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European Journal of Cancer, ISSN 0959-8049, 2017, Volume 76, pp. 84 - 92
Abstract Background Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select... 
Hematology, Oncology and Palliative Medicine | Eribulin | Xenograft | Sarcoma | Ifosfamide | Mice model | Solitary fibrous tumour | Metastasis | Trabectedin | Doxorubicin | Dacarbazine | Chemotherapy | Treatment | Anthracycline | MECHANISM | PHASE-2 | IDENTIFICATION | TEMOZOLOMIDE | MESYLATE | ONCOLOGY | RECURRENT | HEMANGIOPERICYTOMA | EXPRESSION | SOFT-TISSUE SARCOMA | Humans | Middle Aged | Soft Tissue Neoplasms - drug therapy | Male | Response Evaluation Criteria in Solid Tumors | Pleural Neoplasms - drug therapy | Retroperitoneal Neoplasms - mortality | Meningeal Neoplasms - drug therapy | Retroperitoneal Neoplasms - drug therapy | Dioxoles - administration & dosage | Adult | Female | Retrospective Studies | Doxorubicin - administration & dosage | Cerebellar Neoplasms - drug therapy | Dacarbazine - administration & dosage | Soft Tissue Neoplasms - mortality | Solitary Fibrous Tumors - drug therapy | Solitary Fibrous Tumors - mortality | Cerebellar Neoplasms - mortality | Ketones - administration & dosage | Survival Rate | Tetrahydroisoquinolines - administration & dosage | Pleural Neoplasms - mortality | Kidney Neoplasms - mortality | Mice, SCID | Blotting, Western | Meningeal Neoplasms - mortality | Xenograft Model Antitumor Assays | Disease-Free Survival | Animals | Ifosfamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Kidney Neoplasms - drug therapy | Furans - administration & dosage | Analysis | Melanoma | Stem cells | Anthracyclines | Cancer | Drugs | Animal models | Progressions | Xenotransplantation | Immunodeficiency | Clinical trials | Patients | Survival | Anticancer properties | Studies | Molecular modelling | Xenografts | Mice | In vivo methods and tests | Mathematical models | Drug therapy | Tumors | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 508 - 522
The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant... 
LUNG-CANCER | ANGIOGENESIS | ONCOLOGY | PATHWAY | IN-VIVO | VINCRISTINE | TUMOR | CNS | CENTRAL-NERVOUS-SYSTEM | SUBGROUPS | CHEMOTHERAPY | CELL BIOLOGY | Humans | Neoplasm Proteins - physiology | Cerebellar Neoplasms - blood supply | Culture Media, Conditioned - pharmacology | Genetic Vectors - therapeutic use | Medulloblastoma - secretion | Recombinant Fusion Proteins - metabolism | Endothelium, Vascular - ultrastructure | Cerebellar Neoplasms - secretion | Wnt Proteins - genetics | Membrane Proteins - physiology | Pericytes - pathology | Glucose Transporter Type 1 - physiology | Antineoplastic Agents - pharmacokinetics | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Vincristine - pharmacokinetics | Disease Models, Animal | Carrier Proteins - physiology | Cerebellar Neoplasms - drug therapy | Transduction, Genetic | Genetic Association Studies | Genotype | Mice, Transgenic | Cerebellar Neoplasms - genetics | Tight Junctions - ultrastructure | Animals | Wnt Signaling Pathway - drug effects | Endothelium, Vascular - metabolism | Paracrine Communication - drug effects | Vincristine - therapeutic use | Medulloblastoma - blood supply | Mice | Wnt Proteins - physiology | Medulloblastoma - drug therapy | Drug Resistance, Neoplasm - physiology | Medulloblastoma - classification | Blood-Brain Barrier | Chemotherapy | Medulloblastoma | Brain tumors | Genetic aspects | Permeability | Cells | Cancer | Neurophysiology | Endothelium | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2014, Volume 26, Issue 1, pp. 33 - 47
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2006, Volume 24, Issue 25, pp. 4202 - 4208
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue 11, pp. 1542 - 1552
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2015, Volume 27, Issue 1, pp. 72 - 84
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined family... 
AMPLIFICATION | ONCOLOGY | OUTCOME PREDICTION | ANAPLASTIC MEDULLOBLASTOMA | TP53 MUTATION | CHILDHOOD MEDULLOBLASTOMA | N-MYC | CENTRAL-NERVOUS-SYSTEM | NEUROBLASTOMA | SUBGROUPS | CHILDRENS-CANCER | CELL BIOLOGY | Oncogene Proteins - genetics | Humans | Child, Preschool | Molecular Sequence Data | Neoplasm Recurrence, Local - drug therapy | Infant | Male | Antineoplastic Agents - therapeutic use | Tumor Suppressor Protein p53 - genetics | Young Adult | Medulloblastoma - pathology | Neoplasms, Experimental | Adult | Female | N-Myc Proto-Oncogene Protein | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Nuclear Proteins - genetics | Child | Cerebellar Neoplasms - drug therapy | Signal Transduction | Oncogene Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Cerebellar Neoplasms - genetics | Proto-Oncogene Proteins c-myc - metabolism | Animals | Gene Amplification | Adolescent | Neoplasm Recurrence, Local - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Mutation | Medulloblastoma - drug therapy | Neurosciences | Genetic engineering | Tumor proteins | Medulloblastoma | Children's hospitals | Brain tumors | Index Medicus | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Journal Article
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Schmidt, Sabine and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Olaf and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and ICGC PedBrain Tumor Project
Cancer Cell, ISSN 1535-6108, 03/2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
NERVOUS-SYSTEM | TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | PEDIATRIC MEDULLOBLASTOMA | CANCER | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 01/2011, Volume 71, Issue 2, pp. 435 - 444
Journal Article
Journal Article