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Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175486
We optically measured effects of orally available ivacaftor (Kalydeco (R)) on sweat rates of identified glands in 3 R117H subjects, each having a unique set of... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | GLANDS | GENE | MESSENGER-RNA TRANSCRIPTS | PARTIAL PENETRANCE | MULTIDISCIPLINARY SCIENCES | CODING SEQUENCES | MUTATION | DISEASE | CYSTIC-FIBROSIS | CFTR POTENTIATOR | Muscarinic Agonists - pharmacology | Sweat - secretion | Humans | Male | Quinolones - pharmacology | Aminophenols - pharmacology | Methacholine Chloride - administration & dosage | Gene Deletion | Methacholine Chloride - pharmacology | Adrenergic beta-Agonists - administration & dosage | Adult | Female | Injections, Intradermal | Muscarinic Agonists - administration & dosage | Administration, Oral | Chloride Channel Agonists - pharmacology | Adrenergic beta-Agonists - pharmacology | Sweating - genetics | Exons - genetics | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Sweating - drug effects | Quinolones - administration & dosage | Ion Channel Gating - genetics | Analysis of Variance | Chloride Channel Agonists - administration & dosage | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mutation | Aminophenols - administration & dosage | Ion Channel Gating - drug effects | Ivacaftor | Care and treatment | Gene mutations | Methacholine | Cystic fibrosis | Dosage and administration | Research | Wine | Pediatrics | Acetylcholine receptors (muscarinic) | Laboratories | Linkage disequilibrium | Glands | Biology | Iontophoresis | Membrane conductance | Chloride | Intestine | Anion channels | Genetics | Physiology | Children | Sweat | Digestive tract | Gating | Channel opening | Secretion | Channel gating | Bioassays | Organs | Chloride transport | Ion transport | Cultures | Medical screening | Medicine | Clear cells | Lungs | Alleles | In vivo methods and tests | Conductance | Cystic fibrosis transmembrane conductance regulator | Molecular biology
Journal Article
Contraception, ISSN 0010-7824, 2013, Volume 88, Issue 4, pp. 485 - 491
Abstract There is a global need for an ideal method of male contraception. However, the development of male contraceptives has not been well successful.... 
Obstetrics and Gynecology | CatSper | Slo3 | Ion channel | Sperm | Male contraceptives | MALE-FERTILITY | MOUSE SPERM | SPERMATOGENIC CELLS | MALE ANTIFERTILITY COMPOUNDS | OBSTETRICS & GYNECOLOGY | SLO3 K+ CHANNELS | CA2+ CHANNEL | POSTNATAL-DEVELOPMENT | CATSPER CHANNEL | HYPERACTIVATED MOTILITY | TRANSMEMBRANE PROTEIN | Anoctamin-1 | Drugs, Investigational - pharmacology | Calcium Channels - metabolism | Humans | Potassium Channels, Voltage-Gated - agonists | Male | Neoplasm Proteins - antagonists & inhibitors | Spermatozoa - metabolism | Neoplasm Proteins - metabolism | Protein Subunits - metabolism | Potassium Channels, Voltage-Gated - metabolism | Membrane Proteins - metabolism | Chloride Channels - antagonists & inhibitors | Protein Subunits - agonists | Potassium Channels, Voltage-Gated - antagonists & inhibitors | Organ Specificity | Spermatozoa - drug effects | Membrane Proteins - agonists | Ion Channels - antagonists & inhibitors | Chloride Channels - metabolism | Contraceptive Agents, Male - pharmacology | Ion Channels - metabolism | Membrane Proteins - antagonists & inhibitors | Neoplasm Proteins - agonists | Signal Transduction - drug effects | Calcium Channels - chemistry | Chloride Channel Agonists | Ion Channels - agonists | Protein Subunits - antagonists & inhibitors | Oral contraceptives | Spermatozoa | Ion channels
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 20, pp. 4590 - 4600
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, p. 36806
Mucociliary clearance (MCC) is a critical host innate defense mechanism in airways, and it is impaired in cystic fibrosis (CF) and other obstructive lung... 
MUCUS SECRETION | CONDUCTANCE | REGULATOR | TRANSPORT | VASOACTIVE-INTESTINAL-PEPTIDE | TRACHEAL SUBMUCOSAL GLANDS | MULTIDISCIPLINARY SCIENCES | CILIARY BEAT FREQUENCY | CYSTIC-FIBROSIS | ENAC | CFTR | Calcium channels | Secretion | Lung diseases | Cyclic AMP | Cystic fibrosis | Isoproterenol | Velocity | Calcium chloride | Sodium | Carbachol | Anion channels | Obstructive lung disease | Forskolin | Chloride channels
Journal Article
The Journal of Physiology, ISSN 0022-3751, 12/2005, Volume 569, Issue 2, pp. 601 - 615
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cyclic AMP‐regulated chloride channel. Mutations in the CFTR gene result in cystic fibrosis... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | WILD-TYPE | PHOSPHODIESTERASE INHIBITORS | ADENOSINE RECEPTORS | PHYSIOLOGY | CHLORIDE CHANNELS | PROTEIN | CYSTIC-FIBROSIS | QUALITY-CONTROL | CL-SECRETION | NEUROSCIENCES | SMALL-MOLECULE CORRECTORS | Tissue, System and Organ Physiology
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 10/2015, Volume 764, pp. 633 - 642
M/Kv7 K+ channels, Ca2+-activated Cl– channels (CaCCs) and voltage gated Na+ channels expressed in dorsal root ganglia (DRG) play an important role in... 
Tannic acid | CaCCs | M/Kv7 K+ currents | Pain | Voltage-gated Na+ currents | Bradykinin | M/Kv7 K + currents | Voltage-gated Na + currents | Tannicacid | KCNQ POTASSIUM CHANNELS | ACTIVATION | PAIN PATHWAYS | TRP CHANNELS | CURRENTS | GATED CALCIUM-CHANNELS | INHIBITION | CA2+-ACTIVATED CL-CHANNELS | PHARMACOLOGY & PHARMACY | MOLECULAR-BASIS | K+ CHANNELS | Analgesics - pharmacology | Anoctamin-1 | Voltage-Gated Sodium Channels - drug effects | Humans | Ganglia, Spinal - physiopathology | Nociceptive Pain - chemically induced | Chloride Channels - genetics | Nociceptive Pain - drug therapy | KCNQ2 Potassium Channel - agonists | Dose-Response Relationship, Drug | Nociceptive Pain - metabolism | Transfection | KCNQ2 Potassium Channel - metabolism | HEK293 Cells | Nociception - drug effects | Behavior, Animal - drug effects | Sensory Receptor Cells - metabolism | Disease Models, Animal | Chloride Channels - antagonists & inhibitors | KCNQ3 Potassium Channel - metabolism | KCNQ Potassium Channels - agonists | Rats, Sprague-Dawley | Chloride Channels - metabolism | Animals | Nociceptive Pain - physiopathology | Sensory Receptor Cells - drug effects | Membrane Potentials | Tannins - pharmacology | KCNQ Potassium Channels - metabolism | Voltage-Gated Sodium Channel Blockers - pharmacology | Nociceptive Pain - psychology | KCNQ3 Potassium Channel - agonists | Ganglia, Spinal - drug effects | Voltage-Gated Sodium Channels - metabolism | Ganglia, Spinal - metabolism | KCNQ Potassium Channels - genetics | Analgesics | Neurons | Osteoarthritis | Health aspects | Analysis
Journal Article