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Cell, ISSN 0092-8674, 12/2015, Volume 163, Issue 6, pp. 1413 - 1427
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2013, Volume 23, Issue 6, pp. 826 - 838
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 2014, Volume 10, Issue 6, pp. e1004343 - e1004343
Specialized endocrine cells produce and release steroid hormones that govern development, metabolism and reproduction. In order to synthesize steroids, all the... 
MOLTING HORMONE | ECDYSONE BIOSYNTHESIS | BODY-SIZE | CELL-MIGRATION | MIDLINE GLIA | GENETICS & HEREDITY | ECDYSTEROID BIOSYNTHESIS | FACTOR DRIFTER | DEVELOPMENTAL EXPRESSION | CYTOCHROME-P450 ENZYME | P450 ENZYMES | Drosophila melanogaster - embryology | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila Proteins - biosynthesis | Insect Hormones - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | POU Domain Factors - genetics | RNA Interference | Gene Expression Regulation, Developmental | Insect Hormones - metabolism | Ecdysone - biosynthesis | Transcription, Genetic | Biological Transport - genetics | Ecdysone - metabolism | POU Domain Factors - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | Binding Sites | Repressor Proteins - metabolism | DNA-Binding Proteins | POU Domain Factors - metabolism | Gene Expression Regulation | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Cholesterol - metabolism | Ecdysone - genetics | Membrane Proteins - biosynthesis | Animals | Repressor Proteins - biosynthesis | RNA, Small Interfering | Drosophila Proteins - genetics | Drosophila | Physiological aspects | Genetic aspects | Ecdysone | Research | Genetic transcription | Steroid hormones | Index Medicus | Enzymes | Cell growth | Transcription factors | Insects | Microscopy | Technological change | Biosynthesis | Hormones | Gene expression | Experiments | Cholesterol
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2010, Volume 107, Issue 17, pp. 7927 - 7932
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 25, pp. 10139 - 10143
In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR),... 
Molecules | Enzymes | Oxygen | Active sites | Molecular interactions | Electron transfer | Cytochromes | Biochemistry | Cholesterols | Electrons | Hydroxysteroids | Fusion protein | Inner mitochondrial membrane | Ferredoxin-hemeprotein electron transfer | SITE | SIDE-CHAIN CLEAVAGE | CYTOCHROME P450SCC CYP11A1 | inner mitochondrial membrane | CHOLESTEROL | MECHANISM | MULTIDISCIPLINARY SCIENCES | ferredoxin-hemeprotein electron transfer | LYSINE RESIDUES | fusion protein | REDUCTASE-ADRENODOXIN COMPLEX | hydroxysteroids | F-G LOOP | BINDING | STEROIDOGENIC ELECTRON-TRANSPORT | Mitochondria - enzymology | Catalytic Domain | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Oxidation-Reduction | Cholesterol Side-Chain Cleavage Enzyme - chemistry | Humans | Adrenodoxin - metabolism | Models, Molecular | Mixed Function Oxygenases - metabolism | Cholesterol - metabolism | Static Electricity | Animals | Cattle | Protein Binding | Adrenodoxin - chemistry | Protein Conformation | Pregnenolone - biosynthesis | Proteins | Mitochondria | Research | Properties | Structure | Steroid hormones | Eukaryotes | Biosynthesis | Cholesterol | Index Medicus | Cytochrome | Conservation | cholesterol | Iron | Catalysis | steroid hormones | CATALYSIS | STEROID HORMONES | ELECTRON TRANSFER | HYDROXYPREGNENONE | PRECURSOR | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | MEMBRANES | CRYSTAL STRUCTURE | IRON | CLEAVAGE | CYTOCHROMES | HEME | BIOSYNTHESIS | ENZYMES | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | ELECTROSTATICS | REACTION INTERMEDIATES | GEOMETRY | OXIDOREDUCTASES | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5868, pp. 1391 - 1394
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The... 
Carotenoids | Virulence | Pigments | Squalene | Ligands | Reports | Biosynthesis | Infections | Diphosphates | Cholesterols | Staphylococcus aureus | TARGET | SQUALENE SYNTHASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | Organothiophosphorus Compounds - therapeutic use | Virulence - drug effects | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Organothiophosphorus Compounds - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Staphylococcal Infections - microbiology | Organothiophosphorus Compounds - chemical synthesis | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Cell Line | Staphylococcal Infections - drug therapy | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Organothiophosphorus Compounds - metabolism | Protein Structure, Secondary | Farnesyl-Diphosphate Farnesyltransferase - isolation & purification | Enzyme Inhibitors - pharmacology | Polyisoprenyl Phosphates - metabolism | Staphylococcus aureus - pathogenicity | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Anti-Bacterial Agents - chemical synthesis | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Xanthophylls - biosynthesis | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cholesterol - biosynthesis | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial Proteins - isolation & purification | Prevention | Physiological aspects | Staphylococcus aureus infections | Anticholesteremic agents | Enzymes | Inhibitor drugs | Rodents | Bacteria | Biochemistry | Drug resistance | Cholesterol | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e45829 - e45829
Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological... 
CELLS | ACYL-COA SYNTHETASE-4 | CHOLESTEROL TRANSPORT | MULTIDISCIPLINARY SCIENCES | LH/CHORIONIC GONADOTROPIN | PROTEIN-TYROSINE PHOSPHATASES | REGULATORY PROTEIN | ARACHIDONIC-ACID | RAT ADRENAL-GLAND | STAR PROTEIN | STIMULATED STEROIDOGENESIS | Mitochondrial Dynamics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Chorionic Gonadotropin - physiology | Epidermal Growth Factor - physiology | Humans | Endoplasmic Reticulum - metabolism | Male | Mitochondrial Proteins - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Chorionic Gonadotropin - pharmacology | Gene Knockdown Techniques | Cyclic AMP - physiology | Isoquinolines - pharmacology | RNA Interference | Leydig Cells - metabolism | Mitochondrial Proteins - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Membrane Potential, Mitochondrial | Proton Ionophores - pharmacology | Progesterone - biosynthesis | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | GTP Phosphohydrolases - physiology | Gene Expression Regulation | Mitochondrial Proteins - physiology | Mitochondria - metabolism | Mitochondria - drug effects | Sulfonamides - pharmacology | Protein Transport | Cyclic AMP - pharmacology | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Mice | Epidermal Growth Factor - pharmacology | Kinetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Mitochondria - physiology | Organelle Shape | Protein kinase A | Adrenal glands | Extracellular signal-regulated kinase | Exploration | Stimulation | Biosynthesis | Mitochondrial DNA | Hormones | Kinases | Organelles | Biological activity | Mitochondria | Rodents | Steroidogenesis | Fusion protein | Localization | Endoplasmic reticulum | Index Medicus
Journal Article
Journal Article
Journal Article