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1. Full Text Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
by The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group and ALLHAT Collaborative Res Grp and ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
JAMA, ISSN 0098-7484, 12/2002, Volume 288, Issue 23, pp. 2981 - 2997
CONTEXT Antihypertensive therapy is well established to reduce hypertension-related morbidity and mortality, but the optimal first-step therapy is unknown.... 
MORTALITY | GLOMERULAR-FILTRATION-RATE | MEDICINE, GENERAL & INTERNAL | THERAPY | DISEASE | FAILURE | CHLORTHALIDONE | BLOOD-PRESSURE | AFRICAN-AMERICAN | PROGRESSION | PARTICIPANTS | Diuretics - economics | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Lisinopril - economics | Hypertension - drug therapy | Male | Angiotensin-Converting Enzyme Inhibitors - economics | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Calcium Channel Blockers - economics | Antihypertensive Agents - economics | Chlorthalidone - therapeutic use | Double-Blind Method | Risk Factors | Chlorthalidone - economics | Proportional Hazards Models | Treatment Outcome | Antihypertensive Agents - therapeutic use | Amlodipine - therapeutic use | Diuretics - therapeutic use | Aged | Amlodipine - economics | Hypertension | Diuretics | Evaluation | Cookery for hypertensives | Drug therapy | Thiazides | Prevention | Enzymes | Neurotransmitters | Heart attacks | Clinical trials | Lipids | Health risk assessment | Patients | Clinical outcomes | Index Medicus | Abridged Index Medicus
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2. Full Text Azilsartan Medoxomil Plus Chlorthalidone Reduces Blood Pressure More Effectively Than Olmesartan Plus Hydrochlorothiazide in Stage 2 Systolic Hypertension
by Cushman, William C and Bakris, George L and White, William B and Weber, Michael A and Sica, Domenic and Roberts, Andrew and Lloyd, Eric and Kupfer, Stuart
Hypertension, ISSN 0194-911X, 08/2012, Volume 60, Issue 2, pp. 310 - 318
Azilsartan medoxomil, an effective, long-acting angiotensin II receptor blocker, is a new treatment for hypertension that is also being developed in fixed-dose... 
chlorthalidone | angiotensin receptor blocker | azilsartan medoxomil | antihypertensive therapy | thiazide-like diuretic | hypertension | AMLODIPINE | MEASURING DEVICES | THERAPY | PERIPHERAL VASCULAR DISEASE | AGENTS | INTERNATIONAL-PROTOCOL | VALSARTAN | Tetrazoles - pharmacology | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Hypertension - drug therapy | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Dose-Response Relationship, Drug | Hydrochlorothiazide - pharmacology | Oxadiazoles - pharmacology | Female | Blood Pressure - drug effects | Blood Pressure - physiology | Imidazoles - therapeutic use | Drug Therapy, Combination | Benzimidazoles - therapeutic use | Severity of Illness Index | Chlorthalidone - therapeutic use | Double-Blind Method | Diuretics - pharmacology | Hypertension - classification | European Continental Ancestry Group | Treatment Outcome | Imidazoles - pharmacology | Chlorthalidone - pharmacology | Oxadiazoles - therapeutic use | Hypertension - ethnology | Benzimidazoles - pharmacology | Diuretics - therapeutic use | Tetrazoles - therapeutic use | Aged | African Continental Ancestry Group | Hydrochlorothiazide - therapeutic use | Index Medicus
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3. Full Text Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and Lisinopril
by Wright, Jackson T and Dunn, J. Kay and Cutler, Jeffrey A and Davis, Barry R and Cushman, William C and Ford, Charles E and Haywood, L. Julian and Leenen, Frans H. H and Margolis, Karen L and Papademetriou, Vasilios and Probstfield, Jeffrey L and Whelton, Paul K and Habib, Gabriel B and ALLHAT Collaborative Research Group, for the and ALLHAT Collaborative Res Grp and ALLHAT Collaborative Research Group
JAMA, ISSN 0098-7484, 04/2005, Volume 293, Issue 13, pp. 1595 - 1608
CONTEXT Few cardiovascular outcome data are available for blacks with hypertension treated with angiotensin-converting enzyme (ACE) inhibitors or calcium... 
CALCIUM-CHANNEL BLOCKER | LIPID-LOWERING TREATMENT | MEDICINE, GENERAL & INTERNAL | CONVERTING-ENZYME-INHIBITOR | ISOLATED SYSTOLIC HYPERTENSION | LEFT-VENTRICULAR DYSFUNCTION | HEART-ATTACK TRIAL | MAJOR CARDIOVASCULAR EVENTS | RANDOMIZED-TRIAL | JOINT NATIONAL COMMITTEE | HIGH BLOOD-PRESSURE | Chlorthalidone - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Treatment Outcome | Antihypertensive Agents - therapeutic use | Amlodipine - therapeutic use | Randomized Controlled Trials as Topic | African Continental Ancestry Group - statistics & numerical data | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Hypertension - ethnology | Cardiovascular Diseases - epidemiology | Diuretics - therapeutic use | Aged | Calcium channel blockers | African Americans | Research | Cardiovascular diseases | Drug therapy | Health aspects | ACE inhibitors | Hypertension | Comparative studies | Cardiovascular disease | Medical treatment | Index Medicus | Abridged Index Medicus
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4. Full Text Antihypertensive Efficacy of Hydrochlorothiazide vs Chlorthalidone Combined with Azilsartan Medoxomil
by Bakris, George L., MD and Sica, Domenic, MD and White, William B., MD and Cushman, William C., MD and Weber, Michael A., MD and Handley, Alison, PhD and Song, Eric, PhD and Kupfer, Stuart, MD
American Journal of Medicine, The, ISSN 0002-9343, 2012, Volume 125, Issue 12, pp. 1229.e1 - 1229.e10
Abstract Background Chlorthalidone has proven efficacy to reduce cardiovascular morbidity and mortality, yet it is infrequently used in practice. This study... 
Internal Medicine | Hypertension | Chlorthalidone | Angiotensin receptor blocker | Azilsartan medoxomil | CONVERTING ENZYME-INHIBITOR | MANAGEMENT | GUIDELINES | PREVENTION | RISK | AMLODIPINE | MEDICINE, GENERAL & INTERNAL | THERAPY | OUTCOMES | BLOCKER | Chlorthalidone - therapeutic use | Double-Blind Method | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Hypertension - drug therapy | Male | Systole | Antihypertensive Agents - therapeutic use | Oxadiazoles - therapeutic use | Creatinine - blood | Female | Potassium - blood | Aged | Blood Pressure Monitoring, Ambulatory | Drug Therapy, Combination | Hydrochlorothiazide - therapeutic use | Drug Combinations | Benzimidazoles - therapeutic use | Dosage and administration | Research | Hydrochlorothiazide | Drug therapy, Combination | Drug therapy | Index Medicus | Abridged Index Medicus
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5. Full Text Trends in Antihypertensive Medication Use Among US Patients With Resistant Hypertension, 2008 to 2014
by Hwang, Andrew Y and Dave, Chintan and Smith, Steven M
Hypertension, ISSN 0194-911X, 12/2016, Volume 68, Issue 6, pp. 1349 - 1354
Little is known of US trends in antihypertensive drug use for patients with treatment-resistant hypertension (TRH). We analyzed antihypertensive use among... 
chlorthalidone | antihypertensive agents | hypertension | resistant hypertension | spironolactone | trends | UNITED-STATES | IDENTIFY | BLOOD-PRESSURE | HYDROCHLOROTHIAZIDE | TRIAL | HEART-DISEASE | PREDICTORS | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | Antihypertensive Agents - pharmacology | Follow-Up Studies | Drug Utilization - trends | United States | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Male | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Patient Safety | Adult | Female | Retrospective Studies | Drug Therapy, Combination | Hypertension - diagnosis | Spironolactone - therapeutic use | Drug Resistance | Severity of Illness Index | Chlorthalidone - therapeutic use | Risk Assessment | Treatment Outcome | Antihypertensive Agents - therapeutic use | Blood Pressure Determination - methods | Hydrochlorothiazide - therapeutic use | Cohort Studies | Index Medicus
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6. Full Text Role of diuretics in the prevention of heart failure: The antihypertensive and lipid-lowering treatment to prevent heart attack trial
by Davis, Barry R and Piller, Linda B and Cutler, Jeffrey A and Furberg, Curt and Dunn, Kay and Franklin, Stanley and Goff, David and Leenen, Frans and Mohiuddin, Syed and Papademetriou, Vasilios and Proschan, Michael and Ellsworth, Allan and Golden, John and Colon, Pedro and Crow, Richard and Antihyperten Lipid Lowering Treat and Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group
Circulation, ISSN 0009-7322, 05/2006, Volume 113, Issue 18, pp. 2201 - 2210
Background - Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to... 
Heart failure | Hypertension | Diuretics | GLOBAL BURDEN | heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVASCULAR EVENTS | SECONDARY END-POINTS | RISK | REGIMENS | CHLORTHALIDONE | BLOOD-PRESSURE | HYPERTENSIVE PATIENTS | CONVERTING-ENZYME-INHIBITOR | diuretics | PERIPHERAL VASCULAR DISEASE | OUTCOMES | hypertension | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Hospitalization - statistics & numerical data | Hypertension - drug therapy | Male | Risk | Incidence | Heart Failure - prevention & control | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Doxazosin - therapeutic use | Female | Drug Therapy, Combination | Heart Failure - epidemiology | Heart Failure - etiology | Adrenergic beta-Antagonists - therapeutic use | Heart Failure - mortality | Chlorthalidone - therapeutic use | Double-Blind Method | Proportional Hazards Models | Treatment Outcome | Antihypertensive Agents - therapeutic use | Amlodipine - therapeutic use | Atenolol - therapeutic use | Hypertension - complications | Diuretics - therapeutic use | Aged | Myocardial Infarction - prevention & control | Index Medicus | Abridged Index Medicus
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7. Full Text Description of Antihypertensive Use in Patients With Resistant Hypertension Prescribed Four or More Agents
by Hanselin, Michele R and Saseen, Joseph J and Allen, Richard R and Marrs, Joel C and Nair, Kavita V
Hypertension, ISSN 0194-911X, 12/2011, Volume 58, Issue 6, pp. 1008 - 1013
Data describing the use of recommended antihypertensive agents in the resistant hypertension population are limited. Treatment recommendations for resistant... 
Hypertension | Antihypertensive agents/classification/therapeutic use | Chlorthalidone | Combination | Hypertension/drug treatment | Drug therapy | Aldosterone antagonists | drug therapy | METAANALYSIS | MANAGEMENT | LOW-DOSE SPIRONOLACTONE | COMBINATION THERAPY | chlorthalidone | PREVENTION | PREVALENCE | hypertension/drug treatment | SCIENTIFIC STATEMENT | BLOOD-PRESSURE | HYDROCHLOROTHIAZIDE | antihypertensive agents/classification/therapeutic use | PERIPHERAL VASCULAR DISEASE | aldosterone antagonists | hypertension | combination | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Phytotherapy - utilization | Calcium Channel Blockers - therapeutic use | Antihypertensive Agents - administration & dosage | Hypertension - drug therapy | Male | Antihypertensive Agents - classification | Young Adult | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Adrenergic Antagonists - therapeutic use | Aged, 80 and over | Adult | Female | Retrospective Studies | Drug Therapy, Combination | Drug Utilization - statistics & numerical data | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Diuretics - administration & dosage | Adrenergic Antagonists - administration & dosage | Antihypertensive Agents - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Renin - antagonists & inhibitors | Adolescent | Calcium Channel Blockers - administration & dosage | Diuretics - therapeutic use | Aged | Index Medicus
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8. Labetalol plus chlorthalidone in a fixed combination (RG 136)
: a rational approach to antihypertensive therapy
by Zanchetti, Alberto and Condorelli, M and Mancia, Giuseppe and Condorelli, Mario
1984, ISBN 9780881670295, 78
Hypertension | Evaluation | Chemotherapy, Combination | Chemotherapy | Chlorthalidone | Labetalol | Testing
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9. Full Text Chlorthalidone Reduces Cardiovascular Events Compared With Hydrochlorothiazide: A Retrospective Cohort Analysis
by Dorsch, Michael P and Gillespie, Brenda W and Erickson, Steven R and Bleske, Barry E and Weder, Alan B
Hypertension, ISSN 0194-911X, 04/2011, Volume 57, Issue 4, pp. 689 - 694
There is significant controversy around whether chlorthalidone (CTD) is superior to hydrochlorothiazide (HCTZ) in hypertension management. The objective of... 
chlorthalidone | thiazide diuretic | antihypertensive agents | hypertension | hydrochlorothiazide | PERIPHERAL VASCULAR DISEASE | BLOOD-PRESSURE | Angina Pectoris - prevention & control | Cholesterol - blood | Humans | Middle Aged | Hypertension - drug therapy | Male | Angina Pectoris - etiology | Heart Failure - prevention & control | Hypertension - blood | Adult | Blood Pressure - drug effects | Retrospective Studies | Uric Acid - blood | Heart Failure - etiology | Myocardial Infarction - etiology | Hydrochlorothiazide - adverse effects | Chlorthalidone - therapeutic use | Stroke - prevention & control | Risk Factors | Chlorthalidone - adverse effects | Antihypertensive Agents - therapeutic use | Antihypertensive Agents - adverse effects | Regression Analysis | Stroke - etiology | Potassium - blood | Myocardial Infarction - prevention & control | Hydrochlorothiazide - therapeutic use | Index Medicus
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10. Full Text Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial
by Puttnam, Rachel and Davis, Barry R and Pressel, Sara L and Whelton, Paul K and Cushman, William C and Louis, Gail T and Margolis, Karen L and Oparil, Suzanne and Williamson, Jeffrey and Ghosh, Alokananda and Einhorn, Paula T and Barzilay, Joshua I and Antihypertensive Lipid-Lowering Tr and Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group and for the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group
JAMA Internal Medicine, ISSN 2168-6106, 01/2017, Volume 177, Issue 1, pp. 67 - 76
IMPORTANCE: On the basis of observational studies, the use of thiazide diuretics for the treatment of hypertension is associated with reduced fracture risk... 
BLOCKERS | LIPID-LOWERING TREATMENT | MEDICINE, GENERAL & INTERNAL | BONE-MINERAL DENSITY | THIAZIDE DIURETICS | HEART-ATTACK TRIAL | ALLHAT | COHORT | HEALTH | BLOOD-PRESSURE | OSTEOPOROSIS | Chlorthalidone - therapeutic use | United States - epidemiology | Follow-Up Studies | Risk Assessment | Humans | Risk Factors | Male | Hip Fractures - epidemiology | Antihypertensive Agents - therapeutic use | Amlodipine - therapeutic use | Pelvic Bones - injuries | Lisinopril - therapeutic use | Hip Fractures - prevention & control | Intention to Treat Analysis | Female | Aged | Index Medicus | Abridged Index Medicus
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11. Full Text Meta-Analysis of Dose-Response Relationships for Hydrochlorothiazide, Chlorthalidone, and Bendroflumethiazide on Blood Pressure, Serum Potassium, and Urate
by Peterzan, Mark A and Hardy, Rebecca and Chaturvedi, Nish and Hughes, Alun D
Hypertension, ISSN 0194-911X, 06/2012, Volume 59, Issue 6, pp. 1104 - 1109
Thiazide and thiazide-like diuretics are widely used in the management of hypertension, but recently the equivalence of hydrochlorothiazide and chlorthalidone... 
Hypertension | Diuretics | Meta-analysis | CLINICAL-TRIAL | EFFICACY | COMBINATION THERAPY | PLUS HYDROCHLOROTHIAZIDE | meta-analysis | MILD HYPERTENSION | JOINT NATIONAL COMMITTEE | FACTORIAL-DESIGN | diuretics | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | TO-MODERATE HYPERTENSION | hypertension | 7TH REPORT | Chlorthalidone - therapeutic use | Double-Blind Method | Humans | Antihypertensive Agents - administration & dosage | Bendroflumethiazide - administration & dosage | Hypertension - drug therapy | Treatment Outcome | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - therapeutic use | Bendroflumethiazide - therapeutic use | Randomized Controlled Trials as Topic | Dose-Response Relationship, Drug | Hypertension - blood | Chlorthalidone - administration & dosage | Potassium - blood | Blood Pressure - drug effects | Uric Acid - blood | Hydrochlorothiazide - therapeutic use | Index Medicus
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12. Full Text Blood pressure control and cardiovascular outcomes in normal-weight, overweight, and obese hypertensive patients treated with three different antihypertensives in ALLHAT
by Reisin, Efrain and Graves, John W and Yamal, José-Miguel and Barzilay, Joshua I and Pressel, Sara L and Einhorn, Paula T and Dart, Richard A and Retta, Tamrat M and Saklayen, Mohammad G and Davis, Barry R and ALLHAT Collaborative Res Grp and ALLHAT Collaborative Research Group
Journal of Hypertension, ISSN 0263-6352, 2014, Volume 32, Issue 7, pp. 1503 - 1513
Objective: Epidemiologically, there is a strong relationship between BMI and blood pressure (BP) levels. We prospectively examined randomization to first-step... 
Hypertension | Obesity | Blood pressure control | Overweight | SYSTOLIC HYPERTENSION | LIPID-LOWERING TREATMENT | METABOLIC SYNDROME | RISK | blood pressure control | CHLORTHALIDONE | HYDROCHLOROTHIAZIDE | TRIAL | AMLODIPINE | BODY-MASS | PERIPHERAL VASCULAR DISEASE | hypertension | overweight | obesity | CLINICAL-OUTCOMES | Overweight - complications | Prospective Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Calcium Channel Blockers - therapeutic use | Hypertension - drug therapy | Male | Lisinopril - therapeutic use | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aged, 80 and over | Female | Blood Pressure - drug effects | Body Mass Index | Chlorthalidone - therapeutic use | Overweight - pathology | Double-Blind Method | Obesity - complications | Obesity - physiopathology | Overweight - physiopathology | Antihypertensive Agents - therapeutic use | Hypertension - physiopathology | Amlodipine - therapeutic use | Obesity - pathology | Hypertension - complications | Diuretics - therapeutic use | Aged | Cohort Studies | Index Medicus
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13. Full Text Indapamide: is it the better diuretic for hypertension?
by Kaplan, Norman M and Kaplan, Norman M
Hypertension, ISSN 0194-911X, 05/2015, Volume 65, Issue 5, pp. 983 - 984
PERIPHERAL VASCULAR DISEASE | CHLORTHALIDONE | HYDROCHLOROTHIAZIDE | Chlorthalidone - therapeutic use | Humans | Indapamide - therapeutic use | Hypertension - drug therapy | Potassium - blood | Blood Pressure - drug effects | Hydrochlorothiazide - therapeutic use | Index Medicus
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14. Full Text Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial
by Moes, Arthur D., MD and Hesselink, Dennis A., MD, PhD and van den Meiracker, Anton H., MD, PhD and Zietse, Robert, MD, PhD and Hoorn, Ewout J., MD, PhD
American Journal of Kidney Diseases, ISSN 0272-6386, 2017, Volume 69, Issue 6, pp. 796 - 804
Background Chlorthalidone is a very effective antihypertensive drug, but it has not been studied prospectively in kidney transplant recipients with... 
Nephrology | clinical trial | blood pressure | kidney function | edema | proteinuria | kidney transplantation | chlorthalidone | thiazide diuretics | sodium-chloride cotransporter (NCC) | amlodipine | end-stage renal disease (ESRD) | Calcineurin inhibitors (CNIs) | hypertension | ambulatory blood pressure monitoring (ABPM) | Hypertension | Edema | End-stage renal disease (ESRD) | Kidney function | Ambulatory blood pressure monitoring (ABPM) | Chlorthalidone | Sodium-chloride cotransporter (NCC) | Thiazide diuretics | Amlodipine | Clinical trial | Blood pressure | Kidney transplantation | Proteinuria | BLOOD-PRESSURE | PATHOGENESIS | GLOMERULAR-FILTRATION-RATE | SODIUM RESTRICTION | CYCLOSPORINE-INDUCED HYPERTENSION | RETENTION | ARTERIAL-HYPERTENSION | UROLOGY & NEPHROLOGY | RENAL VASOCONSTRICTION | BLOCKADE | ASSOCIATION | Chlorthalidone - therapeutic use | Glomerular Filtration Rate | Kidney Failure, Chronic - surgery | Graft Rejection - prevention & control | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Hypertension - drug therapy | Male | Treatment Outcome | Kidney Transplantation | Antihypertensive Agents - therapeutic use | Amlodipine - therapeutic use | Cross-Over Studies | Tacrolimus - therapeutic use | Kidney Failure, Chronic - complications | Hypertension - complications | Female | Aged | Blood Pressure Monitoring, Ambulatory | Index Medicus
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