Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2118) 2118
Publication (160) 160
Book Review (23) 23
Book / eBook (19) 19
Book Chapter (7) 7
Newsletter (5) 5
Conference Proceeding (4) 4
Government Document (4) 4
Magazine Article (2) 2
Newspaper Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
cholinesterase inhibitors - pharmacology (1092) 1092
index medicus (1072) 1072
animals (1017) 1017
cholinesterase inhibitors - chemical synthesis (981) 981
humans (934) 934
cholinesterase inhibitors - chemistry (895) 895
chemistry, medicinal (831) 831
acetylcholinesterase - metabolism (777) 777
acetylcholinesterase (758) 758
structure-activity relationship (740) 740
alzheimers-disease (551) 551
alzheimer's disease (546) 546
biochemistry & molecular biology (482) 482
molecular structure (471) 471
chemistry, organic (393) 393
alzheimer disease - drug therapy (382) 382
butyrylcholinesterase - metabolism (361) 361
rats (352) 352
butyrylcholinesterase (345) 345
acetylcholinesterase - chemistry (339) 339
dose-response relationship, drug (336) 336
models, molecular (325) 325
drug design (317) 317
acetylcholinesterase inhibitors (295) 295
derivatives (289) 289
male (278) 278
cholinesterase inhibitors (274) 274
mice (273) 273
pharmacology & pharmacy (270) 270
kinetics (268) 268
cholinesterase (265) 265
molecular docking simulation (242) 242
analysis (228) 228
binding sites (225) 225
design (221) 221
chemistry, multidisciplinary (208) 208
toxicology (203) 203
butyrylcholinesterase - chemistry (186) 186
inhibitors (179) 179
cholinesterase-inhibitors (173) 173
binding (172) 172
enzymes (170) 170
biological evaluation (167) 167
enzyme inhibitors (165) 165
alzheimer’s disease (161) 161
inhibition (161) 161
cholinesterases (158) 158
oxidative stress (158) 158
cholinesterase inhibitors - therapeutic use (150) 150
cholinesterase inhibitors - toxicity (145) 145
ligands (138) 138
chemistry (136) 136
inhibitory concentration 50 (135) 135
drug therapy (128) 128
molecular docking (122) 122
tacrine (118) 118
female (117) 117
electrophorus (116) 116
organic chemistry (115) 115
toxicity (115) 115
antioxidants (113) 113
antioxidants - pharmacology (111) 111
research (111) 111
docking (110) 110
in vitro techniques (108) 108
brain (106) 106
tacrine - chemistry (105) 105
antioxidant (104) 104
amyloid beta-peptides - metabolism (103) 103
in-vitro (102) 102
drugs (100) 100
stereoisomerism (100) 100
brain - drug effects (99) 99
cholinesterase inhibitors - metabolism (99) 99
horses (98) 98
magnetic resonance spectroscopy (97) 97
alzheimer disease - metabolism (95) 95
brain - enzymology (95) 95
protein binding (95) 95
beta-amyloid aggregation (94) 94
cholinesterases - metabolism (94) 94
neurodegenerative diseases (94) 94
acetylcholinesterase - drug effects (93) 93
antioxidants - chemistry (92) 92
tacrine - pharmacology (92) 92
catalytic domain (91) 91
cell line, tumor (91) 91
alzheimer disease - enzymology (90) 90
antioxidants - chemical synthesis (90) 90
cell survival - drug effects (87) 87
hybrids (87) 87
neuroprotective agents - pharmacology (87) 87
donepezil (85) 85
alkaloids (84) 84
acetylcholine (82) 82
article (81) 81
rats, wistar (81) 81
synthesis (81) 81
tacrine - analogs & derivatives (81) 81
amyloid beta-peptides - antagonists & inhibitors (80) 80
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2090) 2090
German (37) 37
Chinese (25) 25
Russian (12) 12
Japanese (8) 8
French (6) 6
Italian (3) 3
Czech (1) 1
Polish (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives
by Taslimi, Parham and Caglayan, Cuneyt and Farzaliyev, Vagif and Nabiyev, Oruj and Sujayev, Afsun and Turkan, Fikret and Kaya, Ruya and Gulçin, İlhami
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 04/2018, Volume 32, Issue 4, pp. e22042 - n/a
During this investigation, N , N ′‐bis‐azidomethylamines, N , N ′‐bis‐cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to... 
carbonic anhydrase | bis‐cyanomethylamine | acetylcholinesterase | butyrylcholinesterase | enzyme inhibition | N,N′-bis-cyanomethylamine | PROFILES | ISOENZYMES I | (3,4-DIHYDROXYPHENYL)(2,3,4-TRIHYDROXYPHENYL)METHANONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | N,N '-bis-cyanomethylamine | GLUCOSIDASE INHIBITORS | II INHIBITION | ERYTHROCYTES IN-VITRO | ANTIOXIDANT | HCA I | TOXICOLOGY | BROMOPHENOLS | ESTERASE | Glycoside Hydrolase Inhibitors - chemical synthesis | Animals | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Glycoside Hydrolase Inhibitors - chemistry | Laboratory tests | Enzymes | Inhibitors | Carbonic anhydrase | Isoenzymes | Diabetes mellitus | Isoforms | Acetylcholine receptors | Pharmacology | Carbonic anhydrase I | Derivatives | Acetylcholinesterase | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties
by Fernández-Bachiller, María Isabel and Pérez, Concepción and Monjas, Leticia and Rademann, Jörg and Rodríguez-Franco, María Isabel
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 3, pp. 1303 - 1317
By using fragments endowed with interesting and complementary properties for the treatment of Alzheimer's disease (AD), a new family of... 
CAPACITY | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | TACRINE-MELATONIN HYBRIDS | A-BETA | DRUG CANDIDATES | ACETYLCHOLINESTERASE INHIBITORS | TARGETING ACETYLCHOLINESTERASE | DIRECTED LIGANDS | CHOLINESTERASE INHIBITION | BRAIN | Free Radical Scavengers - pharmacology | Antioxidants - chemistry | Free Radical Scavengers - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Benzopyrans - chemistry | Benzopyrans - chemical synthesis | Tacrine - pharmacology | Butyrylcholinesterase - chemistry | Cattle | Amyloid beta-Peptides - metabolism | Free Radical Scavengers - chemical synthesis | Benzopyrans - pharmacology | Chromones - pharmacology | Tacrine - analogs & derivatives | Tacrine - chemistry | Catalytic Domain | Aspartic Acid Endopeptidases - antagonists & inhibitors | Alzheimer Disease - drug therapy | Membranes, Artificial | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Permeability | Blood-Brain Barrier - metabolism | Chromones - chemistry | Tacrine - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Chromones - chemical synthesis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease
by Bolea, Irene and Juárez-Jiménez, Jordi and De Los Ríos, Cristóbal and Chioua, Mourad and Pouplana, Ramón and Luque, F. Javier and Unzeta, Mercedes and Marco-Contelles, José and Samadi, Abdelouahid
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8251 - 8270
A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase... 
MONOAMINE-OXIDASE | RAT-LIVER | TARGET-DIRECTED LIGANDS | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | BETA-AMYLOID PEPTIDE | DUAL INHIBITORS | DERIVATIVES | BINDING | TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE | Humans | Cholinesterase Inhibitors - chemistry | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Isoenzymes - chemistry | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Butyrylcholinesterase - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Binding Sites | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Rats | Electrophorus | Acetylcholinesterase - chemistry | Piperidines - chemical synthesis | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Horses | Indans - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Amyloid beta-Peptides - chemistry | Kinetics | Indoles - chemistry | Acetylcholinesterase - metabolism | Indans - pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
by Viayna, Elisabet and Sola, Irene and Bartolini, Manuela and De Simone, Angela and Tapia-Rojas, Cheril and Serrano, Felipe G and Sabaté, Raimon and Juárez-Jiménez, Jordi and Pérez, Belén and Luque, F. Javier and Andrisano, Vincenza and Clos, M. Victòria and Inestrosa, Nibaldo C and Muñoz-Torrero, Diego
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 6, pp. 2549 - 2567
We have synthesized a family of rhein huprine hybrids to hit several key targets for Alzheimer's disease. Biological screening performed in vitro and in... 
BETA-AMYLOID AGGREGATION | TARGET-DIRECTED LIGANDS | CHEMISTRY, MEDICINAL | TACRINE-HUPERZINE | MULTIFUNCTIONAL CHOLINESTERASE | IN-VIVO | A-BETA | LONG-TERM POTENTIATION | BLOOD-BRAIN-BARRIER | TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE | NEURODEGENERATIVE DISEASES | Stereoisomerism | Humans | Cholinesterase Inhibitors - chemical synthesis | Hippocampus - drug effects | Enzyme Inhibitors - chemical synthesis | Anthraquinones - chemical synthesis | Synapses - metabolism | Long-Term Potentiation - drug effects | Escherichia coli - metabolism | Binding Sites | tau Proteins - antagonists & inhibitors | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Models, Molecular | Mice, Transgenic | Blood-Brain Barrier - drug effects | Hippocampus - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Anthraquinones - pharmacology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Kinetics | Amyloid beta-Protein Precursor - antagonists & inhibitors | In Vitro Techniques
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease
by Xie, Sai-Sai and Wang, Xiao-Bing and Li, Jiang-Yan and Yang, Lei and Kong, Ling-Yi
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2013, Volume 64, pp. 540 - 553
A series of tacrine–coumarin hybrids ( – ) were designed, synthesized and evaluated as multifunctional cholinesterase (ChE) inhibitors against Alzheimer's... 
Alzheimer's disease | Coumarin | Metal chelator | β-amyloid aggregation | Tacrine | Cholinesterase | beta-amyloid aggregation | MONOAMINE-OXIDASE | TARGET | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | POTENT | ANTIOXIDANT | HYPOTHESIS | BIOLOGICAL EVALUATION | ACETYLCHOLINESTERASE INHIBITORS | AMYLOID-BETA-AGGREGATION | DERIVATIVES | Butyrylcholinesterase - blood | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Coumarins - chemistry | Electrophorus | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Alzheimer Disease - enzymology | Coumarins - pharmacology | Dose-Response Relationship, Drug | Tacrine - pharmacology | Animals | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Drug Design | Molecular Structure | Cholinesterases - metabolism | Tacrine - chemistry | Analysis | Enzyme inhibitors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors
by Hamulakova, Slavka and Janovec, Ladislav and Hrabinova, Martina and Spilovska, Katarina and Korabecny, Jan and Kristian, Pavol and Kuca, Kamil and Imrich, Jan
Journal of Medicinal Chemistry, ISSN 0022-2623, 2014, Volume 57, Issue 16, pp. 7073 - 7084
A series of novel tacrine derivatives and tacrine coumarin heterodimers were designed, synthesized, and biologically evaluated for their potential inhibitory... 
TARGET | BUTYRYLCHOLINESTERASE | DESIGN | POTENT | CHEMISTRY, MEDICINAL | THERAPY | MULTIFUNCTIONAL AGENTS | ANTIOXIDANT | SITE ACETYLCHOLINESTERASE INHIBITORS | CONGENERS | ALZHEIMERS-DISEASE TREATMENT | Drug Evaluation, Preclinical - methods | Chemistry Techniques, Synthetic | Humans | Cholinesterase Inhibitors - chemistry | Coumarins - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Acetylcholinesterase - chemistry | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Inhibitory Concentration 50 | Molecular Docking Simulation | Acetylcholinesterase - metabolism | Tacrine - chemistry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimers Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography
by Zha, Xiaoming and Lamba, Doriano and Zhang, Lili and Lou, Yinghan and Xu, Changxu and Kang, Di and Chen, Li and Xu, Yungen and Zhang, Luyong and De Simone, Angela and Samez, Sarah and Pesaresi, Alessandro and Stojan, Jure and Lopez, Manuela G and Egea, Javier and Andrisano, Vincenza and Bartolini, Manuela
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 114 - 131
Twenty-six new tacrine-benzofuran hybrids were designed, synthesized, and evaluated in vitro on key molecular targets for Alzheimers disease. Most hybrids... 
FIBRIL FORMATION | NO DONOR | CHEMISTRY, MEDICINAL | MULTIFUNCTIONAL AGENTS | ACTIVE-SITE GORGE | SECRETASE INHIBITORS | DRUG DESIGN | BETA-AMYLOID PEPTIDE | CRYSTAL-STRUCTURES | BUTYRYLCHOLINESTERASE INHIBITORS | TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE | Humans | Torpedo | Benzofurans - pharmacology | Crystallography, X-Ray | Male | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Benzofurans - chemistry | Tacrine - pharmacology | Drug Design | Behavior, Animal - drug effects | Chemical and Drug Induced Liver Injury - pathology | Tacrine - chemistry | Cell Line | Aspartic Acid Endopeptidases - antagonists & inhibitors | Cell Survival | Alzheimer Disease - drug therapy | Benzofurans - chemical synthesis | Models, Molecular | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Mice, Inbred ICR | Tacrine - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Nootropic Agents - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease
by Lu, Chuanjun and Guo, Yueyan and Yan, Jun and Luo, Zonghua and Luo, Hai-Bin and Yan, Ming and Huang, Ling and Li, Xingshu
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2013, Volume 56, Issue 14, pp. 5843 - 5859
A series of multitarget-directed resveratrol derivatives was designed and synthesized for the treatment of Alzheimer's disease (AD). In vitro studies indicated... 
MONOAMINE-OXIDASE | FIBRIL FORMATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BETA-AMYLOID PEPTIDES | ACETYLCHOLINESTERASE | A-BETA | BINDING-SITE | HYDROGEN-PEROXIDE | AGGREGATION | ANTIOXIDANT PROPERTIES | Clioquinol - analogs & derivatives | Stilbenes - therapeutic use | Humans | Alzheimer Disease - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Stilbenes - chemistry | Antioxidants - chemical synthesis | Monoamine Oxidase Inhibitors - chemical synthesis | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Peptide Fragments - chemistry | Animals | Peptide Fragments - antagonists & inhibitors | Drug Design | Mice | Amyloid beta-Peptides - chemistry | Blood-Brain Barrier | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: Application to the formal synthesis of (+)-physostigmine
by Bui, Tommy and Syed, Salahuddin and Barbas III, Carlos F
Journal of the American Chemical Society, ISSN 0002-7863, 07/2009, Volume 131, Issue 25, pp. 8758 - 8759
Oxindoles and their indoline derivatives are common structural motifs found in a wide array of natural and biologically active molecules. Most catalytic... 
MICHAEL REACTION | BETA-AMINO ACIDS | MANNICH REACTION | ASYMMETRIC-SYNTHESIS | ENANTIOSELECTIVE SYNTHESIS | INTRAMOLECULAR HECK REACTIONS | CHEMISTRY, MULTIDISCIPLINARY | STRECKER REACTION | BIFUNCTIONAL ORGANOCATALYSTS | CONJUGATE ADDITION | QUATERNARY CARBON | Physostigmine - analogs & derivatives | Stereoisomerism | Cholinesterase Inhibitors - chemistry | Nitro Compounds - chemistry | Indoles - chemical synthesis | Nitro Compounds - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Thiourea - chemistry | Alkenes - chemical synthesis | Alkenes - chemistry | Physostigmine - chemistry | Molecular Structure | Catalysis | Physostigmine - chemical synthesis | Indoles - chemistry | Urea | Thiols | Olefins | Analysis | Indole | Physostigmine | Chemical properties
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds
by Özgeriş, Bünyamin and Göksu, Süleyman and Polat Köse, Leyla and Gülçin, İlhami and Salmas, Ramin Ekhteiari and Durdagi, Serdar and Tümer, Ferhan and Supuran, Claudiu T
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2016, Volume 24, Issue 10, pp. 2318 - 2329
A series of urea and sulfamides incorporating tetralin scaffolds were synthesized for their in vivo and in silico evaluation of hCA and AChE inhibition... 
Sulfamide | Acetylcholine esterase | Urea | Carbonic anhydrase | Molecular dynamics (MD) simulations | Enzyme inhibition | Molecular docking | CHEMISTRY, MEDICINAL | ENZYME-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ERYTHROCYTES IN-VITRO | SULFONAMIDE DERIVATIVES | PROTEASE INHIBITOR | BROMOPHENOL DERIVATIVES | ISOENZYMES HCA I | BIOLOGICAL EVALUATION | SELECTIVE INHIBITORS | MOLECULAR-DYNAMICS SIMULATIONS | TROUT ONCORHYNCHUS-MYKISS | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Tetrahydronaphthalenes - chemical synthesis | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Sulfonamides - pharmacology | Urea - chemical synthesis | Molecular Dynamics Simulation | Sulfonamides - chemical synthesis | Cholinesterase Inhibitors - pharmacology | Tetrahydronaphthalenes - chemistry | Tetrahydronaphthalenes - pharmacology | Urea - analogs & derivatives | Molecular Docking Simulation | Acetylcholinesterase - metabolism | Urea - pharmacology | Analysis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: Novel sulfamoylcarbamates and sulfamides derived from acetophenones
by Akıncıoğlu, Hülya and Akıncıoğlu, Akın and Gülçin, İlhami and Durdagi, Serdar and Supuran, Claudiu T and Göksu, Süleyman
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3592 - 3602
In this study, several novel sulfamides were synthesized and evaluated for their acetylcholine esterase (AChE) and human carbonic anhydrase I, and II... 
Sulfamide | Acetylcholine esterase | Carbonic anhydrase | Enzyme inhibition | Sulfamoylcarbamate | Molecular docking | Hybrid molecules | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | PHENOLIC-COMPOUNDS | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | VITRO INHIBITION | ISOENZYMES INHIBITORS | ERYTHROCYTE ISOZYMES I | SULFONAMIDE DERIVATIVES | BIOLOGICAL EVALUATION | REDUCTIVE AMINATION | CHOLINESTERASE INHIBITOR | Isocyanates | Oxidation-Reduction | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Carbonic Anhydrase II - antagonists & inhibitors | Sulfonamides - chemical synthesis | Acetophenones - chemistry | Amination | Carbonic Anhydrase I - antagonists & inhibitors | Molecular Docking Simulation | Molecular Structure | Kinetics | Carbonic Anhydrase II - chemistry | Acetylcholine | Medicine, Experimental | Medical colleges | Medical research | Isoenzymes
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Potent acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives
by Mohammadi-Khanaposhtani, Maryam and Saeedi, Mina and Zafarghandi, Narges Shamsaei and Mahdavi, Mohammad and Sabourian, Reyhaneh and Razkenari, Elahe Karimpour and Alinezhad, Heshmatollah and Khanavi, Mahnaz and Foroumadi, Alireza and Shafiee, Abbas and Akbarzadeh, Tahmineh
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 799 - 806
A novel series of acridone linked to 1,2,3-triazole derivatives have been synthesized and evaluated for their acetylcholinesterase (AChE) and... 
Docking study | Acridone-1,2,3-triazole | Acetylcholinesterase | Alzheimer's disease | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | ACIDS | CHOLINESTERASE ACTIVITY | ALZHEIMERS-DISEASE | CLICK CHEMISTRY | IN-SITU | SOLUBILITY | Acridines - chemistry | Antioxidants - chemistry | Acridones | Triazoles - chemistry | Cholinesterase Inhibitors - chemistry | Electrophorus | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Dose-Response Relationship, Drug | Acridines - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Acridines - pharmacology | Culicidae | Drug Design | Molecular Docking Simulation | Molecular Structure | Acetylcholinesterase - metabolism | Medicinal plants | Drugstores | Enzyme inhibitors | Aniline | Triazoles | Pharmacy | Medicine, Botanic | Medicine, Herbal
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes
by Bayrak, Çetin and Taslimi, Parham and Gülçin, İlhami and Menzek, Abdullah
Bioorganic Chemistry, ISSN 0045-2068, 06/2017, Volume 72, pp. 359 - 366
The first synthesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl)but-3-en-2-one ( ), (E)-4-(2-bromo-4,5-dihydroxyphenyl)but-3-en-2-one ( ), and... 
Bromophenols | Carbonic anhydrase | Bromination | Natural products | Enzyme inhibition | Phenylbutenone | Acetylcholinesterase | Butyrylcholinesterase | ANTIOXIDANT ACTIVITY | BOVINE-MILK | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ALGA RHODOMELA-CONFERVOIDES | ISOZYMES I | ERYTHROCYTES IN-VITRO | ANTICHOLINERGIC PROPERTIES | RADICAL-SCAVENGING ACTIVITY | ISOENZYMES HCA I | PURIFICATION | TROUT ONCORHYNCHUS-MYKISS | Phenols - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Biological Products - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase I - metabolism | Butanones - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Dose-Response Relationship, Drug | Butanones - chemical synthesis | Butyrylcholinesterase - metabolism | Molecular Structure | Phenols - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Butanones - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Phenols - chemistry | Acetylcholinesterase - metabolism | Enzymes | Isoenzymes | Biological products
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Design, synthesis, and AChE inhibitory activity of new benzothiazole–piperazines
by Demir Özkay, Ümide and Can, Özgür Devrim and Sağlık, Begüm Nurpelin and Acar Çevik, Ulviye and Levent, Serkan and Özkay, Yusuf and Ilgın, Sinem and Atlı, Özlem
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2016, Volume 26, Issue 22, pp. 5387 - 5394
Fourteen new benzothiazole–piparazines were designed and synthesised in order to investigate their AChE inhibition potency. Characterised compounds were... 
Docking | Acetylcholinesterase | Alzheimer disease | Piperazine | Benzothiazole | TORPEDO-CALIFORNICA | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | INTRACEREBROVENTRICULAR STREPTOZOTOCIN | ALZHEIMERS-DISEASE | CHEMISTRY, ORGANIC | DITHIOCARBAMATE DERIVATIVES | LIGAND INTERACTIONS | PERIPHERAL ANIONIC SITE | BIOLOGICAL EVALUATION | ACETYLCHOLINESTERASE INHIBITORS | INDUCED COGNITIVE IMPAIRMENT | NIH 3T3 Cells | Cholinesterase Inhibitors - pharmacokinetics | Benzothiazoles - pharmacology | Humans | Cholinesterase Inhibitors - chemistry | Electrophorus | Cholinesterase Inhibitors - chemical synthesis | Piperazines - chemistry | Benzothiazoles - pharmacokinetics | Piperazines - pharmacology | Animals | Benzothiazoles - chemical synthesis | Cholinesterase Inhibitors - pharmacology | Benzothiazoles - chemistry | Piperazines - chemical synthesis | Mice | Molecular Docking Simulation | Piperazines - pharmacokinetics | Acetylcholinesterase - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase
by Sun, Qi and Peng, Da-Yong and Yang, Wen-Chao and Yang, Guang-Fu and Yang, Sheng-Gang and Zhu, Xiao-Lei
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2014, Volume 22, Issue 17, pp. 4784 - 4791
Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of acetylcholine (Ach) represents the mainstream direction for... 
Butylcholinesterase inhibitor | Acetylcholinesterase inhibitor | Alzheimer’s disease | Coumarin | Alzheimer's disease | BUTYRYLCHOLINESTERASE | TARGET-DIRECTED LIGANDS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | DISCOVERY | ANTI-ALZHEIMER COMPOUNDS | DISEASE | THERAPEUTIC STRATEGIES | DERIVATIVES | AMYLOID AGGREGATION | Humans | Cholinesterase Inhibitors - chemistry | Enzyme Inhibitors - pharmacology | Coumarins - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Coumarins - pharmacology | Dose-Response Relationship, Drug | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Tacrine - pharmacology | Cholinesterase Inhibitors - pharmacology | Enzyme Inhibitors - chemistry | Amyloid beta-Peptides - metabolism | Molecular Structure | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Cholinesterases - metabolism | Acetylcholinesterase - metabolism | Tacrine - chemistry
Journal Article
Details down arrow
Digital rights down arrow