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Nature Neuroscience, ISSN 1097-6256, 08/2013, Volume 16, Issue 8, pp. 1000 - 1007
The construction of cerebral cortex begins with the formation of radial glia. Once formed, polarized radial glial cells divide either symmetrically or... 
JOUBERT-SYNDROME | PROTEIN | CORTICAL-NEURONS | ARL13B | BASAL PROGENITORS | NEUROGENESIS | DIFFERENTIATION | CILIOGENESIS | CEREBROSPINAL-FLUID | DEVELOPING CEREBRAL-CORTEX | NEUROSCIENCES | Cilia - physiology | Cell Polarity | Neuroglia - ultrastructure | Eye Abnormalities - enzymology | Humans | Nerve Tissue Proteins - deficiency | Epithelium - ultrastructure | Cerebellum - abnormalities | Cerebellar Diseases - enzymology | Neural Stem Cells - ultrastructure | Neurogenesis - genetics | Cerebellar Diseases - pathology | Axoneme - ultrastructure | Retina - enzymology | Cell Division | Kidney Diseases, Cystic - genetics | ADP-Ribosylation Factors - physiology | Cilia - enzymology | ADP-Ribosylation Factors - genetics | Cerebral Cortex - abnormalities | Kidney Diseases, Cystic - enzymology | Nerve Tissue Proteins - physiology | Neuroglia - physiology | Abnormalities, Multiple | Neural Stem Cells - physiology | Telencephalon - embryology | Eye Abnormalities - genetics | ADP-Ribosylation Factors - deficiency | Nerve Tissue Proteins - genetics | Mice, Inbred C3H | Kidney Diseases, Cystic - pathology | Mice, Knockout | Animals | Cerebellar Diseases - genetics | Cerebral Cortex - embryology | Eye Abnormalities - pathology | Cerebral Ventricles - abnormalities | Neurogenesis - physiology | Retina - abnormalities | Cerebral Cortex - growth & development | Mice | Retina - pathology | Telencephalon - ultrastructure | Brain | Cerebral cortex | Cilia and ciliary motion | Neuroglia | Physiological aspects | Research | Neurophysiology
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2019, Volume 73, Issue 5, pp. 1001 - 1014.e8
In Parkinson’s disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or... 
synucleinopathy | triglyceride | unsaturated fatty acid | oleic acid | diglyceride | alpha-synuclein | lipid droplets | tetramer | Parkinson’s disease | stearoyl-CoA-desaturase | inclusions | YEAST | FUNCTIONAL-NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | FATTY-ACID-METABOLISM | GENE-EXPRESSION | ADIPOCYTE DEVELOPMENT | SEIPIN | BRAIN | MOLECULAR-WEIGHT COMPLEXES | PHOSPHOLIPID-BINDING | CELL BIOLOGY | Neurons - pathology | Antiparkinson Agents - pharmacology | Lipid Droplets - enzymology | Dopaminergic Neurons - pathology | Saccharomyces cerevisiae - genetics | Humans | Cerebral Cortex - pathology | Drug Discovery - methods | Saccharomyces cerevisiae - drug effects | Parkinson Disease - drug therapy | Molecular Targeted Therapy | Diglycerides - metabolism | Dopaminergic Neurons - drug effects | alpha-Synuclein - genetics | Cerebral Cortex - drug effects | Neurons - drug effects | Disease Models, Animal | Induced Pluripotent Stem Cells - pathology | Cell Line | Lipid Droplets - drug effects | Cerebral Cortex - enzymology | Oleic Acid - metabolism | Parkinson Disease - pathology | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Caenorhabditis elegans - genetics | alpha-Synuclein - toxicity | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Neural Stem Cells - drug effects | Mice, Transgenic | Parkinson Disease - genetics | Stearoyl-CoA Desaturase - antagonists & inhibitors | Metabolomics - methods | Neural Stem Cells - enzymology | Neural Stem Cells - pathology | Rats, Sprague-Dawley | Triglycerides - metabolism | Dopaminergic Neurons - enzymology | Animals | Caenorhabditis elegans - drug effects | Neurons - enzymology | Parkinson Disease - enzymology | Lipid Metabolism - drug effects | Saccharomyces cerevisiae - enzymology | Stearoyl-CoA Desaturase - metabolism | Nerve Degeneration | Caenorhabditis elegans - enzymology
Journal Article
Brain Pathology, ISSN 1015-6305, 01/2008, Volume 18, Issue 1, pp. 86 - 95
Recent studies have revealed extensive cortical demyelination in patients with progressive multiple sclerosis (MS). Demyelination in gray matter lesions is... 
cerebral cortex | micrologia | myeloperoxidase | demyelination | multiple sclerosis | Myeloperoxidase | Cerebral cortex | Multiple sclerosis | Micrologia | Demyelination | CORTICAL DEMYELINATION | CELLS | ACTIVATION | PHAGOCYTOSIS | BETA-AMYLOID PROTEIN | ALZHEIMERS-DISEASE | PATHOLOGY | NEUROSCIENCES | LESIONS | CLINICAL NEUROLOGY | MYELIN | INFLAMMATION | REMYELINATION | Antigens, CD - immunology | Up-Regulation | Reactive Oxygen Species - metabolism | Wallerian Degeneration - pathology | Oxidative Stress | Humans | Middle Aged | Cerebral Cortex - pathology | Male | Gliosis - enzymology | Gliosis - physiopathology | Antigens, CD - metabolism | Cerebral Cortex - physiopathology | Myelin Sheath - metabolism | Gliosis - pathology | Multiple Sclerosis - physiopathology | Encephalitis - physiopathology | Nerve Fibers, Myelinated - pathology | Aged, 80 and over | Microglia - pathology | Adult | Female | HLA-DR Antigens - metabolism | Antigens, Differentiation, Myelomonocytic - immunology | Biomarkers - metabolism | Nerve Fibers, Myelinated - metabolism | Cerebral Cortex - enzymology | Encephalitis - enzymology | Multiple Sclerosis - enzymology | Myelin Sheath - pathology | Biomarkers - analysis | Encephalitis - pathology | Microglia - enzymology | Antigens, Differentiation, Myelomonocytic - metabolism | Multiple Sclerosis - pathology | Aged | HLA-DR Antigens - immunology | Enzyme Activation | Wallerian Degeneration - enzymology | Peroxidase - metabolism
Journal Article
Glia, ISSN 0894-1491, 05/2018, Volume 66, Issue 5, pp. 920 - 933
Human mesial temporal lobe epilepsy (MTLE) features subregion‐specific hippocampal neurodegeneration and reactive astrogliosis, including up‐regulation of the... 
stereology | astroglia | digital pathology | hippocampal sclerosis | GFAP | HUMAN BRAIN | TEMPORAL-LOBE EPILEPSY | SCLEROSIS | INTERNATIONAL CONSENSUS CLASSIFICATION | GLIAL-CELLS | NEUROSCIENCES | FIBRILLARY ACIDIC PROTEIN | SEIZURE-LIKE EVENTS | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | DENTATE GYRUS | Immunohistochemistry | Epilepsy, Temporal Lobe - enzymology | Neurons - pathology | Humans | Astrocytes - pathology | Cerebral Cortex - pathology | Drug Resistant Epilepsy - enzymology | Male | Epilepsy, Temporal Lobe - surgery | Gliosis - enzymology | Astrocytes - enzymology | Glial Fibrillary Acidic Protein - metabolism | Gliosis - pathology | Adult | Female | Epilepsy, Temporal Lobe - pathology | Glutamate-Ammonia Ligase - metabolism | Cerebral Cortex - enzymology | Neurodegenerative Diseases - pathology | White Matter - enzymology | Drug Resistant Epilepsy - pathology | White Matter - pathology | Cell Death - physiology | Neurons - enzymology | Drug Resistant Epilepsy - surgery | Neurodegenerative Diseases - enzymology | Brain | Neurons | Ligases | Glutamine | Neuroimaging | Temporal lobe | Image processing | Astrocytes | Glial fibrillary acidic protein | Epilepsy | Cortex | Substantia alba | Neuronal-glial interactions | Image analysis | Digital imaging | Gliosis | Neurodegeneration | Surgery | Stratum radiatum | Stereology | Degeneration | Glutamate-ammonia ligase | Hippocampus | Cortex (temporal)
Journal Article
Cerebral Cortex, ISSN 1047-3211, 2002, Volume 12, Issue 1, pp. 37 - 53
We examined the development of the occipital lobe in fetal monkeys between embryonic day 37 (E37) and E108 in Nissl-stained and acetylcholine esterase... 
RADIAL GLIAL-CELLS | WHITE-MATTER | SOMATOSENSORY CORTEX | RHESUS-MONKEY | FETAL MONKEY | RAT NEOCORTEX | PRIMATE VISUAL-CORTEX | CORTICAL PLATE | DEVELOPING CEREBRAL-CORTEX | NEUROSCIENCES | MEDIAL GANGLIONIC EMINENCE
Journal Article
Cerebral Cortex, ISSN 1047-3211, 2017, Volume 27, Issue 12, pp. 5696 - 5714
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