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PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21018
Background: Based on its selective cell surface expression in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), receptor tyrosine kinase ROR1... 
MOUSE DEVELOPMENT | CHIMERIC RABBIT/HUMAN FAB | INFECTIONS | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | CHRONIC LYMPHOCYTIC-LEUKEMIA | PHAGE DISPLAY | GENERATION | EXPRESSION | FAMILY | Amino Acid Sequence | Rabbits | Antibody-Dependent Cell Cytotoxicity | Humans | Molecular Sequence Data | Receptor Tyrosine Kinase-like Orphan Receptors - immunology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Sequence Homology, Amino Acid | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | Receptor Tyrosine Kinase-like Orphan Receptors - chemistry | Antibodies, Monoclonal - immunology | Apoptosis | Tyrosine | Biological products | Immunoglobulin G | Monoclonal antibodies | Phenols | B cells | Non-Hodgkin's lymphomas | Antibody-toxin conjugates | Health aspects | Cancer | Antigenic determinants | Toxicity | Leukemia | Phages | Cytotoxicity | Kinases | Cancer therapies | Cell surface | Proteins | Receptors | Phage display | Immunology | Cell cycle | Protein-tyrosine kinase receptors | Protein-tyrosine kinase | Medical research | Antigens | Immunization | Immunoglobulins | Chronic lymphatic leukemia | Fab | FDA approval | Epitopes | Lymphatic leukemia | Gene expression | Lymphoma | Immunotoxins | Chemotherapy | Lymphocytes B | Internalization | Cell lines | Mantle cell lymphoma | Affinity | Lymphomas
Journal Article
Journal Article
Biotechnology Journal, ISSN 1860-6768, 12/2017, Volume 12, Issue 12, pp. 1700441 - n/a
Journal Article
Drug Discoveries & Therapeutics, ISSN 1881-7831, 2015, Volume 9, Issue 3, pp. 147 - 155
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2007, Volume 282, Issue 6, pp. 4094 - 4101
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2189 - 2201
We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface receptor overexpressed on pediatric solid tumors, using chimeric antigen... 
ALK | tumor immunology | CAR | antigen density | anaplastic lymphoma kinase | immunotherapy | neuroblastoma | chimeric antigen receptor | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | TYROSINE KINASE | NEUROBLASTOMA | MODIFIED T-CELLS | ANTITUMOR-ACTIVITY | THERAPEUTIC INDEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ALK KINASE | EXPRESSION | ACTIVATING MUTATIONS | Neoplasms - metabolism | Humans | Recombinant Fusion Proteins | Lymphocyte Activation - immunology | Neoplasms - therapy | Neoplasms - genetics | T-Lymphocytes - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Lentivirus - genetics | Gene Order | Disease Models, Animal | Antigens, Neoplasm - genetics | Gene Expression | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Receptors, Cell Surface - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Genetic Vectors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neoplasms - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Flow cytometry | Pediatrics | Leukemia | Lymphocytes T | Neuroblastoma | Kinases | Cell surface | AACR | Cell activation | Lymphocytes | Immunotherapy | Xenografts | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Medical research | Antigens | Cytokines | Cyclin-dependent kinases | Exploration | Lymphoma | Medical prognosis | Internalization | γ-Interferon | Cell lines | Monoclonal antibodies | Lymphomas | Mutation | Solid tumors | Cancer | Tumors | Original
Journal Article
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 09/2009, Volume 87, Issue 12, pp. 2624 - 2631
Nervous system growth factor gene delivery can promote axonal growth and prevent cell death in animal models of CNS trauma and neurodegenerative diseases. The... 
gene therapy | trkA | neurotrophin | NGF | AP20187 | regeneration | Neurotrophin | Regeneration | Gene therapy | ALZHEIMER-DISEASE | ACTIVATION | NEUROTROPHIC FACTOR | MAMMALIAN-CELLS | NEUROSCIENCES | LENTIVIRAL VECTORS | NERVE GROWTH-FACTOR | DELIVERY | TRANSGENE EXPRESSION | IN-VIVO | FACTOR GENE-THERAPY | Ganglia, Spinal - cytology | Tacrolimus - analogs & derivatives | PC12 Cells | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase 3 - drug effects | Nervous System - growth & development | Tacrolimus - pharmacology | Neurogenesis - drug effects | Phosphorylation - drug effects | Nervous System - embryology | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | Transduction, Genetic - methods | Neurites - drug effects | Recombinant Fusion Proteins - biosynthesis | Nervous System - cytology | Nerve Growth Factor - metabolism | Tacrolimus - chemistry | Nerve Growth Factor - agonists | Rats | Neurites - metabolism | Genetic Vectors - genetics | Mutant Chimeric Proteins - biosynthesis | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Receptor, trkA - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neurogenesis - physiology | Receptor, trkA - chemistry | Receptor, trkA - genetics | Signal Transduction - physiology | Ganglia, Spinal - metabolism | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Proto-Oncogene Proteins c-akt - drug effects
Journal Article