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Journal of Autoimmunity, ISSN 0896-8411, 2013, Volume 41, pp. 111 - 119
Abstract Dominant-negative TGF-β receptor II (dnTGF-βRII) mice spontaneously develop an autoimmune cholangitis resembling human primary biliary cirrhosis... 
Allergy and Immunology | Inflammatory bowel disease | Autoimmunity | Primary biliary cirrhosis | Cholangitis | microRNA | Colitis | miR-21 | MicroRNA | MiR-21 | RHEUMATOID-ARTHRITIS | DENDRITIC CELLS | SYNOVIAL TISSUE | IMMUNOLOGY | CD8 T-CELLS | PRIMARY BILIARY-CIRRHOSIS | GENE-EXPRESSION | AUTOIMMUNE CHOLANGITIS | NF-KAPPA-B | TRANSCRIPTION FACTOR | UP-REGULATION | Liver - pathology | Receptors, Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - immunology | Humans | Interleukin-17 - immunology | Cholangitis - immunology | Interferon-gamma - metabolism | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Liver - immunology | Flow Cytometry | Liver Cirrhosis, Biliary - immunology | Gene Expression - immunology | Inflammation Mediators - metabolism | CD8-Positive T-Lymphocytes - metabolism | Cholangitis - metabolism | Autoimmune Diseases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - immunology | Inflammation Mediators - immunology | Apoptosis Regulatory Proteins - immunology | Cholangitis - genetics | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | RNA-Binding Proteins - immunology | Autoimmune Diseases - immunology | CD4-Positive T-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Liver Cirrhosis, Biliary - genetics | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Interleukin-17 - metabolism | Animals | Receptors, Transforming Growth Factor beta - metabolism | Interferon-gamma - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | MicroRNAs - genetics | CD8-Positive T-Lymphocytes - immunology | Liver Cirrhosis, Biliary - metabolism | RNA-Binding Proteins - metabolism | colitis | autoimmunity | cholangitis | inflammatory bowel disease
Journal Article
Hepatology, ISSN 0270-9139, 06/2007, Volume 45, Issue 6, pp. 1538 - 1546
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e74225
Primary biliary cirrhosis (PBC) is considered a model autoimmune disease, with the most highly directed and specific autoantibody in both murine and human... 
II MICE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | C57BL/6 MICE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | T-CELL | INDUCTION | IL-23 | IL-12 | TH17 CELLS | Autoimmunity | Liver - pathology | Humans | Th1-Th2 Balance | Interleukin-17 - immunology | Cholangitis - immunology | Liver Cirrhosis, Biliary - chemically induced | Mitochondria - immunology | Autoantibodies - biosynthesis | Immunoconjugates - administration & dosage | Fatty Acids, Monounsaturated - immunology | Immunoconjugates - immunology | Interleukins - genetics | Signal Transduction - immunology | Liver - immunology | Liver Cirrhosis, Biliary - immunology | Interleukin-23 Subunit p19 - genetics | Interleukins - immunology | Fatty Acids, Monounsaturated - chemistry | Serum Albumin, Bovine - chemistry | Interleukin-12 Subunit p35 - deficiency | Interferon-gamma - genetics | Interferon-gamma - deficiency | Cholangitis - pathology | Disease Models, Animal | Interleukin-23 Subunit p19 - deficiency | Cholangitis - chemically induced | Cholangitis - genetics | Serum Albumin, Bovine - immunology | Liver - metabolism | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-12 Subunit p35 - genetics | Interleukin-17 - deficiency | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Biliary - genetics | Mice, Knockout | Animals | Interleukin-12 Subunit p35 - immunology | Interferon-gamma - immunology | Interleukins - deficiency | Mice | Interleukin-23 Subunit p19 - immunology | Autoantibodies | Cytokines | Analysis | Biliary cirrhosis | B cells | T cells | Health aspects | Primary biliary cirrhosis | Pathogenesis | Liver | Helper cells | Interleukin 22 | Interleukin 23 | Lymphocytes T | Arthritis | Structure-activity relationships | Signal transduction | Mitochondria | Immunology | Pathways | Clonal deletion | Lymphocytes | Rodents | Deletion | Immunization | Rheumatology | Cholangitis | Interleukin 12 | Inflammation | Medicine | Cirrhosis | Signaling | Tuberculosis | Hepatocytes | γ-Interferon | Interferon | Autoimmune diseases
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 05/2006, Volume 203, Issue 5, pp. 1209 - 1219
Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver... 
ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNIZATION | T-CELL RESPONSES | NOD MOUSE | GENETIC-CONTROL | LIVER | MITOCHONDRIAL AUTO-ANTIGEN | IMMUNOLOGY | IDENTIFICATION | DIHYDROLIPOAMIDE ACETYLTRANSFERASE | INFILTRATION | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Quantitative Trait Loci - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - immunology | Humans | Cholangitis - immunology | Mitochondrial Proteins - genetics | Adoptive Transfer | CD4-Positive T-Lymphocytes - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Liver Cirrhosis, Biliary - immunology | Dihydrolipoyllysine-Residue Acetyltransferase - genetics | Liver Cirrhosis, Experimental - pathology | Autoimmune Diseases - pathology | Cholangitis - pathology | Disease Models, Animal | Granuloma - genetics | Liver Cirrhosis, Experimental - immunology | Cholangitis - genetics | Autoimmune Diseases - immunology | Mice, Transgenic | Chromosome Mapping | Inflammation - immunology | Protein Structure, Tertiary - genetics | Liver Cirrhosis, Biliary - pathology | Liver Cirrhosis, Experimental - genetics | Liver Cirrhosis, Biliary - genetics | Mice, SCID | Granuloma - pathology | Autoantibodies - immunology | Animals | CD4-Positive T-Lymphocytes - transplantation | CD3 Complex - immunology | Inflammation - genetics | Granuloma - immunology | Mice, Inbred NOD | Mice | Mice, Congenic | CD8-Positive T-Lymphocytes - immunology | Mitochondrial Proteins - immunology | Quantitative Trait Loci - genetics
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 02/2014, Volume 175, Issue 2, pp. 192 - 201
Journal Article
Immunological Reviews, ISSN 0105-2896, 2000, Volume 174, Issue 1, pp. 210 - 225
Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly affects women and is characterized by chronic progressive... 
INTERCELLULAR-ADHESION MOLECULE-1 | CHRONIC ACTIVE HEPATITIS | MITOCHONDRIAL AUTO-ANTIGENS | BILE-DUCT EPITHELIUM | HLA-DR ANTIGENS | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | DIHYDROLIPOAMIDE ACETYLTRANSFERASE | PYRUVATE-DEHYDROGENASE COMPLEX | CLASS-II | PRIMARY SCLEROSING CHOLANGITIS | Immunodominant Epitopes - immunology | Age Distribution | Humans | Middle Aged | Scleroderma, Systemic - pathology | Molecular Sequence Data | Male | HLA-D Antigens - immunology | Cytokines - physiology | Liver Cirrhosis, Biliary - epidemiology | Molecular Mimicry | Liver Cirrhosis, Biliary - immunology | Pyruvate Dehydrogenase Complex - immunology | Liver Cirrhosis, Biliary - etiology | Female | Bacterial Proteins - immunology | Autoimmune Diseases - epidemiology | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Genetic Predisposition to Disease | HLA-D Antigens - genetics | Maternal-Fetal Exchange | Peptides - immunology | Autoimmune Diseases - immunology | Acyltransferases - immunology | Epithelial Cells - pathology | Scleroderma, Systemic - immunology | Dihydrolipoyllysine-Residue Acetyltransferase | Amino Acid Motifs | Cross Reactions | Pregnancy | Sequence Homology, Amino Acid | Autoantibodies - immunology | Sequence Alignment | Animals | Autoantigens - immunology | Epithelial Cells - immunology | Immunoglobulin A - immunology | Dogs | Sex Distribution | Escherichia coli Infections - immunology | Bile Ducts - immunology | Bile Ducts - pathology | Escherichia coli Infections - complications | Mitochondria, Liver - immunology
Journal Article