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Biochemical pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 40 - 55
[Display omitted] Many chronic human diseases, including multiple neurodegenerative diseases, are associated with deleterious protein aggregates, also called... 
Covalent mechanisms | Non-covalent mechanisms | Amyloid inhibitor | Natural products | Inhibition mechanisms | Amyloidosis - prevention & control | Drugs, Investigational - pharmacology | Antioxidants - chemistry | Nootropic Agents - metabolism | Antioxidants - metabolism | Healthy Diet | Humans | Polyphenols - pharmacology | Drugs, Investigational - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Flavonoids - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Polyphenols - metabolism | Amyloidogenic Proteins - antagonists & inhibitors | Drugs, Investigational - chemistry | Protein Aggregation, Pathological - prevention & control | Amyloidosis - diet therapy | Drug Design | Flavonoids - pharmacology | Protein Aggregation, Pathological - diet therapy | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Chelating Agents - therapeutic use | Biological Products - therapeutic use | Chelating Agents - chemistry | Nootropic Agents - therapeutic use | Amyloidosis - drug therapy | Antioxidants - pharmacology | Chelating Agents - pharmacology | Nootropic Agents - chemistry | Drug Discovery | Protein Aggregation, Pathological - drug therapy | Amyloidogenic Proteins - metabolism | Antioxidants - therapeutic use | Biological Products - chemistry | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Flavonoids - metabolism | Polyphenols - chemistry | Biological Products - metabolism | Polyphenols - therapeutic use | Chelating Agents - metabolism | Dietary Supplements | Flavonoids - chemistry | Amyloidosis - metabolism | Nootropic Agents - pharmacology | Medicine, Experimental | Medical research | Nervous system diseases | Glycoproteins | Drug discovery | Index Medicus
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 03/2018, Volume 23, Issue 3, p. 566
A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic... 
Epigenetics | Virtual screening | Histone deacetylase (HDAC) inhibitors | Schistosomiasis | Docking | Crystal structure | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Apoptosis - drug effects | Zinc - metabolism | Helminth Proteins - chemistry | Anthelmintics - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Zinc - chemistry | Schistosoma mansoni - genetics | Pyrrolidines - pharmacology | Histone Deacetylase Inhibitors - chemical synthesis | Protein Interaction Domains and Motifs | Schistosoma mansoni - growth & development | Binding Sites | Helminth Proteins - metabolism | Hydroxamic Acids - pharmacology | Schistosoma mansoni - drug effects | Gene Expression | Histone Deacetylases - genetics | Protein Structure, Secondary | Schistosoma mansoni - enzymology | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Helminth Proteins - genetics | Chelating Agents - pharmacology | Animals | Pyrrolidines - chemical synthesis | Anthelmintics - pharmacology | Protein Binding | Histone Deacetylase Inhibitors - pharmacology | Molecular Docking Simulation | Chelating Agents - chemical synthesis | Hydroxamic Acids - chemical synthesis | Helminth Proteins - antagonists & inhibitors | Histone deacetylase | Screening | Chromatin | Inhibitors | Catalysis | In vitro methods and tests | Chelates | Zinc | Index Medicus | Chelating Agents/pharmacology | Helminth Proteins/antagonists & inhibitors | Schistosoma mansoni/enzymology | Pyrrolidines/pharmacology | Life Sciences | Histone Deacetylases/genetics | Anthelmintics/chemical synthesis | Schistosoma mansoni/genetics | Helminth Proteins/genetics | Biomolecules | Histone Deacetylase Inhibitors/chemical synthesis | Chelating Agents/chemical synthesis | Pyrrolidines/chemical synthesis | Schistosoma mansoni/growth & development | Hydroxamic Acids/chemical synthesis | Zinc/chemistry | Biochemistry, Molecular Biology | Apoptosis/drug effects | Helminth Proteins/metabolism | Histone Deacetylases/chemistry | Hydroxamic Acids/pharmacology | Anthelmintics/pharmacology | Schistosoma mansoni/drug effects | Histone Deacetylases/metabolism | Helminth Proteins/chemistry | Histone Deacetylase Inhibitors/pharmacology | Zinc/metabolism | crystal structure | docking | virtual screening | histone deacetylase (HDAC) inhibitors | schistosomiasis | epigenetics
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15148 - 15157
Several behavioral effects of nicotine are mediated by changes in serotonin (5-HT) release in brain areas that receive serotonergic afferents from the dorsal... 
Electric Stimulation | Rats, Wistar | Dihydro-beta-Erythroidine - pharmacology | Male | Nicotinic Antagonists - pharmacology | Raphe Nuclei - cytology | Excitatory Postsynaptic Potentials - drug effects | Nicotine - pharmacology | Excitatory Postsynaptic Potentials - physiology | Muscarinic Antagonists - pharmacology | Egtazic Acid - analogs & derivatives | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Indoles - pharmacology | Tetrodotoxin - pharmacology | Cadmium Chloride - pharmacology | Cholinergic Agonists - pharmacology | Ryanodine - pharmacology | Animals, Newborn | Serotonergic Neurons - physiology | Presynaptic Terminals - drug effects | Acetylcholine - pharmacology | Enzyme Inhibitors - pharmacology | Glutamic Acid - physiology | Rats | Atropine - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Presynaptic Terminals - physiology | Aconitine - analogs & derivatives | Bicuculline - pharmacology | Chelating Agents - pharmacology | Aconitine - pharmacology | GABA Antagonists - pharmacology | Physostigmine - pharmacology | Patch-Clamp Techniques | Animals | Egtazic Acid - pharmacology | Receptors, Nicotinic - physiology | Nicotine - analogs & derivatives | Serotonin - metabolism | In Vitro Techniques | Serotonergic Neurons - cytology | Index Medicus
Journal Article
International journal of stroke, ISSN 1747-4949, 03/2012, Volume 7, Issue 5, pp. 407 - 418
.... Even with the proposed Stroke Therapy Academic Industry Roundtable criteria for preclinical development of neuroprotective agents for stroke, we have still seen limited success in the clinic... 
ischaemic cascade | translation | STAIR | ischaemic stroke | acute stroke therapy | neuroprotection | Neuroprotection | Translation | Acute stroke therapy | Ischaemic cascade | Ischaemic stroke | Clinical Neurology | Peripheral Vascular Disease | Neurosciences & Neurology | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Neuroprotective Agents - therapeutic use | Minocycline - pharmacology | Humans | Egtazic Acid - therapeutic use | Benzenesulfonates - therapeutic use | Benzenesulfonates - pharmacology | Neuroprotective Agents - pharmacology | Minocycline - therapeutic use | Pregnatrienes - therapeutic use | Hypothermia, Induced - methods | Egtazic Acid - analogs & derivatives | Thrombolytic Therapy - methods | Drug Evaluation, Preclinical | Chelating Agents - therapeutic use | Stroke - therapy | Disease Models, Animal | Hematopoietic Cell Growth Factors - therapeutic use | Acute Disease | NADPH Oxidases - antagonists & inhibitors | Translational Medical Research | Clinical Trials as Topic | Combined Modality Therapy | Pregnatrienes - pharmacology | Chelating Agents - pharmacology | Magnesium - pharmacology | Magnesium - therapeutic use | Serum Albumin - therapeutic use | Animals | Egtazic Acid - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Serum Albumin - pharmacology | Brain Ischemia - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Hematopoietic Cell Growth Factors - pharmacology | Diffusion of Innovation | Index Medicus | Oxygen | Stroke | Free radicals | Neurons | Standardization | Albumin | Clinical trials | Parenchyma | Glucose | Neuroprotective agents | NAD(P)H oxidase | Cell death | thrombolysis | Growth factors | Brain injury | Hypothermia
Journal Article
Cell (Cambridge), ISSN 0092-8674, 09/2007, Volume 130, Issue 5, pp. 797 - 810
Antibiotic mode-of-action classification is based upon drug-target interaction and whether the resultant inhibition of cellular function is lethal to bacteria.... 
SYSBIO | MICROBIO | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Free Radical Scavengers - pharmacology | Hydroxyurea - pharmacology | Escherichia coli - drug effects | Gene Expression Profiling | Colony Count, Microbial | DNA, Bacterial - drug effects | Norfloxacin - pharmacology | Time Factors | Carbon-Sulfur Lyases - genetics | Escherichia coli - metabolism | Ampicillin - pharmacology | Membrane Proteins - metabolism | Cell Death - drug effects | Escherichia coli - growth & development | Rec A Recombinases - genetics | NAD - metabolism | Staphylococcus aureus - metabolism | 2,2'-Dipyridyl - pharmacology | Staphylococcus aureus - genetics | Rec A Recombinases - metabolism | Microbial Viability - drug effects | Membrane Proteins - genetics | Citric Acid Cycle - drug effects | Escherichia coli Proteins - metabolism | Hydroxyl Radical - metabolism | Carbon-Sulfur Lyases - metabolism | Kanamycin - pharmacology | Hydrogen Peroxide - metabolism | Gene Expression Regulation, Bacterial - drug effects | Citric Acid Cycle - genetics | Anti-Bacterial Agents - classification | Iron Chelating Agents - pharmacology | Escherichia coli - genetics | Ferrous Compounds - metabolism | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | DNA Damage | Mutation | Oxidative Stress - drug effects | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Metabolites | Antibiotics | Index Medicus
Journal Article
Journal Article