X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (21018) 21018
Book Chapter (27) 27
Dissertation (9) 9
Book / eBook (6) 6
Book Review (3) 3
Conference Proceeding (3) 3
Publication (2) 2
Government Document (1) 1
Streaming Video (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (13618) 13618
animals (6868) 6868
cell biology (6508) 6508
cell cycle (5939) 5939
cancer (5742) 5742
apoptosis (5734) 5734
oncology (5649) 5649
cell line, tumor (5261) 5261
phosphorylation (4851) 4851
biochemistry & molecular biology (4513) 4513
dna damage (4180) 4180
proteins (3788) 3788
mice (3512) 3512
female (3485) 3485
cell cycle proteins - metabolism (3123) 3123
apoptosis - drug effects (3065) 3065
kinases (2963) 2963
research (2746) 2746
protein-serine-threonine kinases - metabolism (2737) 2737
expression (2730) 2730
checkpoint (2682) 2682
signal transduction (2641) 2641
cell cycle checkpoints - drug effects (2489) 2489
mutation (2483) 2483
activation (2465) 2465
cell proliferation - drug effects (2450) 2450
mitosis (2344) 2344
tumors (2316) 2316
male (2229) 2229
gene expression (2135) 2135
cell proliferation (2079) 2079
dna repair (1986) 1986
genetic aspects (1975) 1975
cell cycle proteins - genetics (1905) 1905
immunotherapy (1901) 1901
genetics & heredity (1883) 1883
antineoplastic agents - pharmacology (1859) 1859
analysis (1830) 1830
biology (1755) 1755
chemotherapy (1738) 1738
multidisciplinary sciences (1718) 1718
protein-serine-threonine kinases - genetics (1717) 1717
p53 (1713) 1713
protein kinases - metabolism (1672) 1672
dna (1640) 1640
checkpoint kinase 2 (1621) 1621
deoxyribonucleic acid--dna (1615) 1615
immune checkpoint (1569) 1569
dna-damage (1551) 1551
protein (1546) 1546
checkpoint kinase 1 (1541) 1541
saccharomyces-cerevisiae (1539) 1539
research article (1538) 1538
cancer therapies (1500) 1500
tumor suppressor protein p53 - metabolism (1481) 1481
cell line (1427) 1427
hela cells (1411) 1411
inhibition (1407) 1407
signal transduction - drug effects (1351) 1351
cell cycle checkpoints (1346) 1346
metastasis (1346) 1346
health aspects (1342) 1342
physiological aspects (1326) 1326
dna replication (1322) 1322
cells (1300) 1300
kinase (1285) 1285
cell-cycle (1273) 1273
growth (1257) 1257
dna-binding proteins - metabolism (1249) 1249
care and treatment (1246) 1246
proliferation (1246) 1246
rna interference (1233) 1233
breast cancer (1209) 1209
cell growth (1183) 1183
cell division (1179) 1179
medicine (1139) 1139
flow cytometry (1112) 1112
protein binding (1112) 1112
cell survival - drug effects (1107) 1107
genes (1105) 1105
nuclear proteins - metabolism (1104) 1104
cytotoxicity (1101) 1101
cell death (1100) 1100
chromosomes (1094) 1094
gene expression regulation, neoplastic (1081) 1081
ataxia telangiectasia mutated proteins (1064) 1064
pharmacology & pharmacy (1045) 1045
middle aged (1033) 1033
protein-kinase (1032) 1032
lung cancer (976) 976
melanoma (976) 976
science (959) 959
mice, nude (949) 949
biological phenomena, cell phenomena, and immunity (942) 942
pathway (938) 938
saccharomyces cerevisiae - genetics (933) 933
genetics (931) 931
immunology (926) 926
gene (919) 919
in-vitro (918) 918
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21008) 21008
Japanese (75) 75
German (30) 30
Chinese (26) 26
French (15) 15
Russian (13) 13
Portuguese (8) 8
Norwegian (3) 3
Danish (2) 2
Dutch (2) 2
Czech (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
... and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC 50 values one... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2017, Volume 17, Issue 2, pp. 93 - 115
.... Proliferation depends on progression through four distinct phases of the cell cycle G0/G1, S, G2 and M which is regulated by several cyclin-dependent kinases (CDKs... 
INVESTIGATIONAL AURORA KINASE | PHASE-II TRIAL | POLO-LIKE-KINASE | EARLY EMBRYONIC-DEVELOPMENT | DINACICLIB SCH 727965 | ADVANCED SOLID TUMORS | ONCOLOGY | PREVENTS TUMOR-GROWTH | VOLASERTIB BI 6727 | DEPENDENT KINASE INHIBITOR | SMALL-MOLECULE INHIBITOR | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Humans | Checkpoint Kinase 1 - physiology | Aurora Kinase A - antagonists & inhibitors | Cyclin-Dependent Kinase 2 - physiology | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - physiology | Aurora Kinase A - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Protein-Serine-Threonine Kinases - physiology | Checkpoint Kinase 1 - antagonists & inhibitors | Clinical Trials as Topic | Neoplasms - drug therapy | Animals | Cyclin-Dependent Kinase 4 - physiology | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Cyclin-Dependent Kinase 6 - physiology | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Care and treatment | Usage | MicroRNA | Cell cycle | Research | Cancer
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2009, Volume 15, Issue 9, pp. 3050 - 3057
...), an inhibitor of MAP kinase/extracellular signal-regulated kinase 1/2, on radiation response. Experimental Design... 
RAS | MEK | radiosensitizer | ARREST | IRRADIATION | HEPATOCELLULAR-CARCINOMA | DNA-DAMAGE CHECKPOINT | H-RAS | ONCOLOGY | HUMAN SQUAMOUS CARCINOMA | PROSTATE-CANCER | CELL LINES | IONIZING-RADIATION | RAS ONCOGENES | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Lung Neoplasms - pathology | Male | Pancreatic Neoplasms - drug therapy | Female | Phosphorylation - drug effects | Prostatic Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - pathology | Prostatic Neoplasms - pathology | Tumor Stem Cell Assay | Lung Neoplasms - enzymology | Cell Cycle - radiation effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Pancreatic Neoplasms - pathology | Radiation-Sensitizing Agents - pharmacology | Adenocarcinoma - enzymology | Pancreatic Neoplasms - enzymology | Adenocarcinoma - drug therapy | Blotting, Western | Xenograft Model Antitumor Assays | Phosphorylation - radiation effects | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice, Nude | X-Rays | Fluorescent Antibody Technique | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Cell Cycle - drug effects | In Vitro Techniques | Cell Proliferation - radiation effects | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Journal Article