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1. Full Text Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
by Grupp, Stephan A and Kalos, Michael and Barrett, David and Aplenc, Richard and Porter, David L and Rheingold, Susan R and Teachey, David T and Chew, Anne and Hauck, Bernd and Wright, J. Fraser and Milone, Michael C and Levine, Bruce L and June, Carl H
The New England journal of medicine, ISSN 0028-4793, 04/2013, Volume 368, Issue 16, pp. 1509 - 1518
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | General aspects | Medical sciences | Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy | Humans | Immunotherapy | Antigens, CD19 | Female | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell | Child | Remission Induction | Chimera | Regression (Disease) | Care and treatment | Immune response | Acute lymphocytic leukemia | Research | T cells | Pediatrics | Laboratories | Leukemia | Body weight | Cytotoxicity | Lymphocytes T | Cerebrospinal fluid | Etanercept | Lymphocytes | Bone marrow | Remission | Children | Blast cells | Antigens | Chronic lymphatic leukemia | CD19 antigen | Acute lymphatic leukemia | Cytokines | Tumor cells | T cell receptors | Lymphatic leukemia | Patients | Lymphoma | Fever | Children & youth | Chimeric antigen receptors | Chemotherapy | Aplasia | Lymphocytes B | Index Medicus | Abridged Index Medicus
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2. Full Text Chimeric antigen receptor T-cell therapy-assessment and management of toxicities
by Neelapu, Sattva S and Tummala, Sudhakar and Kebriaei, Partow and Wierda, William and Gutierrez, Cristina and Locke, Frederick L and Komanduri, Krishna V and Lin, Yi and Jain, Nitin and Daver, Naval and Westin, Jason and Gulbis, Alison M and Loghin, Monica E and De Groot, John F and Adkins, Sherry and Davis, Suzanne E and Rezvani, Katayoun and Hwu, Patrick and Shpall, Elizabeth J
Nature reviews. Clinical oncology, ISSN 1759-4774, 01/2018, Volume 15, Issue 1, pp. 47 - 62
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunotherapy, Adoptive - adverse effects | Cytokines - metabolism | Brain Diseases - therapy | Humans | Receptors, Antigen, T-Cell - therapeutic use | Adult | Female | Receptors, Antigen, T-Cell - immunology | Brain Diseases - etiology | Syndrome | Complications and side effects | Cell receptors | Care and treatment | Oncology, Experimental | Cellular therapy | Research | Health aspects | Cancer | Chimeric antigen receptors | Antigens | Neurotoxicity | Hematology | Toxicity | Immunotherapy | Encephalopathy | T cell receptors | Genetic engineering | Lymphocytes T | Management | Morbidity | Index Medicus
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3. Full Text Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes
by Ramos, Carlos A and Ballard, Brandon and Zhang, Huimin and Dakhova, Olga and Gee, Adrian P and Mei, Zhuyong and Bilgi, Mrinalini and Wu, Meng-Fen and Liu, Hao and Grilley, Bambi and Bollard, Catherine M and Chang, Bill H and Rooney, Cliona M and Brenner, Malcolm K and Heslop, Helen E and Dotti, Gianpietro and Savoldo, Barbara
The Journal of clinical investigation, ISSN 0021-9738, 09/2017, Volume 127, Issue 9, pp. 3462 - 3471
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Lymphoma, Large-Cell, Anaplastic - immunology | Receptors, Antigen, T-Cell - chemistry | Lymphoma, Large-Cell, Anaplastic - therapy | Humans | Middle Aged | Neoplasm Recurrence, Local | Immunophenotyping | Male | Treatment Outcome | Antineoplastic Agents - chemistry | Ki-1 Antigen - metabolism | Molecular Targeted Therapy | Immunoconjugates - administration & dosage | Disease Progression | Dose-Response Relationship, Drug | Young Adult | T-Lymphocytes - cytology | Hodgkin Disease - therapy | Immunoconjugates - therapeutic use | Adult | Female | Hodgkin Disease - immunology | CD28 Antigens - chemistry | Transplantation Conditioning | Antigens | Lymphocytes | Health aspects | Immunoglobulins | Leukemia | T cell receptors | Lymphocytes T | Malignancy | CD28 antigen | Kinases | Patients | Cancer therapies | Lymphoma | Chimeric antigen receptors | Chemotherapy | CD30 antigen | Immunotherapy | Peripheral blood | Monoclonal antibodies | Antitumor activity | Anaplastic large-cell lymphoma | Drug dosages | Hodgkin's disease | Index Medicus | Abridged Index Medicus
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4. Full Text Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells
by Lynn, Rachel C and Poussin, Mathilde and Kalota, Anna and Feng, Yang and Low, Philip S and Dimitrov, Dimiter S and Powell, Daniel J
Blood, ISSN 0006-4971, 05/2015, Volume 125, Issue 22, pp. 3466 - 3476
Life Sciences & Biomedicine | Hematology | Science & Technology | Folate Receptor 2 - genetics | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Leukemia, Myeloid, Acute - pathology | Humans | Cells, Cultured | Mice, Transgenic | Leukemia, Myeloid, Acute - immunology | Mice, SCID | Molecular Targeted Therapy | Animals | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Mutant Chimeric Proteins - metabolism | HEK293 Cells | Female | Mice, Inbred NOD | T-Lymphocytes - immunology | Mice | T-Lymphocytes - pathology | Folate Receptor 2 - antagonists & inhibitors | Leukemia, Myeloid, Acute - therapy | Genetic Therapy - methods | Leukemia, Myeloid, Acute - genetics | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
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5. Full Text A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects
by Kagoya, Yuki and Tanaka, Shinya and Guo, Tingxi and Anczurowski, Mark and Wang, Chung-Hsi and Saso, Kayoko and Butler, Marcus O and Minden, Mark D and Hirano, Naoto
Nature medicine, ISSN 1078-8956, 03/2018, Volume 24, Issue 3, pp. 352 - 359
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Humans | Receptors, Antigen, T-Cell - therapeutic use | Antigens, CD19 - genetics | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Neoplasms - therapy | CD28 Antigens - genetics | Neoplasms - genetics | T-Lymphocytes - metabolism | Antigens, CD19 - therapeutic use | Interleukin-2 Receptor beta Subunit - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - therapeutic use | Cell Proliferation - genetics | Immunotherapy, Adoptive | Interleukin-2 Receptor beta Subunit - therapeutic use | Janus Kinases - genetics | Signal Transduction | Xenograft Model Antitumor Assays | Receptors, Chimeric Antigen - therapeutic use | Animals | CD28 Antigens - therapeutic use | Cell Line, Tumor | Receptors, Chimeric Antigen - genetics | Receptors, Antigen, T-Cell - genetics | Neoplasms - pathology | Cell receptors | Care and treatment | Immune response | Innovations | Genetic aspects | T cells | Health aspects | Cancer | Cell proliferation | Transcription factors | Toxicity | Interleukin | Stimulation | Lymphocytes T | CD28 antigen | Adoptive transfer | Anticancer properties | T-cell receptor | Cell activation | Lymphocytes | Janus kinase | Biocompatibility | Tyrosine | Interleukin 2 receptors | Antigens | CD19 antigen | Cytokines | Stat3 protein | T cell receptors | Stat5 protein | Chimeric antigen receptors | Signaling | Immunosuppression | Lymphocytes B | Antitumor activity | Solid tumors | Tumors | Glutamine | Index Medicus
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6. Full Text Effective Targeting of Multiple B-Cell Maturation Antigen–Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells
by Friedman, Kevin M and Garrett, Tracy E and Evans, John W and Horton, Holly M and Latimer, Howard J and Seidel, Stacie L and Horvath, Christopher J and Morgan, Richard A
Human gene therapy, ISSN 1043-0342, 05/2018, Volume 29, Issue 5, pp. 585 - 601
Research Articles | gene therapy | multiple myeloma | BCMA | CAR | adoptive cell therapy | immunotherapy | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hematologic Neoplasms - therapy | Humans | Hematologic Neoplasms - pathology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Multiple Myeloma - therapy | CD3 Complex - genetics | T-Lymphocytes - drug effects | Lentivirus - genetics | Gene Expression Regulation, Neoplastic - drug effects | Cytotoxicity, Immunologic - drug effects | B-Cell Maturation Antigen - antagonists & inhibitors | B-Cell Maturation Antigen - immunology | Immunotherapy, Adoptive | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Xenograft Model Antitumor Assays | Receptors, Chimeric Antigen - therapeutic use | Multiple Myeloma - pathology | Animals | Receptors, Chimeric Antigen - immunology | CD3 Complex - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Hematologic Neoplasms - genetics | Mice | Hematologic Neoplasms - immunology | Multiple Myeloma - genetics | Biotechnology | Animal models | Intravenous administration | Leukemia | Multiple myeloma | Lymphocytes T | Receptors | Lymphocytes | Peripheral blood | Antigens | Chronic lymphatic leukemia | CD137 antigen | Hematology | Maturation | Tumor cells | Therapeutic applications | Pharmacology | Tumor cell lines | Lymphatic leukemia | Lymphoma | Molecular chains | Burkitt's lymphoma | Chimeric antigen receptors | Lymphocytes B | Mantle cell lymphoma | Plasma cells | Tumors | Index Medicus
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7. Full Text Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
by Porter, David L and Levine, Bruce L and Kalos, Michael and Bagg, Adam and June, Carl H
The New England journal of medicine, ISSN 0028-4793, 08/2011, Volume 365, Issue 8, pp. 725 - 733
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | General aspects | Medical sciences | Bone Marrow - immunology | Leukemia, Lymphoid - therapy | Humans | Male | Leukemia, Lymphoid - pathology | Lentivirus | Remission Induction | Immunotherapy - adverse effects | Agammaglobulinemia - etiology | B-Lymphocytes - immunology | Tumor Lysis Syndrome - etiology | Bone Marrow - pathology | Antigens, CD19 | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | Leukemia, Lymphoid - immunology | Chimera | Cytokines - blood | Chronic lymphocytic leukemia | Care and treatment | Antigen receptors, T cell | Usage | Receptors | Genetic aspects | Diagnosis | T cells | Health aspects | Leukemia | Body weight | Clinical trials | Lymphocytes T | Hypogammaglobulinemia | T-cell receptor | Signal transduction | Lymphocytes | Bone marrow | Remission | Chromosomes | Antigens | Autografts | Chronic lymphatic leukemia | CD19 antigen | CD137 antigen | Cytokines | CD3 antigen | T cell receptors | Lymphatic leukemia | Patients | Chimeric antigen receptors | Chemotherapy | Lymphocytes B | Lymphopenia | Lysis | Tumors | Index Medicus | Abridged Index Medicus
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8. Full Text RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: A safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma
by Harrer, Dennis C and Simon, Bianca and Fujii, Shin-ichiro and Shimizu, Kanako and Uslu, Ugur and Schuler, Gerold and Gerer, Kerstin F and Hoyer, Stefanie and Dörrie, Jan and Schaft, Niels
BMC cancer, ISSN 1471-2407, 08/2017, Volume 17, Issue 1, pp. 551 - 551
Cross-reaction | MHC-downregulation | γ/δ T cell | Chimeric antigen receptor | Melanoma | MRNA-electroporation | Immune evasion | Adoptive T-cell therapy | Zoledronate | Life Sciences & Biomedicine | Oncology | Science & Technology | RNA | Humans | Middle Aged | Healthy Volunteers | RNA, Messenger - metabolism | gp100 Melanoma Antigen - immunology | Young Adult | Immunomagnetic Separation | Transfection | Melanoma - genetics | Adult | Cell Culture Techniques | Melanoma - metabolism | T-Lymphocytes, Cytotoxic - immunology | Cytokines - metabolism | HLA-A2 Antigen - immunology | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | RNA, Messenger - genetics | Electroporation | Immunophenotyping | Receptors, Antigen, T-Cell, alpha-beta - genetics | Genetic Engineering | T-Lymphocytes, Cytotoxic - metabolism | Melanoma - immunology | Recombinant Fusion Proteins - genetics | T-Cell Antigen Receptor Specificity | Receptors, Antigen, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Melanoma - therapy | Cytotoxicity, Immunologic | Index Medicus
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