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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Cell stem cell, ISSN 1934-5909, 06/2015, Volume 16, Issue 6, pp. 684 - 698
Journal Article
The Journal of cell biology, ISSN 0021-9525, 2013, Volume 202, Issue 5, pp. 779 - 792
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2003, Volume 161, Issue 2, pp. 267 - 280
The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase... 
Mitotic index | Mitosis | Kinetochores | Microtubules | DNA | Cell lines | HeLa cells | Cultured cells | Chromosomes | Cells | Chemical biology | Aneuploidy | Spindle checkpoint | ZM447439 | KINASE-ACTIVITY | LOCALIZATION | BUDDING YEAST | PHOSPHORYLATION | TENSION | mitosis | MAMMALIAN-CELLS | CELL BIOLOGY | chemical biology | CENTROSOME AMPLIFICATION | HISTONE H3 | aneuploidy | spindle checkpoint | Protein Kinases - metabolism | Protein Kinases - genetics | Paclitaxel - pharmacology | DNA Replication - drug effects | Humans | Chromosome Segregation - drug effects | Mitosis - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase B | Spindle Apparatus - genetics | Eukaryotic Cells - ultrastructure | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Benzamides - pharmacology | Mad2 Proteins | Phosphorylation - drug effects | Calcium-Binding Proteins - metabolism | Eukaryotic Cells - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Genes, cdc - drug effects | Aurora Kinases | Tumor Suppressor Protein p53 - drug effects | Anaphase - drug effects | Chromosomal Proteins, Non-Histone - genetics | Anaphase - genetics | Eukaryotic Cells - drug effects | Mitosis - drug effects | DNA Replication - genetics | Repressor Proteins - drug effects | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Quinazolines - pharmacology | Cell Cycle Proteins | Calcium-Binding Proteins - genetics | Chromosome Segregation - genetics | Research | Cytokinesis | Protein kinases | mitosis; spindle checkpoint; chemical biology; aneuploidy; ZM447439
Journal Article
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 06/2003, Volume 63, Issue 12, pp. 3211 - 3220
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 6, p. e100819
Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG) to form core complexes that induce autophagy. While cells with defective autophagy... 
RECOMBINATION | REPAIR | INHIBITION | GENE | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | ATM | AUTOPHAGY | LC3 | CYCLE | Gamma Rays | Apoptosis - drug effects | Apoptosis - radiation effects | Autophagy - radiation effects | Microtubule-Associated Proteins - metabolism | Humans | Centrosome - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Centrosome - radiation effects | Autophagy - drug effects | DNA Breaks, Double-Stranded - radiation effects | Gene Knockdown Techniques | Cell Nucleus - metabolism | DNA Breaks, Double-Stranded - drug effects | Protein Binding - drug effects | Cytoprotection - drug effects | Protein Binding - radiation effects | Membrane Proteins - metabolism | Colorectal Neoplasms - metabolism | Beclin-1 | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Apoptosis Regulatory Proteins - metabolism | Centrosome - metabolism | Autophagy-Related Protein 5 | Cell Line, Tumor | Fluorouracil - pharmacology | DNA Damage | Tumor Suppressor p53-Binding Protein 1 | Cell Nucleus - drug effects | Colorectal Neoplasms - pathology | Cytoprotection - radiation effects | Prevention | Ionizing radiation | DNA damage | DNA | Colorectal cancer | Genetic aspects | Tubulins | Cancer | Homologous recombination | Colorectal carcinoma | Radiation | Irradiated | Homology | Cytotoxicity | Biology | Kinases | Autophagy | DNA repair | Cancer therapies | Genomic instability | Deletion mutant | Proteins | Tubulin | Clonal deletion | Cell cycle | Tumorigenesis | Chromosomes | Deoxyribonucleic acid--DNA | Radiation effects | Stability | U.V. radiation | Tumor cells | Cell division | siRNA | Metabolism | Ultraviolet radiation | Chemotherapy | Cell death | Irradiation | Hypoxia | Radiation damage | Phagocytosis | Tumors | Apoptosis | Deoxyribonucleic acid
Journal Article
Cancer cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 86 - 100
...-catenin signaling to promote BTIC expansion. We further reveal that AZD6244, a clinical trial drug that inhibits RAF1-ERK signaling, could prevent breast cancer progression... 
STEM-CELLS | INSTABILITY | EPITHELIAL-CELLS | ONCOLOGY | GROUP PROTEIN EZH2 | GENE-EXPRESSION | SELF-RENEWAL | HYPOXIC CANCER-CELLS | DNA-REPAIR | IDENTIFICATION | IN-VITRO PROPAGATION | CELL BIOLOGY | Cell Hypoxia - physiology | Gene Expression - genetics | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | DNA Breaks, Double-Stranded | Benzenesulfonates - pharmacology | Neoplastic Stem Cells - metabolism | DNA Damage - genetics | Neoplastic Stem Cells - pathology | Phosphorylation - drug effects | Benzimidazoles - therapeutic use | Rad51 Recombinase - metabolism | Cell Survival - drug effects | Breast Neoplasms - drug therapy | beta Catenin - metabolism | Enhancer of Zeste Homolog 2 Protein | Polycomb Repressive Complex 2 | Centrosome - pathology | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice, Inbred NOD | Breast Neoplasms - diagnosis | Mice | Niacinamide - analogs & derivatives | Gene Expression - drug effects | Phenylurea Compounds | Extracellular Signal-Regulated MAP Kinases - metabolism | Breast Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Female | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - physiology | Cell Survival - physiology | Proto-Oncogene Proteins c-raf - genetics | Rad51 Recombinase - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Proto-Oncogene Proteins c-raf - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Chromosome Aberrations | Signal Transduction - physiology | Transplantation, Heterologous - pathology | Cell Proliferation - drug effects | Pyridines - pharmacology
Journal Article
Cancer Biology & Therapy, ISSN 1555-8576, 2014, Volume 4, Issue 2, pp. 205 - 214
Journal Article
Cancer cell, ISSN 1535-6108, 2007, Volume 12, Issue 6, pp. 514 - 527
Journal Article
eLife, ISSN 2050-084X, 2018, Volume 7
Journal Article