Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1580) 1580
Book Review (314) 314
Publication (118) 118
Book Chapter (9) 9
Book / eBook (3) 3
Conference Proceeding (2) 2
Dissertation (1) 1
Magazine Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1490) 1490
index medicus (1468) 1468
female (763) 763
male (757) 757
cerebellar neoplasms - drug therapy (609) 609
child (581) 581
medulloblastoma (572) 572
oncology (559) 559
medulloblastoma - drug therapy (520) 520
child, preschool (474) 474
clinical neurology (438) 438
adolescent (411) 411
cerebellar neoplasms - pathology (409) 409
adult (390) 390
medulloblastoma - pathology (313) 313
cerebellar neoplasms - radiotherapy (311) 311
chemotherapy (300) 300
cancer (291) 291
combined modality therapy (271) 271
medulloblastoma - radiotherapy (268) 268
animals (265) 265
middle aged (261) 261
infant (260) 260
cerebellar neoplasms - surgery (243) 243
antineoplastic combined chemotherapy protocols - therapeutic use (236) 236
children (230) 230
pediatrics (224) 224
neurosciences (208) 208
cerebellar neoplasms - genetics (198) 198
magnetic resonance imaging (196) 196
medulloblastoma - genetics (196) 196
radiotherapy (194) 194
medicine & public health (192) 192
prognosis (190) 190
surgery (189) 189
tumors (189) 189
treatment outcome (185) 185
medulloblastoma - metabolism (175) 175
cerebellar neoplasms - metabolism (171) 171
cerebellar neoplasms - therapy (168) 168
mice (167) 167
medulloblastoma - surgery (154) 154
medulloblastoma - therapy (154) 154
brain-tumors (149) 149
cell line, tumor (143) 143
cerebellar neoplasms - mortality (143) 143
central-nervous-system (141) 141
abridged index medicus (140) 140
aged (138) 138
care and treatment (138) 138
brain tumors (135) 135
follow-up studies (133) 133
antineoplastic agents - therapeutic use (132) 132
medulloblastoma - mortality (131) 131
cerebellar neoplasms - diagnosis (130) 130
neurology (125) 125
brain (113) 113
research (113) 113
retrospective studies (104) 104
brain neoplasms - drug therapy (102) 102
adjuvant chemotherapy (101) 101
expression (101) 101
survival (101) 101
apoptosis (100) 100
childhood (97) 97
health aspects (97) 97
radiation (97) 97
primitive neuroectodermal tumors (96) 96
chemotherapy, adjuvant (90) 90
young adult (90) 90
radiation-therapy (87) 87
therapy (87) 87
article (86) 86
tomography, x-ray computed (84) 84
analysis (83) 83
risk factors (82) 82
radiology, nuclear medicine & medical imaging (80) 80
neurosurgery (79) 79
survival rate (79) 79
disease-free survival (78) 78
vincristine - administration & dosage (78) 78
cranial irradiation (77) 77
gliomas (77) 77
radiotherapy dosage (77) 77
apoptosis - drug effects (75) 75
diagnosis (75) 75
hematology (75) 75
medulloblastoma - diagnosis (75) 75
antineoplastic agents - pharmacology (74) 74
cell biology (72) 72
cerebellum (72) 72
dose-response relationship, drug (72) 72
antineoplastic combined chemotherapy protocols - adverse effects (71) 71
cisplatin - administration & dosage (70) 70
signal transduction (69) 69
time factors (69) 69
diagnosis, differential (68) 68
survival analysis (68) 68
brain neoplasms - pathology (65) 65
cerebellar neoplasms - complications (64) 64
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1489) 1489
German (28) 28
Japanese (23) 23
French (14) 14
Spanish (12) 12
Russian (7) 7
Italian (6) 6
Hungarian (4) 4
Polish (3) 3
Turkish (2) 2
Chinese (1) 1
Croatian (1) 1
Portuguese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour
by Stacchiotti, S and Saponara, M and Frapolli, R and Tortoreto, M and Cominetti, D and Provenzano, S and Negri, T and Dagrada, G.P and Gronchi, A and Colombo, C and Vincenzi, B and Badalamenti, G and Zuco, V and Renne, S.L and Collini, P and Morosi, C and Dei Tos, A.P and Bello, E and Pilotti, S and Casali, P.G and D'Incalci, M and Zaffaroni, N
European Journal of Cancer, ISSN 0959-8049, 2017, Volume 76, pp. 84 - 92
Abstract Background Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select... 
Hematology, Oncology and Palliative Medicine | Eribulin | Xenograft | Sarcoma | Ifosfamide | Mice model | Solitary fibrous tumour | Metastasis | Trabectedin | Doxorubicin | Dacarbazine | Chemotherapy | Treatment | Anthracycline | MECHANISM | PHASE-2 | IDENTIFICATION | TEMOZOLOMIDE | MESYLATE | ONCOLOGY | RECURRENT | HEMANGIOPERICYTOMA | EXPRESSION | SOFT-TISSUE SARCOMA | Humans | Middle Aged | Soft Tissue Neoplasms - drug therapy | Male | Response Evaluation Criteria in Solid Tumors | Pleural Neoplasms - drug therapy | Retroperitoneal Neoplasms - mortality | Meningeal Neoplasms - drug therapy | Retroperitoneal Neoplasms - drug therapy | Dioxoles - administration & dosage | Adult | Female | Retrospective Studies | Doxorubicin - administration & dosage | Cerebellar Neoplasms - drug therapy | Dacarbazine - administration & dosage | Soft Tissue Neoplasms - mortality | Solitary Fibrous Tumors - drug therapy | Solitary Fibrous Tumors - mortality | Cerebellar Neoplasms - mortality | Ketones - administration & dosage | Survival Rate | Tetrahydroisoquinolines - administration & dosage | Pleural Neoplasms - mortality | Kidney Neoplasms - mortality | Mice, SCID | Blotting, Western | Meningeal Neoplasms - mortality | Xenograft Model Antitumor Assays | Disease-Free Survival | Animals | Ifosfamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Kidney Neoplasms - drug therapy | Furans - administration & dosage | Analysis | Melanoma | Stem cells | Anthracyclines | Cancer | Drugs | Animal models | Progressions | Xenotransplantation | Immunodeficiency | Clinical trials | Patients | Survival | Anticancer properties | Studies | Molecular modelling | Xenografts | Mice | In vivo methods and tests | Mathematical models | Drug therapy | Tumors | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype
by Phoenix, Timothy N and Patmore, Deanna M and Boop, Scott and Boulos, Nidal and Jacus, Megan O and Patel, Yogesh T and Roussel, Martine F and Finkelstein, David and Goumnerova, Liliana and Perreault, Sebastien and Wadhwa, Elizabeth and Cho, Yoon-Jae and Stewart, Clinton F and Gilbertson, Richard J
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 508 - 522
The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant... 
LUNG-CANCER | ANGIOGENESIS | ONCOLOGY | PATHWAY | IN-VIVO | VINCRISTINE | TUMOR | CNS | CENTRAL-NERVOUS-SYSTEM | SUBGROUPS | CHEMOTHERAPY | CELL BIOLOGY | Humans | Neoplasm Proteins - physiology | Cerebellar Neoplasms - blood supply | Culture Media, Conditioned - pharmacology | Genetic Vectors - therapeutic use | Medulloblastoma - secretion | Recombinant Fusion Proteins - metabolism | Endothelium, Vascular - ultrastructure | Cerebellar Neoplasms - secretion | Wnt Proteins - genetics | Membrane Proteins - physiology | Pericytes - pathology | Glucose Transporter Type 1 - physiology | Antineoplastic Agents - pharmacokinetics | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Vincristine - pharmacokinetics | Disease Models, Animal | Carrier Proteins - physiology | Cerebellar Neoplasms - drug therapy | Transduction, Genetic | Genetic Association Studies | Genotype | Mice, Transgenic | Cerebellar Neoplasms - genetics | Tight Junctions - ultrastructure | Animals | Wnt Signaling Pathway - drug effects | Endothelium, Vascular - metabolism | Paracrine Communication - drug effects | Vincristine - therapeutic use | Medulloblastoma - blood supply | Mice | Wnt Proteins - physiology | Medulloblastoma - drug therapy | Drug Resistance, Neoplasm - physiology | Medulloblastoma - classification | Blood-Brain Barrier | Chemotherapy | Medulloblastoma | Brain tumors | Genetic aspects | Permeability | Cells | Cancer | Neurophysiology | Endothelium | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma
by Vanner, Robert J and Remke, Marc and Gallo, Marco and Selvadurai, Hayden J and Coutinho, Fiona and Lee, Lilian and Kushida, Michelle and Head, Renee and Morrissy, Sorana and Zhu, Xueming and Aviv, Tzvi and Voisin, Veronique and Clarke, Ian D and Li, Yisu and Mungall, Andrew J and Moore, Richard A and Ma, Yussanne and Jones, Steven J.M and Marra, Marco A and Malkin, David and Northcott, Paul A and Kool, Marcel and Pfister, Stefan M and Bader, Gary and Hochedlinger, Konrad and Korshunov, Andrey and Taylor, Michael D and Dirks, Peter B
Cancer Cell, ISSN 1535-6108, 07/2014, Volume 26, Issue 1, pp. 33 - 47
Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2 cells propagate sonic... 
Prognosis | Receptors, G-Protein-Coupled - metabolism | Antigens, Nuclear - metabolism | Microtubule-Associated Proteins - metabolism | Gene Expression Regulation, Neoplastic | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Gene Expression Profiling | Neurogenesis | SOXB1 Transcription Factors - metabolism | Dose-Response Relationship, Drug | Hedgehog Proteins - genetics | SOXB1 Transcription Factors - genetics | Time Factors | Smoothened Receptor | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Cerebellar Neoplasms - pathology | Patched Receptors | Tumor Cells, Cultured | Medulloblastoma - genetics | Cerebellar Neoplasms - metabolism | Cerebellar Neoplasms - drug therapy | Neoplasm Recurrence, Local | Receptors, Cell Surface - metabolism | Mice, Transgenic | Neuropeptides - metabolism | Nuclear Proteins - metabolism | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Plicamycin - pharmacology | Nerve Tissue Proteins - metabolism | Cell Lineage | Animals | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Mice | Medulloblastoma - drug therapy | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Phase III Study of Craniospinal Radiation Therapy Followed by Adjuvant Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma
by Roger J. Packer and Amar Gajjar and Gilbert Vezina and Lucy Rorke-Adams and Peter C. Burger and Patricia L. Robertson and Lisa Bayer and Deborah LaFond and Bernadine R. Donahue and MaryAnne H. Marymont and Karin Muraszko and James Langston and Richard Sposto
Journal of Clinical Oncology, ISSN 0732-183X, 09/2006, Volume 24, Issue 25, pp. 4202 - 4208
Purpose To determine the event-free survival (EFS) and overall survival of children with average-risk medulloblastoma and treated with reduced-dose... 
POSTERIOR-FOSSA | PROSPECTIVE RANDOMIZED-TRIAL | INTERNATIONAL-SOCIETY | ONCOLOGY | CHILDHOOD MEDULLOBLASTOMA | CNS TUMORS | C-MYC | CHILDRENS CANCER GROUP | OF-PEDIATRIC-ONCOLOGY | PRERADIATION CHEMOTHERAPY | BRAIN-TUMORS | Cyclophosphamide - administration & dosage | Prognosis | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Child, Preschool | Male | Cisplatin - administration & dosage | Medulloblastoma - radiotherapy | Chemotherapy, Adjuvant - adverse effects | Radiotherapy, Adjuvant - adverse effects | Medulloblastoma - pathology | Vincristine - administration & dosage | Adult | Female | Cerebellar Neoplasms - pathology | Child | Radiotherapy Dosage | Cerebellar Neoplasms - drug therapy | Risk Factors | Neoplasms, Second Primary - diagnosis | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Survival Analysis | Medulloblastoma - drug therapy | Neoplasm Staging | Cerebellar Neoplasms - radiotherapy | Lomustine - administration & dosage | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Phase i study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma
by Kieran, Mark W and Chisholm, Julia and Casanova, Michela and Brandes, Alba A and Aerts, Isabelle and Bouffet, Eric and Bailey, Simon and Leary, Sarah and Macdonald, Tobey J and Mechinaud, Francoise and Cohen, Kenneth J and Riccardi, Riccardo and Mason, Warren and Hargrave, Darren and Kalambakas, Stacey and Deshpande, Priya and Tai, Feng and Hurh, Eunju and Geoerger, Birgit
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue 11, pp. 1542 - 1552
Background. Sonidegib (LDE225) is a potent, selective hedgehog (Hh) inhibitor of Smoothened. This study explored the safety and pharmacokinetics of sonidegib... 
Sonic hedgehog | Clinical trial | Medulloblastoma | PTCH | SMO | clinical trial | HEDGEHOG PATHWAY | RISK MEDULLOBLASTOMA | medulloblastoma | PTCH | CHEMOTHERAPY | CLINICAL NEUROLOGY | CURRENT CONSENSUS | DOSE-ESCALATION | THERAPY | SMO | ONCOLOGY | CELL SUPPORT | RECURRENT | sonic hedgehog | ONCOLOGY GROUP | Prognosis | Follow-Up Studies | Humans | Middle Aged | Brain Neoplasms - pathology | Child, Preschool | Neoplasm Recurrence, Local - drug therapy | Pyridines - pharmacokinetics | Male | Neoplasm Recurrence, Local - pathology | Tissue Distribution | Young Adult | Biphenyl Compounds - pharmacology | Medulloblastoma - pathology | Adult | Female | Cerebellar Neoplasms - pathology | Child | Biphenyl Compounds - pharmacokinetics | Cerebellar Neoplasms - drug therapy | Pyridines - administration & dosage | Administration, Oral | Brain Neoplasms - drug therapy | Neoplasms - drug therapy | Adolescent | Biphenyl Compounds - administration & dosage | Aged | Pyridines - pharmacology | Medulloblastoma - drug therapy | Neoplasms - pathology | Index Medicus | Pediatric Neuro-Oncology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
by Hill, Rebecca M and Kuijper, Sanne and Lindsey, Janet C and Petrie, Kevin and Schwalbe, Ed C and Barker, Karen and Boult, Jessica K.R and Williamson, Daniel and Ahmad, Zai and Hallsworth, Albert and Ryan, Sarra L and Poon, Evon and Robinson, Simon P and Ruddle, Ruth and Raynaud, Florence I and Howell, Louise and Kwok, Colin and Joshi, Abhijit and Nicholson, Sarah Leigh and Crosier, Stephen and Ellison, David W and Wharton, Stephen B and Robson, Keith and Michalski, Antony and Hargrave, Darren and Jacques, Thomas S and Pizer, Barry and Bailey, Simon and Swartling, Fredrik J and Weiss, William A and Chesler, Louis and Clifford, Steven C and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Neuroonkologi and Uppsala universitet
Cancer Cell, ISSN 1535-6108, 01/2015, Volume 27, Issue 1, pp. 72 - 84
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined family... 
AMPLIFICATION | ONCOLOGY | OUTCOME PREDICTION | ANAPLASTIC MEDULLOBLASTOMA | TP53 MUTATION | CHILDHOOD MEDULLOBLASTOMA | N-MYC | CENTRAL-NERVOUS-SYSTEM | NEUROBLASTOMA | SUBGROUPS | CHILDRENS-CANCER | CELL BIOLOGY | Oncogene Proteins - genetics | Humans | Child, Preschool | Molecular Sequence Data | Neoplasm Recurrence, Local - drug therapy | Infant | Male | Antineoplastic Agents - therapeutic use | Tumor Suppressor Protein p53 - genetics | Young Adult | Medulloblastoma - pathology | Neoplasms, Experimental | Adult | Female | N-Myc Proto-Oncogene Protein | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Nuclear Proteins - genetics | Child | Cerebellar Neoplasms - drug therapy | Signal Transduction | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Cerebellar Neoplasms - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Gene Amplification | Adolescent | Neoplasm Recurrence, Local - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Mutation | Medulloblastoma - drug therapy | Neurosciences | Genetic engineering | Tumor proteins | Medulloblastoma | Children's hospitals | Brain tumors | Index Medicus | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
by Rudin, Charles M and Hann, Christine L and Laterra, John and Yauch, Robert L and Callahan, Christopher A and Fu, Ling and Holcomb, Thomas and Stinson, Jeremy and Gould, Stephen E and Coleman, Barbara and LoRusso, Patricia M and Von Hoff, Daniel D and de Sauvage, Frederic J and Low, Jennifer A
The New England Journal of Medicine, ISSN 0028-4793, 09/2009, Volume 361, Issue 12, pp. 1173 - 1178
The hedgehog pathway is essential for certain aspects of embryonic differentiation. Abnormalities of this pathway have been found in some cases of... 
Medulloblastoma - secondary | Humans | Male | Antineoplastic Agents - therapeutic use | RNA, Messenger - metabolism | Anilides | Polymerase Chain Reaction | Adult | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - metabolism | Benzimidazoles - therapeutic use | Pyridines | Cerebellar Neoplasms - drug therapy | Gene Expression | Receptors, Cell Surface - metabolism | Medulloblastoma - metabolism | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | Transcription Factors - metabolism | Signal Transduction - drug effects | Zinc Finger Protein GLI1 | Medulloblastoma - drug therapy | Patched-1 Receptor | Receptors, Cell Surface - genetics | Case studies | Evaluation | Care and treatment | Enzyme inhibitors | Gene mutations | Analysis | Medulloblastoma | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma
by Moxon-Emre, Iska and Bouffet, Eric and Taylor, Michael D and Laperriere, Normand and Scantlebury, Nadia and Law, Nicole and Spiegler, Brenda J and Malkin, David and Janzen, Laura and Mabbott, Donald
Journal of Clinical Oncology, ISSN 0732-183X, 06/2014, Volume 32, Issue 17, pp. 1760 - 1768
Purpose To examine the impact of radiation (ie, craniospinal irradiation [CSR] dose and boost volume) and complications (ie, hydrocephalus and other neurologic... 
CONFORMAL RADIATION-THERAPY | AVERAGE-RISK MEDULLOBLASTOMA | ONCOLOGY | HYDROCEPHALUS | CRANIAL RADIATION | POSTERIOR-FOSSA TUMORS | PEDIATRIC-PATIENTS | CEREBELLAR MUTISM | CHILDHOOD | BRAIN-TUMORS | CHILDREN | Medulloblastoma - psychology | Cerebellar Neoplasms - psychology | Follow-Up Studies | Craniospinal Irradiation - methods | Humans | Nervous System Diseases - psychology | Child, Preschool | Infant | Male | Medulloblastoma - therapy | Medulloblastoma - radiotherapy | Radiation Injuries - psychology | Female | Retrospective Studies | Craniospinal Irradiation - adverse effects | Child | Radiotherapy Dosage | Cerebellar Neoplasms - drug therapy | Intelligence - radiation effects | Radiation Injuries - etiology | Adolescent | Nervous System Diseases - etiology | Cerebellar Neoplasms - therapy | Medulloblastoma - drug therapy | Cerebellar Neoplasms - radiotherapy | Longitudinal Studies | Cohort Studies | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
by Dijkgraaf, Gerrit J.P and Alicke, Bruno and Weinmann, Lasse and Januario, Thomas and West, Kristina and Modrusan, Zora and Burdick, Dan and Goldsmith, Richard and Robarge, Kirk and Sutherlin, Dan and Scales, Suzie J and Gould, Stephen E and Yauch, Robert L and De Sauvage, Frederic J
Cancer Research, ISSN 0008-5472, 01/2011, Volume 71, Issue 2, pp. 435 - 444
Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway... 
ONCOLOGY | CYCLIN D1 | BASAL-CELL CARCINOMA | TRANSCRIPTION | HEDGEHOG PATHWAY INHIBITOR | MICE | PROLIFERATION | MUTATIONS | MEDULLOBLASTOMA | HUMAN CANCER | GLI2 | Oncogene Proteins - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Smoothened Receptor | HEK293 Cells | Oncogene Proteins - biosynthesis | Trans-Activators - genetics | Trans-Activators - biosynthesis | Medulloblastoma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cerebellar Neoplasms - metabolism | Cerebellar Neoplasms - drug therapy | Mutagenesis, Site-Directed | Signal Transduction | RNA, Messenger - genetics | Mice, Transgenic | Medulloblastoma - metabolism | Cerebellar Neoplasms - genetics | Animals | Mice, Nude | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Mutation | Medulloblastoma - drug therapy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Clinical Experience With Hedgehog Pathway Inhibitors
by Jennifer A. Low and Frederic J. de Sauvage
Journal of Clinical Oncology, ISSN 0732-183X, 12/2010, Volume 28, Issue 36, pp. 5321 - 5326
The Hedgehog (Hh) signaling pathway is critical for cell growth and differentiation during embryogenesis and early development. While it is mostly quiescent in... 
ONCOLOGY | SIGNALING PATHWAY | SONIC HEDGEHOG | BASAL-CELL CARCINOMA | PANCREATIC-CANCER | MOUSE MODEL | MEDULLOBLASTOMA | PRIMARY CILIUM | HUMAN HOMOLOG | CANCER STEM-CELLS | SMALL-MOLECULE INHIBITOR | Anilides - therapeutic use | Cerebellar Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Signal Transduction | Humans | Medulloblastoma - physiopathology | Antineoplastic Agents - therapeutic use | Hedgehog Proteins - physiology | Hedgehog Proteins - antagonists & inhibitors | Skin Neoplasms - physiopathology | Carcinoma, Basal Cell - physiopathology | Paracrine Communication - physiology | Smoothened Receptor | Anilides - pharmacology | Carcinoma, Basal Cell - drug therapy | Adult | Antineoplastic Agents - pharmacology | Pyridines - pharmacology | Cerebellar Neoplasms - physiopathology | Medulloblastoma - drug therapy | Child | Pyridines - therapeutic use | Receptors, G-Protein-Coupled - physiology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Occipital Headache as Initial Manifestation of a Pancreatic Neuroendocrine Tumor
by Tsoukalas, Nikolaos and Triantafyllidis, Agathangelos and Tolia, Maria and Galanopoulos, Michail and Kostakis, Ioannis D and Demiri, Stamatina and Toumpanakis, Christos and Koumakis, Georgios
Journal of Gastrointestinal Cancer, ISSN 1941-6628, 12/2018, Volume 49, Issue 4, pp. 501 - 503
Oncology | Cancer Research | Internal Medicine | Medicine & Public Health | Radiotherapy | Gastroenterology | Headache - etiology | Cerebellar Neoplasms - diagnosis | Pancreatic Neoplasms - diagnosis | Humans | Neuroendocrine Tumors - complications | Male | Neuroendocrine Tumors - diagnosis | Stomach Neoplasms - secondary | Pancreatic Neoplasms - drug therapy | Cerebellar Neoplasms - complications | Pancreatic Neoplasms - secondary | Cerebellum - diagnostic imaging | Cerebellar Neoplasms - secondary | Fatal Outcome | Adult | Intestinal Neoplasms - diagnosis | Stomach Neoplasms - complications | Stomach Neoplasms - diagnosis | Pancreatic Neoplasms - pathology | Stomach Neoplasms - therapy | Intestinal Neoplasms - secondary | Disease Progression | Cerebellum - pathology | Intestinal Neoplasms - therapy | Magnetic Resonance Imaging | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neuroendocrine Tumors - secondary | Cerebellum - surgery | Headache - diagnostic imaging | Neuroendocrine Tumors - therapy | Cerebellar Neoplasms - therapy | Pancreatic Neoplasms - complications | Intestinal Neoplasms - complications | Pancreatic Neoplasms - therapy | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights