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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2535 - 17
Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and... 
GENOMIC INSTABILITY | BREAST-CANCER | DNA-DAMAGE CHECKPOINT | REPLICATION | ASF1 | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | S-PHASE | CELL-CYCLE | IDENTIFICATION | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Protein Multimerization | Protein Kinases - chemistry | Substrate Specificity | Crystallography, X-Ray | Intellectual Disability - genetics | Protein Kinase Inhibitors - chemistry | Adenosine Triphosphate - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Intellectual Disability - enzymology | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Adenosine Triphosphate - analogs & derivatives | Intellectual Disability - physiopathology | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Molecular Docking Simulation | Kinetics | Mutation | Adenosine Triphosphate - chemistry | Indoles - chemistry | Molecular structure | Intellectual disabilities | DNA damage | Activation | Breast cancer | Genomes | Kinases | Molecular chains | Oligomers | Molecular modelling | Docking | Inhibition | Dimerization | Deoxyribonucleic acid--DNA | Crystal structure | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 16856 - 16861
DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of... 
DNA replication | Phosphorylation | Interphase | DNA damage | DNA | Cell cycle | Small interfering RNA | Irradiation | Nucleosides | Cells | CYCLE CHECKPOINT KINASE | ORIGINS | CHK1 | POLYMERASE-ETA | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RNA STABILIZATION | VERTEBRATE S-PHASE | STRESS | FORK PROGRESSION | H2AX PHOSPHORYLATION | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Deoxycytidine - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | MAP Kinase Signaling System | DNA, Single-Stranded - genetics | Ultraviolet Rays | Antimetabolites, Antineoplastic - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA, Single-Stranded - metabolism | Protein-Serine-Threonine Kinases - genetics | p38 Mitogen-Activated Protein Kinases - genetics | DNA Replication | G2 Phase Cell Cycle Checkpoints | Mice, Knockout | Animals | Histones - genetics | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | DNA Damage | Histones - metabolism | Deoxycytidine - analogs & derivatives | Physiological aspects | Research | Health aspects | Mitogen-activated protein kinases | Ultraviolet radiation | DNA polymerase | Kinases | Apoptosis | Index Medicus | Biological Sciences | Teknik och teknologier | Engineering and Technology | Naturvetenskap | Natural Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2014, Volume 74, Issue 6, pp. 1778 - 1788
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2009, Volume 15, Issue 9, pp. 3050 - 3057
Purpose: The mitogen-activated protein (MAP) kinase pathway is important for cell proliferation, survival, and differentiation, and is frequently up-regulated... 
RAS | MEK | radiosensitizer | ARREST | IRRADIATION | HEPATOCELLULAR-CARCINOMA | DNA-DAMAGE CHECKPOINT | H-RAS | ONCOLOGY | HUMAN SQUAMOUS CARCINOMA | PROSTATE-CANCER | CELL LINES | IONIZING-RADIATION | RAS ONCOGENES | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Lung Neoplasms - pathology | Male | Pancreatic Neoplasms - drug therapy | Female | Phosphorylation - drug effects | Prostatic Neoplasms - drug therapy | Carcinoma, Non-Small-Cell Lung - pathology | Prostatic Neoplasms - pathology | Tumor Stem Cell Assay | Lung Neoplasms - enzymology | Cell Cycle - radiation effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Pancreatic Neoplasms - pathology | Radiation-Sensitizing Agents - pharmacology | Adenocarcinoma - enzymology | Pancreatic Neoplasms - enzymology | Adenocarcinoma - drug therapy | Blotting, Western | Xenograft Model Antitumor Assays | Phosphorylation - radiation effects | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mice, Nude | X-Rays | Fluorescent Antibody Technique | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Cell Cycle - drug effects | In Vitro Techniques | Cell Proliferation - radiation effects | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Leukemia Research, ISSN 0145-2126, 11/2018, Volume 74, pp. 68 - 74
Gemtuzumab ozogamicin (GO), the first antibody-drug conjugate (ADC), has attracted the interest of hematologists because more than 90% of acute myeloid... 
mTOR inhibitor | Acute myeloid leukemia | Gemtuzumab ozogamicin | Lysosomal function | Cell cycle | PATHWAYS | APOPTOSIS | DNA-DAMAGE | T-CELL LEUKEMIA | ACIDIFICATION | ANTIGENS | ACUTE MYELOID-LEUKEMIA | AUTOPHAGY | ONCOLOGY | THERAPEUTIC TARGET | RESISTANCE | HEMATOLOGY | Leukemia - pathology | Humans | Lysosomes - genetics | M Phase Cell Cycle Checkpoints - genetics | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | Lysosomes - metabolism | U937 Cells | Antibodies, Monoclonal, Humanized - pharmacology | Indoles - pharmacology | Lysosomes - pathology | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 2 - genetics | Neoplasm Proteins - genetics | Leukemia - genetics | M Phase Cell Cycle Checkpoints - drug effects | Purines - pharmacology | Leukemia - enzymology | THP-1 Cells | Leukemia - drug therapy | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mechanistic Target of Rapamycin Complex 2 - metabolism | G2 Phase Cell Cycle Checkpoints - genetics | HL-60 Cells | Protein Kinase Inhibitors - pharmacology | Aminoglycosides - pharmacology | Fluorescence | Medical colleges | Drug resistance in microorganisms | Biological products | Cell death | Leukemia | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2011, Volume 54, Issue 2, pp. 580 - 590
Journal Article
Journal Article