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1. Full Text Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence
by Walker, Brendan M and Koob, George F
Neuropsychopharmacology, ISSN 0893-133X, 02/2008, Volume 33, Issue 3, pp. 643 - 652
The purpose of this study was to test the hypothesis that activation of the dynorphin/kappa (kappa)-opioid system has a role in the increased consumption of... 
Alcohol self-administration | Reinforcement | Alcoholism | Dependence | Dynorphin | Opioids | RECEPTOR-MEDIATED ANTINOCICEPTION | FREELY MOVING RATS | dynorphin | PSYCHIATRY | CONDITIONED PLACE PREFERENCE | ELEMENT-BINDING PROTEIN | FORCED SWIM TEST | DOPAMINERGIC-NEURONS | NEUROSCIENCES | BETA-ENDORPHIN | RAT NUCLEUS-ACCUMBENS | alcoholism | MICRODIALYSIS PROFILE | dependence | PHARMACOLOGY & PHARMACY | reinforcement | alcohol self-administration | ALCOHOL DEPENDENCE | opioids | Naltrexone - analogs & derivatives | Rats, Wistar | Central Nervous System Depressants - adverse effects | Injections, Intraventricular | Ethanol - administration & dosage | Male | Naltrexone - pharmacology | Self Administration | Ethanol - blood | Conditioning, Operant - drug effects | Motivation | Ethanol - adverse effects | Alcoholism - physiopathology | Alcoholism - psychology | Naltrexone - administration & dosage | Data Interpretation, Statistical | Receptors, Opioid, mu - drug effects | Administration, Inhalation | Rats | Receptors, Opioid, delta - drug effects | Receptors, Opioid, kappa - drug effects | Animals | Narcotic Antagonists - pharmacology | Central Nervous System Depressants - administration & dosage | Dynorphins - pharmacology | Central Nervous System Depressants - blood | Substance Withdrawal Syndrome - psychology
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2. Full Text Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking
by Jeanblanc, Jerome and He, Dao-Yao and Carnicella, Sebastien and Kharazia, Viktor and Janak, Patricia H and Ron, Dorit
Journal of Neuroscience, ISSN 0270-6474, 10/2009, Volume 29, Issue 43, pp. 13494 - 13502
We previously found that brain-derived neurotrophic factor (BDNF)-haplodeficient mice exhibit greater ethanol-induced place preference and psychomotor... 
HOMEOSTATIC PATHWAY | NERVOUS-SYSTEM | MEMORY-SYSTEMS | HABIT FORMATION | COCAINE SEEKING | NEUROTROPHIC FACTOR | FACTOR MESSENGER-RNA | ETHANOL-CONSUMPTION | MESOLIMBIC DOPAMINE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Brain-Derived Neurotrophic Factor - genetics | Humans | Rats, Long-Evans | Ethanol - administration & dosage | Male | RNA, Messenger - metabolism | Corpus Striatum - metabolism | Gene Knockdown Techniques | Central Nervous System Depressants - pharmacology | Self Administration | Ethanol - blood | Time Factors | Brain-Derived Neurotrophic Factor - metabolism | Alcohol Drinking - metabolism | Sucrose - administration & dosage | Signal Transduction | Rats | Ethanol - pharmacology | Animals | Central Nervous System Depressants - administration & dosage | Cell Line, Tumor | Corpus Striatum - drug effects | Drinking Behavior - drug effects | RNA, Small Interfering | Central Nervous System Depressants - blood | Drinking Behavior - physiology
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3. Full Text Best practice guide for the treatment of REM sleep behavior disorder (RBD)
by Aurora, R. Nisha and Zak, Rochelle S and Maganti, Rama K and Auerbach, Sanford H and Casey, Kenneth R and Chowdhuri, Susmita and Karippot, Anoop and Ramar, Kannan and Kristo, David A and Morgenthaler, Timothy I and Tracy, Sharon L and Stand Practice Comm and Standards of Practice Committee and American Academy of Sleep Medicine
Journal of Clinical Sleep Medicine, ISSN 1550-9389, 02/2010, Volume 6, Issue 1, pp. 85 - 95
of Recommendations: Modifying the sleep environment is recommended for the treatment of patients with RBD who have sleep-related injury. Level A Clonazepam is... 
Paroxetine | Melatonin | Desipramine | Benzodiazepine | Clozapine | Clonazepam | Sleep-related injury | Sodium oxybate | Carbamazepine | Pramipexole | REM sleep behavior disorder | Zopiclone | Acetylcholinesterase inhibitor | Synucleinopathy | L-DOPA | Yi-Gan San | synucleinopathy | NEURODEGENERATIVE DISEASE | DEMENTIA | pramipexole | ALZHEIMERS-DISEASE | DOPAMINE TRANSPORTERS | sleep-related injury | desipramine | CLINICAL NEUROLOGY | DELAYED EMERGENCE | sodium oxybate | STATUS DISSOCIATUS | clonazepam | benzodiazepine | PARKINSONS-DISEASE | LEWY-BODY DISEASE | zopiclone | acetylcholinesterase inhibitor | DRUG-TREATMENT | carbamazepine | paroxetine | clozapine | EYE-MOVEMENT SLEEP | melatonin | Clonazepam - administration & dosage | REM Sleep Behavior Disorder - therapy | Central Nervous System Depressants - adverse effects | Humans | Dopamine Agonists - therapeutic use | GABA Modulators - administration & dosage | GABA Modulators - adverse effects | Dopamine Agonists - adverse effects | GABA Modulators - therapeutic use | Melatonin - administration & dosage | REM Sleep Behavior Disorder - drug therapy | Melatonin - adverse effects | Clonazepam - adverse effects | Central Nervous System Depressants - therapeutic use | Central Nervous System Depressants - administration & dosage | Dopamine Agonists - administration & dosage | Melatonin - therapeutic use | Benzothiazoles - therapeutic use | Clonazepam - therapeutic use | Benzothiazoles - adverse effects | REM Sleep Behavior Disorder - diagnosis | Benzothiazoles - administration & dosage | Special
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4. Full Text Human abuse potential of brivaracetam in healthy recreational central nervous system depressant users
by Schoedel, Kerri A and Stockis, Armel and Sellers, Edward M
Epilepsy & Behavior, ISSN 1525-5050, 01/2018, Volume 78, pp. 194 - 201
Brivaracetam is a new antiepileptic drug indicated for adjunctive treatment of focal seizures in adults at a dose of 50–200 mg/day taken in two equal doses.... 
Antiepileptic drug | Alprazolam | Subjective measures | Brivaracetam | Abuse potential | Levetiracetam | SAFETY | PSYCHIATRY | CLINICAL NEUROLOGY | PARTIAL-ONSET SEIZURES | LIABILITY ASSESSMENT | CNS PHARMACODYNAMICS | PHARMACOKINETICS | DOUBLE-BLIND | BEHAVIORAL SCIENCES | PLACEBO-CONTROLLED TRIAL | ADJUNCTIVE BRIVARACETAM | ADVERSE EVENT PROFILE | Hypnotics and Sedatives - adverse effects | Central Nervous System Depressants - adverse effects | Humans | Middle Aged | Hypnotics and Sedatives - administration & dosage | Anticonvulsants - administration & dosage | Male | Anticonvulsants - pharmacology | Levetiracetam - adverse effects | Central Nervous System Depressants - pharmacology | Pyrrolidinones - administration & dosage | Young Adult | Anticonvulsants - adverse effects | Alprazolam - administration & dosage | Drug-Related Side Effects and Adverse Reactions | Pyrrolidinones - pharmacology | Adult | Female | Alprazolam - pharmacology | Pyrrolidinones - adverse effects | Double-Blind Method | Alprazolam - adverse effects | Levetiracetam - administration & dosage | Street Drugs - adverse effects | Cross-Over Studies | Euphoria | Adolescent | Central Nervous System Depressants - administration & dosage | Levetiracetam - pharmacology | Hypnotics and Sedatives - pharmacology | Drug abuse | Anticonvulsants | Seizures (Medicine) | Analysis | Central nervous system
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5. Full Text Same-day use of opioids and other central nervous system depressants amongst people who tamper with pharmaceutical opioids: A retrospective 7-day diary study
by Peacock, Amy and Bruno, Raimondo and Larance, Briony and Lintzeris, Nick and Nielsen, Suzanne and Ali, Robert and Dobbins, Timothy and Degenhardt, Louisa
Drug and Alcohol Dependence, ISSN 0376-8716, 2016, Volume 166, pp. 125 - 133
Highlights • 437 people who tamper with pharmaceutical opioids completed 7-day drug use diary. • Half reported same-day opioid with benzodiazepines/alcohol use... 
Psychiatry | Opioid | Concurrent use | Alcohol | Overdose | Polydrug abuse | Benzodiazepine | UNITED-STATES | RISK-FACTORS | CHRONIC PAIN | PSYCHIATRY | SUBSTANCE ABUSE | BENZODIAZEPINE USE | HEROIN OVERDOSE | ABUSE | BUPRENORPHINE | METHADONE | PRESCRIPTION OPIOIDS | Opioid-Related Disorders - drug therapy | Prospective Studies | Humans | Middle Aged | South Australia - epidemiology | Male | Time Factors | Drug Compounding | Adult | Female | Opiate Substitution Treatment - trends | Retrospective Studies | Prescription Drug Misuse - trends | Alcohol Drinking - prevention & control | Medical Records | Prescription Drug Misuse - prevention & control | Alcohol Drinking - trends | Opioid-Related Disorders - epidemiology | Alcohol Drinking - epidemiology | Analgesics, Opioid - administration & dosage | Central Nervous System Depressants - administration & dosage | Benzodiazepines - administration & dosage | Morphine - administration & dosage | Cohort Studies | New South Wales - epidemiology | Usage | Benzodiazepines | Opioids | Alcoholic beverages | Antianxiety agents
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6. Full Text Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
by Malow, Beth and Adkins, Karen W and McGrew, Susan G and Wang, Lily and Goldman, Suzanne E and Fawkes, Diane and Burnette, Courtney
Journal of Autism and Developmental Disorders, ISSN 0162-3257, 8/2012, Volume 42, Issue 8, pp. 1729 - 1737
Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of... 
Pediatrics | Neurosciences | Child and School Psychology | Melatonin | Child behavior checklist | Autism diagnostic observation schedule | Insomnia | Psychology | Actigraphy | Clinical trial | Public Health/Gesundheitswesen | Children’s sleep habits questionnaire | Children's sleep habits questionnaire | REPETITIVE BEHAVIOR | PSYCHOLOGY, DEVELOPMENTAL | SPECTRUM DISORDERS | VALIDATION | PERVASIVE DEVELOPMENTAL DISORDERS | HABITS QUESTIONNAIRE | INDIVIDUALS | Intervention | Autism | Outcomes of Treatment | Sleep | Drug Therapy | Children | Safety | Symptoms (Individual Disorders) | Sleep Wake Disorders - drug therapy | Central Nervous System Depressants - adverse effects | Humans | Child, Preschool | Male | Treatment Outcome | Sleep Wake Disorders - complications | Sleep - drug effects | Melatonin - administration & dosage | Melatonin - adverse effects | Central Nervous System Depressants - therapeutic use | Central Nervous System Depressants - administration & dosage | Melatonin - therapeutic use | Female | Autistic Disorder - complications | Child | Sleep disorders | Data processing | Neurodevelopmental disorders | Stress | clinical trial | Child Behavior Checklist | actigraphy | Children’s Sleep Habits Questionnaire | melatonin | Autism Diagnostic Observation Schedule | insomnia
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7. Full Text Chronic alcohol produces neuroadaptations to prime dorsal striatal learning
by Lauren DePoy and Rachel Daut and Jonathan L. Brigman and Kathryn MacPherson and Nicole Crowley and Ozge Gunduz-Cinar and Charles L. Pickens and Resat Cinar and Lisa M. Saksida and George Kunos and David M. Lovinger and Timothy J. Bussey and Marguerite C. Camp and Andrew Holmes
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 36, pp. 14783 - 14788
Drug addictions including alcoholism are characterized by degradation of executive control over behavior and increased compulsive drug seeking. These profound... 
Training | Learning | Ethanol | Neurons | Alcoholism | Alcoholic beverages | Discrimination learning | Long term depression | Educational activities | Behavioral neuroscience | Touchscreen | Abuse | Cannabinoid | PFC | Dependence | abuse | cannabinoid | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | touchscreen | SYNAPTIC PLASTICITY | IMPAIRMENT | DISCRIMINATION | DRUG-ADDICTION | STRAIN DIFFERENCES | GENE-EXPRESSION | dependence | INTERMITTENT ETHANOL EXPOSURE | CB1 RECEPTORS | Dendrites - drug effects | Conditioning, Classical - drug effects | Learning - drug effects | Mice, Inbred C57BL | Ethanol - administration & dosage | Neuronal Plasticity - drug effects | Male | Down-Regulation - drug effects | Corpus Striatum - metabolism | Central Nervous System Depressants - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Ethanol - pharmacology | Animals | Prefrontal Cortex - drug effects | Analysis of Variance | Time Factors | Dendrites - physiology | Central Nervous System Depressants - administration & dosage | Corpus Striatum - drug effects | Corpus Striatum - physiology | Mice | In Vitro Techniques | Prefrontal Cortex - physiology | Psychological aspects | Cannabinoids | Cognitive learning | Physiological aspects | Corpus striatum | Research | Biological Sciences
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8. Full Text Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse
by Wang, Jun and Lanfranco, Maria Fe and Gibb, Stuart L and Yowell, Quinn V and Carnicella, Sebastien and Ron, Dorit
Journal of Neuroscience, ISSN 0270-6474, 07/2010, Volume 30, Issue 30, pp. 10187 - 10198
A growing number of studies suggest that the development of compulsive drug seeking and taking depends on dorsostriatal mechanisms. We previously observed that... 
GLUTAMATE RECEPTORS | HABIT FORMATION | TERM POTENTIATION | BASAL GANGLIA | DORSOLATERAL STRIATUM | DORSAL STRIATUM | SURFACE EXPRESSION | D-ASPARTATE RECEPTOR | SYNAPTIC PLASTICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Adaptation, Physiological | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Recurrence | Central Nervous System Depressants - adverse effects | Rats, Long-Evans | Alcohol Drinking - psychology | Receptors, N-Methyl-D-Aspartate - metabolism | Ethanol - administration & dosage | Male | Synaptosomes - metabolism | Corpus Striatum - metabolism | Excitatory Postsynaptic Potentials - drug effects | Behavior, Animal | Ethanol - blood | Self Administration - methods | Conditioning, Operant - drug effects | Piperidines - pharmacology | Ethanol - adverse effects | Phosphorylation - drug effects | Corpus Striatum - pathology | Phenols - pharmacology | Membrane Potentials - drug effects | Sucrose - administration & dosage | Alcohol Drinking - pathology | Choice Behavior | Immunoprecipitation - methods | Rats | Membrane Potentials - physiology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Patch-Clamp Techniques | Alcohol Drinking - blood | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Analysis of Variance | Central Nervous System Depressants - administration & dosage | Corpus Striatum - drug effects | Central Nervous System Depressants - blood | In Vitro Techniques | Sweetening Agents - administration & dosage
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9. Full Text Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
by Alfonso-Loeches, Silvia and Pascual-Lucas, Maya and Blanco, Ana M and Sanchez-Vera, Irene and Guerri, Consuelo
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 24, pp. 8285 - 8295
Toll-like receptors play an important role in the innate immune response, although emerging evidence indicates their role in brain injury and... 
ETHANOL TREATMENT | ALZHEIMERS-DISEASE | IN-VIVO | TOLL-LIKE RECEPTORS | INJURY | NEURODEGENERATION | ENHANCES INFLAMMATORY MEDIATORS | ASTROGLIAL CELLS | ASTROCYTES | NEUROSCIENCES | CELL-DEATH | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Lymphocyte Antigen 96 - metabolism | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Ethanol - administration & dosage | Green Fluorescent Proteins - genetics | Brain Injuries - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - adverse effects | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Ethanol - blood | Time Factors | Toll-Like Receptor 4 - deficiency | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Encephalitis - metabolism | Statistics, Nonparametric | Brain Injuries - blood | Female | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Astrocytes - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Brain Injuries - chemically induced | Encephalitis - pathology | Rats | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Toll-Like Receptor 4 - physiology | Animals | Microfilament Proteins | Central Nervous System Depressants - administration & dosage | Cyclooxygenase 2 - metabolism | Mice | Encephalitis - chemically induced | Central Nervous System Depressants - blood | Brain Injuries - pathology | Encephalitis - blood | Astrocytes - metabolism | Calcium-Binding Proteins - genetics
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10. Full Text Overdose of Drugs for Attention-Deficit Hyperactivity Disorder: Clinical Presentation, Mechanisms of Toxicity, and Management
by Spiller, Henry A and Hays, Hannah L and Aleguas Jr, Alfred
CNS Drugs, ISSN 1172-7047, 7/2013, Volume 27, Issue 7, pp. 531 - 543
The prevalence of attention-deficit hyperactivity disorder (ADHD) in the USA is estimated at approximately 4–9 % in children and 4 % in adults. It is estimated... 
Pharmacotherapy | Neurology | Neurosciences | Medicine & Public Health | Psychiatry | Psychopharmacology | STEADY-STATE PHARMACOKINETICS | HEALTHY ADULT VOLUNTEERS | PSYCHIATRY | OPEN-LABEL | BLOOD-PRESSURE | CLINICAL NEUROLOGY | DEFICIT/HYPERACTIVITY DISORDER | SPONTANEOUSLY HYPERTENSIVE RATS | CLONIDINE OVERDOSE | PHARMACOLOGY & PHARMACY | GUANFACINE OVERDOSE | LISDEXAMFETAMINE DIMESYLATE | PHASE-I | Drug Overdose - therapy | Drug Overdose - diagnosis | Humans | Drug-Related Side Effects and Adverse Reactions - etiology | Attention Deficit Disorder with Hyperactivity - drug therapy | Central Nervous System Stimulants - toxicity | Central Nervous System Stimulants - therapeutic use | Central Nervous System Stimulants - pharmacokinetics | Central Nervous System Depressants - therapeutic use | Central Nervous System Depressants - administration & dosage | Drug Overdose - etiology | Central Nervous System Depressants - pharmacokinetics | Central Nervous System Depressants - toxicity | Central Nervous System Stimulants - administration & dosage | Drug-Related Side Effects and Adverse Reactions - diagnosis | Drug-Related Side Effects and Adverse Reactions - therapy | Attention Deficit Disorder with Hyperactivity - epidemiology | Drugs | Complications and side effects | Care and treatment | Stimulants | Attention-deficit hyperactivity disorder | Overdose | Drug therapy | Health aspects | Attention deficit disorder | Hypertension | Poisons | Cardiac arrhythmia | Plasma | Dopamine | Serotonin | Toxicity | Blood pressure | Drug dosages | Index Medicus
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11. Full Text Treatment outcomes in REM sleep behavior disorder
by McCarter, Stuart J and Boswell, Christopher L and St. Louis, Erik K and Dueffert, Lucas G and Slocumb, Nancy and Boeve, Bradley F and Silber, Michael H and Olson, Eric J and Tippmann-Peikert, Maja
Sleep Medicine, ISSN 1389-9457, 2012, Volume 14, Issue 3, pp. 237 - 242
Abstract Objective REM sleep behavior disorder (RBD) is usually characterized by potentially injurious dream enactment behaviors (DEB). RBD treatment aims to... 
Neurology | Sleep Medicine | Falls | Melatonin | Side effects | Treatment | Parasomnia | Synucleinopathy | Injury | Tolerability | Clonazepam | Retention | REM sleep behavior disorder | NEURODEGENERATIVE DISEASE | DIAGNOSIS | ASSOCIATIONS | MILD COGNITIVE IMPAIRMENT | CLINICAL NEUROLOGY | FEATURES | THERAPY | RBD | RELEVANCE | UPDATE | Clonazepam - administration & dosage | Central Nervous System Depressants - adverse effects | Humans | Middle Aged | GABA Modulators - administration & dosage | REM Sleep Parasomnias - drug therapy | Wounds and Injuries - prevention & control | GABA Modulators - adverse effects | Male | Treatment Outcome | Melatonin - administration & dosage | REM Sleep Behavior Disorder - drug therapy | Melatonin - adverse effects | Clonazepam - adverse effects | Health Surveys | Central Nervous System Depressants - administration & dosage | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Drug Therapy, Combination | Longitudinal Studies | Sleep | Mental illness | Patient outcomes | synucleinopathy | treatment | falls | tolerability | side effects | clonazepam | parasomnia | injury | melatonin | retention
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