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Archives of Toxicology, ISSN 0340-5761, 12/2016, Volume 90, Issue 12, pp. 2831 - 2859
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphorus... 
Biomedicine, general | Uncharged reactivator | Reactivation | Biomedicine | Environmental Health | Organophosphate | Occupational Medicine/Industrial Medicine | Pyridinium oximes | Pharmacology/Toxicology | Acetylcholinesterase | Nerve agents | BIS-PYRIDINIUM OXIMES | EFFICIENT UNCHARGED REACTIVATORS | STEERED MOLECULAR-DYNAMICS | ELECTRIC-EEL ACETYLCHOLINESTERASE | BLOOD-BRAIN-BARRIER | SILICO PHARMACOPHORE MODEL | IN-VITRO EVALUATION | CHEMICAL WARFARE AGENTS | TOXICOLOGY | INHIBITED HUMAN ACETYLCHOLINESTERASE | TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE | Cholinesterase Inhibitors - toxicity | Cholinesterase Reactivators - pharmacology | Humans | Molecular Conformation | Cholinesterase Inhibitors - chemistry | Organophosphate Poisoning - drug therapy | Structure-Activity Relationship | Organophosphorus Compounds - antagonists & inhibitors | Drug Design | Organophosphate Poisoning - metabolism | Molecular Structure | Pyridinium Compounds - chemistry | Binding Sites | Nerve Agents - chemistry | Antidotes - pharmacology | Antidotes - chemistry | Catalytic Domain | Cholinesterase Reactivators - therapeutic use | Acetylcholinesterase - chemistry | Pesticides - antagonists & inhibitors | Cholinesterase Reactivators - chemistry | Nerve Agents - toxicity | Pyridinium Compounds - pharmacology | Animals | Pesticides - toxicity | Ligands | Protein Conformation | Organophosphate Poisoning - etiology | Organophosphorus Compounds - toxicity | Acetylcholinesterase - metabolism | Antidotes - therapeutic use | Nerve gas | Nitriles | Research | War use | Pesticides | Gases, Asphyxiating and poisonous | Studies | Fatalities | Biological & chemical weapons
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Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2014, Volume 281, Issue 3, pp. 254 - 265
The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration... 
Oxime | Efficacy | Guinea pig | Intramuscular | Toxicity | HYDROXAMIC ACIDS | PYRIDINIUM OXIMES | SOMAN | HUMAN ACETYLCHOLINESTERASE | NERVE AGENTS | TABUN | IN-VIVO REACTIVATION | CYCLOSARIN | SARIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | BRAIN | Atropine - therapeutic use | Cholinesterase Reactivators - administration & dosage | Cholinesterase Inhibitors - toxicity | Atropine - adverse effects | Oximes - adverse effects | Muscarinic Antagonists - adverse effects | Cholinesterase Inhibitors - chemistry | Oximes - administration & dosage | Pyridinium Compounds - administration & dosage | Pyridinium Compounds - therapeutic use | Oximes - therapeutic use | Male | Organophosphate Poisoning - drug therapy | Pyridinium Compounds - adverse effects | Antidotes - administration & dosage | Muscarinic Antagonists - therapeutic use | Chemical Warfare Agents - chemistry | Cholinesterases - blood | Organophosphate Poisoning - physiopathology | Drug Therapy, Combination - adverse effects | Injections, Subcutaneous | Cholinesterase Reactivators - adverse effects | Guinea Pigs | Drug Administration Schedule | Cholinesterase Reactivators - therapeutic use | Injections, Intramuscular | Pesticides - antagonists & inhibitors | Random Allocation | Muscarinic Antagonists - administration & dosage | Animals | Cholinesterase Inhibitors - administration & dosage | Pesticides - toxicity | Organophosphate Poisoning - blood | Antidotes - adverse effects | Atropine - administration & dosage | Chemical Warfare Agents - toxicity | Drug Monitoring | Antidotes - therapeutic use | Analysis | Enzyme inhibitors | Pesticides | Index Medicus | CHOLINESTERASE | ATROPINE | GUINEA PIGS | CHLORINE | BLOOD-BRAIN BARRIER | CENTRAL NERVOUS SYSTEM | SYMPTOMS | TOXICITY | STANDARD OF LIVING | US FDA | 60 APPLIED LIFE SCIENCES | MOLECULAR WEIGHT | PESTICIDES | LETHAL DOSES | OXIMES | THERAPY | CHEMICAL WARFARE AGENTS | POISONING | BLOOD | toxicity | intramuscular | guinea pig | oxime | efficacy
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