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1. Full Text Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
by Detsi, Anastasia and Majdalani, Maya and Kontogiorgis, Christos A and Hadjipavlou-Litina, Dimitra and Kefalas, Panagiotis
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 23, pp. 8073 - 8085
Lipid peroxidation | Aureusidin | Soybean lipoxygenase | Antioxidant | Aurones | 2′-Hydroxy-chalcones | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Fundamental and applied biological sciences. Psychology | Food industries | Biological and medical sciences | Fruit and vegetable industries | Chalcones - chemistry | Antioxidants - chemistry | Magnetic Resonance Spectroscopy | Linoleic Acid - metabolism | Picrates - metabolism | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Biphenyl Compounds - metabolism | Benzofurans - chemistry | Linoleic Acid - antagonists & inhibitors | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Picrates - antagonists & inhibitors | Biphenyl Compounds - antagonists & inhibitors | Chalcones - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Mass Spectrometry | Chalcones - pharmacology | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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2. Full Text γ‑Carbonyl Quinones: Radical Strategy for the Synthesis of Evelynin and Its Analogues by C–H Activation of Quinones Using Cyclopropanols
by Ilangovan, Andivelu and Saravanakumar, Shanmugasundar and Malayappasamy, Subramani
Organic letters, ISSN 1523-7060, 10/2013, Volume 15, Issue 19, pp. 4968 - 4971
Biological Products - chemical synthesis | Biological Products - chemistry | Ethers, Cyclic - chemistry | Chalcone - chemistry | Quinones - chemistry | Oxidation-Reduction | Quinones - chemical synthesis | Catalysis | Chalcone - chemical synthesis | Index Medicus
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3. Full Text Synthesis and Electrochemical and Biological Studies of Novel Coumarin–Chalcone Hybrid Compounds
by Pérez-Cruz, Fernanda and Vazquez-Rodriguez, Saleta and Matos, Maria João and Herrera-Morales, Alejandra and Villamena, Frederick A and Das, Amlan and Gopalakrishnan, Bhavani and Olea-Azar, Claudio and Santana, Lourdes and Uriarte, Eugenio
Journal of medicinal chemistry, ISSN 0022-2623, 08/2013, Volume 56, Issue 15, pp. 6136 - 6145
Free Radical Scavengers - pharmacology | Chalcones - chemistry | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Coumarins - chemistry | Structure-Activity Relationship | Cytotoxins - pharmacology | Chalcones - chemical synthesis | Cattle | Chalcones - pharmacology | Free Radical Scavengers - chemical synthesis | Cytoprotection | Cell Survival - drug effects | Cytotoxins - chemical synthesis | Electron Spin Resonance Spectroscopy | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Cells, Cultured | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Coumarins - pharmacology | Animals | Endothelial Cells - cytology | Coumarins - chemical synthesis | Cytotoxins - chemistry | Electrochemistry | Endothelial Cells - drug effects | Index Medicus
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4. Full Text Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death
by Robinson, Michael W and Overmeyer, Jean H and Young, Ashley M and Erhardt, Paul W and Maltese, William A
Journal of medicinal chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 1940 - 1956
Cell Survival - drug effects | Chalcones - chemistry | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Pyridines - chemical synthesis | Indoles - chemical synthesis | Drug Resistance, Neoplasm | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Azides - chemistry | Photoaffinity Labels - chemical synthesis | Chalcones - chemical synthesis | Chalcones - pharmacology | Cell Line, Tumor | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Pyridines - pharmacology | Azides - pharmacology | Cell Death - drug effects | Azides - chemical synthesis | Indoles - chemistry | Drug Screening Assays, Antitumor | Photoaffinity Labels - chemistry | Index Medicus
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5. Full Text Synthesis, biological evaluation and molecular docking of novel chalcone–coumarin hybrids as anticancer and antimalarial agents
by Pingaew, Ratchanok and Saekee, Amporn and Mandi, Prasit and Nantasenamat, Chanin and Prachayasittikul, Supaluk and Ruchirawat, Somsak and Prachayasittikul, Virapong
European journal of medicinal chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 65 - 76
Cytotoxicity | Triazole | Antimalarial activity | Coumarin | Chalcone | Molecular docking | Cysteine Endopeptidases - chemistry | Antimalarials - metabolism | Chalcone - chemistry | Chemistry Techniques, Synthetic | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Coumarins - chemistry | Plasmodium falciparum - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Antineoplastic Agents - metabolism | Tubulin - metabolism | Chalcone - pharmacology | Cysteine Endopeptidases - metabolism | Antimalarials - chemistry | Chalcone - metabolism | Cell Line, Tumor | Protein Conformation | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Tubulin - chemistry | Chalcone - chemical synthesis | Antimalarials - chemical synthesis | Care and treatment | Malaria | Triazoles | Etoposide | Colchicine | Data mining | Cancer | Index Medicus
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6. Full Text Synthesis and Insight into the Structure–Activity Relationships of Chalcones as Antimalarial Agents
by Tadigoppula, Narender and Korthikunta, Venkateswarlu and Gupta, Shweta and Kancharla, Papireddy and Khaliq, Tanvir and Soni, Awakash and Srivastava, Rajeev Kumar and Srivastava, Kumkum and Puri, Sunil Kumar and Raju, Kanumuri Siva Rama and Wahajuddin and Sijwali, Puran Singh and Kumar, Vikash and Mohammad, Imran Siddiqi
Journal of medicinal chemistry, ISSN 0022-2623, 01/2013, Volume 56, Issue 1, pp. 31 - 45
Cysteine Endopeptidases - chemistry | Parasitic Sensitivity Tests | Male | Cysteine Proteinase Inhibitors - pharmacokinetics | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Plasmodium yoelii | Benzopyrans - chemical synthesis | Chalcones - chemical synthesis | Chromans - pharmacokinetics | Chromans - pharmacology | Chalcones - pharmacology | Cysteine Proteinase Inhibitors - chemical synthesis | Benzopyrans - pharmacology | Antimalarials - chemical synthesis | Catalytic Domain | Antimalarials - pharmacokinetics | Crotalaria - chemistry | Rats | Rats, Sprague-Dawley | Antimalarials - pharmacology | Animals | Chalcones - pharmacokinetics | Benzopyrans - pharmacokinetics | Small Molecule Libraries | Cysteine Proteinase Inhibitors - pharmacology | Chromans - chemical synthesis | Mice | Molecular Docking Simulation | Malaria - drug therapy | Index Medicus
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7. Full Text Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles
by Abdel-Wahab, Bakr F and Abdel-Aziz, Hatem A and Ahmed, Essam M
European journal of medicinal chemistry, ISSN 0223-5234, 06/2009, Volume 44, Issue 6, pp. 2632 - 2635
Antimicrobial activity | Nitromethane | Thiazolyl-pyrazoline | Benzofuran | General aspects | Pharmacology. Drug treatments | Antifungal agents | Biological and medical sciences | Medical sciences | Antibacterial agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Chalcones - chemistry | Pyrazoles - chemical synthesis | Stereoisomerism | Escherichia coli - drug effects | Benzofurans - pharmacology | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Benzofurans - chemistry | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Pyrazoles - chemistry | Candida albicans - drug effects | Anti-Bacterial Agents - chemistry | Drug Design | Molecular Structure | Pyrazoles - pharmacology | Antifungal Agents - pharmacology | Thioamides - chemistry | Benzofurans - chemical synthesis | Thioamides - pharmacology | Anti-Bacterial Agents - chemical synthesis | Cyclization | Thioamides - chemical synthesis | Anti-Bacterial Agents - pharmacology | Aspergillus niger - drug effects | Staphylococcus aureus - drug effects | Bacillus subtilis - drug effects | Index Medicus
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8. Full Text Synthesis of novel quinoline–based 4,5–dihydro–1H–pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents
by Ramírez–Prada, Jonathan and Robledo, Sara M and Vélez, Iván D and Crespo, María del Pilar and Quiroga, Jairo and Abonia, Rodrigo and Montoya, Alba and Svetaz, Laura and Zacchino, Susana and Insuasty, Braulio
European journal of medicinal chemistry, ISSN 0223-5234, 05/2017, Volume 131, pp. 237 - 254
Antifungal activity | Chalcones | Antimalarial activity | Antitrypanosomal activity | 2–pyrazolines | Anticancer activity | Quinoline | Antibacterial activity | Antileishmanial activity | Parasitic Sensitivity Tests | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Bacteria - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Pyrazoles - chemistry | Anti-Bacterial Agents - chemistry | Antiprotozoal Agents - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrazoles - pharmacology | Antifungal Agents - pharmacology | Cell Survival - drug effects | Fungi - drug effects | Quinolines - chemistry | Antiprotozoal Agents - chemistry | Antineoplastic Agents - chemistry | Antiprotozoal Agents - pharmacology | Anti-Bacterial Agents - chemical synthesis | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Drug Screening Assays, Antitumor | Care and treatment | Malaria | Antifungal agents | Drug resistance | Antibacterial agents | Cancer | Index Medicus
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9. Full Text Synthesis of chalcones with anticancer activities
by Syam, Suvitha and Abdelwahab, Siddig Ibrahim and Al-Mamary, Mohammed Ali and Mohan, Syam
Molecules (Basel, Switzerland), ISSN 1420-3049, 06/2012, Volume 17, Issue 6, pp. 6179 - 6195
Synthetic | ROS | Caspase | Cytotoxicity | MCF-7 cells | High content screening | Chalcone | Apoptosis | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Chalcones - chemistry | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - chemistry | Enzyme Activation - drug effects | HT29 Cells | Caspases - metabolism | Chalcones - chemical synthesis | Chalcones - pharmacology | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Index Medicus | chalcone | synthetic | high content screening | apoptosis | cytotoxicity | caspase
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10. Full Text Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
by Alswah, Mohamed and Bayoumi, Ashraf H and Elgamal, Kamal and Elmorsy, Ahmed and Ihmaid, Saleh and Ahmed, Hany E. A
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 1, p. 48
Molecular modeling | 3-a]quinoxaline | Triazolo | Docking | Anticancer | Chalcone | EGFR | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cell Proliferation | Tubulin Modulators - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Quinoxalines - pharmacology | Tubulin Modulators - chemical synthesis | Receptor, Epidermal Growth Factor - metabolism | Tubulin - metabolism | Chalcone - pharmacology | Chalcone - analogs & derivatives | Drug Design | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Structure | Quinoxalines - chemical synthesis | Protein Kinase Inhibitors - chemical synthesis | Magnetic Resonance Spectroscopy - methods | Cell Survival | Triazoles - pharmacology | Spectrometry, Mass, Electrospray Ionization - methods | Cell Line, Tumor | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Colchicine | Chalcone - chemical synthesis | Apoptosis | Adenocarcinoma | Quinoxaline | Biotechnology | Epidermal growth factor receptors | Polymerization | Cytotoxicity | Hepatocellular carcinoma | Tumor cell lines | Derivatives | Molecular docking | Anticancer properties | Biological effects | Tubulin | Antitumor agents | Colon | Index Medicus | chalcone | docking | molecular modeling | anticancer | triazolo[4,3-a]quinoxaline
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11. Full Text Synthesis of extended conjugated indolyl chalcones as potent anti-breast cancer, anti-inflammatory and antioxidant agents
by Bhale, Pravin S and Chavan, Hemant V and Dongare, Sakharam B and Shringare, Sadanand N and Mule, Yoginath B and Nagane, Samadhan S and Bandgar, Babasaheb P
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2017, Volume 27, Issue 7, pp. 1502 - 1507
Cytotoxicity | Indole chalcones | Antioxidant | Extended conjugation | Anti-inflammatory | Free Radical Scavengers - pharmacology | Diclofenac - pharmacology | Egg Proteins - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Cercopithecus aethiops | Indoles - chemical synthesis | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Chalcones - chemical synthesis | MCF-7 Cells | Chalcones - pharmacology | Protein Denaturation | Superoxides - metabolism | Free Radical Scavengers - chemical synthesis | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Vero Cells | Albumins - metabolism | Breast Neoplasms - drug therapy | Animals | Nitric Oxide - metabolism | Doxorubicin - pharmacology | Antioxidants | Anti-inflammatory drugs | Breast cancer | Index Medicus
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12. Full Text Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology
by Menezes, José C.J.M.D.S and Diederich, Marc F
European journal of medicinal chemistry, ISSN 0223-5234, 11/2019, Volume 182, pp. 111637 - 111637
Dimer | Coumarin | Chalcone | Resveratrol | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Chalcones - chemistry | Antineoplastic Agents, Phytogenic - chemical synthesis | Resveratrol - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Coumarins - chemistry | Biological Products - pharmacology | DNA Topoisomerases - metabolism | Resveratrol - chemical synthesis | Neoplasms - drug therapy | Coumarins - pharmacology | Resveratrol - chemistry | Topoisomerase Inhibitors - pharmacology | Biological Products - chemical synthesis | Topoisomerase Inhibitors - chemical synthesis | Biological Products - chemistry | Chalcones - chemical synthesis | Coumarins - chemical synthesis | Chalcones - pharmacology | Molecular Structure | Topoisomerase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Dimerization | Index Medicus
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13. Full Text Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors
by Burmaoglu, Serdar and Yilmaz, Ali Osman and Polat, M. Fatih and Kaya, Rüya and Gulcin, İlhami and Algul, Oztekin
Bioorganic chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 191 - 197
α-glycosidase | Carbonic anhydrase | Acetylcholinesterase | Butyrylcholinesterase | Tris-chalcone | Chalcones - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - chemical synthesis | Butyrylcholinesterase - chemistry | Chalcones - chemical synthesis | Molecular Structure | Carbonic Anhydrase II - chemistry | Index Medicus
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