Articles

UofT Libraries is getting a new library services platform in January 2021.
Learn more about the change.

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2771) 2771
Book Chapter (20) 20
Book / eBook (5) 5
Government Document (4) 4
Dissertation (3) 3
Conference Proceeding (2) 2
Magazine Article (2) 2
Newsletter (2) 2
Newspaper Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (1622) 1622
life sciences & biomedicine (1501) 1501
cholinesterase inhibitors - pharmacology (1428) 1428
animals (1417) 1417
humans (1212) 1212
cholinesterase inhibitors - chemistry (1086) 1086
cholinesterase inhibitors - chemical synthesis (1048) 1048
acetylcholinesterase - metabolism (1000) 1000
structure-activity relationship (832) 832
acetylcholinesterase (785) 785
alzheimer's disease (720) 720
pharmacology & pharmacy (681) 681
biological and medical sciences (611) 611
chemistry (598) 598
molecular structure (555) 555
biochemistry & molecular biology (518) 518
medical sciences (513) 513
alzheimer disease - drug therapy (503) 503
physical sciences (499) 499
rats (491) 491
chemistry, medicinal (463) 463
male (455) 455
butyrylcholinesterase - metabolism (448) 448
dose-response relationship, drug (428) 428
acetylcholinesterase - chemistry (405) 405
cholinesterase (388) 388
models, molecular (366) 366
toxicology (365) 365
drug design (352) 352
cholinesterase inhibitors (349) 349
pharmacology. drug treatments (341) 341
analysis (336) 336
mice (330) 330
kinetics (321) 321
alzheimer’s disease (295) 295
molecular docking simulation (292) 292
enzymes (290) 290
binding sites (275) 275
cholinesterase inhibitors - toxicity (245) 245
butyrylcholinesterase (240) 240
enzyme inhibitors (240) 240
neuropharmacology (240) 240
cholinesterase inhibitors - therapeutic use (230) 230
chemistry, multidisciplinary (226) 226
butyrylcholinesterase - chemistry (207) 207
female (199) 199
neurosciences (198) 198
organic chemistry (190) 190
neurosciences & neurology (188) 188
antioxidants (179) 179
chemistry, organic (177) 177
psychology. psychoanalysis. psychiatry (167) 167
brain - drug effects (166) 166
cholinesterase inhibitors - metabolism (161) 161
cholinesterases - metabolism (159) 159
drug therapy (159) 159
psychopharmacology (157) 157
inhibitory concentration 50 (153) 153
psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (153) 153
rats, wistar (153) 153
antioxidants - pharmacology (149) 149
alzheimer disease - metabolism (147) 147
molecular docking (144) 144
neurodegenerative diseases (142) 142
acetylcholine (141) 141
inhibition (141) 141
amyloid beta-peptides - metabolism (138) 138
brain - enzymology (138) 138
electrophorus (137) 137
in vitro techniques (135) 135
research (135) 135
ligands (131) 131
neuroprotective agents - pharmacology (131) 131
fundamental and applied biological sciences. psychology (128) 128
inhibitors (127) 127
protein binding (127) 127
acetylcholinesterase - drug effects (126) 126
alzheimers disease (126) 126
acetylcholinesterase inhibitors (121) 121
toxicity (120) 120
tacrine - chemistry (118) 118
cell line, tumor (117) 117
antioxidants - chemistry (115) 115
neurology (114) 114
tacrine - pharmacology (114) 114
horses (113) 113
stereoisomerism (111) 111
alzheimer disease - enzymology (110) 110
brain (108) 108
magnetic resonance spectroscopy (108) 108
oximes - pharmacology (107) 107
cell survival - drug effects (106) 106
environmental sciences & ecology (105) 105
catalytic domain (104) 104
environmental sciences (104) 104
rats, sprague-dawley (102) 102
pesticides (101) 101
pharmacy (101) 101
amyloid beta-peptides - antagonists & inhibitors (100) 100
cholinesterases (100) 100
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2758) 2758
German (48) 48
Chinese (24) 24
Japanese (17) 17
Russian (15) 15
French (8) 8
Portuguese (8) 8
Croatian (4) 4
Italian (3) 3
Czech (1) 1
Polish (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease
by Bolea, Irene and Juárez-Jiménez, Jordi and de los Rı́os, Cristóbal and Chioua, Mourad and Pouplana, Ramón and Luque, F. Javier and Unzeta, Mercedes and Marco-Contelles, José and Samadi, Abdelouahid
Journal of medicinal chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8251 - 8270
Humans | Cholinesterase Inhibitors - chemistry | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Isoenzymes - chemistry | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Monoamine Oxidase - chemistry | Butyrylcholinesterase - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Binding Sites | Indans - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Piperidines - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Rats | Electrophorus | Acetylcholinesterase - chemistry | Piperidines - chemical synthesis | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Horses | Indans - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Amyloid beta-Peptides - chemistry | Kinetics | Indoles - chemistry | Acetylcholinesterase - metabolism | Indans - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents
by Viayna, Elisabet and Sola, Irene and Bartolini, Manuela and De Simone, Angela and Tapia-Rojas, Cheril and Serrano, Felipe G and Sabaté, Raimon and Juárez-Jiménez, Jordi and Pérez, Belén and Luque, F. Javier and Andrisano, Vincenza and Clos, M. Victòria and Inestrosa, Nibaldo C and Muñoz-Torrero, Diego
Journal of medicinal chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 6, pp. 2549 - 2567
Stereoisomerism | Humans | Cholinesterase Inhibitors - chemical synthesis | Hippocampus - drug effects | Enzyme Inhibitors - chemical synthesis | Anthraquinones - chemical synthesis | Synapses - metabolism | Long-Term Potentiation - drug effects | Escherichia coli - metabolism | Binding Sites | tau Proteins - antagonists & inhibitors | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Models, Molecular | Mice, Transgenic | Blood-Brain Barrier - drug effects | Hippocampus - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Anthraquinones - pharmacology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Kinetics | Amyloid beta-Protein Precursor - antagonists & inhibitors | In Vitro Techniques | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease
by Sang, Zhipei and Pan, Wanli and Wang, Keren and Ma, Qinge and Yu, Lintao and Liu, Wenmin
Bioorganic & medicinal chemistry, ISSN 0968-0896, 06/2017, Volume 25, Issue 12, pp. 3006 - 3017
MAO-B inhibitor | BuChE inhibitor | Alzheimer’s disease | 3,4-Dihydro-2(1H)-quinoline-O-alkylamines | Blood-brain barrier | MAO-A inhibitor | AChE inhibitor | Alzheimer's disease | Monoamine Oxidase Inhibitors - pharmacology | Cholinesterase Inhibitors - pharmacokinetics | Humans | Quinolines - chemistry | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Electrophorus | Cholinesterase Inhibitors - chemical synthesis | Alzheimer Disease - enzymology | Monoamine Oxidase Inhibitors - chemical synthesis | Quinolines - pharmacology | Blood-Brain Barrier - metabolism | Monoamine Oxidase Inhibitors - pharmacokinetics | Quinolines - chemical synthesis | Quinolines - pharmacokinetics | Animals | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Swine | Drug Design | Monoamine Oxidase Inhibitors - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Oxidases | Alkaloids | Enzyme inhibitors | Surface active agents | Analysis | Resveratrol | Quinoline | Acetylcholine | Drug therapy | High performance liquid chromatography | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes
by Bayrak, Çetin and Taslimi, Parham and Gülçin, İlhami and Menzek, Abdullah
Bioorganic chemistry, ISSN 0045-2068, 06/2017, Volume 72, pp. 359 - 366
Bromophenols | Carbonic anhydrase | Bromination | Natural products | Enzyme inhibition | Phenylbutenone | Acetylcholinesterase | Butyrylcholinesterase | Phenols - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Biological Products - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase I - metabolism | Butanones - pharmacology | Carbonic Anhydrase II - antagonists & inhibitors | Dose-Response Relationship, Drug | Butanones - chemical synthesis | Butyrylcholinesterase - metabolism | Molecular Structure | Phenols - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Butanones - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Phenols - chemistry | Acetylcholinesterase - metabolism | Enzymes | Isoenzymes | Biological products | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X‑ray Crystallography
by Zha, Xiaoming and Lamba, Doriano and Zhang, Lili and Lou, Yinghan and Xu, Changxu and Kang, Di and Chen, Li and Xu, Yungen and Zhang, Luyong and De Simone, Angela and Samez, Sarah and Pesaresi, Alessandro and Stojan, Jure and Lopez, Manuela G and Egea, Javier and Andrisano, Vincenza and Bartolini, Manuela
Journal of medicinal chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 114 - 131
Humans | Torpedo | Benzofurans - pharmacology | Crystallography, X-Ray | Male | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Benzofurans - chemistry | Tacrine - pharmacology | Drug Design | Behavior, Animal - drug effects | Chemical and Drug Induced Liver Injury - pathology | Tacrine - chemistry | Cell Line | Aspartic Acid Endopeptidases - antagonists & inhibitors | Cell Survival | Alzheimer Disease - drug therapy | Benzofurans - chemical synthesis | Models, Molecular | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Mice, Inbred ICR | Tacrine - chemical synthesis | Animals | Cholinesterase Inhibitors - pharmacology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Nootropic Agents - pharmacology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer’s disease
by Luo, Zonghua and Liang, Liang and Sheng, Jianfei and Pang, Yanqing and Li, Jianheng and Huang, Ling and Li, Xingshu
Bioorganic & medicinal chemistry, ISSN 0968-0896, 02/2014, Volume 22, Issue 4, pp. 1355 - 1361
Alzheimer’s disease | GPx mimics | Cholinesterase inhibitors | Alzheimer's disease | Biocompatible Materials - metabolism | Organoselenium Compounds - chemical synthesis | Antioxidants - metabolism | Humans | Azoles - metabolism | Azoles - therapeutic use | Cholinesterase Inhibitors - chemical synthesis | Organoselenium Compounds - chemistry | Biocompatible Materials - chemical synthesis | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Glutathione Peroxidase - chemistry | Butyrylcholinesterase - metabolism | Organoselenium Compounds - therapeutic use | Glutathione Peroxidase - metabolism | Alzheimer Disease - drug therapy | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Azoles - chemical synthesis | Azoles - chemistry | Antioxidants - therapeutic use | Protein Binding | Biocompatible Materials - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Peroxidase | Analysis | Amyloid beta-protein | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
by Turkan, Fikret and Cetin, Adnan and Taslimi, Parham and Karaman, Muhammet and Gulçin, İlhami
Bioorganic chemistry, ISSN 0045-2068, 05/2019, Volume 86, pp. 420 - 427
Substituted pyrazole | Enzyme inhibition | Carbonic anhydrase | Acetylcholinesterase | Carbonic Anhydrase Inhibitors - chemistry | Pyrazoles - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Electrophorus | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Dose-Response Relationship, Drug | Pyrazoles - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Carbonic Anhydrase I - isolation & purification | Molecular Docking Simulation | Molecular Structure | Acetylcholinesterase - metabolism | Pyrazoles - pharmacology | Nuclear magnetic resonance spectroscopy | Enzyme inhibitors | Molecular biology | Analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “bio-oxidizable” prodrugs: Synthesis, biological evaluation and structure-activity relationship
by Azzouz, Rabah and Peauger, Ludovic and Gembus, Vincent and Ţînţaş, Mihaela-Liliana and Sopková-de Oliveira Santos, Jana and Papamicaël, Cyril and Levacher, Vincent
European journal of medicinal chemistry, ISSN 0223-5234, 02/2018, Volume 145, pp. 165 - 190
AChEIs | “Bio-oxidizable” prodrug | Alzheimer | Donepezil analogues | Dihydropyridines - chemistry | Cholinesterase Inhibitors - chemistry | Electrophorus | Cholinesterase Inhibitors - chemical synthesis | Prodrugs - chemistry | Structure-Activity Relationship | Pyridinium Compounds - chemical synthesis | Dose-Response Relationship, Drug | Salts - chemistry | Pyridinium Compounds - pharmacology | Salts - pharmacology | Animals | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Salts - chemical synthesis | Dihydropyridines - pharmacology | Horses | Prodrugs - chemical synthesis | Molecular Docking Simulation | Molecular Structure | Pyridinium Compounds - chemistry | Prodrugs - pharmacology | Acetylcholinesterase - metabolism | Index Medicus | Medicinal Chemistry | Chemical Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
by Özbey, Fadime and Taslimi, Parham and Gülçin, İlhami and Maraş, Ahmet and Göksu, Süleyman and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup2, pp. 79 - 85
carbonic anhydrase | butyrylcholinesterase | enzyme inhibition | Acetylcholinesterase | diaryl ethers | Ethers - chemical synthesis | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Ethers - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Isoenzymes - isolation & purification | Dose-Response Relationship, Drug | Ethers - pharmacology | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Isoenzymes - metabolism | Carbonic Anhydrase I - isolation & purification | Molecular Structure | Carbonic Anhydrase II - isolation & purification | Acetylcholinesterase - metabolism | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors
by Gulçin, İlhami and Abbasova, Malahat and Taslimi, Parham and Huyut, Zübeyir and Safarova, Leyla and Sujayev, Afsun and Farzaliyev, Vagif and Beydemir, Şükrü and Alwasel, Saleh H and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 1174 - 1182
carbonic anhydrase | mercaptobenzothiazole | butyrylcholinesterase | mercaptobenzoxazole | Acetylcholinesterase | Benzoxazoles - pharmacology | Benzothiazoles - pharmacology | Carbonic Anhydrase Inhibitors - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Benzoxazoles - chemical synthesis | Carbonic Anhydrases - metabolism | Dose-Response Relationship, Drug | Benzothiazoles - chemical synthesis | Benzoxazoles - chemistry | Cholinesterase Inhibitors - pharmacology | Thiazoles - chemical synthesis | Butyrylcholinesterase - metabolism | Benzothiazoles - chemistry | Thiazoles - chemistry | Molecular Structure | Thiazoles - pharmacology | Acetylcholinesterase - metabolism | Enzymes | Chemistry | Isoenzymes | Carbon dioxide | Physiology | Biochemistry | Carbonic anhydrase I | Sulfur | Pharmaceutical sciences | Alcohols | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities
by Garibov, Emin and Taslimi, Parham and Sujayev, Afsun and Bingol, Zeynebe and Çetinkaya, Songul and Gulçin, İlhami and Beydemir, Sukru and Farzaliyev, Vagif and Alwasel, Saleh H and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 11/2016, Volume 31, Issue sup3, pp. 1 - 9
carbonic anhydrase | butyrylcholinesterase | enzyme inhibition | Acetylcholinesterase | antioxidant activity | Antioxidants - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Carbonic Anhydrase Inhibitors - pharmacology | Pyrimidines - pharmacology | Carbonic Anhydrase I - metabolism | Carbonic Anhydrase II - antagonists & inhibitors | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Carbonic Anhydrase I - antagonists & inhibitors | Molecular Structure | Acetylcholinesterase - metabolism | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease
by Sang, Zhipei and Qiang, Xiaoming and Li, Yan and Yuan, Wen and Liu, Qiang and Shi, Yikun and Ang, Wei and Luo, Youfu and Tan, Zhenghuai and Deng, Yong
European journal of medicinal chemistry, ISSN 0223-5234, 04/2015, Volume 94, pp. 348 - 366
Acetylcholinesterase inhibitors | Aβ aggregation inhibitors | Multifunctional agents | Metal-chelating agents | Alzheimer's disease | Scutellarein-O-alkylamines | Ab aggregation inhibitors | Amines - chemistry | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | PC12 Cells | Apigenin - chemistry | Dose-Response Relationship, Drug | Apigenin - chemical synthesis | Scopolamine Hydrobromide | Amyloid beta-Peptides - metabolism | Drug Design | Molecular Structure | Peptide Fragments - metabolism | Hydrogen Peroxide - pharmacology | Alzheimer Disease - drug therapy | Models, Molecular | Rats | Amines - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Memory Disorders - drug therapy | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Mice | Amines - pharmacology | Hydrogen Peroxide - antagonists & inhibitors | Acetylcholinesterase - metabolism | Apigenin - pharmacology | Memory Disorders - chemically induced | Surface active agents | Drug therapy | Analysis | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors:  New Disease-Modifying Agents for Alzheimer's Disease
by Muñoz-Ruiz, Pilar and Rubio, Laura and García-Palomero, Esther and Dorronsoro, Isabel and del Monte-Millán, María and Valenzuela, Rita and Usán, Paola and de Austria, Celia and Bartolini, Manuela and Andrisano, Vincenza and Bidon-Chanal, Axel and Orozco, Modesto and Luque, F. Javier and Medina, Miguel and Martínez, Ana
Journal of medicinal chemistry, ISSN 0022-2623, 11/2005, Volume 48, Issue 23, pp. 7223 - 7233
Psychology. Psychoanalysis. Psychiatry | Psychopharmacology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Neuropharmacology | Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) | Cholinesterase Inhibitors - toxicity | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Fluorometry | Butyrylcholinesterase - chemistry | Cattle | Drug Design | Erythrocytes - enzymology | Tacrine - analogs & derivatives | Binding Sites | Dimerization | Tacrine - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Acetylcholinesterase - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Nootropic Agents - toxicity | Tacrine - chemical synthesis | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cell Line, Tumor | Protein Binding | Amyloid beta-Peptides - chemistry | Tacrine - toxicity | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
by Bayrak, Cetin and Taslimi, Parham and Karaman, Halide Sedef and Gulcin, Ilhami and Menzek, Abdullah
Bioorganic chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 128 - 139
Enzyme inhibition | Carbonic anhydrase | Acetylcholinesterase | Bromination | Bromophenol | Molecular docking | Bromobenzenes - chemical synthesis | Cholinesterase Inhibitors - pharmacokinetics | Carbonic Anhydrase Inhibitors - pharmacokinetics | Cholinergic Antagonists - chemical synthesis | Biological Products - pharmacokinetics | Phenols - chemical synthesis | Humans | Carbonic Anhydrase II - metabolism | Cholinesterase Inhibitors - chemical synthesis | Carbonic Anhydrase I - metabolism | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Cholinergic Antagonists - pharmacokinetics | Bromobenzenes - metabolism | Carbonic Anhydrase Inhibitors - chemical synthesis | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Phenols - metabolism | Bromobenzenes - pharmacokinetics | Cholinergic Antagonists - metabolism | Biological Products - chemical synthesis | Phenols - pharmacokinetics | Biological Products - metabolism | Protein Binding | Molecular Docking Simulation | Carbonic Anhydrase Inhibitors - metabolism | Acetylcholinesterase - metabolism | Carbonic Anhydrase II - chemistry | Hydroxides | Isoenzymes | Benzene | Resveratrol | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text Coumarin: A natural, privileged and versatile scaffold for bioactive compounds
by Stefanachi, Angela and Leonetti, Francesco and Pisani, Leonardo and Catto, Marco and Carotti, Angelo and Marco Catto and Angela Stefanachi and Francesco Leonetti and Leonardo Pisani and Angelo Carotti
Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 2, p. 250
Multitarget ligands | Monoamine oxidase inhibitors | Cholinesterase inhibitors | Coumarin | Aromatase inhibitors | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Aromatase - metabolism | Parkinson Disease - drug therapy | Structure-Activity Relationship | Nootropic Agents - chemical synthesis | Enzyme Inhibitors - chemical synthesis | Aromatase - chemistry | Coumarins - pharmacology | Monoamine Oxidase - chemistry | Neuroprotective Agents - chemical synthesis | Neuroprotective Agents - pharmacology | Cholinesterases - chemistry | Biotransformation | Coumarins - chemical synthesis | Drug Design | Molecular Structure | Cholinesterases - metabolism | Nootropic Agents - pharmacology | Monoamine Oxidase - metabolism | Transformation | Neurodegenerative diseases | Biosynthesis | Pharmacology | Amine oxidase (flavin-containing) | Cholinesterase | Diseases | Neurological diseases | Inhibitors | Enzyme inhibitors | Reviews | Pathways | Bioactive compounds | Aromatase | Chemists | Scaffolds | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights