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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 8, pp. 1366 - 1375
Drug-induced liver injury (DILI) is a common side effect of several medications and is considered a major factor responsible for the discontinuation of drugs... 
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 08/2019, Volume 42, Issue 8, pp. 1366 - 1375
Drug-induced liver injury (DILI) is a common side effect of several medications and is considered a major factor responsible for the discontinuation of drugs... 
RAT | CHOLESTEROL | bile acid | DRUG-INTERACTIONS | TRANSPORTERS | SALT EXPORT PUMP | INJURY | MODEL | IDENTIFICATION | SANDWICH-CULTURED HEPATOCYTES | INDUCED ELEVATION | cholestasis | chimeric mouse | bile salt export pump | PHARMACOLOGY & PHARMACY | humanized liver
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 02/2018, Volume 33, Issue 1, pp. 31 - 39
Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles... 
Drug metabolism | Metabolite profiles | Drug-drug interactions | Chimeric mice with humanized liver | Pharmacokinetics | Prediction | TK-NOG MICE | IN-VIVO EXTRAPOLATION | MODEL | INDUCTION | CYTOCHROME-P450 3A4 | HEPATIC-CLEARANCE | VITRO DATA | PREDICTABILITY | HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY
Journal Article
Xenobiotica, ISSN 0049-8254, 04/2019, Volume 49, Issue 4, pp. 404 - 414
Journal Article
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 2010, Volume 25, Issue 3, pp. 223 - 235
Journal Article
Journal Article
Drug Testing and Analysis, ISSN 1942-7603, 11/2009, Volume 1, Issue 11-12, pp. 531 - 537
Journal Article
DRUG METABOLISM AND PHARMACOKINETICS, ISSN 1347-4367, 2009, Volume 24, Issue 2, pp. 153 - 160
Chimeric mice, constructed by transplanting human hepatocytes, are useful for predicting the human metabolism of drug candidates. In this study, we... 
7-hydroxywarfarin | R-WARFARIN | CLEARANCE | human liver | WARFARIN ENANTIOMERS | chimeric mice | CYP2C9 | METABOLISM | ENZYMES | IN-VIVO | PHARMACOLOGY & PHARMACY | ANTICOAGULANT ACTIVITY | S-warfarin | FLUCONAZOLE | DRUG-INTERACTION
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2007, Volume 353, Issue 4, pp. 882 - 888
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 02/2018, Volume 154, Issue 3, pp. 652 - 662.e8
NVR3–778 is a capsid assembly modulator in clinical development. We determined the in vivo antiviral efficacy and effects on innate and endoplasmic reticulum... 
ER Stress Response | Replication | Assembly Inhibitor Core Protein | DAA | CAM | HEPATITIS-B-VIRUS | CORE INHIBITOR | ANTIVIRAL THERAPY | RNA | MOUSE | VIRAL-INFECTION | CHIMERIC HUMAN LIVERS | RESPONSES | IN-VITRO | GASTROENTEROLOGY & HEPATOLOGY | Analysis | Interferon alpha | Entecavir | Resveratrol | Albumin | Circular DNA | Biological response modifiers | Health aspects | Hepatitis B
Journal Article