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Journal Article
Journal of General Physiology, ISSN 0022-1295, 01/2011, Volume 137, Issue 1, pp. 111 - 132
We describe rapid massive endocytosis (MEND) of >50% of the plasmalemma in baby hamster kidney (BHK) and HEK293 cells in response to large Ca transients.... 
INDEPENDENT ENDOCYTOSIS | MEMBRANE DOMAINS | PHYSIOLOGY | CARDIAC NA+-CA2+ EXCHANGE | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | SYNAPTIC VESICLE ENDOCYTOSIS | ADRENAL CHROMAFFIN CELLS | REGULATED EXOCYTOSIS | MEDIATED ENDOCYTOSIS | DEPENDENT BULK ENDOCYTOSIS | LIVING CELLS | Dynamins - metabolism | Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology | Calcium - metabolism | Humans | Lipids - physiology | Inositol Polyphosphate 5-Phosphatases | Cell Membrane - physiology | Exocytosis - physiology | Pyrones - pharmacology | beta-Cyclodextrins - pharmacology | Exocytosis - drug effects | Adenosine Triphosphate - pharmacology | Quaternary Ammonium Compounds - analysis | Kidney - metabolism | Actin Cytoskeleton - drug effects | Sodium-Calcium Exchanger - metabolism | Adenosine Triphosphate - metabolism | Estrenes - pharmacology | Phosphoric Monoester Hydrolases - pharmacology | Pyrrolidinones - pharmacology | Sodium-Calcium Exchanger - pharmacology | HEK293 Cells | Cell Membrane - metabolism | Membrane Proteins - metabolism | Pyridinium Compounds - analysis | Cricetinae | Calcium - pharmacology | Kidney - drug effects | Endocytosis - drug effects | Sphingomyelin Phosphodiesterase - pharmacology | Cells, Cultured | Ceramides - pharmacology | Clathrin - metabolism | Endocytosis - physiology | Naphthalenes - pharmacology | Polyamines - pharmacology | Animals | Electric Capacitance | Cholesterol - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Calcineurin - metabolism | Physiological aspects | Endocytosis | Calcium, Dietary | Research | Proteins | Calcium | Cytoskeleton | Physiology | Gene expression | Polyamines | Cytoplasm | Adenosine triphosphatase | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 228 - 236
Proprotein convertase substilisin/kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein (LDL) receptor (LDLR) and thereby increases serum... 
LDL CHOLESTEROL | FAMILIAL HYPERCHOLESTEROLEMIA | PLASMA-CHOLESTEROL | GENE | IN-VIVO | RECEPTOR | DEGRADATION | PHARMACOLOGY & PHARMACY | MICE | SUBTILISIN/KEXIN TYPE-9 | SECRETED PCSK9 | Cholesterol, Dietary - administration & dosage | Cholesterol - blood | Macaca fascicularis | Male | Simvastatin - pharmacology | Epitopes - immunology | Fluorobenzenes - pharmacology | Liver - drug effects | Cholesterol, Dietary - pharmacology | Dietary Fats - administration & dosage | Serine Endopeptidases - immunology | Liver - metabolism | Models, Molecular | Receptors, LDL - metabolism | Rosuvastatin Calcium | Cholesterol, LDL - drug effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Mice, Knockout | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cell Line, Tumor | Cholesterol, HDL - blood | Mice | Proprotein Convertase 9 | Proprotein Convertases - antagonists & inhibitors | Simvastatin - therapeutic use | Serine Endopeptidases - pharmacology | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Dietary Fats - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Primates | Proprotein Convertases - pharmacology | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - adverse effects | Hypercholesterolemia - blood | Antibodies, Monoclonal, Humanized - therapeutic use | Cholesterol, HDL - drug effects | Mice, Inbred C57BL | Proprotein Convertases - immunology | Drug Therapy, Combination - methods | Animals | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Serine Endopeptidases - blood | Hypercholesterolemia - chemically induced | Antibodies, Monoclonal, Humanized - immunology | Catalytic Domain - immunology | Fluorobenzenes - therapeutic use | Index Medicus
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 02/2008, Volume 35, Issue 2, pp. 192 - 200
SUMMARY • The present study evaluated the effect of diabetes, hypercholesterolaemia and their combination on the contribution of nitric oxide (NO) and... 
endothelium-derived hyperpolarising factor | diabetes | endothelium-dependent relaxation | hypercholesterolaemia | superoxide anion | endothelium‐derived hyperpolarising factor | endothelium‐dependent relaxation | Superoxide anion | Diabetes | Hypercholesterolaemia | Endothelium-dependent relaxation | Endothelium-derived hyperpolarising factor | PHYSIOLOGY | ACETYLCHOLINE | NITRIC-OXIDE SYNTHASE | MESENTERIC-ARTERY | MELLITUS | SODIUM-NITROPRUSSIDE | NAD(P)H OXIDASE | DISEASE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | DYSFUNCTION | Body Weight | Oxidative Stress | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Superoxides - metabolism | Aorta, Thoracic - drug effects | Biological Factors - metabolism | Diabetes Mellitus, Experimental - metabolism | Potassium Channel Blockers - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Diabetes Mellitus, Type 1 - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - enzymology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Hypercholesterolemia - physiopathology | Nitric Oxide Synthase - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Charybdotoxin, pharmacology | Diabetes Mellitus, Type 1, physiopathology | Nitric Oxide Synthase, antagonists and inhibitors | Aorta, Thoracic, physiopathology | Potassium Channels, Calcium-Activated, antagonists and inhibitors | Hypercholesterolemia, metabolism | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | Aorta, Thoracic, drug effects | Aorta, Thoracic, metabolism | Receptors, Cytoplasmic and Nuclear, antagonists and inhibitors | Vasodilator Agents, pharmacology | Vasodilation | Nitric Oxide Synthase, metabolism | Cyclooxygenase Inhibitors, pharmacology | Apamin, pharmacology | Nitroarginine, pharmacology | Potassium Channel Blockers, pharmacology | Vasodilation, drug effects | Cholesterol, blood | Receptors, Cytoplasmic and Nuclear, metabolism | Biological Factors, metabolism | Diabetes Mellitus, Experimental, physiopathology | Nitric Oxide, metabolism | Acetylcholine, pharmacology | Diabetes Mellitus, Experimental, metabolism | Nitroprusside, pharmacology | Oxadiazoles, pharmacology | Blood Glucose, metabolism | Potassium Channels, Calcium-Activated, metabolism | Aorta, Thoracic, enzymology | Hypercholesterolemia, physiopathology | Diabetes Mellitus, Type 1, metabolism | Guanylate Cyclase, antagonists and inhibitors | Guanylate Cyclase, metabolism | Superoxides, metabolism | Indomethacin, pharmacology | Superoxide | Hypercholesterolemia | Endothelium-derived relaxing factors | Type 1 diabetes | Endothelium | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2004, Volume 24, Issue 8, pp. 1454 - 1459
OBJECTIVE—Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of... 
HepG2 | QPCR | Primary hepatocytes | Cholesterol | SRE | CELLS | ELEMENT-BINDING PROTEIN-2 | primary hepatocytes | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LOW-DENSITY-LIPOPROTEIN | NUCLEAR RECEPTOR LXR | TARGET GENES | PATHWAY | LIVER | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Consensus Sequence | Lovastatin - pharmacology | Species Specificity | Humans | Regulatory Sequences, Nucleic Acid | Homeostasis | Lovastatin - analogs & derivatives | Hepatocytes - metabolism | Simvastatin - pharmacology | Promoter Regions, Genetic - genetics | Quinolines - pharmacology | RNA, Messenger - biosynthesis | Cell Line - drug effects | Base Sequence | Liver X Receptors | Serine Endopeptidases - genetics | Orphan Nuclear Receptors | Proprotein Convertases | Sp1 Transcription Factor - physiology | Hepatocytes - drug effects | Heptanoic Acids - pharmacology | Tretinoin - pharmacology | Mevalonic Acid - pharmacology | Cell Line - metabolism | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Serine Endopeptidases - biosynthesis | Receptors, Cytoplasmic and Nuclear - drug effects | Rats | Hydroxymethylglutaryl CoA Reductases - physiology | Reverse Transcriptase Polymerase Chain Reaction | Hydroxycholesterols - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Mevalonic Acid - analogs & derivatives | Atorvastatin Calcium | Pyrroles - pharmacology | Sequence Alignment | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Cholesterol - pharmacology | Mice | Pyridines - pharmacology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 2 | Proprotein Convertase 9 | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 24, pp. 8127 - 8137
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2010, Volume 184, Issue 3, pp. 376 - 387
Steatosis is the first step in the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms involved in its pathogenesis are not fully... 
Cultured human hepatocytes | HepG2 | NAFLD | Fatty acids | Nuclear receptor ligands | Steatosis | RAT-LIVER | LIPID-METABOLISM | PROLIFERATOR-ACTIVATED RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETINOIC ACID RECEPTORS | PREGNANE-X-RECEPTOR | PPAR GAMMA 1 | NONALCOHOLIC FATTY LIVER | CONSTITUTIVE ANDROSTANE RECEPTOR | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | DRUG-METABOLISM | Vitamin A - pharmacology | Farnesol - pharmacology | Humans | Hepatocytes - metabolism | PPAR gamma - metabolism | Terpenes - pharmacology | Phloroglucinol - pharmacology | Indoles - pharmacology | Hepatocytes - drug effects | Cholesterol - analogs & derivatives | Fatty Liver - metabolism | Bridged Bicyclo Compounds - pharmacology | Androstenols - pharmacology | Cells, Cultured | Receptors, Cytoplasmic and Nuclear - genetics | Calcifediol - pharmacology | Fatty Liver - drug therapy | Hep G2 Cells | Pregnenediones - pharmacology | PPAR gamma - agonists | Tamoxifen - pharmacology | Cholesterol - pharmacology | Ligands | Phloroglucinol - analogs & derivatives | Selective Estrogen Receptor Modulators - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Phosphates | Cell research | Corticosteroids | Liver diseases | Estrogen | Albumin | Triglycerides | Hepatoma | Retinoids | Tamoxifen | Messenger RNA | Synthesis | Choline | Physiological aspects | Progesterone | Rifampin | Protein binding | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 9982 - 9987
Arginine contains the guanidinium group and thus has structural similarity to ligands of imidazoline and α-2 adrenoceptors (α-2 AR). Therefore, we investigated... 
Cell culture techniques | Signal transduction | Receptors | Imidazolines | Fluorescence | Agonists | Ligands | Toxins | Endothelial cells | Whooping cough | Calcium | Agmatine | Rauwolscine | rauwolscine | calcium | DEPENDENT VASODILATION | VASCULAR RELAXATION | MULTIDISCIPLINARY SCIENCES | agmatine | RELAXING FACTOR | PORCINE CORONARY-ARTERIES | RELEASE | SYNTHASE | SMOOTH-MUSCLE | CHOLESTEROL-FED RABBITS | S-NITROSOTHIOLS | Endothelium, Vascular - cytology | Aniline Compounds | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Culture Media, Serum-Free | Adrenergic alpha-Antagonists - pharmacology | Calcium - analysis | Agmatine - pharmacology | Virulence Factors, Bordetella - pharmacology | Type C Phospholipases - antagonists & inhibitors | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Idazoxan - pharmacology | Arginine - antagonists & inhibitors | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Agmatine - chemistry | Dexmedetomidine - pharmacology | Molecular Structure | Cell Culture Techniques | Nitric Oxide Synthase Type III - metabolism | Umbilical Veins - cytology | Nitrates - analysis | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Nifedipine - pharmacology | Idazoxan - chemistry | Endothelial Cells - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Imidazolines - pharmacology | Calcium Channel Blockers - pharmacology | Enzyme Activation - drug effects | Arginine - chemistry | Xanthenes | Endothelial Cells - cytology | Arginine - pharmacology | Lipopolysaccharides - pharmacology | Second Messenger Systems - physiology | Nitrites - analysis | Endothelial Cells - enzymology | Fluorescent Dyes | Amino acids | Biochemistry | Chemical synthesis | Nitric oxide | Cells | Veins & arteries | Index Medicus | Biological Sciences
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2005, Volume 517, Issue 3, pp. 224 - 231
Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and negation of nitric oxide (NO) bioactivity in cavernosal tissue.... 
Erectile dysfunction | Superoxide | NADPH oxidase | Cholesterol | RISK-FACTORS | ENDOTHELIUM-DEPENDENT RELAXATION | ATHEROSCLEROSIS | PULMONARY-ARTERY | erectile dysfunction | SMOOTH-MUSCLE | IN-VITRO | CORPUS CAVERNOSUM | CYCLIC-GMP | cholesterol | PHARMACOLOGY & PHARMACY | superoxide | CGMP PHOSPHODIESTERASE INHIBITOR | Uncoupling Agents - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Nitroprusside - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Sildenafil Citrate | Penis - drug effects | Purines | Oxadiazoles - pharmacology | Acetophenones - pharmacology | Rotenone - pharmacology | Superoxides - metabolism | Nitric Oxide Donors - pharmacology | Sulfones | Xanthine Oxidase - antagonists & inhibitors | NG-Nitroarginine Methyl Ester - pharmacology | Rabbits | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Penis - physiopathology | Phosphodiesterase Inhibitors - pharmacology | Onium Compounds - pharmacology | Piperazines - pharmacology | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Penis - metabolism | Allopurinol - pharmacology | Hypercholesterolemia - physiopathology | Muscle Relaxation - drug effects | In Vitro Techniques | Oxidases | Hypercholesterolemia | Impotence | Analysis | Nitric oxide | Sodium nitroferricyanide | Sildenafil | Guanylate cyclase | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2016, Volume 305, pp. 55 - 65
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2010, Volume 112, Issue 3, pp. 784 - 796
P>The mechanisms of ethanol actions that produce its behavioral sequelae involve the synthesis of potent GABAergic neuroactive steroids, specifically the... 
ACTH | GABA | Brain | Neuroactive steroid | Ethanol | Adrenal | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSTEROIDS | KINASE-C | brain | BENZODIAZEPINE-RECEPTOR | ethanol | MITOCHONDRIAL CHOLESTEROL IMPORT | NEUROSCIENCES | ACUTE REGULATORY PROTEIN | adrenal | ALCOHOL | ISOLATION-INDUCED INCREASE | NEUROACTIVE STEROID 3-ALPHA-HYDROXY-5-ALPHA-PREGNAN-20-ONE | neuroactive steroid | AXIS | Immunoprecipitation | Male | Pregnanolone - metabolism | Phosphoproteins - metabolism | Pregnenolone - metabolism | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Isoquinolines - pharmacology | Steroids - metabolism | Statistics, Nonparametric | Immunoglobulin G - pharmacology | Pregnenolone - pharmacology | Hypophysectomy - methods | Melphalan - pharmacology | Protein Synthesis Inhibitors - pharmacology | Adrenal Glands - drug effects | Adrenocorticotropic Hormone - blood | Rats | Imidazoles - pharmacology | Phosphoproteins - genetics | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Brain - drug effects | Gene Expression Regulation - drug effects | Ethanol - pharmacology | GABA Agents - pharmacology | Animals | Pregnanolone - pharmacology | Glucocorticoids - pharmacology | Pyridines - pharmacology | Radioimmunoassay - methods | Medical colleges | Alcohol, Denatured | Metabolites | Alcoholism | Alcohol | Progesterone | Peptide hormones | Blood proteins | Endocrine system | Rodents | Steroids | Index Medicus
Journal Article