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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 810 - 821
Context: Polycystic ovary syndrome ( PCOS) is a complex syndrome showing clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and... 
POLYCYSTIC-OVARY-SYNDROME | IONIZATION-MASS-SPECTROMETRY | RISK-FACTORS | TESTOSTERONE | BIOLOGICAL SAMPLES | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | NONALCOHOLIC STEATOHEPATITIS | FAT-CELL LIPOLYSIS | OLDER CHINESE | OBESE WOMEN | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Linoleic Acid - metabolism | Humans | Dehydroepiandrosterone Sulfate - metabolism | Case-Control Studies | Young Adult | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Diet, High-Fat | Mass Spectrometry | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Fatty Acids - metabolism | Phosphatidylglycerols - metabolism | Disease Models, Animal | Hyperinsulinism - metabolism | Ceramides - metabolism | Hyperinsulinism - complications | Polycystic Ovary Syndrome - metabolism | Cholesterol, HDL - metabolism | Obesity - complications | Eicosapentaenoic Acid - metabolism | Rats | Sex Hormone-Binding Globulin - metabolism | Lipid Metabolism | Fatty Acids, Unsaturated - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Triglycerides - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Animals | Cholesterol, LDL - metabolism | Phosphatidic Acids - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Docosahexaenoic Acids - metabolism | Polycystic ovary syndrome | Obesity | Hyperinsulinemia | Lecithin | Polyunsaturated fatty acids | Lipids | Mass spectroscopy | Liquid chromatography | Phospholipids | Metabolism | Arachidonic acid | Insulin | Fatty acids | Patients | Chromatography | Biological activity | Subgroups | Gas chromatography | Androgens | Molecular modelling | Metabolites | Lipid metabolism | Mass spectrometry | Metabolic disorders | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 02/2013, Volume 62, Issue 2, pp. 401 - 410
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 79, pp. 275 - 283
Abstract Background Obesity leads to metabolic heart disease (MHD) that is associated with a pathologic increase in myocardial fatty acid (FA) uptake and... 
Cardiovascular | Obesity | Metabolic heart disease | Mitochondria | Lipid excess | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROLIFERATOR-ACTIVATED RECEPTOR | KINASE-C | FATTY-ACIDS | CELL BIOLOGY | REDUCES DIABETIC CARDIOMYOPATHY | SKELETAL-MUSCLE | LIPOTOXIC CARDIOMYOPATHY | FAILING HEART | COACTIVATOR PGC-1 | TRANSCRIPTIONAL CONTROL | Mitochondria, Heart - ultrastructure | Phosphorylation | Mitochondria, Heart - metabolism | Carnitine - metabolism | RNA, Messenger - metabolism | Fatty Acid Transport Proteins - metabolism | Diglycerides - metabolism | Protein Kinase C - metabolism | Adenosine Triphosphate - metabolism | Myocardium - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Carnitine - analogs & derivatives | Proto-Oncogene Proteins c-akt - metabolism | Myocardium - ultrastructure | Ceramides - metabolism | Sphingomyelins - metabolism | RNA, Messenger - genetics | Gene Expression Regulation | Oxygen Consumption | Lipids - adverse effects | Myocardium - pathology | Organ Specificity | Hydrogen Peroxide - metabolism | Catalase - metabolism | Transcription Factors - metabolism | Animals | Electron Transport Complex II - metabolism | Models, Biological | Cyclic AMP Response Element-Binding Protein - metabolism | Myocytes, Cardiac - metabolism | Mice | PPAR alpha - metabolism | Fatty acids | Analysis | Mitochondrial DNA | Index Medicus | Metabolic Heart Disease | Lipid Excess
Journal Article
The Plant Cell, ISSN 1040-4651, 6/2011, Volume 23, Issue 6, pp. 2362 - 2378
Sphingolipids are a class of structural membrane lipids involved in membrane trafficking and cell polarity. Functional analysis of the ceramide synthase family... 
Ceramides | Cell aggregates | Auxins | Lipids | Sphingolipids | Cell membranes | Plants | Fatty acids | Plant cells | Seedlings | CERAMIDE SYNTHASE | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT-CELLS | SACCHAROMYCES-CEREVISIAE | PLANT SCIENCES | CELL BIOLOGY | AUXIN TRANSPORT | F-SP LYCOPERSICI | FUMONISIN B-1 | LIPID RAFTS | TRANS-GOLGI NETWORK | ROOT-SYSTEM ARCHITECTURE | Oxidoreductases - antagonists & inhibitors | Sphingolipids - chemistry | Cell Polarity | Arabidopsis - physiology | Fumonisins - metabolism | Humans | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Intracellular Membranes - ultrastructure | Arabidopsis Proteins - metabolism | Isoenzymes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Amino Acid Sequence | Arabidopsis Proteins - genetics | Ceramides - metabolism | Enzyme Inhibitors - metabolism | Indoleacetic Acids - metabolism | Oxidoreductases - metabolism | Isoenzymes - genetics | Membrane Proteins - genetics | Oxidoreductases - genetics | Arabidopsis - cytology | Sphingolipids - metabolism | Ceramides - chemistry | Protein Synthesis Inhibitors - metabolism | Brefeldin A - metabolism | Arabidopsis - genetics | Secretory Pathway - physiology | Sequence Alignment | Animals | Membrane Proteins - chemistry | Recombinant Fusion Proteins - genetics | Intracellular Membranes - metabolism | Arabidopsis thaliana | Physiological aspects | Genetic aspects | Index Medicus | Cell Membrane | Enzyme Inhibitors | Secretory Pathway | Intracellular Membranes | Brefeldin A | Recombinant Fusion Proteins | Life Sciences | Arabidopsis Proteins | Vegetal Biology | Protein Synthesis Inhibitors | Fumonisins | Isoenzymes | Arabidopsis | Membrane Proteins | Oxidoreductases | Indoleacetic Acids | Endosomes | s
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2013, Volume 33, Issue 12, pp. 2715 - 2723
OBJECTIVE—High-density lipoprotein (HDL) displays multiple atheroprotective activities and is highly heterogeneous in structure, composition, and function; the... 
Functionality | Lipidome | Lipidomics | Phospholipids | Sphingolipids | HDL, small, dense | Phosphatidylserine | small | HUMAN-SERUM | HUMAN PLASMA | sphingolipids | functionality | phospholipids | TANDEM MASS-SPECTROMETRY | dense | HDL | phosphatidylserine | SCAVENGER RECEPTOR | ENDOTHELIAL-CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | lipidome | HDL PARTICLES | LIPID-COMPOSITION | HEMATOLOGY | BINDING | lipidomics | APOLIPOPROTEIN-A-I | Inflammation - pathology | Oxidative Stress | Cholesterol - blood | Humans | Middle Aged | Male | Inflammation - blood | Tandem Mass Spectrometry | Inflammation - metabolism | Inflammation Mediators - metabolism | Chromatography, Liquid | Adult | Phospholipids - blood | Lipoproteins, LDL - metabolism | Lipoproteins, HDL3 - blood | Lipoproteins, HDL3 - metabolism | Phospholipids - metabolism | Thrombosis - blood | Thrombosis - prevention & control | Atherosclerosis - pathology | Ceramides - metabolism | Oxidation-Reduction | Endothelial Cells - metabolism | Sphingolipids - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Atherosclerosis - blood | Particle Size | Thrombosis - pathology | Macrophages - metabolism | Thrombosis - metabolism | Blood Platelets - metabolism | Cell Line, Tumor | Aged | Inflammation - prevention & control | Endothelial Cells - pathology | Atherosclerosis - prevention & control | Apoptosis | Index Medicus | Endothelial Cells | Macrophages | Atherosclerosis | Ceramides | Inflammation Mediators | Blood Platelets | Lipoproteins, HDL3 | Inflammation | Thrombosis | Cholesterol | Lipoproteins, LDL
Journal Article
Circulation Research, ISSN 0009-7330, 10/2009, Volume 105, Issue 9, pp. 897 - 905
RATIONALE:Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior,... 
Insulin-like growth factor binding protein-3 | Vascular repair | Nitric oxide | Hematopoietic stem cells | nitric oxide | STEM-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | RAT RETINA | LOW-DENSITY-LIPOPROTEIN | RECEPTOR | ENDOTHELIAL-CELL APOPTOSIS | FACTOR-I | CHOROIDAL NEOVASCULARIZATION | vascular repair | SPHINGOSINE 1-PHOSPHATE | RETINOPATHY | PERIPHERAL VASCULAR DISEASE | hematopoietic stem cells | HEMATOLOGY | insulin-like growth factor binding protein-3 | Cell Proliferation | Mesenteric Arteries - physiopathology | Humans | Male | Green Fluorescent Proteins - genetics | Retinal Neovascularization - metabolism | Retinopathy of Prematurity - physiopathology | Vasodilation | Retinal Vessels - pathology | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Infant, Newborn | Cytoprotection | Disease Models, Animal | Animals, Newborn | Gene Transfer Techniques | Sphingomyelins - metabolism | Retinal Vessels - metabolism | Signal Transduction | Endothelial Cells - metabolism | Rats | Mice, Transgenic | Mesenteric Arteries - metabolism | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Cerebral Arteries - metabolism | Stem Cells - pathology | Mice | Retinopathy of Prematurity - metabolism | Endothelial Cells - pathology | Retinal Neovascularization - physiopathology | Retinal Neovascularization - pathology | Astrocytes - metabolism | Cell Movement | Insulin-Like Growth Factor Binding Protein 3 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - metabolism | Stem Cells - metabolism | Cell Death | Female | Microfilament Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Ceramides - metabolism | Mice, Inbred C57BL | Cells, Cultured | Cerebral Arteries - physiopathology | Pregnancy | Animals | Retinal Vessels - physiopathology | Scavenger Receptors, Class B - metabolism | Nitric Oxide - metabolism | Retinopathy of Prematurity - pathology | Index Medicus | Vascular Repair | Hematopoietic Stem Cells
Journal Article
Circulation, ISSN 0009-7322, 06/2012, Volume 125, Issue 23, pp. 2844 - 2853
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2009, Volume 297, Issue 6, pp. 2096 - 2108
Diabetic cardiomyopathy is an important contributor to diastolic and systolic heart failure. We examined the nature and mechanism of the cardiomyopathy in... 
Sarco(endo)plasmic reticulum calcium-ATPase 2a | Insulin | Fibrosis | Hypertrophy | OVERLOAD | PROTEIN-KINASE-C | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | insulin | MECHANISM | hypertrophy | HEART-FAILURE | CHRONIC ACTIVATION | sarco(endo)plasmic reticulum calcium-ATPase 2a | INSULIN-RESISTANCE | EJECTION FRACTION | PERIPHERAL VASCULAR DISEASE | fibrosis | MICE | EXPRESSION | Cardiomyopathies - diagnostic imaging | Mitochondria, Heart - metabolism | Age Factors | Diastole | Natriuretic Peptide, Brain - metabolism | Diabetes Mellitus, Type 1 - metabolism | Myocardial Contraction - drug effects | Male | Diabetes Mellitus, Type 1 - diagnostic imaging | Diabetes Mellitus, Type 1 - complications | Systole | Insulin - blood | Echocardiography, Doppler, Pulsed | Myosin Heavy Chains - metabolism | Cardiomyopathies - genetics | Cardiomyopathies - physiopathology | Diglycerides - metabolism | Ventricular Dysfunction, Left - genetics | Mice, Mutant Strains | Myocardium - metabolism | Lipid Metabolism - genetics | Insulin - genetics | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Cardiomyopathies - drug therapy | Insulin - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Ceramides - metabolism | Acyl-CoA Dehydrogenase, Long-Chain - metabolism | Diabetes Mellitus, Type 1 - physiopathology | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Disease Progression | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Triglycerides - metabolism | Stroke Volume | Ventricular Dysfunction, Left - metabolism | Animals | Ventricular Dysfunction, Left - drug therapy | Cardiomyopathies - metabolism | Lipid Metabolism - drug effects | Mice | Ventricular Pressure | Blood Glucose - metabolism | Heart failure | Complications and side effects | Prognosis | Cardiomyopathy | Type 1 diabetes | Heart diseases | Risk factors | Heart | Rodents | Oxidation | Glucose | Diabetes | Kinases | Index Medicus
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2008, Volume 49, Issue 10, pp. 2101 - 2112
Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is one of the tissues thought to... 
Heart | Glucose | Serine palmitoyltransferase | Lipotoxicity | Fatty acid | glucose | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | fatty acid | CARDIAC DYSFUNCTION | serine palmitoyltransferase | ENDOPLASMIC-RETICULUM STRESS | SATURATED FATTY-ACIDS | heart | INDUCED INSULIN-RESISTANCE | SPHINGOLIPID METABOLISM | SIGNAL-TRANSDUCTION | GLUCOSE-TRANSPORTER | lipotoxicity | Cardiomyopathy, Dilated - pathology | Fatty Acids, Monounsaturated - pharmacology | Humans | Heart Failure - physiopathology | Glycogen Synthase Kinase 3 beta | Serine C-Palmitoyltransferase - genetics | Cattle | Gene Deletion | Myocardium - metabolism | Cardiotoxins - antagonists & inhibitors | Phosphorylation - drug effects | Fatty Acids - metabolism | Lipoprotein Lipase - metabolism | Biomarkers - metabolism | Heart - physiopathology | Ceramides - metabolism | Oxidation-Reduction | Mice, Transgenic | Serine C-Palmitoyltransferase - antagonists & inhibitors | Survival Rate | Ceramides - antagonists & inhibitors | Heart Failure - metabolism | Heart Failure - pathology | Serine C-Palmitoyltransferase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Cardiomyopathy, Dilated - metabolism | Gene Expression Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Cardiomyopathy, Dilated - physiopathology | Glycosylphosphatidylinositols - metabolism | Glucose - metabolism | Heart - drug effects | Myocytes, Cardiac - metabolism | Mice | Cardiotoxins - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2012, Volume 122, Issue 12, pp. 4667 - 4674
Journal Article
Diabetes, ISSN 0012-1797, 04/2018, Volume 67, Issue 4, pp. 769 - 781
Tight junctions (TJs) involve close apposition of transmembrane proteins between cells. Although TJ proteins have been studied in detail, the role of lipids is... 
STARGARDT-3 MACULAR DYSTROPHY | NEONATAL LETHALITY | ELOVL4 PROTEIN | ENDOCRINOLOGY & METABOLISM | BARRIER FUNCTION | RETINOPATHY | FATTY-ACIDS | ENDOTHELIAL-CELL PERMEABILITY | TANDEM MASS-SPECTROMETRY | OCCLUDIN PHOSPHORYLATION | EXPRESSION | Retina - metabolism | Humans | Claudin-5 - metabolism | Retinal Vessels - ultrastructure | Vascular Endothelial Growth Factor A - metabolism | Capillary Permeability - genetics | Occludin - metabolism | Endothelial Cells - ultrastructure | Cattle | Interleukin-1beta - metabolism | Diabetes Mellitus, Experimental - complications | Membrane Proteins - metabolism | Diabetic Retinopathy - etiology | Eye Proteins - genetics | Zonula Occludens-1 Protein - metabolism | Diabetes Mellitus, Experimental - metabolism | Tight Junctions - metabolism | Ceramides - metabolism | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Blood-Retinal Barrier - metabolism | Tight Junctions - ultrastructure | Animals | Eye Proteins - metabolism | Mice | Complications and side effects | Diabetic retinopathy | Diabetes | Research | Gene expression | Vascular endothelial growth factor | Risk factors | Retinopathy | Cytokines | Tight junctions | Diabetes mellitus | Lipids | Retina | Permeability | Fatty acids | Zonula occludens-1 protein | Membrane proteins | Proteins | Apposition | Ultrastructure | Index Medicus | Abridged Index Medicus | Complications | 0107
Journal Article