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by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Adrian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Paolo Tonini, Gian and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas E and von Deimling, Andreas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, André O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Peter Collins, V and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Andrey and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7409, pp. 100 - 105
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is critical... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone Methyltransferases | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Schmidt, Sabine and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Witt, Olaf and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and on behalf of the ICGC PedBrain Tumor Project and ICGC PedBrain Tumor Project
Cancer cell, ISSN 1535-6108, 2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | RESISTANCE | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | SUBGROUPS | PEDIATRIC MEDULLOBLASTOMA | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 488, Issue 7409, pp. 43 - 48
Journal Article
by Morrissy, A. Sorana and Garzia, Livia and Shih, David J. H and Zuyderduyn, Scott and Huang, Xi and Skowron, Patryk and Remke, Marc and Cavalli, Florence M. G and Ramaswamy, Vijay and Lindsay, Patricia E and Jelveh, Salomeh and Donovan, Laura K and Wang, Xin and Luu, Betty and Zayne, Kory and Li, Yisu and Mayoh, Chelsea and Thiessen, Nina and Mercier, Eloi and Mungall, Karen L and Ma, Yusanne and Tse, Kane and Zeng, Thomas and Shumansky, Karey and Roth, Andrew J. L and Shah, Sohrab and Farooq, Hamza and Kijima, Noriyuki and Holgado, Borja L and Lee, John J. Y and Matan-Lithwick, Stuart and Liu, Jessica and Mack, Stephen C and Manno, Alex and Michealraj, K. A and Nor, Carolina and Peacock, John and Qin, Lei and Reimand, Juri and Rolider, Adi and Thompson, Yuan Y and Wu, Xiaochong and Pugh, Trevor and Ally, Adrian and Bilenky, Mikhail and Butterfield, Yaron S. N and Carlsen, Rebecca and Cheng, Young and Chuah, Eric and Corbett, Richard D and Dhalla, Noreen and He, An and Lee, Darlene and Li, Haiyan I and Long, William and Mayo, Michael and Plettner, Patrick and Qian, Jenny Q and Schein, Jacqueline E and Tam, Angela and Wong, Tina and Birol, Inanc and Zhao, Yongjun and Faria, Claudia C and Pimentel, José and Nunes, Sofia and Shalaby, Tarek and Grotzer, Michael and Pollack, Ian F and Hamilton, Ronald L and Li, Xiao-Nan and Bendel, Anne E and Fults, Daniel W and Walter, Andrew W and Kumabe, Toshihiro and Tominaga, Teiji and Collins, V. Peter and Cho, Yoon-Jae and Hoffman, Caitlin and Lyden, David and Wisoff, Jeffrey H and Garvin, James H and Stearns, Duncan S and Massimi, Luca and Schüller, Ulrich and Sterba, Jaroslav and Zitterbart, Karel and Puget, Stephanie and Ayrault, Olivier and Dunn, Sandra E and Tirapelli, Daniela P. C and Carlotti, Carlos G and Wheeler, Helen and Hallahan, Andrew R and Ingram, Wendy and MacDonald, Tobey J and Olson, Jeffrey J and Van Meir, Erwin G and Lee, Ji-Yeoun and Wang, Kyu-Chang and ...
Nature (London), ISSN 1476-4687, 2016, Volume 529, Issue 7586, pp. 351 - 357
... (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5... 
HETEROGENEITY | CANCER EVOLUTION | CELLS | IMPACT | MULTIDISCIPLINARY SCIENCES | SUBGROUP MEDULLOBLASTOMA | DYNAMICS | MUTATIONS | SEQUENCING DATA | LYMPHOBLASTIC-LEUKEMIA | GENOME | Clone Cells - drug effects | Humans | Male | Medulloblastoma - therapy | Radiotherapy, Image-Guided | Selection, Genetic - drug effects | Drosophila melanogaster - genetics | Neoplasm Recurrence, Local - pathology | Medulloblastoma - radiotherapy | DNA Mutational Analysis | Medulloblastoma - pathology | Female | Medulloblastoma - surgery | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Molecular Targeted Therapy - methods | Disease Models, Animal | Signal Transduction | Neoplasm Recurrence, Local - therapy | Drosophila melanogaster - cytology | Cerebellar Neoplasms - genetics | Clone Cells - metabolism | Genome, Human - genetics | Xenograft Model Antitumor Assays | Animals | Clone Cells - pathology | Craniospinal Irradiation | Neoplasm Recurrence, Local - genetics | Mice | Cerebellar Neoplasms - therapy | Cerebellar Neoplasms - surgery | Cerebellar Neoplasms - radiotherapy | Clonal selection theory | Care and treatment | Medulloblastoma | Oncology, Experimental | Genetic aspects | Research | Cancer | Genes | Cloning | Clinical trials | Cytotoxicity | Genomes | Radiation therapy | Metastasis | Cancer therapies | Rodents | Medical prognosis | Mutation | Tumors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2008, Volume 3, Issue 8, p. e3088
Background: Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome... 
PRIMITIVE NEUROECTODERMAL TUMORS | TRILATERAL RETINOBLASTOMA | PHOTORECEPTOR MARKERS | S-ANTIGEN IMMUNOREACTIVITY | MULTIDISCIPLINARY SCIENCES | IMMUNOCYTOCHEMICAL DEMONSTRATION | CHILDHOOD MEDULLOBLASTOMA | WNT/WINGLESS PATHWAY | BETA-CATENIN | ARRAY CGH | RAS/MAPK PATHWAY | Nucleic Acid Hybridization | Signal Transduction | Genomics | Humans | Transforming Growth Factor beta - physiology | Child, Preschool | Male | Gene Expression Profiling | Cerebellar Neoplasms - genetics | DNA Mutational Analysis | Medulloblastoma - pathology | Adolescent | RNA, Neoplasm - genetics | Adult | Female | Cerebellar Neoplasms - pathology | DNA, Neoplasm - genetics | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Child | Medulloblastoma - classification | Care and treatment | Prognosis | RNA | Medulloblastoma | Analysis | Genes | Brain tumors | Genetic research | Cytogenetics | Metastasis | Molecular biology | Gene expression | Brain | Pediatrics | Wnt protein | Neuropathology | Pathogenesis | Copy number | Brain cancer | Clinical trials | Oncology | Hybridization | Cancer therapies | Metastases | β-catenin | Transgenic animals | Rodents | Classification | Genetics | Diagnosis | Children | Monosomy | Chromosome 17 | Deoxyribonucleic acid--DNA | Medical research | Antigens | Integrated approach | Chromosome 6 | Histology | Patients | Quality of life | Studies | Pathology | Side effects | Brain research | Algorithms | Hedgehog protein | Mutation | Aberration | Chromosome aberrations | Tumors | Deoxyribonucleic acid | DNA
Journal Article
The lancet oncology, ISSN 1470-2045, 2013, Volume 14, Issue 12, pp. 1200 - 1207
Journal Article
Journal Article