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Journal of Clinical Investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 79 - 88
Despite great interest in cancer chemoprevention, effective agents are few. Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53... 
MEDICINE, RESEARCH & EXPERIMENTAL | BCL-X-L | SIGNALING PATHWAYS | INDUCED APOPTOSIS | PHOSPHORYLATION | ATM | AUTOPHAGY | CYTOCHROME-C RELEASE | MYC-INDUCED LYMPHOMAGENESIS | TRANSGENIC MICE | P53 | Apoptosis - drug effects | Humans | Apoptosis - genetics | Male | Autophagy - drug effects | Burkitt Lymphoma - pathology | Neoplasms, Experimental - pathology | Chloroquine - pharmacology | Cell Transformation, Neoplastic - genetics | Autophagy - genetics | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Embryo, Mammalian - pathology | Cell Cycle Proteins - metabolism | Neoplasms, Experimental - prevention & control | bcl-2-Associated X Protein - metabolism | Ataxia Telangiectasia Mutated Proteins | Fibroblasts - pathology | Ataxia Telangiectasia - pathology | Ataxia Telangiectasia - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms, Experimental - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Burkitt Lymphoma - prevention & control | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Neoplasms, Experimental - genetics | Burkitt Lymphoma - genetics | Cell Cycle Proteins - genetics | Female | Lysosomes - pathology | Antirheumatic Agents - pharmacology | bcl-2-Associated X Protein - genetics | Antirheumatic Agents - therapeutic use | Ataxia Telangiectasia - prevention & control | Caspases - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Burkitt Lymphoma - metabolism | Chloroquine - therapeutic use | Ataxia Telangiectasia - metabolism | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cell Transformation, Neoplastic - pathology | Prevention | Chloroquine | Lysosomes | Dosage and administration | Research | Drug therapy | Health aspects | Cancer
Journal Article
Cell Cycle, ISSN 1538-4101, 09/2010, Volume 9, Issue 17, pp. 3515 - 3533
Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts,... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Caveolin-1 | Oxidative stress | TIGAR | NFκB | BNIP3 | Tumor stroma | Cancer associated fibroblasts | Mitophagy | Autophagy | HIF1 | Hypoxia | LC3 | Predictive biomarker | hypoxia | autophagy | ONCOGENICALLY TRANSFORMED-CELLS | NITRIC-OXIDE SYNTHASE | DOWN-REGULATION | INDUCIBLE FACTOR INDUCTION | cancer associated fibroblasts | CELL BIOLOGY | BREAST-CANCER | caveolin-1 | mitophagy | predictive biomarker | tumor stroma | CAROTID-BODY | EXPRESSION | NF kappa B | oxidative stress | MITOCHONDRIAL COMPLEX-III | Up-Regulation | Oxidative Stress | Microtubule-Associated Proteins - metabolism | Coculture Techniques | Humans | Tumor Microenvironment | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Breast Neoplasms - metabolism | Cell Hypoxia | Chloroquine - pharmacology | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Glutathione Synthase - metabolism | Membrane Proteins - metabolism | Antirheumatic Agents - pharmacology | Glutathione Synthase - antagonists & inhibitors | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Paracrine Communication | Cell Survival | Stromal Cells - metabolism | Caveolin 1 - genetics | Mice, Knockout | Caveolin 1 - metabolism | Animals | Apoptosis Regulatory Proteins | Breast Neoplasms - pathology | Cell Line, Tumor | Mice | RNA, Small Interfering - metabolism | Report | cancer-associated fibroblasts
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12455 - 12468
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress. However, the functional... 
PROGRAMMED CELL-DEATH | INHIBITION | BECLIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIF-1 | MITOCHONDRIA | DEGRADATION | MEDIATED CLEAVAGE | MACROAUTOPHAGY | CHLOROQUINE | SPHINGOSINE KINASE | Death Domain Receptor Signaling Adaptor Proteins - physiology | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Protein Multimerization | Caspase 3 - metabolism | Caspase 8 - metabolism | Leukemia, Myeloid, Acute | Autophagy | Heat-Shock Proteins - genetics | Cell Membrane - metabolism | Tumor Cells, Cultured | Pyrazoles - pharmacology | Cell Survival - drug effects | Hydrazines - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Autophagy-Related Protein 5 | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Caspase-8 | Bortezomib | Cell Death | Caspase | Sphingolipid | SKI-I | p62 | Sequestosome 1 | Atg5 | Cell Biology
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2006, Volume 172, Issue 7, pp. 1057 - 1068
Toll-like receptors (TLRs) recognize molecular patterns preferentially expressed by pathogens. In endosomes, TLR9 is activated by unmethylated bacterial DNA,... 
Phosphorylation | Monocytes | Receptors | Cytokines | B lymphocytes | Secretion | Cell adhesion | Actins | Cellular immunity | Macrophages | SIGNAL-TRANSDUCTION | KINASE-ACTIVITY | CELLS | ACTIVATION | MACROPHAGES | TOLL-LIKE RECEPTORS | INTERLEUKIN-1 RECEPTOR | NF-KAPPA-B | DEPENDENT MANNER | BACTERIAL-DNA | CELL BIOLOGY | RNA, Small Interfering - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Toll-Like Receptor 9 - physiology | Antigens, CD - metabolism | Chloroquine - pharmacology | Actin Cytoskeleton - drug effects | Cell Membrane - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Syk Kinase | Cell Membrane - drug effects | NF-KappaB Inhibitor alpha | Actin Cytoskeleton - metabolism | Proto-Oncogene Proteins c-hck - metabolism | Pyrimidines - pharmacology | Cell Adhesion - drug effects | Mice, Knockout | Monocytes - drug effects | Macrophages - metabolism | Tyrosine - metabolism | Models, Biological | Cell Line, Tumor | CpG Islands | Cytoskeleton - metabolism | Mice | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | src-Family Kinases - genetics | Toll-Like Receptor 9 - genetics | Monocytes - metabolism | I-kappa B Proteins - metabolism | Quinacrine - pharmacology | src-Family Kinases - metabolism | Dendritic Cells - drug effects | Dendritic Cells - metabolism | Pyrazoles - pharmacology | Interferon-alpha - metabolism | src-Family Kinases - antagonists & inhibitors | Cytokines - secretion | Myeloid Differentiation Factor 88 | Animals | Androstadienes - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Macrophages - drug effects | Proto-Oncogene Proteins c-hck - genetics | Protein Kinase Inhibitors - pharmacology | Cytoskeleton - drug effects
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 737 - 750
Receptor-like tyrosine kinase (RYK) functions as a transmembrane receptor for the Wnt family of secreted protein ligands. Although RYK undergoes endocytosis in... 
INTERNALIZATION | PROTEIN | PATHWAY | WNT RECEPTOR RYK | TYROSINE KINASE | ELEGANS | AXON GUIDANCE | SPECIFICATION | BETA-CATENIN | BOMB | CELL BIOLOGY | Wnt Proteins - pharmacology | RNA, Small Interfering - genetics | Animal Structures - abnormalities | Gene Expression - genetics | Humans | Ubiquitin - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | rab5 GTP-Binding Proteins - metabolism | Chloroquine - pharmacology | Mutation - physiology | Cell Membrane - metabolism | Phosphorylation - drug effects | Ubiquitination - physiology | Wnt Signaling Pathway | Caenorhabditis elegans - genetics | Ubiquitin-Protein Ligases - metabolism | Ubiquitin - genetics | Caenorhabditis elegans - embryology | Receptor Protein-Tyrosine Kinases - metabolism | beta Catenin - metabolism | Leupeptins - pharmacology | Protein Interaction Mapping - methods | Amyloid Precursor Protein Secretases - metabolism | Cell Line, Tumor | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Caenorhabditis elegans Proteins - genetics | Intracellular Membranes - metabolism | Protein Binding - physiology | Phosphorylation - physiology | Protein Interaction Domains and Motifs - physiology | Protein Transport - physiology | DNA-Binding Proteins - metabolism | Wnt3A Protein - pharmacology | Lysosomes - metabolism | Transfection | HEK293 Cells | Female | Lysosomes - drug effects | Endosomal Sorting Complexes Required for Transport - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - physiology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Proteasome Inhibitors
Journal Article
Autophagy, ISSN 1554-8627, 01/2015, Volume 11, Issue 1, pp. 46 - 59
Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate... 
GOT1/AST, glutamic-oxaloacetic transaminase 1, soluble | IPGTTs, intraperitoneal glucose tolerance tests | MTOR, mechanistic target of rapamycin | autophagy | hepatoseatosis | metformin | NAFLD, nonalcoholic fatty liver disease | SIRT1 | CQ, chloroquine | SIRT1, sirtuin 1 | TG, triglyceride | OA, oleic acid | ORO, Oil Red O | GPT/ALT, glutamic-pyruvate transaminase (alanine aminotransferase) | siRNA, short interfering RNA | T-CHO, total cholesterol | PRKA, protein kinase, AMP-activated | 3MA, 3-methyladenine | Met, metformin | PRKA | CR, caloric restriction | Hepatoseatosis | Metformin | Autophagy | HEPATIC GLUCONEOGENESIS | LIPID-METABOLISM | INFLAMMATION | CALORIC RESTRICTION | MICE | CELL BIOLOGY | Sirtuin 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Liver - pathology | Caloric Restriction | Fatty Liver - pathology | Humans | Body Weight - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Autophagy - drug effects | Oleic Acid - pharmacology | Liver - drug effects | Phagosomes - ultrastructure | Hepatocytes - drug effects | Phagosomes - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Fatty Liver - metabolism | Fatty Liver - blood | Fatty Liver - physiopathology | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Phagosomes - metabolism | Down-Regulation - drug effects | Hep G2 Cells | Up-Regulation - drug effects | Animals | Signal Transduction - drug effects | Models, Biological | Lipid Metabolism - drug effects | Mice, Obese | Diabetes Mellitus, Type 2 - pathology | Blood Glucose - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2005, Volume 280, Issue 46, pp. 38133 - 38145
Studies involving Toll-like receptor 3 (TLR3)-deficient mice suggest that this receptor binds double-stranded RNA. In the present study, we analyzed... 
FC-RECEPTOR | ACTIVATION | HUMAN DENDRITIC CELLS | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CPG-DNA | APOPTOTIC CELLS | SUBCELLULAR-LOCALIZATION | ENDOPLASMIC-RETICULUM | NF-KAPPA-B | ESSENTIAL COMPONENTS | Leukocytes, Mononuclear - metabolism | Calcium - metabolism | Humans | NF-kappa B - metabolism | Endosomes - metabolism | Time Factors | U937 Cells | Base Sequence | Cell Membrane - metabolism | Cysteine - metabolism | Binding Sites | Dimerization | Tyrosine - chemistry | Amino Acid Sequence | Signal Transduction | Cell Separation | Enzyme Inhibitors - pharmacology | Glycosylation | DNA - metabolism | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 3 - metabolism | Blotting, Western | Chloroquine - chemistry | Ligands | Mutation | Hydrogen-Ion Concentration | Phagosomes - chemistry | Luciferases - metabolism | Lysosomes - chemistry | Cross-Linking Reagents - pharmacology | Receptors, IgG - chemistry | Molecular Sequence Data | Receptors, IgG - biosynthesis | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Flow Cytometry | Lysosomes - metabolism | Transfection | Genes, Dominant | Macrolides - pharmacology | Antigens, CD - chemistry | Antirheumatic Agents - pharmacology | Dendritic Cells - metabolism | Genes, Reporter | Protein Structure, Tertiary | Cell Line | Mutagenesis, Site-Directed | Cytokines - metabolism | Cysteine - chemistry | Leucine - chemistry | Sequence Homology, Amino Acid | Protein Binding | Toll-Like Receptor 3 - chemistry
Journal Article
Cell Death and Disease, ISSN 2041-4889, 08/2015, Volume 6, Issue 8, pp. e1860 - e1860
alpha-Solanine is a glycoalkaloid found in species of the nightshade family including potato. It was primarily reported to have toxic effects in humans.... 
TARGET | APOPTOSIS | COMPLEX | UNFOLDED PROTEIN RESPONSE | POTATO GLYCOALKALOIDS | PHOSPHORYLATION | MAMMALIAN AUTOPHAGY | MECHANISMS | CLEAVAGE | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | eIF-2 Kinase - metabolism | Humans | Gene Expression Regulation, Neoplastic | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | Proto-Oncogene Proteins c-akt - genetics | Reactive Oxygen Species - agonists | DNA-Binding Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Chloroquine - pharmacology | TOR Serine-Threonine Kinases - genetics | Macrolides - pharmacology | Microfilament Proteins - metabolism | Solanine - pharmacology | CCAAT-Enhancer-Binding Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | eIF-2 Kinase - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Activating Transcription Factor 4 - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Autophagy-Related Protein 8 Family | Activating Transcription Factor 6 - metabolism | Activating Transcription Factor 4 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Original
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