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1. Full Text Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia
by Inaba, Hiroto and Gaur, Aditya H and Cao, Xueyuan and Flynn, Patricia M and Pounds, Stanley B and Avutu, Viswatej and Marszal, Lindsay N and Howard, Scott C and Pui, Ching‐Hon and Ribeiro, Raul C and Hayden, Randall T and Rubnitz, Jeffrey E
Cancer, ISSN 0008-543X, 07/2014, Volume 120, Issue 13, pp. 1985 - 1992
BACKGROUND Intensive chemotherapy for pediatric acute myeloid leukemia incurs the risk of infectious complications, but the benefits of antibiotic prophylaxis... 
infection | acute myeloid leukemia | children | antibiotics | prophylaxis | MORTALITY | PEDIATRIC ONCOLOGY PATIENTS | CANCER | CHEMOTHERAPY | TRIAL | INTENSIVE TREATMENT | THERAPY | ONCOLOGY | BACTERIAL-INFECTION | MINIMAL RESIDUAL DISEASE | EPIDEMIOLOGY | Humans | Chemotherapy-Induced Febrile Neutropenia - prevention & control | Child, Preschool | Infant | Male | Antibiotic Prophylaxis - adverse effects | Candidiasis - diagnosis | Feasibility Studies | Incidence | Outpatients - statistics & numerical data | Bacteremia - microbiology | Young Adult | Anti-Bacterial Agents - therapeutic use | Bacteremia - prevention & control | Leukemia, Myeloid, Acute - drug therapy | Female | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Drug Therapy, Combination | Child | Antibiotic Prophylaxis - utilization | Bacterial Infections - microbiology | Rectum - microbiology | Vancomycin - administration & dosage | Administration, Oral | Leukemia, Myeloid, Acute - pathology | Antibiotic Prophylaxis - methods | Treatment Outcome | Cephalosporins - administration & dosage | Induction Chemotherapy - adverse effects | Bacterial Infections - prevention & control | Ciprofloxacin - administration & dosage | Adolescent | Bacterial Infections - epidemiology | Antibiotic Prophylaxis - trends | Infusions, Intravenous | Nose - microbiology | Consolidation Chemotherapy - adverse effects | Neoplasm Staging | Anti-Bacterial Agents - administration & dosage | Antibacterial agents | Usage | Patient outcomes | Index Medicus | Abridged Index Medicus
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2. Full Text Seizures as adverse events of antibiotic drugs: A systematic review
by Sutter, Raoul and Rüegg, Stephan and Tschudin-Sutter, Sarah
Neurology, ISSN 0028-3878, 10/2015, Volume 85, Issue 15, pp. 1332 - 1341
OBJECTIVE:Antibiotic drugs are commonly associated with seizures. Tailoring antibiotics to the individual risk for seizures is challenged as avoidance of... 
MEROPENEM | VALPROIC ACID LEVELS | GABA(A) RECEPTOR | IMIPENEM-CILASTATIN | METABOLIC-ACIDOSIS | INTENSIVE-CARE-UNIT | PATIENT | DORIPENEM | NONCONVULSIVE STATUS EPILEPTICUS | CLINICAL NEUROLOGY | INTRAVENOUS-INFUSION | Animals | Humans | Central Nervous System - drug effects | Risk | Anti-Bacterial Agents - adverse effects | Anti-Bacterial Agents - administration & dosage | Cephalosporins - adverse effects | Imipenem - adverse effects | Seizures - chemically induced
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3. Full Text Emergency Department Visits for Antibiotic-Associated Adverse Events
by Nadine Shehab and Priti R. Patel and Arjun Srinivasan and Daniel S. Budnitz
Clinical Infectious Diseases, ISSN 1058-4838, 9/2008, Volume 47, Issue 6, pp. 735 - 743
Background. Drug-related adverse events are an underappreciated consequence of antibiotic use, and the national magnitude and scope of these events have not... 
Fluoroquinolones | Prescription drugs | Emergency departments | Antibiotics | Sulfonamides | Articles and Commentaries | Patient care | Health care statistics | Adverse effects | Drug prescriptions | Allergies | UNITED-STATES | DRUG-REACTIONS | INFECTIOUS DISEASES | OLDER-ADULTS | PREVENTION | MICROBIOLOGY | IMMUNOLOGY | ANTIMICROBIAL RESISTANCE | GENERAL-PRACTITIONERS | SURVEILLANCE | ENDOCARDITIS | SORE THROAT | RESPIRATORY-TRACT INFECTIONS | United States - epidemiology | Adverse Drug Reaction Reporting Systems | Drug Hypersensitivity - epidemiology | Humans | Penicillins - adverse effects | Anti-Bacterial Agents - adverse effects | Emergency Service, Hospital - utilization | Cephalosporins - adverse effects | Drugs | Complications and side effects | Care and treatment | Emergency service | Usage | Hospitals | Adverse and side effects | Research | Risk factors | Index Medicus
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4. Full Text Drug allergy
by Khan, David A., MD and Solensky, Roland, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2010, Volume 125, Issue 2, pp. S126 - S137.e1
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical... 
Allergy and Immunology | penicillin | graded challenge | angiotensin-converting enzyme inhibitors | radiocontrast media | cephalosporin | desensitization | Drug allergy | biologic modifiers | adverse drug reactions | carbapenem | local anesthetic | sulfonamide | drug hypersensitivity | tolerance | nonsteroidal anti-inflammatory drug | HOSPITALIZED-PATIENTS | CONVERTING ENZYME-INHIBITORS | IMMUNOLOGY | ANGIOTENSIN RECEPTOR BLOCKERS | ALLERGY | CROSS-REACTIVITY | PENICILLIN ALLERGY | IGE-MEDIATED HYPERSENSITIVITY | ADVERSE-REACTIONS | IODINATED CONTRAST-MEDIA | IMMEDIATE HYPERSENSITIVITY | BETA-LACTAM ANTIBIOTICS | Medical History Taking | Anti-HIV Agents - adverse effects | Humans | Drug Hypersensitivity - therapy | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Contrast Media - adverse effects | Antineoplastic Agents - adverse effects | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Drug Hypersensitivity - diagnosis | beta-Lactams - adverse effects | Drug-Related Side Effects and Adverse Reactions - physiopathology | Drug Hypersensitivity - physiopathology | Drug-Related Side Effects and Adverse Reactions - diagnosis | Drug-Related Side Effects and Adverse Reactions - therapy | Lupus | Allergy | Enzymes | Aspirin | Sulfonamides | Beta lactam antibiotics | Respiratory tract diseases | Salicylates | Drug therapy | Anesthetics | Allergic reaction | Nonsteroidal anti-inflammatory drugs | Drug dosages | Patients | Management decisions | Allergies | Penicillin
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5. Full Text Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance A Randomized Clinical Trial
by Harris, PNA and Tambyah, PA and Lye, DC and Mo, Y and Lee, TH and Yilmaz, M and Alenazi, TH and Arabi, Y and Falcone, M and Bassetti, M and Righi, E and Rogers, BA and Kanj, S and Bhally, H and Iredell, J and Mendelson, M and Boyles, TH and Looke, D and Miyakis, S and Walls, G and Al Khamis, M and Zikri, A and Crowe, A and Ingram, P and Daneman, N and Griffin, P and Athan, E and Lorenc, P and Baker, P and Roberts, L and Beatson, SA and Peleg, AY and Harris-Brown, T and Paterson, DL and Merino Trial Investigators and Australasian Soc Infect Dis Clinic and MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN) and for the MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN)
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 09/2018, Volume 320, Issue 10, pp. 984 - 994
IMPORTANCE Extended-spectrum beta-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella... 
UNITED-STATES | MEDICINE, GENERAL & INTERNAL | EXTENDED-SPECTRUM | CEFEPIME | THERAPY | BACTEREMIA | LACTAMASE-PRODUCING ENTEROBACTERIACEAE | SPECTRUM BETA-LACTAMASES | EXTENSION | Escherichia coli Infections - mortality | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Humans | Middle Aged | Drug Resistance, Bacterial | Bacteremia - mortality | Ceftriaxone - pharmacology | Male | Cause of Death | Anti-Bacterial Agents - therapeutic use | Penicillanic Acid - therapeutic use | Adult | Female | Anti-Bacterial Agents - adverse effects | Meropenem | Penicillanic Acid - adverse effects | Thienamycins - adverse effects | Penicillanic Acid - analogs & derivatives | Thienamycins - therapeutic use | Escherichia coli Infections - drug therapy | Klebsiella Infections - drug therapy | Piperacillin, Tazobactam Drug Combination | Bacteremia - drug therapy | Piperacillin - adverse effects | Klebsiella Infections - mortality | Aged | Anti-Bacterial Agents - pharmacology | Piperacillin - therapeutic use | Klebsiella | Treatment outcome | Safety and security measures | Tazobactam | Escherichia coli | Patient outcomes | Analysis | Comparative analysis | Risk factors | Bacterial infections | Intravenous administration | Mortality | Clinical trials | Piperacillin-tazobactam | Infections | Ceftriaxone | Drug resistance | Patients | Side effects | Randomization | Cephalosporins | E coli | Piperacillin | Drug therapy | Blood diseases | Blood culture | Carbapenems | Original Investigation | Research
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6. Full Text Severe Cutaneous Adverse Reactions Related to Systemic Antibiotics
by Lin, Ying-Fang and Yang, Chih-Hsun and Sindy, Hu and Lin, Jing-Yi and Rosaline Hui, Chung-Yee and Tsai, Yun-Chen and Wu, Ting-Shu and Huang, Ching-Tai and Kao, Kuo-Chin and Hu, Han-Chung and Chiu, Cheng-Hsun and Hung, Shuen-Iu and Chung, Wen-Hung
Clinical Infectious Diseases, ISSN 1058-4838, 05/2014, Volume 58, Issue 10, pp. 1377 - 1385
Severe cutaneous adverse reactions (SCARs) are mostly induced by a variety of drugs and are life-threatening. Systemic antibiotics are a major cause of SCARs.... 
Systemic antibiotics | SCARs | ERYTHEMA MULTIFORME | PENICILLINS | INFECTIOUS DISEASES | MICROBIOLOGY | IGE-MEDIATED HYPERSENSITIVITY | IMMUNOLOGY | TOXIC EPIDERMAL NECROLYSIS | IMMEDIATE HYPERSENSITIVITY | VANCOMYCIN | TEICOPLANIN | systemic antibiotics | CROSS-REACTIVITY | BETA-LACTAM ANTIBIOTICS | STEVENS-JOHNSON-SYNDROME | Drug Eruptions - etiology | Humans | Middle Aged | Stevens-Johnson Syndrome - etiology | Drug Eruptions - therapy | Male | Glycopeptides - adverse effects | Eosinophilia | Carbapenems - adverse effects | Drug Eruptions - mortality | Quinolones - adverse effects | Acute Generalized Exanthematous Pustulosis - etiology | Quinolones - therapeutic use | Taiwan | Aged, 80 and over | Penicillins - adverse effects | Adult | Female | Aged | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Cephalosporins - adverse effects | Stevens-Johnson syndrome | Usage | Care and treatment | Diagnosis | Antibiotics | Index Medicus
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7. Full Text Antibiotic-associated encephalopathy
by Bhattacharyya, Shamik and Darby, R Ryan and Raibagkar, Pooja and Gonzalez Castro, L Nicolas and Berkowitz, Aaron L
Neurology, ISSN 0028-3878, 03/2016, Volume 86, Issue 10, pp. 963 - 971
Delirium is a common and costly complication of hospitalization. Although medications are a known cause of delirium, antibiotics are an underrecognized class... 
MECHANICALLY VENTILATED PATIENTS | DELIRIUM | INTENSIVE-CARE-UNIT | FLUOROQUINOLONES | BETA-LACTAM ANTIBIOTICS | CENTRAL-NERVOUS-SYSTEM | INTRAVENOUS PROCAINE | MECHANISMS | NEUROTOXICITY | CLINICAL NEUROLOGY | PENICILLIN | Brain Diseases - epidemiology | Brain Diseases - diagnosis | Humans | Middle Aged | Metronidazole - adverse effects | Penicillins - adverse effects | Female | Male | Anti-Bacterial Agents - adverse effects | Brain Diseases - chemically induced | Cephalosporins - adverse effects
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8. Full Text Risk of acute kidney injury in patients on concomitant vancomycin and piperacillin-tazobactam compared to those on vancomycin and cefepime
by Navalkele, Bhagyashri and Pogue, Jason M and Karino, Shigehiko and Nishan, Bakht and Salim, Madiha and Solanki, Shantanu and Pervaiz, Amina and Tashtoush, Nader and Shaikh, Hamadullah and Koppula, Sunitha and Koons, Jonathan and Hussain, Tanveer and Perry, William and Evans, Richard and Martin, Emily T and Mynatt, Ryan P and Murray, Kyle P and Rybak, Michael J and Kaye, Keith S
Clinical Infectious Diseases, ISSN 1058-4838, 2017, Volume 64, Issue 2, pp. 116 - 123
Background. Recent evidence suggests that among patients receiving vancomycin, receipt of concomitant piperacillin-tazobactam increases the risk of... 
Piperacillin-tazobactam | Vancomycin | Cefepime | Nephrotoxicity | Acute kidney injury | INFECTIOUS DISEASES | nephrotoxicity | GUIDELINES | vancomycin | cefepime | MICROBIOLOGY | acute kidney injury | ACUTE-RENAL-FAILURE | IMMUNOLOGY | piperacillin-tazobactam | Prognosis | Humans | Middle Aged | Male | Risk | Cephalosporins - therapeutic use | Anti-Bacterial Agents - therapeutic use | Adult | Female | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Drug Therapy, Combination | Odds Ratio | Penicillanic Acid - adverse effects | Acute Kidney Injury - etiology | Penicillanic Acid - analogs & derivatives | Cephalosporins - adverse effects | Length of Stay | Severity of Illness Index | Piperacillin, Tazobactam Drug Combination | Combined Modality Therapy | Piperacillin - adverse effects | Vancomycin - adverse effects | Vancomycin - therapeutic use | Acute Kidney Injury - diagnosis | Acute Kidney Injury - therapy | Aged | Acute Kidney Injury - epidemiology | Index Medicus
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9. Full Text Acquired factor V inhibitor after antibiotic treatment in a patient with pneumonia: a case report
by Taniwaki, Masaya and Katsutani, Shinya and Yamasaki, Masahiro and Kawamoto, Kazuma and Funaishi, Kunihiko and Matsumoto, Yu and Matsumoto, Naoko and Ohashi, Nobuyuki and Hattori, Noboru
Annals of Hematology, ISSN 0939-5555, 8/2019, Volume 98, Issue 8, pp. 1989 - 1990
Medicine & Public Health | Hematology | Oncology | HEMATOLOGY | Factor V Deficiency - chemically induced | Antibody Specificity | Antifungal Agents - adverse effects | Ciprofloxacin - adverse effects | Humans | Prothrombin Time | Male | Meropenem - adverse effects | Fluoroquinolones - adverse effects | Factor V - immunology | Micafungin - adverse effects | Autoantibodies - immunology | Pneumonia - drug therapy | Ceftriaxone - adverse effects | Partial Thromboplastin Time | Aged | Anti-Bacterial Agents - adverse effects | Autoimmune Diseases - chemically induced | Drug Substitution | Drug Therapy, Combination | Anti-Bacterial Agents - administration & dosage | Antifungal Agents - administration & dosage | Cephalosporins - adverse effects | Levofloxacin - adverse effects | Antibiotics
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10. Full Text Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
by Wagenlehner, Florian M, Dr Prof and Umeh, Obiamiwe, MD and Steenbergen, Judith, PhD and Yuan, Guojun, PhD and Darouiche, Rabih O, Prof
Lancet, The, ISSN 0140-6736, 2015, Volume 385, Issue 9981, pp. 1949 - 1956
Summary Background Treatment of complicated urinary-tract infections is challenging due to rising antimicrobial resistance. We assessed the efficacy and safety... 
Internal Medicine | UNITED-STATES | INTRAVENOUS DORIPENEM | MEDICINE, GENERAL & INTERNAL | MULTICENTER | GRAM-NEGATIVE BACILLI | RESISTANCE PATTERNS | ESCHERICHIA-COLI | PREVENTION | PREVALENCE | CIPROFLOXACIN | TRIMETHOPRIM-SULFAMETHOXAZOLE | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Anti-Infective Agents, Urinary - administration & dosage | Gram-Negative Bacterial Infections - drug therapy | Male | Treatment Outcome | Cephalosporins - administration & dosage | Urinary Tract Infections - drug therapy | Young Adult | Anti-Infective Agents, Urinary - adverse effects | Adult | Female | Aged | Infusions, Intravenous | Pyelonephritis - drug therapy | Gram-Positive Bacterial Infections - drug therapy | Penicillanic Acid - adverse effects | Levofloxacin - administration & dosage | Penicillanic Acid - analogs & derivatives | Cephalosporins - adverse effects | Levofloxacin - adverse effects | Penicillanic Acid - administration & dosage | Levofloxacin | Care and treatment | Pyelonephritis | Clinical trials | Urinary tract infections | Comparative analysis | Health aspects | Urine | Antibiotics | Antimicrobial agents | Infections | Drug therapy | Drug resistance | Drug dosages | Urogenital system
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11. Full Text Nephrotoxicity during vancomycin therapy in combination with piperacillin-tazobactam or cefepime
by Rutter, W. Cliff and Cox, Jessica N and Martin, Craig A and Burgess, Donna R and Burgess, David S
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2017, Volume 61, Issue 2, p. AAC.02089-16
Recent reports have demonstrated that vancomycin (VAN) may lead to an increase in the incidence of acute kidney injury (AKI) when it is combined with... 
Piperacillin-tazobactam | Adverse drug effects | Vancomycin | Cefepime | Beta-lactams | Nephrotoxicity | ACUTE KIDNEY INJURY | beta-lactams | nephrotoxicity | adverse drug effects | STAPHYLOCOCCUS-AUREUS INFECTIONS | cefepime | vancomycin | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ACUTE-RENAL-FAILURE | piperacillin-tazobactam | Multivariate Analysis | Kidney - drug effects | Humans | Middle Aged | Male | Cephalosporins - therapeutic use | Piperacillin - adverse effects | Vancomycin - adverse effects | Anti-Bacterial Agents - therapeutic use | Vancomycin - therapeutic use | Penicillanic Acid - therapeutic use | Adult | Female | Acute Kidney Injury - chemically induced | Aged | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Penicillanic Acid - adverse effects | Penicillanic Acid - analogs & derivatives | Cephalosporins - adverse effects | Piperacillin - therapeutic use | Index Medicus
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12. Full Text Adverse reactions associated with oral and parenteral use of cephalosporins: A retrospective population-based analysis
by Macy, Eric, MS, MD and Contreras, Richard, MS
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 3, pp. 745 - 752.e5
Background Few studies have provided population-based, route-specific data on allergy to cephalosporin or incidence of serious adverse drug reactions (ADRs).... 
Allergy and Immunology | Stevens-Johnson syndrome | death | Clostridium difficile | allergy | Adverse drug reaction | outpatient | serious cutaneous adverse reaction | cephalosporin | hospitalized | parenteral | nephropathy | oral | hemolytic anemia | SAFETY | PENICILLIN ALLERGY | PREVALENCE | IMMUNOLOGY | ANAPHYLAXIS | HYPERSENSITIVITY | Drug Hypersensitivity - etiology | Nephritis - physiopathology | Administration, Oral | Humans | Middle Aged | Infusions, Parenteral | Male | Enterocolitis, Pseudomembranous - microbiology | California | Enterocolitis, Pseudomembranous - chemically induced | Clostridium difficile - physiology | Drug Hypersensitivity - immunology | State Health Plans | Adolescent | Adult | Enterocolitis, Pseudomembranous - physiopathology | Female | Nephritis - chemically induced | Anti-Bacterial Agents - adverse effects | Retrospective Studies | Drug Hypersensitivity - physiopathology | Cephalosporins - adverse effects | Health maintenance organizations | Moxalactam | Complications and side effects | Usage | Cephalosporins | Analysis | Cephaloridine | Health care | Infections | Hospitals | Antibiotics | Allergies | Penicillin
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