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Journal of Neuroscience Research, ISSN 0360-4012, 03/2020, Volume 98, Issue 3, pp. 471 - 480
BioLuminescent (BL) light production can modulate neural activity and behavior through co‐expressed OptoGenetic (OG) elements, an approach termed “BL‐OG.” Yet,... 
chemogenetic | noninvasive | bioluminescence | optogenetic | injection | BL-OG | coelenterazine | OPTICAL CONTROL | CHEMOGENETICS | NEURAL ACTIVITY | DREADDS | NEUROSCIENCES
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2020, Volume 98, Issue 3, pp. 458 - 468
The need to develop efficient therapies for neurodegenerative diseases is urgent, especially given the increasing percentages of the population living longer,... 
luminopsin | chemogenetic | multielectrode array | neural differentiation | embryonic stem cells | Pitx3 | GRAFTS | SUBSTANTIA-NIGRA | NEUROSCIENCES | DOPAMINE NEURONS | APHAKIA | CHEMOGENETICS | STEM-CELL | MICE
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2020, Volume 98, Issue 3, pp. 422 - 436
Although molecular tools for controlling neuronal activity by light have vastly expanded, there are still unmet needs which require development and refinement.... 
LED | behavior | bioluminescence | opsin | coelenterazine | METABOLISM | CHEMOGENETICS | CLOZAPINE-N-OXIDE | CHANNELRHODOPSIN-2 | NEUROSCIENCES
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3840 - 10
Clozapine-N-oxide (CNO) has long been the ligand of choice for selectively activating Designer Receptors Exclusively Activated by Designer Drugs (DREADDs).... 
DOPAMINE-BETA-HYDROXYLASE | COCAINE | DESIGNER DRUGS | TYPICAL ANTIPSYCHOTIC-DRUGS | CHEMOGENETICS | MULTIDISCIPLINARY SCIENCES | Drug discrimination | Rodents | Clozapine
Journal Article
Current Biology, ISSN 0960-9822, 03/2019, Volume 29, Issue 5, pp. 763 - 774.e5
Retinal dopamine is released by a specialized subset of amacrine cells in response to light and has a potent influence on how the retina responds to, and... 
melanopsin | retina | cones | chemogenetics | rods | adaptation | dopamine | GANGLION-CELL PHOTORECEPTORS | TRANSMISSION | AMACRINE CELLS | AII AMACRINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAT RETINA | NEURONS | MICE | CHEMOGENETIC ACTIVATION | CONE | PHOTOTRANSDUCTION | CELL BIOLOGY | Phenols | Medical colleges | Neurosciences | Dopamine
Journal Article
Neuropharmacology, ISSN 0028-3908, 12/2019, Volume 161, p. 107663
Amphetamine (AMPH) acts as a substrate of the dopamine transporter (DAT) and causes a dramatic increase in extracellular dopamine (DA). Upon entering DA... 
Amphetamine | Dopamine | G protein-coupled receptor signaling | Chemogenetics | Dopamine transporter | DREADDs | Cocaine | Hyperlocomotion
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 06/2019, Volume 40, Issue 6, pp. 362 - 364
Chemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise inert effector molecules. A recent... 
neuromodulation | gene therapy | drug design | chemogenetics | Proteins | Actuators | Drug approval | Neurophysiology
Journal Article
Addiction Biology, ISSN 1355-6215, 2019, p. e12782
Combined use of nicotine and alcohol constitute a significant public health risk. An important aspect of drug use and dependence are the various cues, both... 
drug-discrimination | interoception | chemogenetic | poly-drug | addiction
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2020, Volume 98, Issue 3, pp. 410 - 421
Previous work has demonstrated that fusion of a luciferase to an opsin, to create a luminescent opsin or luminopsin, provides a genetically encoded means of... 
GLucM23 | 6‐OHDA rat | bioluminescence | chemogenetics | optogenetics | iChloC | 6-OHDA rat | PURIFICATION | RATS | NEUROSCIENCES | LESIONS
Journal Article
Brain Structure and Function, ISSN 1863-2653, 8/2017, Volume 222, Issue 6, pp. 2907 - 2915
A growing body of evidence suggests that dopamine plays a role in sleep–wake regulation, but the dopamine-producing brain areas that control sleep–wake states... 
Neurology | Neurosciences | Biomedicine | Sleep | D 1 receptors | Chemogenetics | Substantia nigra | DAT-Cre mice | Midbrain | Cell Biology | receptors
Journal Article