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Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 63 - 74
The gut microbiota has been implicated in obesity and cardiometabolic diseases, although evidence in humans is scarce. We investigated how gut microbiota... 
BODY-WEIGHT | NORFLOXACIN | VANCOMYCIN | CHAIN FATTY-ACIDS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | SENSITIVITY | CHROMATOGRAPHY-MASS SPECTROMETRY | SECRETION | GLUCOSE-TOLERANCE | MODULATION | CELL BIOLOGY | Organ Specificity - drug effects | Inflammation - pathology | Humans | Middle Aged | Male | Adipocytes - drug effects | Obesity - genetics | Obesity - microbiology | Vancomycin - pharmacology | Placebos | Adult | Butyric Acid - blood | Biomarkers - metabolism | Insulin - pharmacology | Double-Blind Method | Permeability | Adipocytes - pathology | Obesity - metabolism | Cell Shape - drug effects | Gene Expression Regulation - drug effects | Feces - chemistry | Gastrointestinal Microbiome - drug effects | Substrate Specificity - drug effects | Amoxicillin - pharmacology | Adipocytes - metabolism | Aged | Anti-Bacterial Agents - pharmacology | Energy Metabolism - drug effects | Obesity | Metabolites | Microbiota (Symbiotic organisms) | Physiological aspects | Clinical trials | Electric power production | Gene expression | Fatty acids | Antibacterial agents | Prediabetic state | Deoxycholic acid | Nutrition, Metabolism and Genomics | Microbiologie | Microbiology | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | Laboratorium voor Microbiologie | Microbiological Laboratory | HNE Nutrition, Metabolism and Genomics | WIMEK
Journal Article
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 12, pp. 1546 - 1555
Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality control mechanism to clear misfolded proteins in the ER; however, its... 
Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics | INTESTINAL INFLAMMATION | UNFOLDED-PROTEIN RESPONSE | CHAPERONE BIP | MISFOLDED GLYCOPROTEINS | PATHWAY | SEL1L | ER-ASSOCIATED DEGRADATION | UBIQUITIN-LIGASE | STRESS | TRANSMEMBRANE PROTEIN | CELL BIOLOGY | Endoribonucleases - genetics | Oligonucleotide Array Sequence Analysis | Enterocytes - metabolism | Humans | Endoplasmic Reticulum - metabolism | Male | Gene Expression Profiling | Neoplasm Proteins - metabolism | Heat-Shock Proteins - genetics | Lectins - metabolism | Base Sequence | HEK293 Cells | Female | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Endoplasmic Reticulum-Associated Degradation - genetics | Heat-Shock Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Proteins - genetics | Animals | Proteins - metabolism | Lectins - genetics | Mice | Ubiquitin-Protein Ligases - genetics | ERAD | colitis | Sel1L | Hrd1 | inflammation | UPR | intestinal epithelium
Journal Article
The Plant Cell, ISSN 1040-4651, 2019, Volume 31, pp. 52 - 67
Land plants can reproduce sexually by developing an embryo from a fertilized egg cell. However, embryos can also be formed from other cell types in many plant... 
Nutrition, Metabolism and Genomics | VLAG | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | Voeding, Metabolisme en Genomica | EPS | Biochemistry | Biochemie | HNE Nutrition, Metabolism and Genomics
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2018, Volume 115, Issue 30, pp. 7789 - 7794
Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes. However, direct effects of circadian misalignment on... 
Nutrition, Metabolism and Genomics | VLAG | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
Diabetologia, ISSN 0012-186X, 2018, Volume 61, Issue 4, pp. 942 - 953
Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate... 
Immunometabolism | Adipose tissue | Medicine & Public Health | Human Physiology | Oxidative phosphorylation | Metabolic Diseases | Internal Medicine | Inflammation | Glycolysis obesity | Macrophages | CELLS | LOCALIZATION | ADIPOCYTES | NECROSIS-FACTOR-ALPHA | Immuno metabolism | CIRCULATING LEVELS | INSULIN-RESISTANCE | FUNCTIONAL POLARIZATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CHEMOKINE | HIF-1-ALPHA | Myeloid Cells - cytology | Activation, Metabolic | Cytokines - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Adipose Tissue - cytology | Male | Gene Expression Profiling | Mice, Knockout | Obesity - metabolism | Macrophages - metabolism | Phenotype | Animals | Adipocytes - metabolism | Oxygen - chemistry | Glycolysis | Mice | Adipose tissues | Lactates | Obesity | Glucose metabolism | Analysis | Leptin | Insulin resistance | Metabolic rate | Energy metabolism | CD14 antigen | Cell activation | Bone marrow | Oxidation | Enzyme-linked immunosorbent assay | Hypoxia-inducible factors | Explants | Cytokines | Diabetes mellitus | Metabolism | Gene expression | Insulin | DNA microarrays | Metabolic activation | Hypoxia | Lactic acid | Intracellular | Peritoneum | Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 37, pp. 14224 - 14236
Obesity and the metabolic syndrome are characterized by chronic, low-grade inflammation mainly originating from expanding adipose tissue and resulting in... 
Nutrition, Metabolism and Genomics | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | VLAG | Voeding, Metabolisme en Genomica | HNE Nutrition, Metabolism and Genomics
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, p. e0184274
A mucus layer covers and protects the intestinal epithelial cells from direct contact with microbes. This mucus layer not only prevents inflammation but also... 
SYSTEM | PATHOGENESIS | CELLS | HOMEOSTASIS | INFLAMMATORY-BOWEL-DISEASE | COLITIS | GUT-MICROBIOTA | GASTROINTESTINAL-TRACT | BARRIER | ANTIGENS | MULTIDISCIPLINARY SCIENCES | Colon - cytology | Intestinal Mucosa - metabolism | Spleen - immunology | Age Factors | Peyer's Patches - metabolism | Dendritic Cells - immunology | Immunity, Mucosal | Metagenomics - methods | Transcriptome | Colon - immunology | Male | Gene Expression Profiling | Biodiversity | Intestinal Mucosa - cytology | Cell Differentiation - genetics | Aging - immunology | T-Lymphocytes - metabolism | Intestinal Mucosa - immunology | Female | Mucus - metabolism | Dendritic Cells - metabolism | Signal Transduction | Gene Expression Regulation | Colon - metabolism | Cell Differentiation - immunology | Animals | Spleen - metabolism | T-Lymphocytes - cytology | Sex Factors | Colon - microbiology | Dendritic Cells - cytology | Mice | Gastrointestinal Microbiome - immunology | Peyer's Patches - immunology | Metagenome | Aging - metabolism | Intestines | Microbiota (Symbiotic organisms) | Health aspects | Age | Laboratories | Epithelial cells | Sex | Effector cells | Mucus | Biosynthesis | Lymphocytes T | Biology | Arthritis | Males | Immunity | Composition effects | Immunology | Lymphocytes | Intestine | Rodents | Aging | Bacteria | Intestinal microflora | Food | Immune system | Immune response | Nutrition | Sex differences | Abundance | Shrinkage | Permeability | Gene expression | Epithelium | Age factors | Thickness | Inflammatory bowel disease | Pathology | Females | Colonization | Host-Microbe Interactomics | Nutrition, Metabolism and Genomics | Microbiology | Chair Nutrition Metabolism and Genomics | HNE Voeding, Metabolisme en Genomics | Voeding, Metabolisme en Genomica | Host Microbe Interactomics | Leerstoelgroep Host Microbe Interactomics | Microbiologie | VLAG | Laboratorium voor Microbiologie | Microbiological Laboratory | HNE Nutrition, Metabolism and Genomics
Journal Article