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1. Full Text Cerebroside C Increases Tolerance to Chilling Injury and Alters Lipid Composition in Wheat Roots
by Li, Hong-Xia and Xiao, Yu and Cao, Ling-Ling and Yan, Xu and Li, Cong and Shi, Hai-Yan and Wang, Jian-Wen and Ye, Yong-Hao
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e73380
Chilling tolerance was increased in seed germination and root growth of wheat seedlings grown in media containing 20 mu g/mL cerebroside C (CC), isolated from... 
OXIDATIVE STRESS | XANTHINE-OXIDASE | ABIOTIC STRESS | PHOSPHOLIPASE-D | TEMPERATURE | MEMBRANE | MULTIDISCIPLINARY SCIENCES | FATTY-ACID | INVOLVEMENT | LIPOXYGENASE ACTIVITY | PLANT-GROWTH | Superoxide Dismutase - genetics | Gene Expression - drug effects | Adaptation, Physiological - drug effects | Cell Membrane Permeability | Plant Roots - genetics | Seedlings - genetics | Biomass | Plant Roots - drug effects | Triticum - metabolism | Lipoxygenase - metabolism | Saccharomycetales - chemistry | Plant Leaves - drug effects | Plant Proteins - metabolism | Phospholipids - metabolism | Superoxide Dismutase - metabolism | Germination - drug effects | Glutathione Peroxidase - metabolism | Cold Temperature | Plant Roots - metabolism | Seeds - metabolism | Catalase - genetics | Seeds - drug effects | Seeds - genetics | Cerebrosides - isolation & purification | Fatty Acids, Unsaturated - metabolism | Seedlings - drug effects | Glutathione Peroxidase - genetics | Malondialdehyde | Catalase - metabolism | Triticum - genetics | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Lipoxygenase - genetics | Lipid Peroxidation | Cerebrosides - pharmacology | Seedlings - metabolism | Triticum - drug effects | Lipid peroxidation | Superoxide | Saturated fatty acids | Wheat | Germination | Linolenic acids | Plasma | Lipid composition | Seeds | Media (culture) | Laboratories | Roots | Membrane permeability | Science | Lipids | Superoxide dismutase | Phospholipids | Palmitic acid | Fungi | Antioxidants | Catalase | Metabolites | Education | Chilling | Endophytes | Physiology | Peroxidase | Stearic acid | Glutathione | Peroxidation | Glutathione peroxidase | Enzymes | Cooling | Cold | Cultivation | Pesticides | Programmable logic controllers | Permeability | Fatty acids | Phospholipase D | Seed germination | Seedlings | Linoleic acid | Linolenic acid | Plant growth | Programmable logic devices | Liquid oxygen | Crop diseases | Lipoxygenase
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2. Full Text Lipid-dependent Targeting of G Proteins into Rafts
by Serge Moffett and Deborah A. Brown and Maurine E. Linder
Journal of Biological Chemistry, ISSN 0021-9258, 01/2000, Volume 275, Issue 3, pp. 2191 - 2198
Domains rich in sphingolipids and cholesterol, or rafts, may organize signal transduction complexes at the plasma membrane. Raft lipids are believed to exist... 
SIGNAL-TRANSDUCTION | ALPHA-SUBUNITS | MODEL MEMBRANES | MEMBRANE-BINDING | HETEROTRIMERIC G-PROTEINS | ADENYLYL-CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | T-CELL ACTIVATION | TYROSINE KINASES | PLASMA-MEMBRANE | GPI-ANCHORED PROTEINS | Protein Structure, Tertiary | Sphingomyelins - metabolism | GTP-Binding Proteins - chemistry | Signal Transduction | Sphingolipids - metabolism | Cerebrosides - metabolism | Recombinant Proteins | Cholesterol - metabolism | Phosphatidylcholines - metabolism | Surface-Active Agents - pharmacology | Saccharomyces cerevisiae - metabolism | Animals | Membrane Proteins - chemistry | Escherichia coli - metabolism | Liposomes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Octoxynol - pharmacology | Phosphatidylethanolamines - metabolism | Acylation | GTP-Binding Proteins - metabolism
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3. Full Text Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy
by Viader, Andreu and Sasaki, Yo and Kim, Sungsu and Strickland, Amy and Workman, Cayce S and Yang, Kui and Gross, Richard W and Milbrandt, Jeffrey
Neuron, ISSN 0896-6273, 03/2013, Volume 77, Issue 5, pp. 886 - 898
Mitochondrial dysfunction is a common cause of peripheral neuropathy. Much effort has been devoted to examining the role played by neuronal/axonal... 
PERIPHERAL-NERVE | BETA-OXIDATION | MULTIDIMENSIONAL MASS-SPECTROMETRY | DISEASE | GENE-EXPRESSION | MICE | SHOTGUN LIPIDOMICS | LONG-CHAIN ACYLCARNITINE | TRANSCRIPTION FACTOR | DIABETIC-NEUROPATHY | NEUROSCIENCES | Aniline Compounds | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Carnitine - metabolism | Ganglia, Spinal - cytology | Schwann Cells - metabolism | Blotting, Western | Nerve Degeneration - metabolism | Nerve Degeneration - pathology | Mice, Knockout | Peripheral Nervous System Diseases - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Xanthenes | Animals | Mitochondrial Encephalomyopathies - metabolism | Microarray Analysis | Axons - pathology | Mice | Peripheral Nervous System Diseases - pathology | Carnitine - analogs & derivatives | Fatty Acids - metabolism | Fluorescent Dyes | Lipid Metabolism - physiology | Physiological aspects | Mitochondrial DNA | Synthesis | Fatty acids | Analysis | Cell culture | Disease | Neurons | Lipids | Nervous system | Genomes | Metabolism | Gene expression | Proteins | Pathology | Mitochondria | Hospitals | Rodents | Diabetes | Cancer | sulfatides | heme-regulated inhibitor kinase | diabetic neuropathy | cerebrosides | TFAM | eukaryotic elongation factor 2 alpha | acylcarnitines | integrated stress response
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4. Full Text Circulating sphingolipid biomarkers in models of type 1 diabetes
by Fox, Todd E and Bewley, Maria C and Unrath, Kellee A and Pedersen, Michelle M and Anderson, Robert E and Jung, Dae Young and Jefferson, Leonard S and Kim, Jason K and Bronson, Sarah K and Flanagan, John M and Kester, Mark
Journal of Lipid Research, ISSN 0022-2275, 03/2011, Volume 52, Issue 3, pp. 509 - 517
Alterations in lipid metabolism may contribute to diabetic complications. Sphingolipids are essential components of cell membranes and have essential roles in... 
Ceramide | Sphingomyelin cerebrosides | Lipidomics | Nervonic acid | Sphingosine-1-phosphate | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TANDEM MASS-SPECTROMETRY | ceramide | OBESITY | RECEPTOR SUBTYPES | METABOLISM | INSULIN-RESISTANCE | cerebrosides | nervonic acid | sphingomyelin | sphingosine-1-phosphate | MICE | ACCUMULATION | lipidomics | ADIPOSE-TISSUE | Sphingolipids - chemistry | Lysophospholipids - metabolism | Diabetes Mellitus, Type 1 - metabolism | Male | Diabetes Mellitus, Experimental - blood | Sphingolipids - blood | Liver - drug effects | Myocardium - metabolism | Female | Sphingosine - metabolism | Fatty Acids - blood | Diabetes Mellitus, Experimental - metabolism | Insulin - genetics | Disease Models, Animal | Biomarkers - metabolism | Insulin - pharmacology | Liver - metabolism | Diabetes Mellitus, Type 1 - genetics | Rats | Sphingolipids - metabolism | Biomarkers - blood | Sphingosine - analogs & derivatives | Animals | Diabetes Mellitus, Type 1 - blood | Alleles | Mice | Mutation | Biomarkers - chemistry
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5. Full Text Defensins from Insects and Plants Interact with Fungal Glucosylceramides
by Karin Thevissen and Dirk C. Warnecke and Isabelle E. J. A. François and Martina Leipelt and Ernst Heinz and Claudia Ott and Ulrich Zähringer and Bart P. H. J. Thomma and Kathelijne K. A. Ferket and Bruno P. A. Cammue
Journal of Biological Chemistry, ISSN 0021-9258, 02/2004, Volume 279, Issue 6, pp. 3900 - 3905
Growth of the yeast species Candida albicans and Pichia pastoris is inhibited by RsAFP2, a plant defensin isolated from radish seed ( Raphanus sativus ), at... 
protein-synthesis | cells | saccharomyces-cerevisiae | barley endosperm | cerebrosides | candida-albicans | binding-sites | antifungal activity | tandem mass-spectrometry | dahlia dahlia-merckii | CELLS | BARLEY ENDOSPERM | CANDIDA-ALBICANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIFUNGAL ACTIVITY | CEREBROSIDES | TANDEM MASS-SPECTROMETRY | BINDING-SITES | SACCHAROMYCES-CEREVISIAE | PROTEIN-SYNTHESIS | DAHLIA DAHLIA-MERCKII | Defensins - metabolism | Candida albicans - metabolism | Antimicrobial Cationic Peptides - metabolism | Candida albicans - growth & development | Fungi - metabolism | Pichia - metabolism | Candida albicans - drug effects | Defensins - pharmacology | Antifungal Agents - metabolism | Genes, Fungal | Plant Proteins - metabolism | Fungi - growth & development | Insect Proteins - metabolism | Antifungal Agents - pharmacology | Glucosylceramides - genetics | Pichia - drug effects | Plant Proteins - pharmacology | Fungi - drug effects | Insect Proteins - pharmacology | Glucosylceramides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Animals | Pichia - genetics | Mutation | In Vitro Techniques | Glucosylceramides - metabolism | Pichia - growth & development | glucosylceramides | heliomicin | defensins | AFP2 protein | RsAFP2 protein
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6. Full Text Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells
by Pituch, Katarzyna C and Moyano, Ana L and Lopez-Rosas, Aurora and Marottoli, Felecia M and Li, Guannan and Hu, Chenqi and Van Breemen, Richard and Månsson, Jan E and Givogri, Maria I
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 11, pp. 7040 - 7053
The membrane-bound receptor for platelet-derived growth factor A (PDGFRα) is crucial for controlling the production of oligodendrocytes (OLs) for myelination,... 
Exosomes - metabolism | Oligodendroglia - metabolism | Exosomes - genetics | Neural Stem Cells - cytology | Neurogenesis | Myelin Sheath - metabolism | Leukodystrophy, Metachromatic - metabolism | Proteolysis | Transcription, Genetic | Oligodendroglia - cytology | Fatty Acids - metabolism | Leukodystrophy, Metachromatic - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Neural Stem Cells - pathology | Oligodendroglia - pathology | Leukodystrophy, Metachromatic - genetics | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Sulfoglycosphingolipids - metabolism | Cerebroside-Sulfatase - metabolism | Neural Stem Cells - metabolism | Cerebroside-Sulfatase - genetics | Lipid Raft | PDGFRalpha | Sulfatides | Oligodendrocyte | Exosome | Neural Precursor Cells | Arylsulfatase A | Lysosomal Storage Disease | AKT PKB | Cell Biology | Glycolipid
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7. Full Text Two types of detergent‐insoluble, glycosphingolipid/cholesterol‐rich membrane domains from isolated myelin
by Arvanitis, Dina N and Min, Weixian and Gong, Yanping and Heng, Yew M and Boggs, Joan M
Journal of Neurochemistry, ISSN 0022-3042, 09/2005, Volume 94, Issue 6, pp. 1696 - 1710
Two different types of low‐density detergent‐insoluble glycosphingolipid‐enriched membrane domain (DIG) fractions were isolated from myelin by extraction with... 
galactosylceramide | rafts | oligodendrocytes | cerebroside sulfate | cytoskeleton | caveolin | Cerebroside sulfate | Cytoskeleton | Caveolin | Galactosylceramide | Oligodendrocytes | Rafts | PROTEOLIPID PROTEIN | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NERVOUS-SYSTEM MYELIN | PLASMA-MEMBRANE | NEUROSCIENCES | FYN KINASE | LIPID RAFTS | TRITON X-100 | ACTIN CYTOSKELETON | BASIC-PROTEIN | GPI-ANCHORED PROTEINS | Detergents - chemistry | Membrane Microdomains - metabolism | Actins - metabolism | Octoxynol - chemistry | Galactosylceramides - metabolism | Caveolins - metabolism | Membrane Microdomains - ultrastructure | Myelin Sheath - metabolism | Brain - metabolism | Cholesterol - chemistry | Galactosylceramides - isolation & purification | Tubulin - metabolism | Caveolin 1 | Cattle | Axons - ultrastructure | G(M1) Ganglioside - chemistry | Membrane Proteins - metabolism | Glycosphingolipids - isolation & purification | Microscopy, Electron, Transmission | Cholesterol - isolation & purification | Neural Cell Adhesion Molecules - chemistry | Solubility | Axons - metabolism | Membrane Microdomains - chemistry | Axons - chemistry | Cholesterol - metabolism | Galactosylceramides - chemistry | Neural Cell Adhesion Molecules - isolation & purification | Animals | Neural Cell Adhesion Molecules - metabolism | Cytoskeleton - metabolism | Glycosphingolipids - metabolism | Signal Transduction - physiology | Myelin Sheath - ultrastructure | Myelin Sheath - chemistry | G(M1) Ganglioside - metabolism | Subcellular Fractions - chemistry | Glycosphingolipids - chemistry | Proteins | Neurons | Membranes
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8. Full Text Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α -/- mouse cortex: A potential lipidomic role of PGC-1α in neurodegeneration
by Kiebish, Michael A and Young, Dee M and Lehman, John J and Han, Xianlin
Journal of Lipid Research, ISSN 0022-2275, 02/2012, Volume 53, Issue 2, pp. 273 - 281
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), a key regulator of energy metabolism and lipid homeostasis in multiple... 
Shotgun lipidomics | Sphingolipidomics | Apolipoprotein E | Alzheimer's disease | 1-ALPHA PGC-1-ALPHA | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | AMYLOID DEPOSITION | MULTIDIMENSIONAL MASS-SPECTROMETRY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | APOLIPOPROTEIN-E | shotgun lipidomics | PGC-1 COACTIVATORS | apolipoprotein E | sphingolipidomics | CENTRAL-NERVOUS-SYSTEM | LIVER-X-RECEPTOR | Caloric Restriction | Proteolipids - metabolism | Neurodegenerative Diseases - metabolism | Orphan Nuclear Receptors - metabolism | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Trans-Activators - physiology | Animals | Mice, Mutant Strains | Liver X Receptors | Myelin and Lymphocyte-Associated Proteolipid Proteins | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Membrane Transport Proteins - metabolism | Sulfotransferases - metabolism | Mice | Transcription Factors | Sulfoglycosphingolipids - metabolism | Myelin Proteins - metabolism | Cerebroside-Sulfatase - metabolism | Retinoid X Receptors - metabolism | Enzymes - metabolism | Homeostasis - genetics
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9. Full Text How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's β amyloid peptide (Aβ1-40)
by Yahi, Nouara and Aulas, Anaïs and Fantini, Jacques
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9079
Membrane lipids play a pivotal role in the pathogenesis of Alzheimer's disease, which is associated with conformational changes, oligomerization and/or... 
FORM | SPHINGOLIPID-BINDING DOMAIN | DISEASE | BIOLOGY | MEMBRANES | CEREBROSIDE | GM1 | PRECURSOR PROTEIN | LIPID MONOLAYERS | FIBRILLOGENESIS | HELICOBACTER-PYLORI | Sodium Chloride - pharmacology | Humans | Molecular Conformation | Crystallography, X-Ray | G(M3) Ganglioside - chemistry | Cholesterol - chemistry | Protein Binding - drug effects | Surface Properties | Amyloid beta-Peptides - metabolism | Glycolipids - chemistry | G(M1) Ganglioside - chemistry | G(M3) Ganglioside - metabolism | Molecular Structure | Fatty Acids - metabolism | Peptide Fragments - metabolism | Fatty Acids - chemistry | Models, Molecular | Cholesterol - metabolism | Glycolipids - metabolism | Molecular Dynamics Simulation | Peptide Fragments - chemistry | Alzheimer Disease - metabolism | Glycosphingolipids - metabolism | Amyloid beta-Peptides - chemistry | Lipid Bilayers - chemistry | Lipid Bilayers - metabolism | G(M1) Ganglioside - metabolism | Glycosphingolipids - chemistry | Peptides | Pathogenesis | Molecular dynamics | Lipids | Biochemistry | Crystallography | Cell surface | Proteins | Human immunodeficiency virus--HIV | Ceramide | Inhibition | Alzheimer's disease | Sugar | Antigens | Oligomerization | Neurodegenerative diseases | Fatty acids | Cholesterol | Dilution | Molecular modelling | Glycosphingolipids | Monolayers | β-Amyloid | Lymphomas | Alzheimers disease | Conformation | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | HIV | Human immunodeficiency virus
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10. Full Text Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy
by Doerr, Jonas and Böckenhoff, Annika and Ewald, Benjamin and Ladewig, Julia and Eckhardt, Matthias and Gieselmann, Volkmar and Matzner, Ulrich and Brüstle, Oliver and Koch, Philipp
Molecular Therapy, ISSN 1525-0016, 09/2015, Volume 23, Issue 9, pp. 1519 - 1531
Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder resulting from a functional deficiency of arylsulfatase A (ARSA), an enzyme that... 
MEDICINE, RESEARCH & EXPERIMENTAL | PATHOLOGY | DELIVERY | PLURIPOTENT STEM-CELLS | ENZYME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | NEURONS | GENE-THERAPY | MICE | DYSFUNCTION | DEFICITS | BRAIN | Cell- and Tissue-Based Therapy - methods | Central Nervous System - metabolism | Humans | Cell Survival - genetics | Neurons - cytology | DNA-Binding Proteins - deficiency | Brain - metabolism | Leukodystrophy, Metachromatic - metabolism | Neuroglia - cytology | Lentivirus - genetics | Cell Differentiation | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Gene Order | Disease Models, Animal | Induced Pluripotent Stem Cells - metabolism | Gene Expression | Transduction, Genetic | Axons - metabolism | Genetic Vectors - genetics | Mice, Knockout | Leukodystrophy, Metachromatic - genetics | Animals | Neuroglia - metabolism | Mice | Sulfoglycosphingolipids - metabolism | Cerebroside-Sulfatase - metabolism | Cerebroside-Sulfatase - genetics | Genetic Therapy - methods | Original
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11. Full Text Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
by Kalvodova, Lucie and Kahya, Nicoletta and Schwille, Petra and Ehehalt, Robert and Verkade, Paul and Drechsel, David and Simons, Kai
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 44, pp. 36815 - 36823
The beta-secretase, BACE, is a membrane spanning aspartic protease, which cleaves the amyloid precursor protein (APP) in the first step of proteolytic... 
BETA-SECRETASE | RAFTS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANES | NEURONS | ASYMMETRIC VESICLES | RECEPTOR | GENERATION | AMYLOID PRECURSOR PROTEIN | CYTOSOLIC DOMAIN | Recombinant Proteins - metabolism | Endopeptidases - metabolism | Humans | Phosphatidylserines - metabolism | Recombinant Proteins - chemistry | Baculoviridae - genetics | Cerebrosides - metabolism | Recombinant Proteins - genetics | Cholesterol - metabolism | Endopeptidases - genetics | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Glycosphingolipids - metabolism | In Vitro Techniques
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12. Full Text Novel molecular insights into the critical role of sulfatide in myelin maintenance/function
by Palavicini, Juan Pablo and Wang, Chunyan and Chen, Linyuan and Ahmar, Sareen and Higuera, Juan Diego and Dupree, Jeffrey L and Han, Xianlin
Journal of Neurochemistry, ISSN 0022-3042, 10/2016, Volume 139, Issue 1, pp. 40 - 54
Cerebroside sulfotransferase (CST) catalyzes the production of sulfatide, a major class of myelin‐specific lipids. CST knockout (CST−/−) mice in which... 
sulfatide | myelin lipidome | proteolipid protein | cerebroside sulfotransferase | myelin‐associated glycoprotein | shotgun lipidomics | myelin-associated glycoprotein | MULTIDIMENSIONAL MASS-SPECTROMETRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | INCREASED NUMBER | MONOCLONAL-ANTIBODY | NEUROSCIENCES | APOLIPOPROTEIN-E | OLIGODENDROCYTE DIFFERENTIATION | EARLY ALZHEIMERS-DISEASE | CENTRAL-NERVOUS-SYSTEM | BASIC-PROTEIN | Oligodendroglia - metabolism | Myelin Sheath - physiology | Mice, Inbred C57BL | Myelin-Associated Glycoprotein - metabolism | Axons - metabolism | Homeostasis | Lipid Metabolism | Male | Myelin Proteins - genetics | Mice, Knockout | Myelin Sheath - metabolism | Phenotype | Animals | Axons - ultrastructure | Myelin Proteolipid Protein - metabolism | Sulfotransferases - metabolism | Mice | Myelin Sheath - ultrastructure | Sulfoglycosphingolipids - metabolism | Myelin Proteins - metabolism | Lipids | Tremor | Analysis | Myelin proteins | Neurochemistry | Proteins | Catalysis
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