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1. Full Text Carbohydrate CuAAC click chemistry for therapy and diagnosis
by He, Xiao-Peng and Zeng, Ya-Li and Zang, Yi and Li, Jia and Field, Robert A and Chen, Guo-Rong
Carbohydrate Research, ISSN 0008-6215, 06/2016, Volume 429, pp. 1 - 22
We summarize the impressive progress since 2010 made in CuAAC-based carbohydrate click chemistry for therapy and diagnosis. Carbohydrates are important as... 
Therapy | Carbohydrate | Click chemistry | Diagnosis | CuAAC | GLYCOGEN-PHOSPHORYLASE INHIBITORS | GALACTOSYL CERAMIDE ANALOGS | AZIDE-ALKYNE CYCLOADDITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | TRIAZOLE-LINKED GLYCOLIPIDS | AERUGINOSA LECTIN LECA | TYROSINE-PHOSPHATASE INHIBITORS | ESCHERICHIA-COLI ADHESION | N-SUBSTITUTED AMINOCYCLITOLS | RING-OPENING POLYMERIZATION | CHEMISTRY, APPLIED | AGGREGATION-INDUCED-EMISSION | Carbohydrates - therapeutic use | Neoplasms - metabolism | Chemistry, Pharmaceutical - methods | Signal Transduction | Antineoplastic Agents - chemical synthesis | Humans | Imino Sugars - therapeutic use | Anti-Infective Agents - therapeutic use | Click Chemistry - methods | Alkynes - chemistry | Antineoplastic Agents - therapeutic use | Glycosylation | Neoplasms - diagnosis | Carbohydrates - chemical synthesis | Azides - chemistry | Cycloaddition Reaction | Anti-Infective Agents - chemical synthesis | Neoplasms - drug therapy | Triazoles - chemical synthesis | Catalysis | Imino Sugars - chemical synthesis | Chemistry, Pharmaceutical - trends | Click Chemistry - trends | Triazoles - therapeutic use | Memory (Computers) | Fine chemicals | Research institutes
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2. Full Text Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines Using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry
by Castro-Perez, J and Roddy, T.P and Nibbering, N.M.M and Shah, V and McLaren, D.G and Previs, S and Attygalle, A.B and Herath, K and Chen, Z and Wang, S.P and Mitnaul, L and Hubbard, B.K and Vreeken, R.J and Johns, D.G and Hankemeier, Th
Journal of the American Society for Mass Spectrometry, ISSN 1044-0305, 2011, Volume 22, Issue 9, pp. 1552 - 1567
A high content molecular fragmentation for the analysis of phosphatidylcholines (PC) was achieved utilizing a two-stage [trap (first generation fragmentation)... 
Biotechnology | Fatty acids | Chemistry | Analytical Chemistry | Ion mobility | Proteomics | CID fragmentation | Bioinformatics | Mass spectrometry | Time-of-flight | Double bond position | Organic Chemistry | Phosholipids | ELUCIDATION | CHEMISTRY, ANALYTICAL | FAST-ATOM-BOMBARDMENT | COMPLEX | ACIDS | BIOLOGICAL SAMPLES | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, PHYSICAL | PHOSPHOLIPIDS | LITHIATED ADDUCTS | SPECTROSCOPY | INDUCED DISSOCIATION | ELECTROSPRAY-IONIZATION | LIPIDS | Ions - chemistry | Molecular Weight | Phosphatidylcholines - blood | Mice, Inbred C57BL | Phospholipids - chemistry | Ceramides - blood | Male | Ceramides - chemistry | Phosphatidylcholines - chemistry | Animals | Spectrometry, Mass, Electrospray Ionization - methods | Sphingomyelins - blood | Water - chemistry | Phospholipids - blood | Sphingomyelins - chemistry | Mice | Molecular Structure | Spectroscopy | Water loss | Alkali metals | Choline | Ionic mobility | Hydrocarbons | Chemical bonds | Ions | Scientific imaging | Carbonyls | Fragmentation
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3. Full Text Fibrillar amyloid-β peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase: Implications for Alzheimer's disease
by Jana, Arundhati and Pahan, Kalipada
Journal of Biological Chemistry, ISSN 0021-9258, 12/2004, Volume 279, Issue 49, pp. 51451 - 51459
Alzheimer's disease is a major illness of dementia characterized by the presence of amyloid plaques, neurofibrillary tangles, and extensive neuronal apoptosis.... 
APOPTOSIS | ADOPTIVE TRANSFER | CHOLESTEROL | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | PRECURSOR-PROTEIN | ASTROCYTES | CERAMIDE PRODUCTION | TRANSGENIC MICE | CELL-DEATH | Reactive Oxygen Species | NADPH Dehydrogenase - metabolism | Humans | NADPH Oxidases - metabolism | Hypoxanthine - chemistry | Phosphoproteins - metabolism | Oxygen - metabolism | Xanthine Oxidase - chemistry | Hydrogen Peroxide - chemistry | Peptide Fragments - physiology | Lipids - chemistry | Time Factors | Sphingomyelin Phosphodiesterase - metabolism | Membrane Transport Proteins - metabolism | Neurons - metabolism | In Situ Nick-End Labeling | Amyloid beta-Peptides - physiology | Ceramides - metabolism | Oxidation-Reduction | Peptides - chemistry | Cell Survival | Diacylglycerol Kinase - metabolism | Cells, Cultured | Hydrogen Peroxide - pharmacology | Oligonucleotides, Antisense - chemistry | Superoxides - chemistry | Ceramides - chemistry | DNA - chemistry | Peptide Fragments - chemistry | Alzheimer Disease - metabolism | Amyloid beta-Peptides - chemistry | Enzyme Activation | Apoptosis
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4. Full Text Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: Impact on mitochondrial S-adenosyl-L-methionine and glutathione
by Caballero, Francisco and Fernández, Anna and Matías, Nuria and Martínez, Laura and Fucho, Raquel and Elena, Montserrat and Caballeria, Joan and Morales, Albert and Fernández-Checa, José C and García-Ruiz, Carmen
Journal of Biological Chemistry, ISSN 0021-9258, 06/2010, Volume 285, Issue 24, pp. 18528 - 18536
The pathogenesis and treatment of nonalcoholic steatohepatitis (NASH) are not well established. Feeding a diet deficient in both methionine and choline (MCD)... 
ISCHEMIA-REPERFUSION INJURY | DEFICIENT DIET | RAT HEPATOCYTES | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | DISEASE | FREE-CHOLESTEROL | MICE | MODEL | PHOSPHATIDYLCHOLINE | Fatty Liver - metabolism | Sphingomyelin Phosphodiesterase - chemistry | Mice, Inbred C57BL | Male | Ceramides - chemistry | Inflammation | Mitochondria - metabolism | Prodrugs - chemistry | S-Adenosylmethionine - chemistry | Choline - chemistry | Lipids - chemistry | Animals | Methionine - chemistry | Glutathione - chemistry | Mice | Animal Feed
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5. Full Text Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide
by Xu, Xiaolian and Bittman, Robert and Duportail, Guy and Heissler, Denis and Vilcheze, Catherine and London, Erwin
Journal of Biological Chemistry, ISSN 0021-9258, 09/2001, Volume 276, Issue 36, pp. 33540 - 33546
Ordered lipid domains enriched in sphingolipids and cholesterol (lipid rafts) have been implicated in numerous functions in biological membranes. We recently... 
Cerebrosides - chemistry | Sphingolipids - chemistry | Temperature | Models, Chemical | Sterols - chemistry | Humans | Membrane Microdomains - chemistry | Spectrometry, Fluorescence | Yeasts - chemistry | Ceramides - chemistry | Cholesterol - chemistry | Dose-Response Relationship, Drug | Sphingomyelins - chemistry | 1,2-Dipalmitoylphosphatidylcholine - pharmacology | Plants - chemistry
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6. Full Text Alcyonacea: A potential source for production of nitrogen-containing metabolites
by Alarif, Walied Mohamed and Abdel-Lateff, Ahmed and Alorfi, Hajer Saeed and Alburae, Najla Ali
Molecules, ISSN 1420-3049, 01/2019, Volume 24, Issue 2, p. 286
Alcyonacea (soft corals and gorgonia) are well known for their production of a wide array of unprecedented architecture of bioactive metabolites. This... 
Diterpenes | Cytotoxicity | Sesquiterpenes | Alcyonacea | Antitumor | TETRAPRENYLATED ALKALOIDS | BIOACTIVE COMPOUNDS | antitumor | BIOCHEMISTRY & MOLECULAR BIOLOGY | diterpenes | CHEMISTRY, MULTIDISCIPLINARY | INDONESIAN SOFT CORAL | SESQUITERPENOIDS | MARINE NATURAL-PRODUCTS | A-F | DERIVATIVES | cytotoxicity | ERYTHROPODIUM-CARIBAEORUM | sesquiterpenes | SARCODICTYIN | Cerebrosides - chemistry | Metabolome | Anthozoa - metabolism | Ceramides - chemistry | Anthozoa - chemistry | Metabolomics - methods | Terpenes - chemistry | Tubulin - metabolism | Animals | Nitrogen - chemistry | Protein Binding | Molecular Structure | Alkaloids - chemistry | Diterpenes - chemistry
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7. Full Text Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes
by Paz Ramos, Adrian and Lafleur, Michel
Langmuir, ISSN 0743-7463, 10/2015, Volume 31, Issue 42, pp. 11621 - 11629
The skin, the largest organ of the human body, forms a flexible interface between our internal and external environment that protects our organism from... 
MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | X-RAY-DIFFRACTION | DIFFERENTIAL SCANNING CALORIMETRY | SKIN BARRIER FUNCTION | INTERCELLULAR MEMBRANES | CHEMISTRY, MULTIDISCIPLINARY | LIPID ORGANIZATION | PALMITIC ACID/CHOLESTEROL SYSTEM | ATOPIC ECZEMA PATIENTS | TRANSFORM INFRARED-SPECTROSCOPY | H-2 NMR | PERMEABILITY BARRIER | Cholesterol - chemistry | Skin - chemistry | Animals | Fatty Acids - chemistry | Humans | Fatty Acids, Nonesterified - chemistry | Ceramides - chemistry | Membrane Lipids - chemistry | Palmitic Acid - chemistry | Epidermis - chemistry
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8. Full Text Accumulation of long-chain bases in yeast promotes their conversion to a long-chain base vinyl ether
by Martinez-Montanes, Fernando and Lone, Museer A and Hsu, Fong-Fu and Schneiter, Roger
Journal of Lipid Research, ISSN 0022-2275, 2016, Volume 57, Issue 11, pp. 2040 - 2050
Long-chain bases (LCBs) are the precursors to ceramide and sphingolipids in eukaryotic cells. They are formed by the action of serine palmitoyl-CoA transferase... 
Ceramide | Sphingolipids | Mass spectrometry | Saccharomyces cerevisiae | FATTY-ACID ELONGATION | sphingolipids | CERAMIDE SYNTHESIS | KEY REGULATOR | BUDDING YEAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | TANDEM MASS-SPECTROMETRY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | ceramide | ACETYL-COENZYME | mass spectrometry | ENDOPLASMIC-RETICULUM | SPHINGOLIPID HOMEOSTASIS | Acetyl Coenzyme A - chemistry | Serine C-Palmitoyltransferase - chemistry | Sphingolipids - chemistry | Vinyl Compounds - chemistry | Ceramides - metabolism | Phosphates - chemistry | Endoplasmic Reticulum - metabolism | Sphingolipids - metabolism | Ceramides - chemistry | Serine C-Palmitoyltransferase - metabolism | Saccharomyces cerevisiae - chemistry | Saccharomyces cerevisiae - metabolism | Endoplasmic Reticulum - chemistry | Phosphates - metabolism | Sphingosine - analogs & derivatives | Acetyl Coenzyme A - biosynthesis | Saccharomyces cerevisiae Proteins - metabolism | Sphingosine - metabolism | Vinyl Compounds - metabolism | Sphingosine - chemistry | Saccharomyces cerevisiae Proteins - chemistry
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9. Full Text Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel
by Cho, Hyun-Jong and Yoon, Hong Yeol and Koo, Heebeom and Ko, Seung-Hak and Shim, Jae-Seong and Lee, Ju-Hee and Kim, Kwangmeyung and Chan Kwon, Ick and Kim, Dae-Duk
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 29, pp. 7181 - 7190
Abstract Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for intravenous docetaxel (DCT) delivery. In this study,... 
Advanced Basic Science | Dentistry | Hyaluronic acid-ceramide | Nanoparticle | CD44 | Poloxamer | Docetaxel | GOLD NANOPARTICLES | THERAPEUTICS | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | INTRACELLULAR DRUG-DELIVERY | ANTITUMOR-ACTIVITY | IN-VITRO | PHARMACOKINETICS | TISSUE DISTRIBUTION | LIPID EMULSION | COPOLYMER MICELLES | MDR CANCER-CELLS | Taxoids - chemistry | Taxoids - pharmacology | Nanoparticles - chemistry | Hyaluronic Acid - chemistry | Materials Testing | Antineoplastic Agents - therapeutic use | Cell Line, Tumor - drug effects | Ceramides - chemistry | Taxoids - metabolism | Antineoplastic Agents - chemistry | Drug Carriers - chemistry | Drug Delivery Systems | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Taxoids - therapeutic use | Animals | Antineoplastic Agents - pharmacology | Mice | Molecular Structure | Poloxalene - chemistry
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10. Full Text Enamides and enecarbamates as nucleophiles in stereoselective C-C and C-N bond-forming reactions
by Matsubara, Ryosuke and Kobayashi, Shu
Accounts of Chemical Research, ISSN 0001-4842, 02/2008, Volume 41, Issue 2, pp. 292 - 301
Because the backbone of most of organic compounds is a carbon chain, carbon-carbon bond-forming reactions are among the most important reactions in organic... 
ALPHA-AMINO | ASYMMETRIC MICHAEL-ADDITION | MANNICH-TYPE REACTIONS | AMINO-ACID DERIVATIVES | ALDOL REACTIONS | ENANTIOSELECTIVE ADDITION | DIASTEREOSELECTIVE ADDITION | CERAMIDE TRAFFICKING | CHEMISTRY, MULTIDISCIPLINARY | CHIRAL IMINES | BIS(OXAZOLINE) COPPER(II) COMPLEXES | Biological Products - chemistry | Nitrogen - chemistry | Glyoxylates - chemistry | Stereoisomerism | Amides - chemistry | Molecular Structure | Carbamates - chemistry | Carbon - chemistry | Aldehydes - chemistry | Analysis | Amides | Lewis structures | Nuclear magnetic resonance spectroscopy | Spectra | Chemical properties | Research | Structure
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11. Full Text How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's β amyloid peptide (Aβ1-40)
by Yahi, Nouara and Aulas, Anaïs and Fantini, Jacques
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9079
Membrane lipids play a pivotal role in the pathogenesis of Alzheimer's disease, which is associated with conformational changes, oligomerization and/or... 
FORM | SPHINGOLIPID-BINDING DOMAIN | DISEASE | BIOLOGY | MEMBRANES | CEREBROSIDE | GM1 | PRECURSOR PROTEIN | LIPID MONOLAYERS | FIBRILLOGENESIS | HELICOBACTER-PYLORI | Sodium Chloride - pharmacology | Humans | Molecular Conformation | Crystallography, X-Ray | G(M3) Ganglioside - chemistry | Cholesterol - chemistry | Protein Binding - drug effects | Surface Properties | Amyloid beta-Peptides - metabolism | Glycolipids - chemistry | G(M1) Ganglioside - chemistry | G(M3) Ganglioside - metabolism | Molecular Structure | Fatty Acids - metabolism | Peptide Fragments - metabolism | Fatty Acids - chemistry | Models, Molecular | Cholesterol - metabolism | Glycolipids - metabolism | Molecular Dynamics Simulation | Peptide Fragments - chemistry | Alzheimer Disease - metabolism | Glycosphingolipids - metabolism | Amyloid beta-Peptides - chemistry | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | G(M1) Ganglioside - metabolism | Glycosphingolipids - chemistry | Peptides | Pathogenesis | Molecular dynamics | Lipids | Biochemistry | Crystallography | Cell surface | Proteins | Human immunodeficiency virus--HIV | Ceramide | Inhibition | Alzheimer's disease | Sugar | Antigens | Oligomerization | Neurodegenerative diseases | Fatty acids | Cholesterol | Dilution | Molecular modelling | Glycosphingolipids | Monolayers | β-Amyloid | Lymphomas | Alzheimers disease | Conformation | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | HIV | Human immunodeficiency virus
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12. Full Text Lipid Classes and Fatty Acid Composition of the Tropical Nudibranch Mollusks Chromodoris sp. and Phyllidia coelestis
by Zhukova, Natalia V
Lipids, ISSN 0024-4201, 12/2007, Volume 42, Issue 12, pp. 1169 - 1175
Two nudibranch mollusks, Chromodoris sp. and Phyllidia coelestis, collected from tropical waters of the Northwestern Pacific, were analyzed for lipids. The aim... 
Biochemistry, general | Very long chain fatty acids | Nudibranchia | Nutrition | Mollusk | Medical Biochemistry | Lipids | Phospholipids | Non-methylene-interrupted fatty acid | Fatty acids | Bioorganic Chemistry | Phyllidia coelestis | Life Sciences | Medicinal Chemistry | Sea slugs | Microbial Genetics and Genomics | Chromodoris | Non‐methylene‐interrupted fatty acid | lipids | GASTROPODA | fatty acids | sea slugs | non-methylene-interrupted fatty acid | very long chain fatty acids | METHYLENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | OPISTHOBRANCH MOLLUSKS | phospholipids | SEA | NUTRITION & DIETETICS | BIOSYNTHESIS | ECOLOGY | MARINE | mollusk | nudibranchia | Gas Chromatography-Mass Spectrometry | Sterols - analysis | Phospholipids - analysis | Chromatography, Thin Layer | Mollusca - chemistry | Lipids - chemistry | Aminoethylphosphonic Acid - analogs & derivatives | Fatty Acids, Unsaturated - analysis | Phosphatidylcholines - analysis | Aminoethylphosphonic Acid - analysis | Aminoethylphosphonic Acid - chemistry | Fatty Acids - chemistry | Phosphatidylethanolamines - analysis | Sterols - chemistry | Phosphatidylserines - chemistry | Fatty Acids - analysis | Phospholipids - chemistry | Ceramides - analysis | Ceramides - chemistry | Phosphatidylcholines - chemistry | Phosphatidylserines - analysis | Animals | Fatty Acids, Unsaturated - chemistry | Lipids - analysis | Phosphatidylethanolamines - chemistry | Measurement | Nudibranchiata | Health aspects | Analysis
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13. Full Text Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells
by Legros, Nadine and Dusny, Stefanie and Humpf, Hans-Ulrich and Pohlentz, Gottfried and Karch, Helge and Müthing, Johannes
Glycobiology, ISSN 0959-6658, 2017, Volume 27, Issue 1, pp. 99 - 109
Shiga toxin (Stx)-mediated injury to microvascular endothelial cells in the brain significantly contributes to the pathogenesis of the hemolytic-uremic... 
Lyso-phosphatidylcholine | Sphingomyelin | Lipid rafts | Detergent-resistant membranes | Glycolipids | Primary human brain microvascular endothelial cells | lipid rafts | glycolipids | HEMOLYTIC-UREMIC SYNDROME | HUMAN NEUTROPHILS | BIOCHEMISTRY & MOLECULAR BIOLOGY | primary human brain microvascular endothelial cells | lyso-phosphatidylcholine | GLOBOTRIAOSYL CERAMIDE | TANDEM MASS-SPECTROMETRY | THROMBOTIC MICROANGIOPATHY | PLASMA-MEMBRANE | ENTEROHEMORRHAGIC ESCHERICHIA-COLI | INFECTIOUS-DISEASES | THIN-LAYER-CHROMATOGRAPHY | detergent-resistant membranes | sphingomyelin | Endothelial Cells - chemistry | Trihexosylceramides - genetics | Globosides - chemistry | Shiga Toxin 2 - chemistry | Trihexosylceramides - chemistry | Antibodies - chemistry | Humans | Globosides - genetics | Membrane Microdomains - chemistry | Glycosphingolipids - genetics | Chromatography, Thin Layer | Blood-Brain Barrier - metabolism | Shiga Toxin 2 - genetics | Blood-Brain Barrier - chemistry | Escherichia coli - pathogenicity | Receptors, Cell Surface - chemistry | Membrane Microdomains - genetics | Shiga Toxin 1 - genetics | Glycosphingolipids - chemistry | Receptors, Cell Surface - genetics | Shiga Toxin 1 - chemistry
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14. Full Text Detection and Characterization of the Product of Hydroethidine and Intracellular Superoxide by HPLC and Limitations of Fluorescence
by Hongtao Zhao and Joy Joseph and Henry M. Fales and Edward A. Sokoloski and Rodney L. Levine and Jeannette Vasquez-Vivar and B. Kalyanaraman and Helmut Beinert
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2005, Volume 102, Issue 16, pp. 5727 - 5732
Here we report the structural characterization of the product formed from the reaction between hydroethidine (HE) and superoxide ( O ). By using mass spectral... 
Reaction products | Biological Sciences | Free radicals | Wavelengths | Neurons | Fluorescence | Ceramides | Atoms | Oxidation | Wave excitation | Endothelial cells | 2-hydroxyethidium | Reactive oxygen species | Spin trapping | EPR | Free radical | OXIDATIVE STRESS | IN-VIVO EVIDENCE | MULTIDISCIPLINARY SCIENCES | INJURY | ATHEROSCLEROSIS | spin trapping | SPONTANEOUSLY HYPERTENSIVE RATS | reactive oxygen species | ENDOTHELIAL-CELLS | NEURONS | DISMUTASE DEFICIENCY | MICE | free radical | EXPRESSION | Endothelial Cells - chemistry | Fluorescent Dyes - chemistry | Chromatography, High Pressure Liquid - methods | Oxidation-Reduction | Phenanthridines - chemistry | Superoxides - chemistry | Biological Assay - methods | Ceramides - pharmacology | Cyclic N-Oxides - chemistry | Animals | Reactive Oxygen Species - chemistry | Vitamin K 3 - chemistry | Cattle | Spin Trapping | Molecular Structure | Aorta - cytology | Endothelial Cells - drug effects | Free radicals (Chemistry) | Research
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