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Journal of the American Chemical Society, ISSN 0002-7863, 08/2014, Volume 136, Issue 33, pp. 11748 - 11756
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug... 
NANOPARTICLES | POLYMERS | EFFICACY | VESICLES | TUMOR | NANOMEDICINE | AGENTS | NANOCAPSULES | COPOLYMER MICELLES | CHEMISTRY, MULTIDISCIPLINARY | Prodrugs - administration & dosage | Small Molecule Libraries - pharmacology | Nanoparticles - chemistry | Apoptosis - drug effects | Small Molecule Libraries - administration & dosage | Drug Resistance, Multiple - drug effects | Humans | Prodrugs - chemistry | Chlorambucil - pharmacology | MCF-7 Cells | Mammary Neoplasms, Experimental - pathology | Molecular Structure | Iridium - chemistry | Mammary Neoplasms, Experimental - drug therapy | Chlorambucil - chemistry | Rats | Breast Neoplasms - drug therapy | Surface-Active Agents - pharmacology | Small Molecule Libraries - chemistry | Animals | Surface-Active Agents - administration & dosage | Breast Neoplasms - pathology | Mice, Nude | Organometallic Compounds - chemical synthesis | Organometallic Compounds - chemistry | Cell Proliferation - drug effects | Mice | Nanoparticles - administration & dosage | Surface-Active Agents - chemistry | Cell Cycle - drug effects | Surface-Active Agents - chemical synthesis | Drug Delivery Systems - methods | Prodrugs - pharmacology | Organometallic Compounds - pharmacology | Drug Resistance, Neoplasm - drug effects | Organometallic Compounds - administration & dosage | Drugs | Drug delivery systems | Care and treatment | Prodrugs | Dosage and administration | Research | Methods | Cancer | Vehicles
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2015, Volume 54, Issue 3, pp. 1002 - 1006
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 20, pp. 5692 - 5708
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2001, Volume 8, Issue 5, pp. 533 - 544
Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen... 
CHEMISTRY, MEDICINAL | DUOCARMYCIN SA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO TRANSCRIPTION | NITROGEN-MUSTARD | ANTITUMOR-ACTIVITY | BENZOIC-ACID MUSTARD | INTERSTRAND CROSS-LINKING | SEQUENCE PREFERENTIAL ALKYLATION | DIRECTED ANILINE MUSTARDS | BIOLOGICAL-ACTIVITY | PHARMACOLOGY & PHARMACY | SECO-CBI-TMI | Anthramycin - metabolism | Distamycins - metabolism | Antibiotics, Antineoplastic - pharmacology | Alkylating Agents - pharmacology | Humans | Cyclohexenes | Benzofurans - pharmacology | Structure-Activity Relationship | Nitrogen Mustard Compounds - chemistry | Netropsin - metabolism | Benzofurans - chemistry | Alkylating Agents - metabolism | Indoles - metabolism | Antibiotics, Antineoplastic - chemistry | Indoles - pharmacology | Cyclohexanecarboxylic Acids - metabolism | Chlorambucil - metabolism | DNA - drug effects | Bisbenzimidazole - metabolism | Chlorambucil - chemistry | Pyrroles - metabolism | Nitrogen Mustard Compounds - pharmacology | Bisbenzimidazole - chemistry | DNA - metabolism | Alkylating Agents - chemistry | Netropsin - analogs & derivatives | Anthramycin - pharmacology | Distamycins - chemistry | DNA - chemistry | Animals | Netropsin - chemistry | Cyclohexanecarboxylic Acids - pharmacology | Nitrogen Mustard Compounds - metabolism | Pyrroles - chemistry | Anthramycin - chemistry | Antibiotics, Antineoplastic - metabolism | Indoles - chemistry | Cyclohexanecarboxylic Acids - chemistry | Benzofurans - metabolism
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 01/2008, Volume 19, Issue 1, pp. 70 - 75
Chemotherapy is often limited by toxicity to normal cells. Therefore, an ideal anticancer drug should discriminate between normal tissue and tumors. This would... 
ZIP CODES | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | VASCULATURE | MOUSE MODEL | IN-VIVO | NITROGEN MUSTARDS | AMINOPEPTIDASE-P | SPECIALIZATION | Chlorambucil - chemistry | Amino Acid Sequence | Drug Carriers - metabolism | Peptides - chemistry | Humans | Molecular Sequence Data | Drug Carriers - chemical synthesis | Antineoplastic Agents - chemistry | Chlorambucil - pharmacology | Organ Specificity | Breast Neoplasms - drug therapy | Drug Carriers - chemistry | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Animals | Peptides - chemical synthesis | Peptides - metabolism | Peptides - toxicity | Drug Design | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Mice | Tissue | Molecules | Chemotherapy | Peptides | Toxicity | Cells | Tumors | Neurochemistry | Biological Sciences | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Drug delivery | MEDICINE | Neurokemi | Chemistry | Naturvetenskap | Biokemi och molekylärbiologi | Tumor targeting | MEDICIN | Kemi | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Biochemistry and Molecular Biology | Natural Sciences | Neurovetenskaper | Cell-penetrating peptide | Homing peptide
Journal Article
Journal Article