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The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 810 - 821
We found serum lipid profiles changed in women with PCOS. Obesity and compensatory hyperinsulinemia promoted the metabolism of arachidonic acid and other PUFAs, whereas androgen had an inhibitory effect. Abstract Context... 
POLYCYSTIC-OVARY-SYNDROME | IONIZATION-MASS-SPECTROMETRY | RISK-FACTORS | TESTOSTERONE | BIOLOGICAL SAMPLES | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | NONALCOHOLIC STEATOHEPATITIS | FAT-CELL LIPOLYSIS | OLDER CHINESE | OBESE WOMEN | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Linoleic Acid - metabolism | Humans | Dehydroepiandrosterone Sulfate - metabolism | Case-Control Studies | Young Adult | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Diet, High-Fat | Mass Spectrometry | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Fatty Acids - metabolism | Phosphatidylglycerols - metabolism | Disease Models, Animal | Hyperinsulinism - metabolism | Ceramides - metabolism | Hyperinsulinism - complications | Polycystic Ovary Syndrome - metabolism | Cholesterol, HDL - metabolism | Obesity - complications | Eicosapentaenoic Acid - metabolism | Rats | Sex Hormone-Binding Globulin - metabolism | Lipid Metabolism | Fatty Acids, Unsaturated - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Triglycerides - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Animals | Cholesterol, LDL - metabolism | Phosphatidic Acids - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Docosahexaenoic Acids - metabolism | Polycystic ovary syndrome | Obesity | Hyperinsulinemia | Lecithin | Polyunsaturated fatty acids | Lipids | Mass spectroscopy | Liquid chromatography | Phospholipids | Metabolism | Arachidonic acid | Insulin | Fatty acids | Patients | Chromatography | Biological activity | Subgroups | Gas chromatography | Androgens | Molecular modelling | Metabolites | Lipid metabolism | Mass spectrometry | Metabolic disorders
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 4, pp. 1662 - 1676
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 1522-1555, 2015, Volume 309, Issue 8, pp. E736 - E746
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 535, Issue 7611, pp. 303 - 307
Cellular mechanisms that mediate steatohepatitis, an increasingly prevalent condition in the Western world for which no therapies are available, are poorly... 
Fatty Liver/genetics | Cholesterol, HDL/metabolism | Atherosclerosis/genetics | Male | Lipoproteins, HDL/deficiency | Ubiquitination | Proteolysis | Diet, High-Fat | Liver X Receptors | Female | Protein Stability | Cholesterol, Dietary/metabolism | Lipogenesis/genetics | Orphan Nuclear Receptors/genetics | Receptors, LDL/deficiency | Gene Expression Regulation | Lipoproteins, LDL/metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 5 | ATP-Binding Cassette Transporters/metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 8 | Sterol Regulatory Element Binding Protein 1/metabolism | Lipoproteins/metabolism | Phosphatidylcholines/biosynthesis | Animals | Hepatocytes/metabolism | Fatty Acids, Unsaturated/metabolism | Ligands | ATP Binding Cassette Transporter 1/metabolism | Mice | Bile Acids and Salts/metabolism | FATTY LIVER-DISEASE | REVERSE CHOLESTEROL TRANSPORT | ER STRESS | MULTIDISCIPLINARY SCIENCES | ELEMENT-BINDING PROTEIN-1C | IN-VIVO | ALPHA | X-RECEPTOR | MICE | OXIDATION-PRODUCTS | INTESTINAL EPITHELIAL-CELLS | Lipoproteins, HDL - genetics | Atherosclerosis - genetics | Cholesterol, Dietary - metabolism | Phosphatidylcholines - biosynthesis | Lipoproteins, HDL - metabolism | Fatty Liver - therapy | Hepatocytes - metabolism | Orphan Nuclear Receptors - metabolism | Phosphatidylcholines - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Atherosclerosis - therapy | Lipogenesis - genetics | Lipoproteins - metabolism | Receptors, LDL - deficiency | ATP-Binding Cassette Transporters - metabolism | Lipoproteins, HDL - deficiency | Lipoproteins, LDL - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Cholesterol, HDL - metabolism | Fatty Liver - prevention & control | Bile Acids and Salts - metabolism | Fatty Acids, Unsaturated - metabolism | Orphan Nuclear Receptors - genetics | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Atherosclerosis - prevention & control | ATP Binding Cassette Transporter, Sub-Family G, Member 5 | Proteolipids | Transcription factors | Lipoproteins | Liver diseases | Atherosclerosis | Genetic aspects | Blood lipoproteins | Properties | Ubiquitin-proteasome system | Health aspects | Risk factors | Proteins | Diet | Liver | Gene expression | Cholesterol
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol
Journal Article
Nature cell biology, ISSN 1476-4679, 2014, Volume 16, Issue 4, pp. 357 - 366
.... However, how their biological properties intersect with cellular metabolism remains unexplained... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
Journal Article
Cell metabolism, ISSN 1550-4131, 2013, Volume 17, Issue 5, pp. 695 - 708
Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,... 
DIABETES-MELLITUS | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | LEUKOCYTE COUNT | RECEPTOR | STEM-CELL PROLIFERATION | APOE(-/-) MICE | DEFICIENT MICE | G-CSF | CELL BIOLOGY | Leukocytes - pathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Leukocytosis - metabolism | Coronary Disease - metabolism | Bone Marrow - metabolism | Hyperglycemia - pathology | Monocytes - pathology | Diabetes Mellitus, Experimental - metabolism | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Leukocytosis - pathology | Neutrophils - pathology | Myeloid Progenitor Cells - metabolism | Atherosclerosis - pathology | Myelopoiesis - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Myeloid Progenitor Cells - pathology | Atherosclerosis - metabolism | Hyperglycemia - metabolism | Coronary Disease - pathology | Animals | Bone Marrow - pathology | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Mice | Leukocytes - metabolism | Receptors, Immunologic - metabolism | Hyperglycemia | Type 1 diabetes | Atherosclerosis | Development and progression | Universities and colleges | Blood lipids | Coronary heart disease | Medicine, Preventive | Cholesterol | Preventive health services
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
The journal of clinical endocrinology and metabolism, ISSN 1945-7197, 2017, Volume 102, Issue 5, pp. 1642 - 1651
Context: Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has... 
SUPPLEMENTATION | OBESE MEN | ALKALINE-PHOSPHATASE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | SECRETION | HEALTH | CORONARY-ARTERY-DISEASE | CHALLENGES | Blood Pressure | Body Composition | Stilbenes - therapeutic use | Humans | Leptin - metabolism | Middle Aged | Male | Metabolic Syndrome - metabolism | Muscle, Skeletal - metabolism | Adipose Tissue - immunology | Metabolic Syndrome - drug therapy | Fructosamine - metabolism | Adipose Tissue - metabolism | Muscle, Skeletal - immunology | Liver - diagnostic imaging | Quadriceps Muscle - immunology | Metabolic Syndrome - immunology | Real-Time Polymerase Chain Reaction | Double-Blind Method | Magnetic Resonance Spectroscopy | Cholesterol, HDL - metabolism | Liver - metabolism | Insulin Resistance | Cholesterol - metabolism | Intra-Abdominal Fat - metabolism | Absorptiometry, Photon | Blotting, Western | Triglycerides - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Intra-Abdominal Fat - diagnostic imaging | Magnetic Resonance Imaging | Antioxidants - therapeutic use | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Interleukin-6 - immunology | Cholesterol, LDL - metabolism | Blood Glucose - metabolism | Quadriceps Muscle - metabolism | C-Reactive Protein - immunology | C-reactive protein | Pressure effects | Liver | Interleukin | Homeostasis | Clinical trials | Lipids | Standard error | Glucose | Metabolic syndrome | Composition effects | Blood | Body composition | Interleukin 6 | Body mass index | Urokinase | Glucose metabolism | Randomization | Body composition (biology) | Resveratrol | Blood pressure | Lipid metabolism | Supplementation | Deposition | Middle age | Dietary supplements | Muscles | Inflammation | Gene expression | Metabolism | Low density lipoprotein | Cholesterol | Skeletal muscle | U-Plasminogen activator | Body mass | Biopsy | Body size | Men | Plasma levels | Metabolic disorders
Journal Article