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European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, pp. 221 - 234
Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since... 
Acetylcholinesterase inhibitors | Diphenylpyrimidine | MAO inhibitors | Alzheimer's disease | Dual inhibitors | Neurological disorders | Acetylchollnesterase inhibitors | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | NEUROPROTECTION | MULTITARGET-DIRECTED LIGANDS | DONEPEZIL | BIOLOGICAL EVALUATION | POTENTIAL TREATMENT | MULTIPOTENT MAO | HYBRIDS | Alkynes - chemical synthesis | Cholinesterase Inhibitors - toxicity | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Pyrimidines - chemistry | Monoamine Oxidase - chemistry | Pyrimidines - toxicity | Drug Design | Alkynes - pharmacology | Molecular Structure | Monoamine Oxidase Inhibitors - pharmacology | Catalytic Domain | Alzheimer Disease - drug therapy | Alkynes - chemistry | Acetylcholinesterase - chemistry | Pyrimidines - pharmacology | Molecular Dynamics Simulation | Monoamine Oxidase Inhibitors - toxicity | Cholinesterase Inhibitors - pharmacology | Alkynes - toxicity | Cell Line, Tumor | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Kinetics | Oxidases | Molecular dynamics | Development and progression | Nervous system diseases | Enzyme inhibitors
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2015, Volume 58, Issue 14, pp. 5561 - 5578
Journal Article
1970, 1st ed., International encyclopedia of pharmacology and therapeutics, ISBN 008006633X, Volume section 13., v.
Book
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
Current Alzheimer Research, ISSN 1567-2050, 04/2009, Volume 6, Issue 2, pp. 86 - 96
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 01/2018, Volume 319, Issue 2, pp. 130 - 142
IMPORTANCE New therapeutic approaches for Alzheimer disease (AD) are needed. OBJECTIVE To assess whether idalopirdine, a selective 5-hydroxytryptamine-6... 
DONEPEZIL | 5-HT6 RECEPTOR ANTAGONIST | MODERATE | MEDICINE, GENERAL & INTERNAL | DOUBLE-BLIND | SEROTONIN | SB-742457 | RATING-SCALE | VALIDITY | Serotonin Antagonists - administration & dosage | Benzylamines - adverse effects | Humans | Middle Aged | Male | Indans - therapeutic use | Benzylamines - administration & dosage | Indoles - administration & dosage | Dose-Response Relationship, Drug | Serotonin Antagonists - adverse effects | Treatment Failure | Aged, 80 and over | Female | Drug Therapy, Combination | Accidental Falls | Alzheimer Disease - psychology | Double-Blind Method | Alzheimer Disease - drug therapy | Serotonin Antagonists - therapeutic use | Cognition - drug effects | Indoles - adverse effects | Galantamine - therapeutic use | Piperidines - therapeutic use | Cholinesterase Inhibitors - adverse effects | Indoles - therapeutic use | Aged | Rivastigmine - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Benzylamines - therapeutic use | Treatment outcome | Care and treatment | Safety and security measures | Analysis | Clinical trials | Dosage and administration | Cholinesterase inhibitors | Alzheimer's disease | Drugs | Medical research | Activities of daily living | Galantamine | Neurodegenerative diseases | Serotonin | Medical treatment | Cognitive ability | Medical services | Cognition | Patients | Cholinesterase | Randomization | Safety engineering | Donepezil | Alzheimers disease | Original Investigation | Research
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2017, Volume 25, Issue 3, pp. 1030 - 1041
A series of 4′-aminochalcone-revastigmine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer’s disease.... 
Acetylcholinesterase inhibitors | Monoamine oxidase B inhibitors | Aβ aggregation inhibitors | Multifunctional agents | Chalcone carbamate derivatives | Alzheimer’s disease | Alzheimer's disease | CHEMISTRY, MEDICINAL | ANALOGS | TACRINE-COUMARIN HYBRIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | B INHIBITION | CHOLINESTERASE-INHIBITORS | CHALCONE DERIVATIVES | ANTIOXIDANT | MONOAMINE-OXIDASE INHIBITORS | A beta aggregation inhibitors | PHARMACOLOGICAL EVALUATION | Chalcones - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Humans | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Dose-Response Relationship, Drug | Animals | Rivastigmine - pharmacology | Cholinesterase Inhibitors - pharmacology | Swine | Chalcones - pharmacology | Drug Design | Molecular Docking Simulation | Molecular Structure | Monoamine Oxidase Inhibitors - chemistry | Rivastigmine - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Drug therapy | Analysis | Drugs | Drug delivery systems | Monoamine oxidase | Enzyme inhibitors | Surface active agents | Carbamates | Vehicles
Journal Article
Journal Article