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Advanced Drug Delivery Reviews, ISSN 0169-409X, 2008, Volume 60, Issue 13, pp. 1463 - 1470
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social... 
Lipoic acid | Treatment | Antioxidant | Anti-inflammatory drug | Dementia | Nutraceuticals | CHOLINE ACETYL TRANSFERASE | DENDRITIC PATHOLOGY | NITRIC-OXIDE SYNTHASE | TEA POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE | AMYLOID PRECURSOR PROTEIN | AGE-RELATED LOSS | GREEN TEA | ADVANCED GLYCATION ENDPRODUCTS | MOUSE MODEL | DIHYDROLIPOIC ACID | PHARMACOLOGY & PHARMACY | Free Radical Scavengers - pharmacology | Neuroprotective Agents - therapeutic use | Acetylcholine - biosynthesis | Humans | Choline O-Acetyltransferase - biosynthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroprotective Agents - pharmacology | Chelating Agents - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Free Radical Scavengers - therapeutic use | Chelating Agents - therapeutic use | Thioctic Acid - pharmacokinetics | Alzheimer Disease - drug therapy | Thioctic Acid - pharmacology | Clinical Trials as Topic | Antioxidants - pharmacology | Chelating Agents - pharmacology | Antioxidants - therapeutic use | Reactive Oxygen Species - antagonists & inhibitors | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Alzheimer Disease - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Free Radical Scavengers - pharmacokinetics | Antioxidants - pharmacokinetics | Dietary Supplements | Thioctic Acid - therapeutic use | Development and progression | Anti-inflammatory drugs | Drug therapy | Alzheimer's disease
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 02/2015, Volume 23, Issue 4, pp. 668 - 680
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized... 
Neuroprotective effects | Scutellarein carbamate derivatives | Metal-chelating agents | Alzheimer's disease | Cholinesterase inhibitors | Antioxidant activity | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | ACETYLCHOLINESTERASE | METALS | HYDROGEN-PEROXIDE | AGENTS | BRAIN | Neuroprotective Agents - therapeutic use | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Apigenin - therapeutic use | Humans | Cholinesterase Inhibitors - chemistry | Carbamates - pharmacokinetics | Carbamates - chemistry | Apigenin - chemistry | Chelating Agents - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Glucuronates - therapeutic use | Glucuronates - chemistry | Chelating Agents - therapeutic use | Cell Line | Neuroprotective Agents - chemistry | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Apigenin - pharmacokinetics | Cognition - drug effects | Blood-Brain Barrier - metabolism | Glucuronates - pharmacokinetics | Antioxidants - therapeutic use | Animals | Alzheimer Disease - metabolism | Mice | Molecular Docking Simulation | Antioxidants - pharmacokinetics | Carbamates - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Drug therapy | Index Medicus
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 11/2014, Volume 22, Issue 21, pp. 6089 - 6104
A series of tacrine-(β-carboline) hybrids (11a-q) were designed, synthesized and evaluated as multifunctional cholinesterase inhibitors against Alzheimer's... 
β-Amyloid aggregation | β-Carboline | Alzheimers disease | Antioxidant | Metal chelator | Tacrine | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | TACRINE HYBRIDS | RADICAL SCAVENGERS | CARBOLINE ALKALOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | beta-Carboline | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | ANTIOXIDANT PROPERTIES | L-TRYPTOPHAN | beta-Amyloid aggregation | BIOLOGICAL EVALUATION | Alzheimer's disease | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbolines - chemistry | Tacrine - pharmacology | Tacrine - pharmacokinetics | Chelating Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Drug Design | Tacrine - chemistry | Cell Line | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Electrophorus | Alzheimer Disease - enzymology | Antioxidants - pharmacology | Chelating Agents - pharmacology | Protein Aggregation, Pathological - drug therapy | Blood-Brain Barrier - metabolism | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Horses | Molecular Docking Simulation | Carbolines - pharmacokinetics | Antioxidants - pharmacokinetics | Acetylcholinesterase - metabolism | Protein Aggregation, Pathological - metabolism | Carbolines - pharmacology | Drug therapy | Analysis
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