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Hepatology, ISSN 0270-9139, 04/2015, Volume 61, Issue 4, pp. 1332 - 1342
The mechanism of idiosyncratic drug‐induced liver injury (IDILI) remains poorly understood, to a large degree because of the lack of a valid animal model.... 
GENOME-WIDE | ADVERSE DRUG-REACTIONS | GASTROENTEROLOGY & HEPATOLOGY | SERIOUS HEPATOTOXICITY | Animals | Mice, Inbred C57BL | Amodiaquine - adverse effects | Female | Antibodies - adverse effects | Mice | CTLA-4 Antigen - immunology | Chemical and Drug Induced Liver Injury - etiology | Disease Models, Animal | Medical research | Liver | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 773 - 794
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a... 
Gastroenterology and Hepatology | Drugs | Obesity | Oxidative stress | Mitochondria | Cell death | Lipids | Hepatotoxicity | Steatosis | TRIGLYCERIDE TRANSFER PROTEIN | DNA-POLYMERASE-GAMMA | PREGNANE X-RECEPTOR | PROLIFERATOR-ACTIVATED RECEPTOR | HEPATIC CYTOCHROME-P450 2E1 | ELEMENT-BINDING PROTEINS | FATTY-ACID OXIDATION | CONSTITUTIVE ANDROSTANE RECEPTOR | MANGANESE SUPEROXIDE-DISMUTASE | STRESS-RELATED PARAMETERS | GASTROENTEROLOGY & HEPATOLOGY | Carbohydrate Metabolism - drug effects | Reactive Oxygen Species - metabolism | Mitochondria, Liver - metabolism | Humans | Leptin - metabolism | Oxidative Phosphorylation - drug effects | Adipose Tissue - metabolism | Adiponectin - metabolism | Hepatitis C - complications | Cell Death - drug effects | Fatty Acids - metabolism | Chemical and Drug Induced Liver Injury - etiology | Diabetes Mellitus, Type 2 - complications | Genetic Predisposition to Disease | Fatty Liver - metabolism | Oxidation-Reduction | Obesity - complications | Insulin Resistance | Mitochondrial Membrane Transport Proteins - drug effects | Chemical and Drug Induced Liver Injury - genetics | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Models, Biological | Lipid Metabolism - drug effects | Alcoholic Intoxication - complications | Genome, Mitochondrial | Adipose Tissue - drug effects | Energy Metabolism - drug effects | Fatty Liver - etiology | Divalproex | Liver diseases | Thiols | Liver | Cytochrome P-450 | Mitochondrial DNA | Triglycerides | Stavudine | Permeability | Valproic acid | Fatty acids | Cells | Carnitine | Metabolites | Glutathione transferase | Acetaminophen | Physiological aspects | DNA polymerases | Health aspects | Zidovudine | Index Medicus | Reactive Oxygen Species | Fatty Acids | Adiponectin | Mitochondria, Liver | Life Sciences | Mitochondrial Membrane Transport Proteins | Cell Death | Diabetes Mellitus, Type 2 | Adipose Tissue | Alcoholic Intoxication | Hépatology and Gastroenterology | Oxidative Phosphorylation | Carbohydrate Metabolism | Lipid Metabolism | Drug-Induced Liver Injury | Fatty Liver | Human health and pathology | Energy Metabolism | Leptin | Hepatitis C
Journal Article