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1. Full Text mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis
by Iglesias-Bartolome, Ramiro and Patel, Vyomesh and Cotrim, Ana and Leelahavanichkul, Kantima and Molinolo, Alfredo A and Mitchell, James B and Gutkind, J. Silvio
Cell stem cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 401 - 414
Cell & Tissue Engineering | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell differentiation, maturation, development, hematopoiesis | Cell Death - radiation effects | TOR Serine-Threonine Kinases - metabolism | Keratinocytes - radiation effects | Carcinoma, Squamous Cell - pathology | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Cell Compartmentation - radiation effects | Mucositis - prevention & control | Mouth Mucosa - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Mouth Mucosa - radiation effects | Mucositis - pathology | Stem Cells - enzymology | Mucositis - enzymology | Cellular Senescence - radiation effects | Cytoprotection - drug effects | Clone Cells | Oxidative Stress - radiation effects | Cell Death - drug effects | Head and Neck Neoplasms - enzymology | Mouth Mucosa - pathology | Keratinocytes - enzymology | Superoxide Dismutase - metabolism | Radiation, Ionizing | Carcinoma, Squamous Cell - enzymology | Epithelial Cells - radiation effects | Cells, Cultured | Stem Cells - radiation effects | Epithelial Cells - pathology | Radiation Injuries - enzymology | Sirolimus - pharmacology | Head and Neck Neoplasms - pathology | Keratinocytes - pathology | Animals | Keratinocytes - drug effects | Radiation Injuries - prevention & control | Epithelial Cells - enzymology | Cell Compartmentation - drug effects | Stem Cells - drug effects | Stem Cells - pathology | Radiation Injuries - pathology | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Cytoprotection - radiation effects | Cell Proliferation - radiation effects | Index Medicus
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2. Full Text In vivo inhibition of cysteine proteases provides evidence for the involvement of 'senescence-associated vacuoles' in chloroplast protein degradation during dark-induced senescence of tobacco leaves
by Cristian A. Carrión and María Lorenza Costa and Dana E. Martínez and Christina Mohr and Klaus Humbeck and Juan J. Guiamet
Journal of experimental botany, ISSN 0022-0957, 1/2013, Volume 64, Issue 16, pp. 4967 - 4980
Leaves | Chloroplasts | Incubation | Cellular senescence | Botany | Plants | Plastids | Vacuoles | Chlorophylls | RESEARCH PAPER | Plant cells | Cysteine proteases | Rubisco | Senescence-associated vacuoles | Tobacco | SAG12 | Proteolysis | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Vegetative apparatus, growth and morphogenesis. Senescence | Biological and medical sciences | Senescence and abscission | Plant physiology and development | Darkness | Vacuoles - enzymology | Chloroplasts - enzymology | Cellular Senescence - drug effects | Cysteine Proteases - metabolism | Down-Regulation - radiation effects | Vacuoles - drug effects | Proteolysis - drug effects | Plant Proteins - antagonists & inhibitors | Cellular Senescence - radiation effects | Chloroplasts - radiation effects | Plant Leaves - drug effects | Plant Proteins - metabolism | Chloroplasts - drug effects | Plant Leaves - enzymology | Proteolysis - radiation effects | Chloroplasts - genetics | Vacuoles - genetics | Tobacco - drug effects | Plant Leaves - radiation effects | Down-Regulation - drug effects | Tobacco - radiation effects | Plant Proteins - genetics | Vacuoles - radiation effects | Cysteine Proteases - genetics | Plant Leaves - genetics | Tobacco - genetics | Cysteine Proteinase Inhibitors - pharmacology | Tobacco - enzymology | Index Medicus
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3. Full Text Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
by Glück, Selene and Guey, Baptiste and Gulen, Muhammet Fatih and Wolter, Katharina and Kang, Tae-Won and Schmacke, Niklas Arndt and Bridgeman, Anne and Rehwinkel, Jan and Zender, Lars and Ablasser, Andrea
Nature cell biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 9, pp. 1061 - 1070
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Oxidative Stress | Cytosol - immunology | Male | Cytosol - enzymology | Transfection | RNA Interference | Time Factors | Chromatin - immunology | Cellular Senescence - radiation effects | Female | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Paracrine Communication | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Genotype | Mice, Knockout | Phenotype | Animals | Chromatin - radiation effects | Nucleotidyltransferases - genetics | Chromatin - enzymology | Immunity, Innate - radiation effects | Enzyme Activation | Cytosol - radiation effects | Nucleotidyltransferases - immunology | Chromatin | Interferon | Biological response modifiers | Cyclic guanylic acid | Genes | Senescence | AMP | Radiation | Fragments | Paracrine signalling | Activation | Inflammation | Cyclic GMP | Cell cycle | Irradiation | Deoxyribonucleic acid--DNA | Index Medicus
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4. Full Text Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
by Gewirtz, David A and Holt, Shawn E and Elmore, Lynne W
Biochemical pharmacology, ISSN 0006-2952, 2008, Volume 76, Issue 8, pp. 947 - 957
Chemotherapy | Radiation | Replicative senescence | Accelerated senescence | Telomere | Telomerase | p21 | cdc2 | p53 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Humans | Cell Division - radiation effects | Cellular Senescence - drug effects | Antineoplastic Agents - therapeutic use | Telomere - drug effects | Cell Division - drug effects | Neoplasms - drug therapy | Telomere - radiation effects | Cisplatin - therapeutic use | Signal Transduction - drug effects | Cellular Senescence - radiation effects | Cell Line, Tumor | Neoplasms - radiotherapy | Neoplasms - physiopathology | Signal Transduction - radiation effects | DNA Damage - radiation effects | Radiation, Ionizing | Index Medicus
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5. Full Text NEMO Modulates Radiation-Induced Endothelial Senescence of Human Umbilical Veins Through NF-κB Signal Pathway
by Xiaorong Dong and Fan Tong and Cai Qian and Ruiguang Zhang and Jihua Dong and Gang Wu and Yu Hu
Radiation Research, ISSN 0033-7587, 2015, Volume 183, Issue 1, pp. 82 - 93
Biology | Life Sciences & Biomedicine - Other Topics | Biophysics | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Neovascularization, Physiologic - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Cellular Senescence - drug effects | NF-kappa B - metabolism | Death Domain Receptor Signaling Adaptor Proteins - genetics | Neovascularization, Physiologic - radiation effects | DNA Breaks, Double-Stranded - radiation effects | Radiation Tolerance - radiation effects | DNA Breaks, Double-Stranded - drug effects | Human Umbilical Vein Endothelial Cells - cytology | Cellular Senescence - radiation effects | Signal Transduction - radiation effects | Human Umbilical Vein Endothelial Cells - drug effects | Interleukin-6 - genetics | Gene Expression Regulation - drug effects | Radiation Tolerance - drug effects | Phenotype | Signal Transduction - drug effects | Gene Expression Regulation - radiation effects | Cell Proliferation - drug effects | Pyridines - pharmacology | Human Umbilical Vein Endothelial Cells - radiation effects | Dose-Response Relationship, Radiation | Cell Proliferation - radiation effects | Index Medicus | Space life sciences | Human | Veins | Pathways | Irradiation | Survival | Endothelial cells | Gain | Modulators
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6. Is senescence reversible?
by Chakradeo, Shweta and Elmore, Lynne W and Gewirtz, David A
Current drug targets, ISSN 1389-4501, 03/2016, Volume 17, Issue 4, pp. 460 - 466
Chemotherapy | Senescence | p16 | DNA damage | p21 | Tumor cell | p53 | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neoplasms - metabolism | Polyploidy | Cell Survival | Neoplastic Stem Cells - drug effects | Humans | Cellular Senescence - drug effects | Drug Resistance, Neoplasm | Neoplasms - therapy | Animals | Neoplasms - genetics | Signal Transduction - drug effects | Cellular Senescence - radiation effects | Biomarkers, Tumor - metabolism | Signal Transduction - radiation effects | Neoplasms - pathology | Neoplastic Stem Cells - radiation effects
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7. Full Text Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
by Wang, Yingying and Boerma, Marjan and Zhou, Daohong
Radiation research, ISSN 0033-7587, 08/2016, Volume 186, Issue 2, pp. 153 - 161
Biology | Life Sciences & Biomedicine - Other Topics | Biophysics | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Cardiovascular Diseases - etiology | Animals | Endothelial Cells - cytology | Humans | Cellular Senescence - radiation effects | Endothelial Cells - radiation effects | Neoplasms - radiotherapy | Radiation Injuries - pathology | Cardiovascular Diseases - pathology | Endothelial Cells - pathology | Neoplasms - pathology | Radiation Injuries - etiology | Ionizing radiation | Causes of | Aging | Radiation injuries | Development and progression | Cardiovascular diseases | Health aspects | Apoptosis | Index Medicus | Space life sciences | Molecular structure | Cytokines | In vitro testing | Adhesion | Heart diseases | Endothelial cells | Vasodilation
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8. Full Text Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin
by Cavinato, Maria and Jansen-Dürr, Pidder
Experimental gerontology, ISSN 0531-5565, 08/2017, Volume 94, pp. 78 - 82
UVB | Fibroblasts | Skin aging | Photoaging | Autophagy | Proteasome | Autophagy - radiation effects | Skin - metabolism | Humans | Skin Aging - radiation effects | Fibroblasts - pathology | Ultraviolet Rays - adverse effects | Fibroblasts - radiation effects | Signal Transduction - drug effects | Proteolysis | Skin - radiation effects | Cellular Senescence - radiation effects | Oxidative Stress - radiation effects | DNA Damage | Proteasome Endopeptidase Complex - metabolism | Proteasome Endopeptidase Complex - radiation effects | Skin - pathology | Fibroblasts - metabolism | Analysis | Skin | Index Medicus
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9. Full Text <