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1. Psychiatric side effects of prescription and over-the-counter medications
: recognition and management
by Brown, Thomas Markham and Stoudemire, Alan
1998, 1st ed., ISBN 9780880488686, xi, 443
Drugs -- Side effects | Behavioral toxicology | Neurotoxicology
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2. Neurological drug reactions and interactions
by Litt, Jerome Z
2005, 1, ISBN 9780415383806, xxxiii, 277
A must-have resource for the doctor's office and hospital consultations, this handy pocket reference describes and catalogs the adverse effects of commonly... 
Drugs -- Side effects | Neuropharmacology | Neurology | Pharmaceutical Medicine | Handbooks, manuals, etc | Pharmacology
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3. Full Text Ageing with HIV: medication use and risk for potential drug-drug interactions
by Marzolini, Catia and Back, David and Weber, Rainer and Furrer, Hansjakob and Cavassini, Matthias and Calmy, Alexandra and Vernazza, Pietro and Bernasconi, Enos and Khoo, Saye and Battegay, Manuel and Elzi, Luigia and Swiss HIV Cohort Study and Swiss HIV Cohort Study Members and on behalf of the Swiss HIV Cohort Study
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 9/2011, Volume 66, Issue 9, pp. 2107 - 2111
Objectives To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and... 
HIV/AIDS | Older patients | Drug-drug interactions | Polypharmacy | Cardiovascular drugs | older patients | INFECTIOUS DISEASES | drug-drug interactions | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | cardiovascular drugs | COHORT | COMBINATION ANTIRETROVIRAL THERAPY | polypharmacy | Central Nervous System Agents - therapeutic use | Follow-Up Studies | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Hormones - therapeutic use | Methadone - therapeutic use | Male | Narcotics - therapeutic use | Hormones - adverse effects | Central Nervous System Agents - adverse effects | Narcotics - adverse effects | Socioeconomic Factors | Drug Interactions | Adult | Anti-HIV Agents - therapeutic use | Female | Substance Abuse, Intravenous - complications | Anti-HIV Agents - adverse effects | HIV Infections - virology | Substance-Related Disorders - complications | Cardiovascular Agents - therapeutic use | Drug Prescriptions - statistics & numerical data | Aging - physiology | Switzerland - epidemiology | Gastrointestinal Agents - therapeutic use | HIV Infections - complications | HIV Infections - drug therapy | Aged | Gastrointestinal Agents - adverse effects | Methadone - adverse effects | Cardiovascular Agents - adverse effects | Cohort Studies
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4. Full Text Clinical Implications of P-Glycoprotein Modulation in Drug–Drug Interactions
by Lund, Marie and Petersen, Tonny Studsgaard and Dalhoff, Kim Peder
Drugs, ISSN 0012-6667, 05/2017, Volume 77, Issue 8, pp. 859 - 883
Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support... 
SDZ PSC 833 | EFFLUX TRANSPORTERS | CACO-2 CELL MONOLAYERS | IN-VIVO INVESTIGATIONS | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | TOXICOLOGY | SERUM DIGOXIN LEVELS | MULTIDRUG-RESISTANCE | BLOOD-BRAIN-BARRIER | INCREASED ORAL BIOAVAILABILITY | CANCER RESISTANCE PROTEIN | Anti-Infective Agents - metabolism | Anti-Infective Agents - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gastrointestinal Agents - administration & dosage | Antineoplastic Agents - administration & dosage | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Central Nervous System Agents - adverse effects | Antineoplastic Agents - metabolism | Drug Interactions | Antineoplastic Agents - adverse effects | Antineoplastic Agents - pharmacology | Cell Line | Anti-Infective Agents - adverse effects | Immunologic Factors - administration & dosage | Gastrointestinal Agents - pharmacology | Anti-Infective Agents - administration & dosage | Cytochrome P-450 CYP3A Inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cytochrome P-450 CYP3A - metabolism | Central Nervous System Agents - administration & dosage | Central Nervous System Agents - pharmacology | Central Nervous System Agents - metabolism | Gastrointestinal Agents - adverse effects | Immunologic Factors - adverse effects | Immunologic Factors - metabolism | Immunologic Factors - pharmacology | Gastrointestinal Agents - metabolism | Decision-making | Usage | Drug interactions | Analysis | Glycoproteins | Dosage and administration | Research | Cytochrome | Health care | Drugs | Enzymes | Membranes | Excretion | Decision making | Glycoprotein | Organs | Substrate inhibition | Breast cancer | Metabolism | Substrates | Proteins | Side effects | Blood-brain barrier | Plasma membranes | Protein expression | Protein transport | P-Glycoprotein | Transporter | Inducers
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5. Full Text Central Nervous System–Active Medications and Risk for Falls in Older Women
by Ensrud, Kristine E and Blackwell, Terri L and Mangione, Carol M and Bowman, Paula J and Whooley, Mary A and Bauer, Douglas C and Schwartz, Ann V and Hanlon, Joseph T and Nevitt, Michael C and For The Study of Osteoporotic Fractures Research Group and Study of Osteoporotic Fractures Re and Study of Osteoporotic Fractures Research Group
Journal of the American Geriatrics Society, ISSN 0002-8614, 10/2002, Volume 50, Issue 10, pp. 1629 - 1637
OBJECTIVES: To determine whether current use of central nervous system (CNS)‐active medications, including benzodiazepines, antidepressants, anticonvulsants,... 
accidental falls | older people | medications | Medications | Accidental falls | Older people | DEPRESSION | METAANALYSIS | INJURIES | ELDERLY PEOPLE | PSYCHOTROPIC-DRUGS | GERIATRICS & GERONTOLOGY | DENSITY | ANTIDEPRESSANTS | NURSING-HOME RESIDENTS | PREDICTORS | GERONTOLOGY | FRACTURES | Prospective Studies | Humans | Accidental Falls - statistics & numerical data | Risk | Central Nervous System Agents - adverse effects | Benzodiazepines | Narcotics - adverse effects | Anticonvulsants - adverse effects | Anti-Anxiety Agents - adverse effects | Female | Aged | Antidepressive Agents - adverse effects | Health Status | Odds Ratio | Falls (Accidents) | Aged women | Demographic aspects | Health aspects | Risk factors
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6. Full Text Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial
by Avidan, Michael S, Dr Prof and Maybrier, Hannah R, BS and Abdallah, Arbi Ben, PhD and Jacobsohn, Eric, Prof and Vlisides, Phillip E, MD and Pryor, Kane O, MBBS and Veselis, Robert A, Prof and Grocott, Hillary P, Prof and Emmert, Daniel A, MD and Rogers, Emma M, BS and Downey, Robert J, MD and Yulico, Heidi, DNP and Noh, Gyu-Jeong, Prof and Lee, Yonghun H, MD and Waszynski, Christine M, DNP and Arya, Virendra K, Prof and Pagel, Paul S, Prof and Hudetz, Judith A, PhD and Muench, Maxwell R, BS and Fritz, Bradley A, MD and Waberski, Witold, MD and Inouye, Sharon K, Prof and Mashour, George A, Prof and PODCAST Res Grp and PODCAST Research Group
Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10091, pp. 267 - 275
Summary Background Delirium is a common and serious postoperative complication. Subanaesthetic ketamine is often administered intraoperatively for... 
Internal Medicine | ANESTHESIA | DEPRESSION | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | CONFUSION ASSESSMENT METHOD | RELIABILITY | TIME | ICU | VALIDITY | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Postoperative Complications - prevention & control | Analgesics - administration & dosage | Male | Treatment Outcome | Central Nervous System Agents - adverse effects | Ketamine - administration & dosage | Pain, Postoperative - prevention & control | Ketamine - adverse effects | Delirium - prevention & control | Intraoperative Care - methods | Central Nervous System Agents - administration & dosage | Female | Aged | Analgesics - adverse effects | Delirium | Prevention | Clinical trials | Anesthesia | Elderly people | Pain perception | Postoperative period | Complications | Patients | Bleeding | Analgesia | Pain | Ketamine | Analgesics | Older people | Surgery | Hallucinations | Adults | Clinical medicine | Drug dosages
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7. Full Text Barbiturates for acute traumatic brain injury
by Roberts, Ian and Sydenham, Emma
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2012, Volume 12, Issue 12, p. CD000033
Background Raised intracranial pressure (ICP) is an important complication of severe brain injury, and is associated with high mortality. Barbiturates are... 
Barbiturates [therapeutic use] | Intracranial Hypertension [etiology; prevention & control] | MEDICINE, GENERAL & INTERNAL | REFRACTORY INTRACRANIAL HYPERTENSION | MANAGEMENT | Brain Injuries [complications; drug therapy] | Central Nervous System Agents [therapeutic use] | Cerebrovascular Circulation [drug effects] | Humans | Risk | CARE | Barbiturates - adverse effects | Central Nervous System Agents - therapeutic use | Intracranial Pressure - drug effects | Brain Injuries - drug therapy | Cerebrovascular Circulation - drug effects | Brain Injuries - complications | Brain Injuries - mortality | Central Nervous System Agents - adverse effects | Hypotension - chemically induced | Barbiturates - therapeutic use | Randomized Controlled Trials as Topic | Intracranial Hypertension - prevention & control | Intracranial Hypertension - etiology
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8. Full Text Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study
by Hanlon, Joseph T and Boudreau, Robert M and Roumani, Yazan F and Newman, Anne B and Ruby, Christine M and Wright, Rollin M and Hilmer, Sarah N and Shorr, Ronald I and Bauer, Douglas C and Simonsick, Eleanor M and Studenski, Stephanie A and Health ABC Study and for the Health ABC study
Journals of Gerontology: Series A, ISSN 1079-5006, 4/2009, Volume 64A, Issue 4, pp. 492 - 498
Background Few studies have examined the risk of multiple or high doses of combined central nervous system (CNS) medication use for recurrent falls in the... 
Falls | Central nervous system medications | Aged | METAANALYSIS | OLDER-ADULTS | CONSENSUS | RISK | GERIATRICS & GERONTOLOGY | EUROPE | DRUGS | GERONTOLOGY | PEOPLE | ANALGESICS | WITHDRAWAL | HOME | Body Composition | Central Nervous System Agents - therapeutic use | Geriatric Assessment | Recurrence | Residence Characteristics | Confidence Intervals | Prognosis | Antipsychotic Agents - adverse effects | Humans | Aging - drug effects | Male | Central Nervous System Agents - adverse effects | Drug Utilization | Incidence | Dose-Response Relationship, Drug | Accidental Falls - prevention & control | Antipsychotic Agents - therapeutic use | Female | Odds Ratio | Risk Assessment | Accidental Falls - statistics & numerical data | Antidepressive Agents - therapeutic use | Aging - physiology | Benzodiazepines - adverse effects | Antidepressive Agents - adverse effects | Health Status | Benzodiazepines - therapeutic use | Longitudinal Studies | Cohort Studies | Falls (Accidents) | Dosage and administration | Health aspects | Central nervous system agents | Risk factors | Index Medicus | Abridged Index Medicus | Medical Sciences | Journal of Gerontology
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9. Full Text Impact of Lipophilic Efficiency on Compound Quality
by Tarcsay, Ákos and Nyíri, Kinga and Keserű, György M
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 3, pp. 1252 - 1260
Lipophilic efficiency indices such as LLE and LELP were suggested to support balanced optimization of potency and ADMET profile. Here we investigated the... 
DESIGN | CHEMISTRY, MEDICINAL | LEAD DISCOVERY | LIGAND EFFICIENCY | SAFETY | DRUG DISCOVERY | BINDING THERMODYNAMICS | OPTIMIZATION | INHIBITORS | CANDIDATES | PROTEASE | Water | Microsomes - metabolism | Central Nervous System Agents - chemistry | Structure-Activity Relationship | Octanols | Permeability | Central Nervous System Agents - adverse effects | Chemistry, Physical | Drug Discovery | Thermodynamics | Biological Transport, Active | Pharmaceutical Preparations - metabolism | Drug-Related Side Effects and Adverse Reactions | Pharmaceutical Preparations - chemistry | Protein Binding | Central Nervous System Agents - metabolism
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10. Full Text Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry
by Andrade, Raúl J and Lucena, M. Isabel and Kaplowitz, Neil and García‐Muņoz, Beatriz and Borraz, Yolanda and Pachkoria, Ketevan and García‐Cortés, Miren and Fernández, M. Carmen and Pelaez, Gloria and Rodrigo, Luis and Durán, José A and Costa, Joan and Planas, Ramón and Barriocanal, Anabel and Guarner, Carlos and Romero‐Gomez, Manuel and Muņoz‐Yagüe, Teresa and Salmerón, Javier and Hidalgo, Ramón
Hepatology, ISSN 0270-9139, 12/2006, Volume 44, Issue 6, pp. 1581 - 1588
A chronic adverse reaction may occur in some instances of drug‐induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from... 
UNITED-STATES | EBROTIDINE | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | FAILURE | TRANSPLANTATION | DUCTOPENIA | Azepines - adverse effects | Follow-Up Studies | Humans | Middle Aged | Male | Heptanoic Acids - adverse effects | Liver Diseases - epidemiology | Central Nervous System Agents - adverse effects | Disease Progression | Atorvastatin Calcium | Liver - drug effects | Spain - epidemiology | Drug-Related Side Effects and Adverse Reactions | Aged, 80 and over | Amoxicillin-Potassium Clavulanate Combination - adverse effects | Pyrroles - adverse effects | Adult | Female | Registries | Aged | Captopril - adverse effects | Chemical and Drug Induced Liver Injury | Cardiovascular Agents - adverse effects | Chronic Disease
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11. Full Text Drug development for CNS disorders: strategies for balancing risk and reducing attrition
by Hurko, Orest and Schechter, Lee E and Pangalos, Menelas N
Nature Reviews Drug Discovery, ISSN 1474-1776, 07/2007, Volume 6, Issue 7, pp. 521 - 532
Disorders of the central nervous system (CNS) are some of the most prevalent, devastating and yet poorly treated illnesses. The development of new therapies... 
SENILE DEMENTIA | ACTIVATED RECEPTOR-GAMMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALZHEIMERS-DISEASE | AMYLOID-BETA | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | MAJOR DEPRESSION | PRECURSOR PROTEIN | KNOCKOUT MICE | BISPECTRAL INDEX | WORKING-MEMORY | Central Nervous System Agents - therapeutic use | Animals | Humans | Drug Design | Alzheimer Disease - drug therapy | Central Nervous System Agents - adverse effects | Central Nervous System Agents - economics | Disease Models, Animal | Central nervous system diseases | Forecasts and trends | Research | Drug therapy | Central nervous system agents
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