X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (5941) 5941
Publication (758) 758
Newsletter (93) 93
Book Review (50) 50
Conference Proceeding (29) 29
Book Chapter (17) 17
Book / eBook (2) 2
Transcript (2) 2
Dissertation (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (3222) 3222
animals (3096) 3096
ceramide (2850) 2850
index medicus (2098) 2098
apoptosis (1783) 1783
biochemistry & molecular biology (1730) 1730
ceramides - metabolism (1580) 1580
mice (1368) 1368
ceramides - pharmacology (1297) 1297
apoptosis - drug effects (1254) 1254
cell biology (981) 981
rats (980) 980
male (885) 885
cells, cultured (861) 861
pharmacology & pharmacy (861) 861
ceramides (779) 779
lipids (751) 751
activation (734) 734
enzyme inhibitors - pharmacology (733) 733
sphingosine - analogs & derivatives (731) 731
sphingolipids (690) 690
female (668) 668
cell line, tumor (605) 605
signal transduction (603) 603
cell line (598) 598
sphingomyelin phosphodiesterase - metabolism (581) 581
sphingosine - pharmacology (549) 549
oncology (542) 542
tumor cells, cultured (495) 495
expression (487) 487
signal transduction - drug effects (471) 471
sphingosine (471) 471
dose-response relationship, drug (457) 457
phosphorylation (442) 442
inhibition (436) 436
cells (435) 435
induced apoptosis (435) 435
cancer (433) 433
ceramides - biosynthesis (433) 433
metabolism (421) 421
death (407) 407
research (395) 395
oxidative stress (390) 390
article (388) 388
antineoplastic agents - pharmacology (387) 387
cell survival - drug effects (387) 387
ceramides - chemistry (383) 383
apoptosis - physiology (372) 372
physiological aspects (363) 363
sphingomyelins - metabolism (363) 363
tumor-necrosis-factor (359) 359
signal-transduction (352) 352
chemistry, medicinal (347) 347
time factors (344) 344
biophysics (342) 342
kinetics (339) 339
sphingosine - metabolism (333) 333
enzyme activation (329) 329
neurosciences (328) 328
sphingolipids - metabolism (325) 325
tumor necrosis factor-alpha - pharmacology (321) 321
analysis (318) 318
physiology (317) 317
enzyme activation - drug effects (316) 316
biochemistry (314) 314
proteins (312) 312
caspases - metabolism (311) 311
in-vitro (310) 310
sphingomyelinase (302) 302
sphingomyelin (299) 299
protein-kinase-c (294) 294
necrosis-factor-alpha (283) 283
research article (281) 281
cell death (269) 269
mice, inbred c57bl (268) 268
blotting, western (263) 263
sphingosine-1-phosphate (261) 261
immunology (258) 258
calcium - metabolism (254) 254
reactive oxygen species - metabolism (252) 252
cell-death (251) 251
rats, sprague-dawley (251) 251
acid sphingomyelinase (250) 250
sphingosine 1-phosphate (250) 250
multidisciplinary sciences (243) 243
ceramides - physiology (239) 239
differentiation (236) 236
hl-60 cells (235) 235
pathway (232) 232
enzymes (225) 225
cell membrane - metabolism (223) 223
plant lipids (220) 220
signal transduction - physiology (216) 216
transfection (214) 214
inflammation (210) 210
lipid metabolism (209) 209
flow cytometry (207) 207
gene expression (206) 206
protein (205) 205
biology (204) 204
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (5991) 5991
Japanese (31) 31
Chinese (12) 12
Russian (7) 7
French (5) 5
Korean (2) 2
Polish (2) 2
German (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Neuroscience, ISSN 0270-6474, 04/2005, Volume 25, Issue 17, pp. 4279 - 4287
The mechanism by which physiological synaptic NMDA receptor activity promotes neuronal survival is not well understood. Here, we show that that an episode of... 
Neuroprotection | CREB | Calcium | NMDA receptors | Ca | CaM kinase | Apoptosis | CREB PHOSPHORYLATION | calcium | apoptosis | KINASE-B | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | SIGNALING PATHWAY | neuroprotection | GENE-EXPRESSION | TRANSCRIPTION FACTOR | Muscimol - pharmacology | Gene Expression - drug effects | Apoptosis - drug effects | Calcium - metabolism | Calcium Signaling - physiology | Neurons - cytology | Phosphatidylinositol 3-Kinases - metabolism | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Drug Interactions | Neuroprotective Agents - pharmacology | Transfection - methods | Time Factors | Gene Expression - physiology | Neurons - physiology | Tetrodotoxin - pharmacology | Neurons - drug effects | Oncogene Protein v-akt - metabolism | Tretinoin - pharmacology | Animals, Newborn | Blotting, Western - methods | GABA Agonists | Enzyme Inhibitors - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Ceramides - pharmacology | GABA Antagonists - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Calcium Signaling - drug effects | Green Fluorescent Proteins - biosynthesis | Cyclic AMP Response Element-Binding Protein - metabolism | Apoptosis - physiology | Cell Nucleus - drug effects | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Hippocampus | Cellular | Molecular
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 1/2014, Volume 71, Issue 2, pp. 331 - 348
Programmed necrosis is important in many (patho)physiological settings. For specific therapeutic intervention, however, a better knowledge is required whether... 
Life Sciences | Biochemistry, general | Life Sciences, general | Necroptosis | TNF | PARP-1 | Biomedicine general | Programmed necrosis | Cell Biology | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PARP | CELL BIOLOGY | INHIBITION | RECEPTOR-INTERACTING PROTEIN | POLYMERASE-1 | CASPASES | EXPRESSION | Free Radical Scavengers - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Calpain - metabolism | Apoptosis - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Guanidines - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Necrosis | MCF-7 Cells | RNA Interference | HEK293 Cells | Benzamides - pharmacology | Cell Line | Ceramides - metabolism | Jurkat Cells | Nuclear Pore Complex Proteins - metabolism | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | HT29 Cells | Phthalazines - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cathepsins - metabolism | Mice | HeLa Cells | Methyl Methanesulfonate - pharmacology | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Proteases | Tumor necrosis factor | Cell death | Biochemistry | Phosphotransferases | Sugars | Monosaccharides | Proteins | Gangrene | Signal transduction | Apoptosis | Index Medicus
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2009, Volume 63, Issue 4, pp. 691 - 701
Cannabinoids (CBs) have been found to exert antiproliferative effects upon a variety of cancer cells, including colorectal carcinoma cells. However, little is... 
Cannabinoids | Biomedicine | 5-Fluorouracil | Polyunsaturated fatty acids | Colorectal cancer | Cancer Research | Oncology | Cytotoxicity | Pharmacology/Toxicology | MOLECULAR CHARACTERIZATION | ACTIVATION | TUMOR ANGIOGENESIS | CERAMIDE | CANCER | ONCOLOGY | VANILLOID RECEPTORS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ARACHIDONYLETHANOLAMIDE ANANDAMIDE | ADENYLATE-CYCLASE | EXPRESSION | Adenocarcinoma - pathology | Oxidative Stress | Cannabinoid Receptor Antagonists | Colonic Neoplasms - drug therapy | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Colonic Neoplasms - metabolism | Receptors, Cannabinoid - metabolism | Adenocarcinoma - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Antimetabolites, Antineoplastic - pharmacology | Tumor Cells, Cultured | Dronabinol - pharmacology | Drug Therapy, Combination | Cyclic AMP - metabolism | Pyrazoles - pharmacology | Thymidine - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Cell Survival - drug effects | Enzyme Inhibitors - pharmacology | Fatty Acids, Unsaturated - pharmacology | Antioxidants - pharmacology | Adenocarcinoma - drug therapy | Cannabinoids - pharmacology | Drug Synergism | Colonic Neoplasms - pathology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Neurosciences | Care and treatment | Carcinoma | Fluorescence | Arachidonic acid | Glycine | Unsaturated fatty acids | Analysis | Nitric oxide | Phenols | Omega-3 fatty acids | Fluorouracil | Cancer | Index Medicus | Basic Medicine | toxikologi | Medical and Health Sciences | Medicin och hälsovetenskap | biokemisk farmakologi | Toxicology | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology
Journal Article
Bone, ISSN 8756-3282, 2008, Volume 43, Issue 2, pp. 394 - 404
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 11/2012, Volume 303, Issue 9, pp. C991 - C999
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0124481
Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide... 
SPHINGOLIPID METABOLISM | NMDA RECEPTORS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL EVALUATION | SELECTIVE INHIBITORS | EXOSOMES | SIRTUIN INHIBITORS | NECROSIS-FACTOR-ALPHA | HUMAN-IMMUNODEFICIENCY-VIRUS | CERAMIDE | Dendrites - pathology | Interleukin-1beta - pharmacology | Humans | Fluorescence | Structure-Activity Relationship | Ceramides - biosynthesis | Pyrimidinones - chemistry | Neuroprotective Agents - pharmacology | Cattle | Sphingomyelin Phosphodiesterase - metabolism | HEK293 Cells | Pyrimidinones - pharmacology | Neurons - metabolism | Cell Death - drug effects | Drug Evaluation, Preclinical | Neurons - drug effects | Radioactivity | Naphthalenes - chemistry | Cell Survival - drug effects | Dendrites - drug effects | Neuroprotective Agents - chemistry | Enzyme Inhibitors - pharmacology | Enzyme Assays | Hippocampus - pathology | Recombinant Proteins - pharmacology | Rats, Sprague-Dawley | Naphthalenes - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Sphingomyelin Phosphodiesterase - antagonists & inhibitors | Cytokines - pharmacology | Hydrolysis | Multiple sclerosis | Neurons | Alzheimer's disease | Neurophysiology | Apoptosis | Drugs | Neuroprotection | Brain | Oxidative stress | Physicians | Interleukin | Science | Viruses | Assaying | Optimization | Cell adhesion & migration | Proteins | Neurodegeneration | Human immunodeficiency virus--HIV | Interleukin 1 | Ceramide | Bacteria | Inhibition | Recombinant | Enzymes | Research & development--R&D | Pharmacology | Inflammation | Tumor necrosis factor-α | Medical screening | SIRT1 protein | Sphingomyelin phosphodiesterase | Medicine | Neurology | Silence | Brain research | Inhibitors | Cell death | Sphingomyelin | In vivo methods and tests | Scaffolds | Research & development | R&D | HIV | Human immunodeficiency virus
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2000, Volume 164, Issue 12, pp. 6509 - 6519
Resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenolic phytoalexin found in grapes, fruits, and root extracts of the weed Polygonum cuspidatum, exhibits... 
SIGNAL-TRANSDUCTION | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE SYNTHASE | C-JUN KINASE | GENE-EXPRESSION | CYCLOOXYGENASE-2 EXPRESSION | DEPENDENT APOPTOSIS | RED WINE | IMMUNOLOGY | CORONARY HEART-DISEASE | FACTOR-ALPHA | Okadaic Acid - pharmacology | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Apoptosis - drug effects | Humans | Transcription Factor RelA | NF-kappa B - metabolism | Lipopolysaccharides - antagonists & inhibitors | Stilbenes - pharmacology | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Reactive Oxygen Species - physiology | Cell Nucleus - metabolism | Lipid Peroxidation - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Resveratrol | JNK Mitogen-Activated Protein Kinases | Biological Transport - drug effects | Phosphorylation - drug effects | Cytotoxicity, Immunologic - drug effects | Immunosuppressive Agents - pharmacology | Cell Line | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | NF-kappa B p50 Subunit | Okadaic Acid - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | I-kappa B Proteins | Ceramides - antagonists & inhibitors | Caspase Inhibitors | Ceramides - pharmacology | Gene Expression Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Transcription Factor AP-1 - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Genes, Reporter - drug effects | Cell Nucleus - drug effects | Hydrogen Peroxide - antagonists & inhibitors | MAP Kinase Kinase Kinase 1 | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Immunology, ISSN 0019-2805, 03/2010, Volume 129, Issue 3, pp. 375 - 385
Summary The synthetic phospho‐ceramide analogue‐1 (PCERA‐1) down‐regulates production of the pro‐inflammatory cytokine tumour necrosis factor‐α (TNF‐α) and... 
macrophages | cyclic adenosine monophosphate response element binding protein | lipopolysaccharide | inflammation | interleukin‐10 | tumour necrosis factor‐α | Cyclic adenosine monophosphate response element binding protein | Lipopolysaccharide | Inflammation | Tumour necrosis factor-α | Interleukin-10 | Macrophages | PROTEIN-KINASE-C | TRANSCRIPTIONAL ACTIVATION | VASOACTIVE-INTESTINAL-PEPTIDE | BETA-ADRENOCEPTOR | IMMUNOLOGY | interleukin-10 | CYTOKINE EXPRESSION | THYROID FRTL-5 CELLS | LIPOPOLYSACCHARIDE INDUCTION | CERAMIDE 1-PHOSPHATE | HIGHLY POTENT INHIBITIONS | TNF-ALPHA | tumour necrosis factor-alpha | Tumor Necrosis Factor-alpha - metabolism | Guanosine Triphosphate - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Isoquinolines - pharmacology | Transfection | Cyclic AMP - analogs & derivatives | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Interleukin-10 - metabolism | Indoles - pharmacology | Cell Membrane - metabolism | Response Elements - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Rolipram - pharmacology | Cyclic AMP - metabolism | Cell Membrane - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Dinoprostone - pharmacology | Enzyme Inhibitors - pharmacology | Genes, Reporter - genetics | Imidazoles - pharmacology | Adenylyl Cyclases - metabolism | Sulfonamides - pharmacology | Ceramides - pharmacology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Calcium Signaling - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Signal Transduction - physiology | Bucladesine - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | tumour necrosis factor-α | Original
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 2017, Volume 42, Issue 4, pp. 1575 - 1591
Background/Aims: The mammalian target of rapamycin (mTOR) inhibitor temsirolimus is utilized for the treatment of malignancy. Temsirolimus is at least in part... 
Ceramide | Eryptosis | Oxidative stress | Calcium | Staurosporine | Phosphatidylserine | PHYSIOLOGY | GYNECOLOGIC-ONCOLOGY-GROUP | RENAL-CELL CARCINOMA | CELL BIOLOGY | ENERGY DEPLETION | PHASE-II TRIAL | IN-VITRO | CANCER-PATIENTS | ENDOTHELIAL-CELLS | INDUCED ADHESION | PHOSPHATIDYLSERINE EXPOSURE | Hemolysis - drug effects | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Calcium - metabolism | Casein Kinase I - genetics | Humans | TOR Serine-Threonine Kinases - antagonists & inhibitors | Caspases - metabolism | TOR Serine-Threonine Kinases - genetics | Casein Kinase I - antagonists & inhibitors | Erythrocytes - cytology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Eryptosis - drug effects | Fluoresceins - chemistry | Sirolimus - analogs & derivatives | Ceramides - metabolism | Signal Transduction | Caspases - genetics | Xanthenes - chemistry | Phosphatidylserines - metabolism | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Sirolimus - pharmacology | Benzophenanthridines - pharmacology | Eryptosis - genetics | Erythrocytes - drug effects | Annexin A5 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Erythrocytes - metabolism | Casein Kinase I - metabolism | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Aniline Compounds - chemistry | Primary Cell Culture | Oligopeptides - pharmacology | Staurosporine - pharmacology
Journal Article