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Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2010, Volume 10, Issue 13, pp. 1278 - 1298
Inhibition of CCR2 has been considered as a target for multiple therapeutic diseases including autoimmune disease, atherosclerosis, pain, and metabolic... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | CHEMISTRY, MEDICINAL | SMALL-MOLECULE | BONE-MARROW | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | CHEMOKINE RECEPTOR 2 | BLOOD-BRAIN-BARRIER | II-INDUCED PROGRESSION | ADIPOSE-TISSUE
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NATURE REVIEWS DRUG DISCOVERY, ISSN 1474-1776, 01/2009, Volume 8, Issue 1, pp. 23 - 33
Chemokine receptors have a key role in the pathogenesis of auto immune diseases, inflammation and viral infection. However, with the exception of selective... 
RHEUMATOID-ARTHRITIS | DUAL ANGIOTENSIN-II | MULTIPLE-SCLEROSIS | SMALL-MOLECULE | CC-CHEMOKINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | PHARMACOLOGY & PHARMACY | PERIPHERAL-BLOOD | MONOCYTE CHEMOTACTIC PROTEIN-1 | T-CELLS | AUTOIMMUNE ENCEPHALOMYELITIS
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2018, Volume 13, Issue 9, pp. 916 - 930
Herein we describe the synthesis and structure–activity relationships of 3‐aminocyclohex‐2‐en‐1‐one derivatives as novel chemokine receptor 2 (CXCR2)... 
CXCR2 antagonists | chemokine receptors | structure–activity relationships | ADMET | Synthesis | CXCR2 protein | Toxicity | Cytotoxicity | Derivatives | Chemokines | Optimization
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