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2012, ISBN 0470874325, xii, 289
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the... 
Ion channels | Metabolism | Cholesterol | Membrane proteins | Life Sciences | Science | Biology | Molecular Biology
Book
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 309, Issue 8, pp. E736 - E746
Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked... 
Branched-chain amino acids | Cardiometabolic risk factors | Visceral obesity | HOMEOSTASIS | PHYSIOLOGY | TRYPTOPHAN-METABOLISM | WEIGHT-LOSS | visceral obesity | PATTERNS | branched-chain amino acids | cardiometabolic risk factors | AMINO-ACID-METABOLISM | METABOLOMICS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | FAT | HUMAN OBESITY | EXPRESSION | Metabolomics | Amino Acids, Branched-Chain - metabolism | Humans | Middle Aged | Gene Expression Profiling | RNA, Messenger - metabolism | Thinness - metabolism | Tryptophan - metabolism | Adipose Tissue - metabolism | Amino Acids - metabolism | Overweight - metabolism | Subcutaneous Fat - metabolism | Adult | Female | Body Fat Distribution | Kynurenine - metabolism | Cardiovascular Diseases - metabolism | Cholesterol, HDL - metabolism | Risk Factors | Insulin Resistance | Cell Size | Adipokines - metabolism | Intra-Abdominal Fat - metabolism | Adipocytes - pathology | Blotting, Western | Obesity - metabolism | Triglycerides - metabolism | Cholesterol, LDL - metabolism | Dyslipidemias - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - genetics | Blood Glucose - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - metabolism | Adipose tissues | Metabolic diseases | Amino acids | Metabolites | Health aspects | Risk factors | Enzymes | Tissue | Obesity | Gene expression | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2013, Volume 17, Issue 5, pp. 695 - 708
Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,... 
DIABETES-MELLITUS | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | LEUKOCYTE COUNT | RECEPTOR | STEM-CELL PROLIFERATION | APOE(-/-) MICE | DEFICIENT MICE | G-CSF | CELL BIOLOGY | Leukocytes - pathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Leukocytosis - metabolism | Coronary Disease - metabolism | Bone Marrow - metabolism | Hyperglycemia - pathology | Monocytes - pathology | Diabetes Mellitus, Experimental - metabolism | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Leukocytosis - pathology | Neutrophils - pathology | Myeloid Progenitor Cells - metabolism | Atherosclerosis - pathology | Myelopoiesis - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Myeloid Progenitor Cells - pathology | Atherosclerosis - metabolism | Hyperglycemia - metabolism | Coronary Disease - pathology | Animals | Bone Marrow - pathology | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Mice | Leukocytes - metabolism | Receptors, Immunologic - metabolism | Hyperglycemia | Type 1 diabetes | Atherosclerosis | Development and progression | Universities and colleges | Blood lipids | Coronary heart disease | Medicine, Preventive | Cholesterol | Preventive health services | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 4, pp. 1006 - 1011
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose... 
Messenger RNA | Diabetes complications | Glycogen | Liver | Adenoviruses | Mice | Liver glycogen | Insulin | Cholesterols | Blood plasma | GW4064 | triglyceride | glucose | TRIGLYCERIDE LEVELS | MYOCARDIAL-INFARCTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | farnesoid x receptor-VP16 | INSULIN-RESISTANCE | GENE-EXPRESSION | cholesterol | FARNESOID-X-RECEPTOR | BILE-ACID BIOSYNTHESIS | LIPID HOMEOSTASIS | CARBOHYDRATE-METABOLISM | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear | DNA-Binding Proteins - metabolism | Lipids - chemistry | Glycogen - metabolism | Time Factors | Adenoviridae - genetics | Diabetes Mellitus, Experimental - metabolism | Gluconeogenesis | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Hyperlipidemias - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Etoposide - metabolism | Mice, Transgenic | Models, Statistical | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Triglycerides - metabolism | Hyperglycemia - metabolism | Isoxazoles - pharmacology | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Animals | 3-Hydroxybutyric Acid - metabolism | Glucose - metabolism | Blood Glucose - metabolism | Glucose metabolism | Control | Genes | Rattus | Homeostasis | Rats | Physiological aspects | Research | Structure | Lipids | Diabetes | Glucose | Metabolism | Rodents | Cholesterol | Index Medicus | Biological Sciences | farnesoid X receptor-VP16
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1662 - 1676
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 848 - 860
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 05/2017, Volume 102, Issue 5, pp. 1642 - 1651
Context: Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has... 
SUPPLEMENTATION | OBESE MEN | ALKALINE-PHOSPHATASE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | SECRETION | HEALTH | CORONARY-ARTERY-DISEASE | CHALLENGES | Blood Pressure | Body Composition | Stilbenes - therapeutic use | Humans | Leptin - metabolism | Middle Aged | Male | Metabolic Syndrome - metabolism | Muscle, Skeletal - metabolism | Adipose Tissue - immunology | Metabolic Syndrome - drug therapy | Fructosamine - metabolism | Adipose Tissue - metabolism | Muscle, Skeletal - immunology | Liver - diagnostic imaging | Quadriceps Muscle - immunology | Metabolic Syndrome - immunology | Real-Time Polymerase Chain Reaction | Double-Blind Method | Magnetic Resonance Spectroscopy | Cholesterol, HDL - metabolism | Liver - metabolism | Insulin Resistance | Cholesterol - metabolism | Intra-Abdominal Fat - metabolism | Absorptiometry, Photon | Blotting, Western | Triglycerides - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Intra-Abdominal Fat - diagnostic imaging | Magnetic Resonance Imaging | Antioxidants - therapeutic use | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Interleukin-6 - immunology | Cholesterol, LDL - metabolism | Blood Glucose - metabolism | Quadriceps Muscle - metabolism | C-Reactive Protein - immunology | C-reactive protein | Pressure effects | Liver | Interleukin | Medical services | Homeostasis | Clinical trials | Lipids | Standard error | Glucose | Metabolic syndrome | Composition effects | Blood | Body composition | Interleukin 6 | Body mass index | Urokinase | Glucose metabolism | Randomization | Body composition (biology) | Resveratrol | Blood pressure | Bioindicators | Lipid metabolism | Supplementation | Deposition | Middle age | Dietary supplements | Muscles | Inflammation | Gene expression | Metabolism | Low density lipoprotein | Cholesterol | Skeletal muscle | U-Plasminogen activator | Body mass | Biopsy | Body size | Men | Plasma levels | Metabolic disorders | Index Medicus | Abridged Index Medicus
Journal Article
Molecular systems biology, ISSN 1744-4292, 2017, Volume 13, Issue 3, pp. 916 - n/a
To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis... 
serine | NAFLD | personalized genome‐scale metabolic modeling | glutathione | personalized genome-scale metabolic modeling | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | DRUG TARGETS | CANCER | AMINO-ACID-METABOLISM | HEPATOCELLULAR-CARCINOMA | INSULIN-RESISTANCE | ADIPOSE-TISSUE | GENOME-SCALE | REVEALS | Glycine - blood | Liver - enzymology | Non-alcoholic Fatty Liver Disease - genetics | Glutathione - metabolism | Serine - blood | Humans | Liver - metabolism | Middle Aged | Male | Non-alcoholic Fatty Liver Disease - metabolism | Patient-Specific Modeling | Metabolomics - methods | Gene Expression Regulation, Enzymologic | Serine - administration & dosage | Animals | Lipoproteins - metabolism | Female | Mice | Non-alcoholic Fatty Liver Disease - diet therapy | Genome | NAD - metabolism | Serine - therapeutic use | Disease Models, Animal | Genomes | Metabolites | Metabolism | Liver | Rodents | Serine | Lipids | Biosynthesis | Glycine | Body mass index | Fatty liver | Precursors | Supplementation | Glutathione | Level (quantity) | Liver diseases | Fasting | Demand analysis | Dietary supplements | Triglycerides | Fluxes | Apolipoproteins | Gene expression | Cholesterol | Steatosis | NAD | Molecular modelling | Insulin resistance | Plasma levels | Laboratory animals | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article