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Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 16, pp. 4137 - 4149
Abstract Chemotherapeutic agents often cause severe side effects because they produce a similar cytotoxicity in both cancerous and healthy cells. In this... 
Advanced Basic Science | Dentistry | Tumor microenvironment-sensitive polypeptides (TMSP) | Cell-penetrating peptides | Folate | Docetaxel | Nanostructured lipid carrier (NLC) | Cancer-targeted therapy | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | RECEPTOR | CELLULAR UPTAKE | NANOPARTICLES | IN-VITRO | THERAPY | PROSTATE-CANCER | CONJUGATE | LIPOSOMES | ANTITUMOR EFFICACY | Taxoids - pharmacology | Humans | Spheroids, Cellular - pathology | Molecular Sequence Data | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Drug Carriers - chemistry | Drug Delivery Systems | Cell-Penetrating Peptides - pharmacology | Female | Antineoplastic Agents - pharmacology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Spheroids, Cellular - drug effects | Cell Death - drug effects | Cell-Penetrating Peptides - chemistry | Tumor Microenvironment - drug effects | Amino Acid Sequence | Cell Survival - drug effects | Nanostructures - ultrastructure | Spheroids, Cellular - metabolism | Folate Receptors, GPI-Anchored - metabolism | Neoplasms - drug therapy | Animals | Mice, Nude | Cell Line, Tumor | Folic Acid - metabolism | Nanostructures - chemistry | Ligands | Mice | Matrix Metalloproteinases - metabolism | Neoplasms - pathology | Phosphatidylethanolamines - chemistry | Drugs | Drug delivery systems | Chemotherapy | Peptides | Proteases | Analysis | Cancer cells | Drug therapy | Biopolymers | Folic acid | Cancer | Vehicles | Index Medicus
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 21, pp. 5294 - 5302
Abstract A tumor targeting nanoparticle system has been successfully developed to response to the lowered tumor extracellular pH (pHe) and upregulated matrix... 
Advanced Basic Science | Dentistry | Gene delivery | Tumor targeting nanoparticles | Tumor microenvironment | Activatable | Cell-penetrating peptide | SYSTEM | DESIGN | MATERIALS SCIENCE, BIOMATERIALS | SOLID TUMORS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | CELL-PENETRATING PEPTIDES | MOLECULES | MATRIX METALLOPROTEINASES | PH | INTRACELLULAR DELIVERY | CANCER PROGRESSION | Neoplasms - metabolism | Nanoparticles - chemistry | Humans | Fluorescence | Male | Polyethylene Glycols - chemistry | Polylysine - chemistry | Drug Carriers - chemistry | Cell-Penetrating Peptides - pharmacology | Electrophoresis | Cell Death - drug effects | Cell-Penetrating Peptides - chemical synthesis | Gene Expression Regulation, Neoplastic - drug effects | Cell-Penetrating Peptides - chemistry | Polyethylene Glycols - pharmacology | Tumor Microenvironment - drug effects | Gene Transfer Techniques | Polylysine - pharmacology | Tissue Distribution - drug effects | Magnetic Resonance Spectroscopy | Endocytosis - drug effects | DNA - metabolism | Nanoparticles - toxicity | Animals | Mice, Nude | Polylysine - chemical synthesis | Cell Line, Tumor | Mice | Polyethylene Glycols - chemical synthesis | Neoplasms - pathology | Drugs | Nanoparticles | Drug delivery systems | Peptides | Genes | Genetic research | Permeability | Vehicles | Tumors | Index Medicus | Cellular | Matrix metalloproteinases | Masking | Assessments
Journal Article
Nano Letters, ISSN 1530-6984, 02/2016, Volume 16, Issue 2, pp. 1118 - 1126
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92248
Three-dimensional (3D) cell culture is gaining acceptance in response to the need for cellular models that better mimic physiologic tissues. Spheroids are one... 
CANCER-CELLS | CARCINOMA-CELLS | CROSS-TALK | GROWTH-FACTOR RECEPTOR | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ERLOTINIB RESISTANCE | C-MET ANTIBODY | MULTICELLULAR SPHEROIDS | KINASE INHIBITORS | ANTICANCER DRUGS | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Humans | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Hepatocyte Growth Factor - pharmacology | Cell Culture Techniques - methods | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Reproducibility of Results | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Treatment Outcome | Drug Discovery | Cell Movement - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Epidermal growth factor | Health aspects | Lung cancer | Tumors | Monomolecular films | Cell proliferation | Drugs | Self assembly | Cell culture | Flow cytometry | Biotechnology | Phosphorylation | Systematic review | Drug development | Kinases | Tissues | Pharmaceutical industry | Growth factors | Epidermal growth factor receptors | Hepatocyte growth factor | Research & development--R&D | Tumor cells | Cultures | Pharmacology | Tumor cell lines | Chemical compounds | Spheroids | Studies | Cytometry | Self-assembly | Inhibitors | Lungs | Monolayers | Mutation | Three dimensional models | Cell migration | Research & development | R&D
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3390 - 18
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier... 
ASSEMBLED GOLD NANOPARTICLES | HSP47 SIRNA | IN-VITRO | RETINOIC ACID | COLLAGEN-SPECIFIC CHAPERONE | DUCTAL ADENOCARCINOMA | A-COUPLED LIPOSOMES | MULTIDISCIPLINARY SCIENCES | EXTRACELLULAR-MATRIX | SIRNA DELIVERY | CANCER MODEL | Gene Silencing - drug effects | Stromal Cells - pathology | Humans | Pancreatic Stellate Cells - drug effects | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Homeostasis | Polyethylene Glycols - chemistry | Polyethyleneimine - chemistry | Stromal Cells - drug effects | Female | Spheroids, Cellular - drug effects | Tretinoin - pharmacokinetics | Pancreatic Stellate Cells - pathology | Metal Nanoparticles - ultrastructure | Tretinoin - pharmacology | Gold - chemistry | Tumor Microenvironment - drug effects | Tissue Distribution - drug effects | Endocytosis - drug effects | Extracellular Matrix - drug effects | Metal Nanoparticles - chemistry | Pancreatic Neoplasms - pathology | Spheroids, Cellular - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Mice, Inbred BALB C | Cell Cycle - drug effects | Hydrogen-Ion Concentration | Pancreatic Stellate Cells - metabolism | RNA, Small Interfering - metabolism | Adenocarcinoma | Gold | Stellate cells | Drug delivery systems | Hyperplasia | Heat shock proteins | Recovery of function | siRNA | Drug delivery | Cobalt | Anticancer properties | Nanoparticles | Proteins | Chemotherapy | Polyethylenimine | Stromal cells | Collagen | Extracellular matrix | Pancreas | Retinoic acid | Tumors | Heat shock
Journal Article
Journal Article