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Human Molecular Genetics, ISSN 0964-6906, 2015, Volume 24, Issue 21, pp. 5965 - 5976
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/1999, Volume 96, Issue 13, pp. 7238 - 7243
The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily... 
Brain | Enzymes | Messenger RNA | Complementary DNA | Sterols | RNA | Neurons | Genes | Mice | Cholesterols | INHIBITION | CIRCULATION | ACID BIOSYNTHETIC ENZYME | MULTIDISCIPLINARY SCIENCES | LIVER | 24S-HYDROXYCHOLESTEROL | OXYSTEROL | ELIMINATION | RAT-BRAIN | EXPRESSION | STEROL 27-HYDROXYLASE | Homeostasis | Circular DNA | Research | Hydroxylases | Cholesterol
Journal Article
Neuroscience Letters, ISSN 0304-3940, 08/2002, Volume 328, Issue 1, pp. 9 - 12
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 31, pp. 12934 - 12946
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we... 
BRAIN CHOLESTEROL | TURNOVER | cholesterol metabolism | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | D-ASPARTATE RECEPTORS | enzyme catalysis | cytochrome P450 | central nervous system (CNS) | MASS-SPECTROMETRY | HEPATIC-MICROSOMAL CYTOCHROME | cholesterol | 24-HYDROXYLASE | TRANSCRIPTIONAL REGULATION | EXPRESSION | glutamate | DRUG-INTERACTION | Anti-HIV Agents - pharmacology | gamma-Aminobutyric Acid - metabolism | Benzoxazines - metabolism | Acetylcholine - metabolism | Cholesterol 24-Hydroxylase - genetics | Recombinant Fusion Proteins - metabolism | Deuterium Exchange Measurement | Nerve Tissue Proteins - chemistry | Biocatalysis - drug effects | Anti-HIV Agents - metabolism | Cholesterol 24-Hydroxylase - metabolism | Binding Sites | Peptide Fragments - genetics | Benzoxazines - chemistry | Cholesterol 24-Hydroxylase - chemistry | Allosteric Regulation - drug effects | Acetylcholine - chemistry | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Nerve Tissue Proteins - agonists | gamma-Aminobutyric Acid - chemistry | Models, Molecular | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Anti-HIV Agents - chemistry | Peptide Fragments - chemistry | Benzoxazines - pharmacology | Aspartic Acid - metabolism | Ligands | Protein Conformation | Glutamic Acid - metabolism | Molecular Docking Simulation | Aspartic Acid - chemistry | Mutation | Amino Acid Substitution | Glutamic Acid - chemistry | Enzymology
Journal Article
British Journal of Biomedical Science, ISSN 0967-4845, 01/2017, Volume 74, Issue 1, pp. 30 - 35
Background: The involvement of genetic factors like gene polymorphisms has been found to contribute significantly to the development and progression of type 2... 
type 2 diabetes mellitus | gene polymorphism | MDR1 | CYP46A1 | POPULATION | TRANSPORTER | RISK | CHINESE | CYP3A4 | ACUTE-LEUKEMIA | C3435T | MDR1 GENE | MEDICAL LABORATORY TECHNOLOGY | ASSOCIATION | MULTIDRUG-RESISTANCE GENE
Journal Article