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Journal of experimental botany, ISSN 0022-0957, 1/2013, Volume 64, Issue 16, pp. 4967 - 4980
.... Senescence-associated vacuoles (SAVs) are small, acidic vacuoles with high cysteine peptidase activity... 
Leaves | Chloroplasts | Incubation | Cellular senescence | Botany | Plants | Plastids | Vacuoles | Chlorophylls | RESEARCH PAPER | Plant cells | Cysteine proteases | Rubisco | Senescence-associated vacuoles | Tobacco | SAG12 | Proteolysis | RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE | WHEAT TRITICUM-AESTIVUM | ARABIDOPSIS-THALIANA | NICOTIANA-TABACUM | senescence-associated vacuoles | STAY-GREEN MUTANTS | NITROGEN REMOBILIZATION | TRANSCRIPTOME ANALYSIS | PLANT SCIENCES | LEAF SENESCENCE | GENE-EXPRESSION | PHOTOSYSTEM-II | tobacco | proteolysis | Darkness | Vacuoles - enzymology | Chloroplasts - enzymology | Cellular Senescence - drug effects | Cysteine Proteases - metabolism | Down-Regulation - radiation effects | Vacuoles - drug effects | Proteolysis - drug effects | Plant Proteins - antagonists & inhibitors | Cellular Senescence - radiation effects | Chloroplasts - radiation effects | Plant Leaves - drug effects | Plant Proteins - metabolism | Chloroplasts - drug effects | Plant Leaves - enzymology | Proteolysis - radiation effects | Chloroplasts - genetics | Vacuoles - genetics | Tobacco - drug effects | Plant Leaves - radiation effects | Down-Regulation - drug effects | Tobacco - radiation effects | Plant Proteins - genetics | Vacuoles - radiation effects | Cysteine Proteases - genetics | Plant Leaves - genetics | Tobacco - genetics | Cysteine Proteinase Inhibitors - pharmacology | Tobacco - enzymology
Journal Article
Journal Article
Nature medicine, ISSN 1078-8956, 2017, Volume 23, Issue 9, pp. 1072 - 1079
Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities(1... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | SECRETORY PHENOTYPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MATURE | IDENTIFICATION | CELL BIOLOGY | OSTEOCLASTOGENESIS | ACTIVATOR | MASS | ESTROGEN | FRACTURES | DYSFUNCTION | Osteocytes - drug effects | Cancellous Bone - metabolism | beta-Galactosidase | Cellular Senescence - drug effects | Apoptosis - genetics | Cancellous Bone - drug effects | Gene Expression Profiling | Osteoclasts - cytology | Bone and Bones - drug effects | Caspase 8 - genetics | Flow Cytometry | Osteoporosis - metabolism | Bone and Bones - metabolism | Osteoporosis - genetics | Cell Differentiation | Osteoblasts - cytology | Real-Time Polymerase Chain Reaction | Pyrazoles - pharmacology | Cellular Senescence - genetics | Osteoblasts - drug effects | Mice, Transgenic | Absorptiometry, Photon | Cortical Bone - metabolism | Janus Kinases - antagonists & inhibitors | Culture Media, Conditioned | Animals | Cortical Bone - drug effects | Weight-Bearing | Mice | In Vitro Techniques | Osteoclasts - drug effects | Prevention | Osteoporosis | Aging | Physiological aspects | Genetic aspects | Research | Cells | Senescence | Bone (trabecular) | Suicide | Bone resorption | Bone growth | Biomedical materials | Mineralization | Rodents | Computer architecture | Biocompatibility | Inhibition | Conditioning | Bone loss | Bone (cortical) | Suicide genes | Age | Cardiovascular system | Cell survival | Aging (artificial) | Caspase | Pharmacology | Secretome | Inflammation | Insulin | Osteoclastogenesis | Caspase-8 | Bone mass | Cellular biology | Sensitivity enhancement | In vitro methods and tests | Osteogenesis | Disease prevention | Osteoclast | Drug therapy | Osteocyte
Journal Article
Journal Article
Cell stem cell, ISSN 1934-5909, 2012, Volume 11, Issue 3, pp. 401 - 414
.... Here, we show that inhibiting the mammalian target of rapamycin (mTOR) with rapamycin increases the clonogenic capacity of primary human oral keratinocytes and their resident self-renewing cells by preventing stem cell senescence... 
MAMMALIAN TARGET | CANCER PATIENTS | RAPAMYCIN | HEAD | AGING PHENOTYPES | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RESPONSE | TUMOR | NECK | SKIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 7, pp. 2601 - 2612
Journal Article
American journal of physiology. Lung cellular and molecular physiology, ISSN 1522-1504, 2011, Volume 300, Issue 3, pp. L391 - L401
Journal Article
Clinical cancer research, ISSN 1557-3265, 2013, Volume 19, Issue 22, pp. 6173 - 6182
Journal Article
The Plant cell, ISSN 1532-298X, 2010, Volume 22, Issue 5, pp. 1463 - 1482
.... Transgenic Arabidopsis overexpressing ACBP3 (ACBP3-OEs) displayed accelerated leaf senescence, whereas an acbp3 T-DNA insertional mutant and ACBP3 RNA interference transgenic Arabidopsis lines were delayed in dark-induced leaf senescence... 
Proteins | Membrane lipids | Phenotypes | Messenger RNA | RNA | Cellular senescence | Lipids | Phospholipids | Plants | Plant cells | PATHWAYS | OXYLIPINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | PHOSPHOLIPASE D-ALPHA | CONJUGATION SYSTEM | CELL-DEATH | PLANT SCIENCES | CELL BIOLOGY | ANKYRIN REPEATS | THALIANA | INTERACTS | PHOSPHATIDIC-ACID | Darkness | RNA Interference - drug effects | Arabidopsis - growth & development | Cellular Senescence - drug effects | Esters - metabolism | Phosphatidylcholines - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Arabidopsis Proteins - metabolism | Salicylic Acid - pharmacology | Protein Processing, Post-Translational - drug effects | Plants, Genetically Modified | Protein Binding - drug effects | Oxidation-Reduction - drug effects | Plant Leaves - drug effects | Acyl Coenzyme A - metabolism | Phagosomes - drug effects | Cellular Senescence - genetics | Green Fluorescent Proteins - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Arabidopsis - cytology | Phagosomes - metabolism | RNA, Messenger - genetics | Down-Regulation - drug effects | Mutagenesis, Insertional - genetics | Plant Leaves - cytology | Arabidopsis - genetics | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Carrier Proteins - metabolism | DNA, Bacterial - genetics | Plant Leaves - genetics | Plant Leaves - growth & development | Membrane Lipids - metabolism | Phosphatidylethanolamines - metabolism | Arabidopsis thaliana | Leaves | Growth | Physiological aspects | Aging | Genetic aspects | Gene expression | Binding proteins | Properties
Journal Article