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Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 102, pp. 58 - 71
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 18, pp. 4324 - 4338
A novel series of compounds obtained by fusing the acetylcholinesterase (AChE) inhibitor donepezil and the antioxidant melatonin were designed as... 
Melatonin | Biometal chelators | Alzheimer's disease | Antioxidant activity | Donepezil | Cholinesterase | AMYLOID-BETA AGGREGATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NEUROPROTECTIVE PROPERTIES | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | NEURODEGENERATIVE DISEASES | TACRINE-TROLOX HYBRIDS | MULTIFUNCTIONAL AGENTS | BIOLOGICAL EVALUATION | PHARMACOLOGICAL EVALUATION | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 174, pp. 216 - 225
Journal Article
ACS Applied Materials & Interfaces, ISSN 1944-8244, 06/2013, Volume 5, Issue 11, pp. 4632 - 4639
Journal Article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 09/2019, Volume 177, pp. 247 - 258
Alzheimer's disease (AD) is a chronic, fatal and complex neurodegenerative disorder, which is characterized by cholinergic system dysregulation, metal... 
TARGET-DIRECTED LIGANDS | CHEMISTRY, MEDICINAL | SEARCH | COPPER | MODEL | DISCOVERY | Multifunctional agents | A beta | THERAPY | ACETYLCHOLINESTERASE | METALS | HYPOTHESIS | Alzheimer's disease | DERIVATIVES | Cholinesterase Inhibitors - pharmacokinetics | Cholinesterase Inhibitors - toxicity | Microsomes, Liver - metabolism | Male | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Quinolines - pharmacology | Quinolines - pharmacokinetics | Chelating Agents - pharmacokinetics | Drug Design | Molecular Structure | Quinolines - toxicity | Nootropic Agents - pharmacokinetics | Zebrafish | Acetylcholinesterase - chemistry | Chelating Agents - pharmacology | Nootropic Agents - chemical synthesis | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Nootropic Agents - toxicity | Quinolines - chemical synthesis | Peptide Fragments - chemistry | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | ERG1 Potassium Channel - antagonists & inhibitors | Chelating Agents - chemical synthesis | Acetylcholinesterase - metabolism | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Enzyme inhibitors | Metabolites | Analysis | Quinoline | Drug discovery | Drug therapy | Target marketing
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 11/2017, Volume 8, Issue 11, pp. 2496 - 2511
A novel series of donepezil-trolox hybrids were designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD). Biological... 
acetylcholinesterase inhibitors | antioxidant | Alzheimer's disease | neuroprotection | β-amyloid aggregation | cognitive improvement | beta-amyloid aggregation | ACETYLCHOLINESTERASE ACTIVITY | TARGET-DIRECTED LIGANDS | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | MONOAMINE-OXIDASE B | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | D-GALACTOSE | INDUCED NEURODEGENERATION | AMYLOID-BETA | BIOLOGICAL EVALUATION | MICE | DERIVATIVES | Central Nervous System Agents - therapeutic use | Cholinesterase Inhibitors - toxicity | Humans | Amyloid beta-Peptides - drug effects | Male | Structure-Activity Relationship | Indans - therapeutic use | PC12 Cells | Chromans - pharmacology | Piperidines - pharmacology | Drug Design | Copper | Drug Evaluation, Preclinical | Chelating Agents - therapeutic use | Monoamine Oxidase Inhibitors - therapeutic use | Cell Line | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - toxicity | Microglia - drug effects | Oxidants - toxicity | Alzheimer Disease - drug therapy | Rats | Neurotoxins - toxicity | Antioxidants - pharmacology | Chelating Agents - pharmacology | Protein Aggregation, Pathological - drug therapy | Mice, Inbred ICR | Antioxidants - toxicity | Monoamine Oxidase Inhibitors - toxicity | Antioxidants - therapeutic use | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Chromans - therapeutic use | Piperidines - therapeutic use | Central Nervous System Agents - pharmacology | Peptide Fragments - drug effects | Indans - toxicity | Molecular Docking Simulation | Chromans - toxicity | Cholinesterase Inhibitors - therapeutic use | Central Nervous System Agents - toxicity | Blood-Brain Barrier | Indans - pharmacology | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2014, Volume 80, pp. 543 - 561
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 08/2017, Volume 134, Issue 4, pp. 203 - 210
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e112059 - e112059
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against... 
LABILE IRON | OXIDATIVE STRESS | POTENT |