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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5887, pp. 408 - 411
.... Upon viral infection, mice with T cells lacking both T-bet and Eomes develop a CD8(+) T cell-dependent, progressive inflammatory and wasting syndrome characterized by multi-organ infiltration of neutrophils. T-bet and Eomes, thus, ensure that CD8(+) T cells adopt an appropriate course of intracellular rather than extracellular destruction. 
T lymphocytes | Spleen | Pathology | Lymphocytic choriomeningitis virus | Cytokines | Neutrophils | Viruses | Reports | Infections | Mice | Genotypes | LINEAGE COMMITMENT | EFFECTOR | CD4 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISTINCT | DIRECTS | DIFFERENTIATION | TRANSCRIPTION FACTOR | IL-21 | Lymphocytic choriomeningitis virus - immunology | T-Box Domain Proteins - physiology | Arenaviridae Infections - virology | Interferon-gamma - metabolism | Lymphocyte Depletion | CD4-Positive T-Lymphocytes - immunology | Lymphocytic choriomeningitis virus - isolation & purification | Wasting Syndrome - immunology | CD8-Positive T-Lymphocytes - metabolism | Wasting Syndrome - virology | Cell Differentiation | Lymphocytic choriomeningitis virus - physiology | Arenaviridae Infections - immunology | T-Box Domain Proteins - deficiency | Mice, Inbred C57BL | Arenaviridae Infections - pathology | T-Box Domain Proteins - genetics | Mice, Knockout | Antigens, Viral - immunology | Interleukin-17 - metabolism | Animals | Virus Replication | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic | Wasting Syndrome - pathology | Virus diseases | Killer cells | CD8 lymphocytes | Influence | Genetic aspects | Cell-mediated cytotoxicity | DNA binding proteins | Research | Properties | Cell differentiation | Immunology | Biomedical research | Cellular biology | Rodents | Tc17 | autoimmunity | IL-17 | IL-23 | Th17 | IL-22 | RORγt
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Current opinion in infectious diseases, ISSN 0951-7375, 2013, Volume 26, Issue 3, pp. 213 - 218
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