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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 349, Issue 3, pp. 458 - 469
.... To this end, we evaluated the STAT3-inhibitory activities of three compounds (CPA-7 [trichloronitritodiammineplatinum... 
MALIGNANT GLIOMA | MURINE MELANOMA | APOPTOSIS | MODELS | PATHWAY | STAT3 | GROWTH | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TUMOR MICROENVIRONMENT | T-CELLS | Small Molecule Libraries - pharmacology | Chlorine Compounds - therapeutic use | Apoptosis - drug effects | Humans | Melanoma, Experimental - drug therapy | Brain Neoplasms - pathology | Chlorine Compounds - pharmacokinetics | Pyridines - pharmacokinetics | Melanoma, Experimental - metabolism | Antineoplastic Agents - therapeutic use | Platinum Compounds - pharmacokinetics | Brain Neoplasms - metabolism | Glioma - metabolism | Platinum Compounds - therapeutic use | Tissue Distribution | Piperidines - pharmacology | Heterocyclic Compounds, 2-Ring - therapeutic use | Melanoma, Experimental - secondary | Glioma - pathology | HEK293 Cells | Piperidines - pharmacokinetics | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | STAT3 Transcription Factor - genetics | Pyridines - therapeutic use | Small Molecule Libraries - therapeutic use | Melanoma, Experimental - pathology | Tyrphostins - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Brain Neoplasms - drug therapy | Tyrphostins - therapeutic use | Blood-Brain Barrier - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Piperidines - therapeutic use | Chlorine Compounds - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | STAT3 Transcription Factor - antagonists & inhibitors | Small Molecule Libraries - pharmacokinetics | Platinum Compounds - pharmacology | Tyrphostins - pharmacokinetics | Glioma - drug therapy | Drug Screening Assays, Antitumor
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0156136
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 255, Issue 1, pp. 65 - 75
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e29828
... a nitrile moiety could be effective against the common T315I mutant. We also report that two distinct chemical compounds are currently being sold under the name "bosutinib", and report... 
CHRONIC MYELOGENOUS LEUKEMIA | CHRONIC PHASE | COMPLEX | C-ABL | ACTIVE-SITE | SRC | MULTIDISCIPLINARY SCIENCES | ELECTRIC-FIELDS | IMATINIB | MUTATION | CLINICAL RESISTANCE | Nitriles - pharmacology | Protein-Tyrosine Kinases - metabolism | Escherichia coli | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Piperazines - chemistry | Isomerism | Pyrimidines - chemistry | Quinolines - pharmacology | Protein Kinase Inhibitors - chemistry | Spectrophotometry, Infrared | X-Ray Diffraction | Protein-Tyrosine Kinases - chemistry | Binding Sites | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Dasatinib | Recombinant Proteins - antagonists & inhibitors | Aniline Compounds - pharmacology | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Pyrimidines - pharmacology | Static Electricity | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - antagonists & inhibitors | Nitriles - chemistry | Thiazoles - chemistry | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Aniline Compounds - chemistry | Benzamides | Mutation | Fusion Proteins, bcr-abl - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Phenols | Phosphotransferases | BCR protein | Phosphorylation | Peptides | Leukemia | Clinical trials | Fluorescence | Infrared absorption | Biochemistry | Kinases | Cancer therapies | Proteins | Sulfur | Fusion protein | Growth factors | Electric fields | Protein-tyrosine kinase | Crystal structure | Medical research | Enzymes | Imatinib | Chlorine | Myeloid leukemia | Abl protein | Chronic myeloid leukemia | Chemical compounds | Mutants | Gene amplification | Inhibitors | Resistant mutant | Binding sites
Journal Article
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, ISSN 1661-7827, 06/2019, Volume 16, Issue 11, p. 1895
.... We analysed the in vitro activity of five antimicrobial products (phenolic compounds, didecyldimethylammonium chloride (DDAC... 
Enterococcus faecalis | disinfection | EFFICACY | CARE-ASSOCIATED INFECTIONS | ANTIBIOTIC-RESISTANCE | MECHANISMS | BIOFILM | RESISTANT STAPHYLOCOCCUS-AUREUS | BIOCIDES | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TECHNOLOGIES | nosocomial bacteria | Pseudomonas aeruginosa | antimicrobial agent | HEALTH-CARE | ENVIRONMENTAL SURFACES | Klebsiella pneumoniae | Staphylococcus aureus | Hospitals | Cross Infection - prevention & control | Disinfectants - pharmacology | Bacteria - drug effects | Hydrogen Peroxide - pharmacology | Ammonium Compounds - pharmacology | Water Supply | Sodium Hypochlorite - pharmacology | 2-Propanol - pharmacology | Water Microbiology | Phenols - pharmacology | Health care | Nosocomial infection | Ammonium | Hydrogen peroxide | Sodium hypochlorite | Alcohol | Drug resistance | Immunosuppressive agents | Microorganisms | Illnesses | Disinfectants | Bacteria | Antibacterial activity | Air conditioners | Air conditioning | Statistical analysis | Quaternary | Antiseptics | Chlorine | Distilled water | Staphylococcus infections | Disinfection | Antimicrobial agents | Environmental factors | Health care facilities | Phenolic compounds | Disease control | Multidrug resistant organisms | Ammonium compounds | Dilution | Quaternary ammonium compounds | Sodium | Phenols | Air pollution | Quaternary ammonium salts | Disinfection & disinfectants
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 256, Issue 2, pp. 95 - 102
Both low-molecular-mass thiols (LMM-SH) and protein thiols (P-SH) can modulate the biological activity of S-nitrosothiols (RSNO) via S-transnitrosation... 
Albumin | Thiols | S-Nitrosothiols | Vasorelaxation | HOMOCYSTEINE | NITROSOALBUMIN | HUMAN PLASMA | CYSTEINE | SULFHYDRYL-GROUPS | BLOOD IN-VITRO | WHOLE-BLOOD | GLUTATHIONE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NITROSYLATION | Sulfhydryl Compounds - pharmacology | Humans | Middle Aged | Male | Sulfhydryl Compounds - blood | Sulfhydryl Compounds - physiology | Dose-Response Relationship, Drug | Young Adult | Aorta, Thoracic - physiology | Aged, 80 and over | Adult | Biological Assay | Female | Aorta, Thoracic - drug effects | Vasodilation - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | S-Nitrosothiols - pharmacology | Vasodilator Agents - pharmacology | Rats | Rats, Sprague-Dawley | Animals | Serum Albumin - pharmacology | Serum Albumin - physiology | Nitrosation - drug effects | Adolescent | Aged | Vasodilation - drug effects | Dilatation | Nitric oxide | Blood vessels | Nitrogen compounds | Sodium nitroferricyanide | Amino acids | Index Medicus | BODY FLUIDS | OXYGEN COMPOUNDS | DOMESTIC ANIMALS | NITRIC OXIDE | CATTLE | 60 APPLIED LIFE SCIENCES | BIOASSAY | ORGANIC HALOGEN COMPOUNDS | RUMINANTS | THIOLS | PLASMA | NITROGEN OXIDES | IN VITRO | AMINO ACIDS | DRUGS | ESTERS | ORGANIC SULFUR COMPOUNDS | VERTEBRATES | BLOOD CELLS | NITROGEN COMPOUNDS | RADIOPROTECTIVE SUBSTANCES | BLOOD | MAMMALS | ANIMALS | EXPLOSIVES | ORGANIC CHLORINE COMPOUNDS | RESPONSE MODIFYING FACTORS | BIOLOGICAL MATERIALS | ORGANIC COMPOUNDS | BLOOD CIRCULATION | ALBUMINS | ORGANIC ACIDS | POLYPEPTIDES | CHALCOGENIDES | PEPTIDES | HALOGENATED ALIPHATIC HYDROCARBONS | NITRIC ACID ESTERS | CHEMICAL EXPLOSIVES | NITROGLYCERIN | CHLORINATED ALIPHATIC HYDROCARBONS | CARBOXYLIC ACIDS | OXIDES | PROTEINS | MATERIALS | CONTROL
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 243, Issue 3, pp. 323 - 331
Mercury is a well-known highly toxic metal. In this study, we characterize and investigate the cytotoxicity and its possible mechanisms of inorganic mercury in... 
HgCl 2 | Pancreatic β-cell | ROS | Apoptosis | Necrosis | HgCl | ACTIVATION | HEPATOCYTES | RAT | TOXICITY | HgCl2 | MITOCHONDRIAL PERMEABILITY TRANSITION | IN-VITRO | Pancreatic beta-cell | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DYSFUNCTION | LYMPHOCYTES | CHLORIDE | L-Lactate Dehydrogenase - metabolism | Cell Line | Cricetinae | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Cell Separation | Antioxidants - pharmacology | Blotting, Western | DNA - genetics | Mitochondrial Membranes - drug effects | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Flow Cytometry | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Adenosine Triphosphate - metabolism | Acetylcysteine - pharmacology | Mercuric Chloride - toxicity | DNA - biosynthesis | Mice | Cell Death - drug effects | Oxidative Stress - drug effects | Index Medicus | HALIDES | APOPTOSIS | CHLORINE COMPOUNDS | DIGESTIVE SYSTEM | MITOCHONDRIA | PANCREAS | HETEROCYCLIC COMPOUNDS | PYRIDINES | 60 APPLIED LIFE SCIENCES | AZINES | ACRIDINE ORANGE | MERCURY HALIDES | ELEMENTS | MERCURY | NECROSIS | GLANDS | METALS | CHEMICAL REACTIONS | ENDOCRINE GLANDS | VERTEBRATES | MICE | AROMATICS | ORGANIC NITROGEN COMPOUNDS | ACRIDINES | MAMMALS | OXIDATION | ANIMALS | DYES | RODENTS | ANTIOXIDANTS | MERCURY COMPOUNDS | ORGANIC COMPOUNDS | MERCURY CHLORIDES | MEMBRANES | PEPTIDE HORMONES | INSULIN | ORGANS | DOSES | AMINES | CHLORIDES | HALOGEN COMPOUNDS | PROTEINS | BODY | PATHOLOGICAL CHANGES | AZAARENES | CELL CONSTITUENTS | HORMONES
Journal Article