X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (21349) 21349
Publication (1113) 1113
Book Review (1096) 1096
Newspaper Article (384) 384
Book Chapter (115) 115
Conference Proceeding (73) 73
Book / eBook (28) 28
Magazine Article (24) 24
Newsletter (10) 10
Dissertation (9) 9
Government Document (3) 3
Trade Publication Article (3) 3
Reference (2) 2
Web Resource (2) 2
Journal / eJournal (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (16181) 16181
animals (6696) 6696
humans (5398) 5398
chelating agents - chemistry (5005) 5005
chelating agents (4788) 4788
chelating agents - pharmacology (4636) 4636
biochemistry & molecular biology (4405) 4405
rats (2411) 2411
male (2228) 2228
kinetics (2226) 2226
mice (2082) 2082
ligands (1946) 1946
iron (1890) 1890
hydrogen-ion concentration (1870) 1870
chemistry (1705) 1705
copper (1621) 1621
analysis (1587) 1587
chemistry, multidisciplinary (1542) 1542
environmental sciences (1460) 1460
iron chelating agents - pharmacology (1444) 1444
female (1423) 1423
iron - metabolism (1339) 1339
oxidation-reduction (1277) 1277
molecular structure (1270) 1270
chemistry, analytical (1219) 1219
calcium - metabolism (1194) 1194
adsorption (1188) 1188
chemistry, inorganic & nuclear (1188) 1188
pharmacology & pharmacy (1179) 1179
proteins (1065) 1065
oxidative stress (1061) 1061
research (1057) 1057
complexes (1037) 1037
zinc (1023) 1023
chelating-agents (999) 999
time factors (995) 995
egtazic acid - pharmacology (994) 994
metals (957) 957
chelation (950) 950
chemistry, organic (908) 908
chelating (903) 903
chemistry, medicinal (902) 902
iron chelating agents - chemistry (874) 874
edta (867) 867
chelating agents - metabolism (851) 851
chelating agents - chemical synthesis (848) 848
ions (833) 833
chemistry, physical (827) 827
calcium (825) 825
cell biology (825) 825
models, molecular (820) 820
copper - chemistry (783) 783
dose-response relationship, drug (773) 773
biophysics (770) 770
edetic acid - pharmacology (768) 768
antioxidants (758) 758
antioxidants - pharmacology (751) 751
cells, cultured (750) 750
binding sites (744) 744
edetic acid - chemistry (741) 741
toxicology (740) 740
temperature (729) 729
egtazic acid - analogs & derivatives (713) 713
cell line, tumor (708) 708
chemical phenomena (704) 704
structure-activity relationship (701) 701
chemical properties (691) 691
binding (688) 688
article (684) 684
chemistry, applied (682) 682
protein binding (680) 680
cells (673) 673
biochemical research methods (670) 670
toxicity (663) 663
food science & technology (660) 660
cadmium (645) 645
catalysis (645) 645
chelating agents - therapeutic use (644) 644
in vitro techniques (641) 641
in-vitro (641) 641
acid (616) 616
cell line (607) 607
molecular sequence data (586) 586
iron - chemistry (577) 577
enzymes (575) 575
engineering, environmental (564) 564
tissue distribution (564) 564
chelates (563) 563
magnetic resonance spectroscopy (563) 563
neurosciences (563) 563
enzyme inhibitors - pharmacology (562) 562
engineering, chemical (559) 559
lead (555) 555
heavy metals (552) 552
heavy-metals (551) 551
cattle (544) 544
derivatives (544) 544
oxidation (544) 544
rats, wistar (539) 539
cancer (536) 536
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (16) 16
Engineering & Comp. Sci. - Stacks (2) 2
Online Resources - Online (2) 2
UofT at Mississauga - Stacks (2) 2
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Gerstein Science - Circulation Desk (1) 1
UTL at Downsview - May be requested (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (21423) 21423
Chinese (166) 166
German (79) 79
Japanese (64) 64
Russian (58) 58
French (48) 48
Czech (14) 14
Polish (11) 11
Italian (9) 9
Spanish (9) 9
Dutch (6) 6
Ukrainian (4) 4
Croatian (3) 3
Portuguese (3) 3
Danish (2) 2
Romanian (2) 2
Indonesian (1) 1
Lithuanian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Photochemistry & Photobiology, B: Biology, ISSN 1011-1344, 09/2016, Volume 162, pp. 298 - 308
Journal Article
Science of the Total Environment, ISSN 0048-9697, 02/2014, Volume 472, pp. 800 - 808
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 6089 - 6104
A series of tacrine-(β-carboline) hybrids (11a-q) were designed, synthesized and evaluated as multifunctional cholinesterase inhibitors against Alzheimer's... 
β-Amyloid aggregation | β-Carboline | Alzheimers disease | Antioxidant | Metal chelator | Tacrine | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | TACRINE HYBRIDS | RADICAL SCAVENGERS | CARBOLINE ALKALOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | beta-Carboline | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | ANTIOXIDANT PROPERTIES | L-TRYPTOPHAN | beta-Amyloid aggregation | BIOLOGICAL EVALUATION | Alzheimer's disease | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbolines - chemistry | Tacrine - pharmacology | Tacrine - pharmacokinetics | Chelating Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Drug Design | Tacrine - chemistry | Cell Line | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Electrophorus | Alzheimer Disease - enzymology | Antioxidants - pharmacology | Chelating Agents - pharmacology | Protein Aggregation, Pathological - drug therapy | Blood-Brain Barrier - metabolism | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Horses | Molecular Docking Simulation | Carbolines - pharmacokinetics | Antioxidants - pharmacokinetics | Acetylcholinesterase - metabolism | Protein Aggregation, Pathological - metabolism | Carbolines - pharmacology | Drug therapy | Analysis | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2010, Volume 53, Issue 13, pp. 4927 - 4937
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 864 - 879
Currently available drugs against Alzheimer's disease (AD) are only able to ameliorate the disease symptoms resulting in a moderate improvement in memory and... 
Human acetylcholinesterase | MAO-A | Molecular modeling | Human butyrylcholinesterase | Metal chelating properties | ADME+T properties | Antioxidant properties | MAO-B | Alzheimer's disease | Molecular docking | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | SEROTONIN 5-HT1A | DRUGS | POTENTIAL TREATMENT | NITRIC-OXIDE | FORCE-FIELD | OXIDASE-INHIBITORS | ADME plus T properties | RATIONAL DESIGN | HYBRIDS | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Piperidines - pharmacology | Drug Design | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Chemistry Techniques, Synthetic | Piperidines - metabolism | Chelating Agents - chemistry | Indans - metabolism | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Monoamine Oxidase Inhibitors - metabolism | Indans - chemical synthesis | Protein Conformation | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Chelating Agents - metabolism | Acetylcholinesterase - metabolism | Indans - pharmacology | Monoamine Oxidase - metabolism | Antioxidants | Enzymes | Monoamine oxidase | Analysis | Models | Drug discovery | Target marketing | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 03/2018, Volume 26, Issue 5, pp. 1102 - 1115
A series of 4′-OH-flurbiprofen-chalcone hybrids were designed, synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's... 
Aβ aggregation inhibitors | Monoamine oxidase inhibitors | Multifunctional agents | Flurbiprofen-chalcone hybrids | Alzheimer's disease | Anti-inflammatory agents | MONOAMINE-OXIDASE | CHEMISTRY, MEDICINAL | ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MAO-B | FLURBIPROFEN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BETA-AMYLOID PLAQUES | ANTIOXIDANT | BIOLOGICAL EVALUATION | A beta aggregation inhibitors | INHIBITORS | DERIVATIVES | Chalcones - chemistry | Antioxidants - chemistry | Humans | Structure-Activity Relationship | Monoamine Oxidase - genetics | Recombinant Proteins - biosynthesis | Alzheimer Disease - pathology | Monoamine Oxidase - chemistry | Copper - chemistry | Amyloid beta-Peptides - metabolism | Drug Design | Monoamine Oxidase Inhibitors - therapeutic use | Cell Line | Cell Survival - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Peptide Fragments - metabolism | Lipopolysaccharides - toxicity | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antioxidants - pharmacology | Flurbiprofen - chemistry | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Peptide Fragments - antagonists & inhibitors | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Nitric Oxide - metabolism | Monoamine Oxidase - metabolism | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 02/2015, Volume 23, Issue 4, pp. 668 - 680
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized... 
Neuroprotective effects | Scutellarein carbamate derivatives | Metal-chelating agents | Alzheimer's disease | Cholinesterase inhibitors | Antioxidant activity | BUTYRYLCHOLINESTERASE | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | ACETYLCHOLINESTERASE | METALS | HYDROGEN-PEROXIDE | AGENTS | BRAIN | Neuroprotective Agents - therapeutic use | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Apigenin - therapeutic use | Humans | Cholinesterase Inhibitors - chemistry | Carbamates - pharmacokinetics | Carbamates - chemistry | Apigenin - chemistry | Chelating Agents - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Glucuronates - therapeutic use | Glucuronates - chemistry | Chelating Agents - therapeutic use | Cell Line | Neuroprotective Agents - chemistry | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Apigenin - pharmacokinetics | Cognition - drug effects | Blood-Brain Barrier - metabolism | Glucuronates - pharmacokinetics | Antioxidants - therapeutic use | Animals | Alzheimer Disease - metabolism | Mice | Molecular Docking Simulation | Antioxidants - pharmacokinetics | Carbamates - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Drug therapy | Index Medicus
Journal Article
Journal Article