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Journal Article
Journal Article
Carcinogenesis, ISSN 0143-3334, 01/2015, Volume 36, Issue 1, pp. 104 - 114
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 587 - 601
The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a... 
BREAST-CANCER | HEPATOCELLULAR-CARCINOMA | ANTAGONIST | ONCOLOGY | MIGRATION INHIBITORY FACTOR | IMMUNOTHERAPY | INFLAMMATION | EXPRESSION | CHEMOKINE RECEPTOR CCR5 | CHEMOTHERAPY | PROGRESSION | CELL BIOLOGY | Liver Neoplasms - secretion | Lung Neoplasms - drug therapy | Clodronic Acid - pharmacology | Apoptosis - drug effects | Cyclohexanes - pharmacology | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Chemokine CCL5 - secretion | Chemokine CCL5 - antagonists & inhibitors | Cyclohexanes - therapeutic use | Macrophages - secretion | Receptors, CCR5 - metabolism | STAT3 Transcription Factor - physiology | Lung Neoplasms - secondary | Tumor Cells, Cultured | Liver Neoplasms - secondary | Pyridines - therapeutic use | Triazoles - therapeutic use | NG-Nitroarginine Methyl Ester - pharmacology | Tumor Microenvironment - drug effects | Neoplasm Invasiveness | Adenocarcinoma - immunology | Liver Neoplasms - drug therapy | Chemokines - physiology | Phenylurea Compounds - therapeutic use | Receptors, CCR5 - drug effects | Liver Neoplasms - immunology | Adenocarcinoma - drug therapy | Chemotaxis | Adenocarcinoma - secondary | Triazoles - pharmacology | Pilot Projects | Chemokine CCL5 - biosynthesis | Colorectal Neoplasms - immunology | Interferon-alpha - secretion | Survival Analysis | Macrophages - drug effects | Lymphocytes, Tumor-Infiltrating - secretion | Clinical Trials, Phase I as Topic | Lymphocytes, Tumor-Infiltrating - immunology | Care and treatment | Liver | Colorectal cancer | Metastasis | T cells | Health aspects | Cancer | Macrophages
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 12, p. e28842
Increased CCL5 levels are markers of an unfavourable outcome in patients with melanoma, breast, cervical, prostate, gastric or pancreatic cancer. Here, we have... 
CCR5 ANTAGONIST | CELLS | GASTRIC-CANCER | RANTES LEVELS | MULTIDISCIPLINARY SCIENCES | TYROSINE KINASES | COLON | TUMOR STROMA | FACTOR RECEPTOR | EXPRESSION | BREAST | Cricetulus | Colorectal Neoplasms - genetics | Humans | Molecular Targeted Therapy | Receptor, Platelet-Derived Growth Factor beta - genetics | Chemokine CCL5 - antagonists & inhibitors | Leukocytes - immunology | Antibodies, Neutralizing - immunology | Neoplasm Metastasis | Receptors, CCR5 - metabolism | Colorectal Neoplasms - drug therapy | Female | Chemokine CCL5 - metabolism | Colorectal Neoplasms - metabolism | CHO Cells | Receptor, Platelet-Derived Growth Factor beta - metabolism | Amides - pharmacology | Cricetinae | Treatment Outcome | Disease Progression | HT29 Cells | Cell Movement - drug effects | Animals | Leukocytes - drug effects | Cell Proliferation - drug effects | Mice | Colorectal Neoplasms - pathology | Chemokine CCL5 - immunology | Quaternary Ammonium Compounds - pharmacology | Pathogenesis | Liver | Colorectal carcinoma | Colorectal cancer | Antibodies | Vaccines | Metastasis | Kinases | CD45 antigen | Metastases | Receptors | Colon cancer | Rodents | Animal tissues | Colon | Lesions | Growth factors | CCR5 protein | Cytokines | Melanoma | Stroma | Breast cancer | Gene expression | Cervix | Patients | Biopsy | Pancreatic cancer | Laboratory animals | Prostate | Prostate cancer | Chemokines | Tumors | Peritoneum | Cancer | Neutralization
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2016, Volume 66, Issue 4, pp. 743 - 753
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2013, Volume 33, Issue 4, pp. 718 - 726
OBJECTIVE—Macrophages are critical contributors to abdominal aortic aneurysm (AAA) disease. We examined the ability of MKEY, a peptide inhibitor of CXCL4–CCL5... 
chemokines | mice | CCL5 | abdominal aortic aneurysm | CXCL4 | ATHEROSCLEROTIC LESIONS | PROGENITOR CELLS | RECRUITMENT | WALL | RECEPTOR CCR2 | RANTES | BONE-MARROW | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INFUSION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | E-DEFICIENT MICE | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Injections, Intravenous | Aortic Aneurysm, Abdominal - immunology | Apolipoproteins E - deficiency | Male | Aorta, Abdominal - drug effects | Chemokine CCL5 - antagonists & inhibitors | Aortic Aneurysm, Abdominal - metabolism | Leukocytes - immunology | Matrix Metalloproteinase 9 - metabolism | Receptors, CCR5 - metabolism | Chemotaxis, Leukocyte - drug effects | Time Factors | Chemokine CCL5 - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Myocytes, Smooth Muscle - drug effects | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Platelet Factor 4 - antagonists & inhibitors | Disease Progression | Mice, Knockout | Aorta, Abdominal - immunology | Animals | Apolipoproteins E - genetics | Myocytes, Smooth Muscle - immunology | Pancreatic Elastase | Leukocytes - drug effects | Macrophages - drug effects | Mice | Oligopeptides - administration & dosage | Platelet Factor 4 - metabolism | Oligopeptides - pharmacology
Journal Article
Nature Communications, ISSN 2041-1723, 09/2014, Volume 5, Issue 1, p. 4715
Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRANSCRIPTION FACTORS | STAT3 ACTIVATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RESISTANCE | LYMPHANGIOGENESIS | C-JUN | INTERLEUKIN-6 | TUMOR-GROWTH | SIGNAL TRANSDUCER | Neoplasm Transplantation | Interleukin-6 - antagonists & inhibitors | Lymph Nodes - pathology | Cyclohexanes - pharmacology | Humans | Culture Media, Conditioned - pharmacology | Transplantation, Heterologous | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Triple Negative Breast Neoplasms - drug therapy | Vascular Endothelial Growth Factor A - genetics | Chemokine CCL5 - antagonists & inhibitors | Lymphatic Vessels - drug effects | Benzenesulfonates - pharmacology | Lymphatic Vessels - metabolism | MCF-7 Cells | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Triple Negative Breast Neoplasms - pathology | Female | Lymph Nodes - drug effects | Chemokine CCL5 - metabolism | Lung - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Gene Expression | Lung - pathology | Aminosalicylic Acids - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Interleukin-6 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Lymph Nodes - metabolism | Antibodies, Neutralizing - pharmacology | Lymphatic Metastasis | Cell Adhesion - drug effects | Triazoles - pharmacology | Cell Movement - drug effects | Animals | Triple Negative Breast Neoplasms - genetics | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Lung - drug effects | Lymphatic Vessels - pathology | Chemokine CCL5 - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | STAT3 Transcription Factor - antagonists & inhibitors
Journal Article