotes metal... 
CELLBIO | HUMDISEASE | MOLNEURO | PROTEIN | AMYLOID-BETA | IN-VIVO | DISEASE | TAU | PATHOLOGY | MODEL | NEUROSCIENCES | ZINC | OLIGOMERS | SYNAPTOPHYSIN
Journal Article
Immunity, ISSN 1074-7613, 10/2006, Volume 25, Issue 4, pp. 583 - 594
We used negative stain electron microscopy (EM) to examine the conformational changes in the ectodomains required for activation of the leukocyte integrins α β... 
CELLBIO | PROTEINS | MOLIMMUNO
Journal Article
Neuron, ISSN 0896-6273, 01/2008, Volume 57, Issue 2, pp. 210 - 216
Short-term synaptic plasticity shapes the postsynaptic response to bursts of impulses and is crucial for encoding information in neurons, but the molecular... 
CELLBIO | MOLNEURO | SIGNALING | Proteins | Cell culture | Mutation | Neurons
Journal Article
Current Biology, ISSN 0960-9822, 09/2006, Volume 16, Issue 18, pp. 1796 - 1806
Integrin receptors, composed of transmembrane α and β subunits, are essential for the development and functioning of multicellular animals. Agonist stimulation... 
CELLBIO | SIGNALING
Journal Article
Current Biology, ISSN 0960-9822, 2008, Volume 18, Issue 14, pp. 1034 - 1043
Studies show that high phosphotidylinositol 3,4,5-trisphosphate (PIP ) promotes cytoskeletal rearrangements and alters cell motility and chemotaxis, possibly... 
CELLBIO | SIGNALING
Journal Article
Cancer Cell, ISSN 1535-6108, 2008, Volume 13, Issue 3, pp. 272 - 286
Deregulation of E2F1 activity and resistance to TGFβ are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in... 
CELLBIO | TRANSCRIPTION FACTORS | BREAST-CANCER | EPITHELIAL-CELLS | ONCOLOGY | COPY-NUMBER | E2F FAMILY | GROWTH | BIM | COMPARATIVE GENOMIC HYBRIDIZATION | EXPRESSION | TUMORS
Journal Article
Developmental Cell, ISSN 1534-5807, 2009, Volume 16, Issue 6, pp. 856 - 866
oocyte death is partly controlled by the apoptotic initiator caspase-2 (C2). We reported previously that oocyte nutrient depletion activates C2 upstream of... 
CELLBIO | CELLCYCLE | 14-3-3 | glucose-6-phosphate | oocyte | caspase-2 | protein phosphatase-1
Journal Article