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Publication Date2010, 1. Aufl., ISBN 9780470410301, xviii, 625
"This book offers an important reference source about the most common classes of pesticides for researchers engaged in the area of neurotoxicology, metabolism,...
Cholinesterase-inhibiting insecticides | Toxicology | Chemistry | SCIENCE | Industrial & Technical
Cholinesterase-inhibiting insecticides | Toxicology | Chemistry | SCIENCE | Industrial & Technical
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Journal of Medicinal Chemistry, ISSN 0022-2623, 2/2008, Volume 51, Issue 3, pp. 347 - 372
OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | H-3 RECEPTOR ANTAGONISTS | ANTI-PARKINSON DRUG | ALZHEIMERS-DISEASE | NAD(P)H-QUINONE OXIDOREDUCTASE ACTIVITY | AMYOTROPHIC-LATERAL-SCLEROSIS | AMYLOID PRECURSOR PROTEIN | MONOAMINE-OXIDASE INHIBITION | MOLECULAR-WEIGHT COMPLEXES | CU,ZN SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Humans | Calcium Channel Blockers - therapeutic use | Cholinesterase Inhibitors - chemistry | Parkinson Disease - drug therapy | Neurodegenerative Diseases - drug therapy | Alzheimer Disease - pathology | Neurofibrillary Tangles - metabolism | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Binding Sites | Chelating Agents - therapeutic use | Multiple Sclerosis - metabolism | Neurofibrillary Tangles - pathology | Neurodegenerative Diseases - pathology | Plaque, Amyloid - pathology | Chelating Agents - chemistry | Neurotransmitter Agents - metabolism | Alzheimer Disease - drug therapy | Antioxidants - pharmacology | Chelating Agents - pharmacology | Neurodegenerative Diseases - metabolism | Calcium Channel Blockers - pharmacology | Huntington Disease - metabolism | Antioxidants - therapeutic use | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Calcium Channel Blockers - chemistry | Ligands | Plaque, Amyloid - metabolism | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Multiple Sclerosis - drug therapy
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Loading RightsJournal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 2724 - 2732
Tacripyrines (1-14) have been designed by combining an ACNE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a...
APOPTOSIS | BETA-AMYLOID AGGREGATION | PERIPHERAL SITE | CHEMISTRY, MEDICINAL | CALCIUM-CHANNELS | CRYSTAL-STRUCTURE | BIOLOGICAL EVALUATION | DRUG CANDIDATES | ACETYLCHOLINESTERASE INHIBITORS | DUAL INHIBITORS | CHROMAFFIN CELL-DEATH | Calcium - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Cholinesterase Inhibitors - chemistry | Cytosol - drug effects | Dihydropyridines - metabolism | Alzheimer Disease - pathology | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Cell Death - drug effects | Calcium Channel Blockers - metabolism | Tacrine - analogs & derivatives | Catalytic Domain | Peptide Fragments - metabolism | Permeability - drug effects | Dihydropyridines - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Alzheimer Disease - enzymology | Calcium Channel Blockers - pharmacology | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Hydrogen Peroxide - metabolism | Dihydropyridines - therapeutic use | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Calcium Channel Blockers - chemistry | Cell Line, Tumor | Dihydropyridines - pharmacology | Cytosol - metabolism | Ligands | Kinetics | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism
APOPTOSIS | BETA-AMYLOID AGGREGATION | PERIPHERAL SITE | CHEMISTRY, MEDICINAL | CALCIUM-CHANNELS | CRYSTAL-STRUCTURE | BIOLOGICAL EVALUATION | DRUG CANDIDATES | ACETYLCHOLINESTERASE INHIBITORS | DUAL INHIBITORS | CHROMAFFIN CELL-DEATH | Calcium - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Cholinesterase Inhibitors - chemistry | Cytosol - drug effects | Dihydropyridines - metabolism | Alzheimer Disease - pathology | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Cell Death - drug effects | Calcium Channel Blockers - metabolism | Tacrine - analogs & derivatives | Catalytic Domain | Peptide Fragments - metabolism | Permeability - drug effects | Dihydropyridines - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Alzheimer Disease - enzymology | Calcium Channel Blockers - pharmacology | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Hydrogen Peroxide - metabolism | Dihydropyridines - therapeutic use | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Calcium Channel Blockers - chemistry | Cell Line, Tumor | Dihydropyridines - pharmacology | Cytosol - metabolism | Ligands | Kinetics | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism
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Loading RightsJournal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9089 - 9099
A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and the antioxidant ebselen were designed as multi-target-directed...
MAMMALIAN THIOREDOXIN | CHEMISTRY, MEDICINAL | ACETYLCHOLINESTERASE | PEROXYNITRITE | DIPHENYL DISELENIDE | AMYLOID-BETA-PEPTIDES | ORGANOSELENIUM COMPOUNDS | HUMAN HEALTH | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | BIOLOGICAL ASSESSMENT | Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
MAMMALIAN THIOREDOXIN | CHEMISTRY, MEDICINAL | ACETYLCHOLINESTERASE | PEROXYNITRITE | DIPHENYL DISELENIDE | AMYLOID-BETA-PEPTIDES | ORGANOSELENIUM COMPOUNDS | HUMAN HEALTH | NITRIC-OXIDE | THIOREDOXIN REDUCTASE | BIOLOGICAL ASSESSMENT | Cholinesterase Inhibitors - toxicity | Organoselenium Compounds - chemical synthesis | Humans | Azoles - metabolism | Cholinesterase Inhibitors - chemical synthesis | Toxicity Tests, Acute | Molecular Targeted Therapy | Organoselenium Compounds - pharmacology | Cholinesterase Inhibitors - metabolism | Piperidines - pharmacology | Thioredoxin-Disulfide Reductase - metabolism | Butyrylcholinesterase - metabolism | Azoles - toxicity | Glutathione Peroxidase - metabolism | Piperidines - toxicity | Chemistry Techniques, Synthetic | Protein Structure, Secondary | Piperidines - metabolism | Indans - metabolism | Alzheimer Disease - drug therapy | Electrophorus | Acetylcholinesterase - chemistry | Azoles - chemical synthesis | Azoles - pharmacology | Piperidines - chemical synthesis | Organoselenium Compounds - toxicity | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Peroxynitrous Acid - metabolism | Indans - toxicity | Indans - chemical synthesis | Ligands | Mice | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Kinetics | Acetylcholinesterase - metabolism | Organoselenium Compounds - metabolism | Protein Multimerization - drug effects | Indans - pharmacology | Index Medicus
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Molecular targets for components of essential oils in the insect nervous system—a review
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 1, p. 34
Essential oils (EOs) are lipophilic secondary metabolites obtained from plants; terpenoids represent the main components of them. A lot of studies showed...
Insect nervous system | Octopamine receptor | Bioinsecticides | Acetylcholinesterase | Essential oils | GABA receptors | Insecticides - chemistry | Oils, Volatile - chemistry | Calcium - metabolism | Allosteric Regulation | Nervous System - metabolism | Cholinesterase Inhibitors - chemistry | Octopamine - metabolism | Secondary Metabolism | Terpenes - chemistry | Animals | Insecticides - metabolism | Terpenes - metabolism | Cholinesterase Inhibitors - metabolism | Insect Control | Receptors, Biogenic Amine - metabolism | Receptors, GABA - metabolism | Insecta - physiology | Ligands | Oils, Volatile - metabolism | Cyclic AMP - metabolism | Acetylcholinesterase - metabolism | Binding | Potentiation | Octopamine receptors | Calcium | Insecticides | Nervous system | Lipophilic | Receptors | γ-Aminobutyric acid | Neurotoxicity | Secondary metabolites | Allosteric properties | Metabolites | Insects | Octopamine | Oils & fats | Paralysis | Terpenes | γ-Aminobutyric acid receptors | acetylcholinesterase | essential oils | octopamine receptor | insect nervous system | bioinsecticides
Insect nervous system | Octopamine receptor | Bioinsecticides | Acetylcholinesterase | Essential oils | GABA receptors | Insecticides - chemistry | Oils, Volatile - chemistry | Calcium - metabolism | Allosteric Regulation | Nervous System - metabolism | Cholinesterase Inhibitors - chemistry | Octopamine - metabolism | Secondary Metabolism | Terpenes - chemistry | Animals | Insecticides - metabolism | Terpenes - metabolism | Cholinesterase Inhibitors - metabolism | Insect Control | Receptors, Biogenic Amine - metabolism | Receptors, GABA - metabolism | Insecta - physiology | Ligands | Oils, Volatile - metabolism | Cyclic AMP - metabolism | Acetylcholinesterase - metabolism | Binding | Potentiation | Octopamine receptors | Calcium | Insecticides | Nervous system | Lipophilic | Receptors | γ-Aminobutyric acid | Neurotoxicity | Secondary metabolites | Allosteric properties | Metabolites | Insects | Octopamine | Oils & fats | Paralysis | Terpenes | γ-Aminobutyric acid receptors | acetylcholinesterase | essential oils | octopamine receptor | insect nervous system | bioinsecticides
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Loading RightsFood and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 96 - 103
Inhibitory effect of the -hexane, dichloromethane, ethyl acetate, and ethanol extracts from L. (dill) cultivated under organic (AG-O) and conventional (AG-C)...
Enzyme inhibition | Anethum graveolens | Oil | Dill | Phenolic acid | Antioxidant activity | CHOLINESTERASE | BUTYRYLCHOLINESTERASE | ESSENTIAL OILS | TURKEY | FOOD SCIENCE & TECHNOLOGY | IN-VITRO | ACETYLCHOLINESTERASE | PLANTS | TOXICOLOGY | VEGETABLES | EXTRACTS | CONSTITUENTS | Oils, Volatile - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Anethum graveolens - chemistry | Antioxidants - metabolism | Oils, Volatile - pharmacology | Iron Chelating Agents - metabolism | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Cholinesterase Inhibitors - isolation & purification | Fish Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Fruit - chemistry | Enzyme Inhibitors - pharmacology | Fish Proteins - metabolism | Cholinesterase Inhibitors - analysis | Electrophorus | Enzyme Inhibitors - analysis | Food, Organic - analysis | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Enzyme Inhibitors - isolation & purification | Iron Chelating Agents - analysis | Iron Chelating Agents - isolation & purification | Fruit - growth & development | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Monoterpenes - metabolism | Monoterpenes - analysis | Acetylcholinesterase - metabolism | Plant Extracts - chemistry | Anethum graveolens - metabolism | Depsides - analysis | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Cinnamates - metabolism | Antioxidants - analysis | Fruit - metabolism | Depsides - metabolism | Nitric Oxide - antagonists & inhibitors | Antioxidants - pharmacology | Oils, Volatile - isolation & purification | Drug Discovery | Animals | Iron Chelating Agents - pharmacology | Horses | Cinnamates - analysis | Anethum graveolens - growth & development | Fungal Proteins - metabolism | Antioxidants | Monounsaturated fatty acids | Analysis | Index Medicus
Enzyme inhibition | Anethum graveolens | Oil | Dill | Phenolic acid | Antioxidant activity | CHOLINESTERASE | BUTYRYLCHOLINESTERASE | ESSENTIAL OILS | TURKEY | FOOD SCIENCE & TECHNOLOGY | IN-VITRO | ACETYLCHOLINESTERASE | PLANTS | TOXICOLOGY | VEGETABLES | EXTRACTS | CONSTITUENTS | Oils, Volatile - chemistry | Plant Extracts - pharmacology | Solvents - chemistry | Anethum graveolens - chemistry | Antioxidants - metabolism | Oils, Volatile - pharmacology | Iron Chelating Agents - metabolism | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Cholinesterase Inhibitors - isolation & purification | Fish Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Fruit - chemistry | Enzyme Inhibitors - pharmacology | Fish Proteins - metabolism | Cholinesterase Inhibitors - analysis | Electrophorus | Enzyme Inhibitors - analysis | Food, Organic - analysis | Plant Extracts - isolation & purification | Acetylcholinesterase - chemistry | Enzyme Inhibitors - isolation & purification | Iron Chelating Agents - analysis | Iron Chelating Agents - isolation & purification | Fruit - growth & development | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Monoterpenes - metabolism | Monoterpenes - analysis | Acetylcholinesterase - metabolism | Plant Extracts - chemistry | Anethum graveolens - metabolism | Depsides - analysis | Fungal Proteins - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Monophenol Monooxygenase - metabolism | Cinnamates - metabolism | Antioxidants - analysis | Fruit - metabolism | Depsides - metabolism | Nitric Oxide - antagonists & inhibitors | Antioxidants - pharmacology | Oils, Volatile - isolation & purification | Drug Discovery | Animals | Iron Chelating Agents - pharmacology | Horses | Cinnamates - analysis | Anethum graveolens - growth & development | Fungal Proteins - metabolism | Antioxidants | Monounsaturated fatty acids | Analysis | Index Medicus
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Loading RightsToxicology and Applied Pharmacology, ISSN 0041-008X, 12/2017, Volume 337, pp. 67 - 75
The prevalence of obesity is increasing at an alarming rate in the United States with 36.5% of adults being classified as obese. Compared to normal...
Chlorpyrifos | Organophosphate | Endocannabinoid | Acetylcholinesterase | Carboxylesterase | High-fat diet | TRIACYLGLYCEROL HYDROLASE | PARAOXONASE-1 RESPONSE | NATIONAL-HEALTH | PERSISTENT ORGANIC POLLUTANTS | RAT-LIVER MICROSOMES | NONDIABETIC ADULTS | SERUM CONCENTRATIONS | DECREASES BLOOD-LIPIDS | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATIC STEATOSIS | Endocannabinoids - metabolism | Activation, Metabolic | Cholinesterase Inhibitors - toxicity | Liver - enzymology | Male | Obesity - blood | Chlorpyrifos - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Cholinesterase Inhibitors - metabolism | Liver - drug effects | Diet, High-Fat | Erythrocytes - enzymology | Hepatocytes - drug effects | Disease Models, Animal | Amidohydrolases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Rats, Sprague-Dawley | GPI-Linked Proteins - metabolism | Erythrocytes - drug effects | Obesity - metabolism | Hydrolysis | Phenotype | Animals | Insecticides - metabolism | Chlorpyrifos - toxicity | Obesity - enzymology | Insecticides - toxicity | Acetylcholinesterase - metabolism | Carboxylic Ester Hydrolases - metabolism | Hepatocytes - enzymology | Obesity | Enzyme inhibitors | Analysis | Insecticides | Mice | Xenobiotics | Fatty acids | Index Medicus
Chlorpyrifos | Organophosphate | Endocannabinoid | Acetylcholinesterase | Carboxylesterase | High-fat diet | TRIACYLGLYCEROL HYDROLASE | PARAOXONASE-1 RESPONSE | NATIONAL-HEALTH | PERSISTENT ORGANIC POLLUTANTS | RAT-LIVER MICROSOMES | NONDIABETIC ADULTS | SERUM CONCENTRATIONS | DECREASES BLOOD-LIPIDS | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEPATIC STEATOSIS | Endocannabinoids - metabolism | Activation, Metabolic | Cholinesterase Inhibitors - toxicity | Liver - enzymology | Male | Obesity - blood | Chlorpyrifos - metabolism | Monoacylglycerol Lipases - metabolism | Arachidonic Acids - metabolism | Cholinesterase Inhibitors - metabolism | Liver - drug effects | Diet, High-Fat | Erythrocytes - enzymology | Hepatocytes - drug effects | Disease Models, Animal | Amidohydrolases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Glycerides - metabolism | Polyunsaturated Alkamides - metabolism | Rats, Sprague-Dawley | GPI-Linked Proteins - metabolism | Erythrocytes - drug effects | Obesity - metabolism | Hydrolysis | Phenotype | Animals | Insecticides - metabolism | Chlorpyrifos - toxicity | Obesity - enzymology | Insecticides - toxicity | Acetylcholinesterase - metabolism | Carboxylic Ester Hydrolases - metabolism | Hepatocytes - enzymology | Obesity | Enzyme inhibitors | Analysis | Insecticides | Mice | Xenobiotics | Fatty acids | Index Medicus
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Ecotoxicology and Environmental Safety, ISSN 0147-6513, 04/2017, Volume 138, pp. 154 - 162
We investigated in the liver of dice snakes during pre- and post-hibernation changes in the following antioxidant parameters: total, manganese and copper zinc...
Oxidative stress | Natrix tessellate | Hibernation | Liver | Heavy metals | Dice snake | METALLOTHIONEIN | LIPID-PEROXIDATION | MYTILUS-GALLOPROVINCIALIS | ANTIOXIDANT ENZYMES | GLUTATHIONE S-TRANSFERASES | ENVIRONMENTAL SCIENCES | SEASONAL-CHANGES | TOXICOLOGY | METABOLIC-RATE | THAMNOPHIS-SIRTALIS-PARIETALIS | EXPOSURE | RANA-RIDIBUNDA | Adaptation, Physiological | Biomarkers - metabolism | Glutathione Peroxidase - metabolism | Metallothionein - metabolism | Metals, Heavy - metabolism | Oxidative Stress | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Liver - metabolism | Glutathione Transferase - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Colubridae - metabolism | Catalase - metabolism | Animals | Water - chemistry | Hibernation - physiology | Metals, Heavy - analysis | Female | Colubridae - physiology | Cholinesterases - metabolism | Lipid Peroxidation | Superoxide Dismutase - metabolism | Antioxidants | Zoology | Physiological aspects | Superoxide | Peroxidase | Snakes | Metallothionein | Enzymes | Biological monitoring | Index Medicus
Oxidative stress | Natrix tessellate | Hibernation | Liver | Heavy metals | Dice snake | METALLOTHIONEIN | LIPID-PEROXIDATION | MYTILUS-GALLOPROVINCIALIS | ANTIOXIDANT ENZYMES | GLUTATHIONE S-TRANSFERASES | ENVIRONMENTAL SCIENCES | SEASONAL-CHANGES | TOXICOLOGY | METABOLIC-RATE | THAMNOPHIS-SIRTALIS-PARIETALIS | EXPOSURE | RANA-RIDIBUNDA | Adaptation, Physiological | Biomarkers - metabolism | Glutathione Peroxidase - metabolism | Metallothionein - metabolism | Metals, Heavy - metabolism | Oxidative Stress | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Liver - metabolism | Glutathione Transferase - metabolism | Thiobarbituric Acid Reactive Substances - metabolism | Colubridae - metabolism | Catalase - metabolism | Animals | Water - chemistry | Hibernation - physiology | Metals, Heavy - analysis | Female | Colubridae - physiology | Cholinesterases - metabolism | Lipid Peroxidation | Superoxide Dismutase - metabolism | Antioxidants | Zoology | Physiological aspects | Superoxide | Peroxidase | Snakes | Metallothionein | Enzymes | Biological monitoring | Index Medicus
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Loading RightsEcotoxicology and Environmental Safety, ISSN 0147-6513, 06/2016, Volume 128, pp. 21 - 29
Heavy metal pollution of the aquatic environment is of great concern worldwide. Heavy metals are capable of inducing oxidative stress by increasing the...
Heavy metal ions | Oxidative stress | Pelophylax kl. esculentus | Frogs tissues | Antioxidative defense system | GLUTATHIONE-REDUCTASE | AQUATIC ORGANISMS | ACETYLCHOLINESTERASE ACTIVITY | LIPID-PEROXIDATION | VOLUME DECREASE RVD | ENVIRONMENTAL SCIENCES | CADMIUM | CYSTEINE METABOLISM | INDUCED OXIDATIVE STRESS | TOXICOLOGY | RISK-ASSESSMENT | RANA-RIDIBUNDA | Glutathione Peroxidase - metabolism | Environmental Monitoring | Glutathione - metabolism | Glutathione Reductase - metabolism | Skin - metabolism | Liver - metabolism | Glutathione Transferase - metabolism | Rivers | Water Pollutants, Chemical - analysis | Catalase - metabolism | Sulfhydryl Compounds - metabolism | Animals | Water Pollutants, Chemical - toxicity | Metals, Heavy - toxicity | Metals, Heavy - analysis | Ranidae - metabolism | Cholinesterases - metabolism | Oxidative Stress - drug effects | Muscles - metabolism | Serbia | Superoxide Dismutase - metabolism | Pollution | Glutathione transferase | Liver | Physiological aspects | Environmental aspects | Superoxide | Skin | Heavy metals | Index Medicus
Heavy metal ions | Oxidative stress | Pelophylax kl. esculentus | Frogs tissues | Antioxidative defense system | GLUTATHIONE-REDUCTASE | AQUATIC ORGANISMS | ACETYLCHOLINESTERASE ACTIVITY | LIPID-PEROXIDATION | VOLUME DECREASE RVD | ENVIRONMENTAL SCIENCES | CADMIUM | CYSTEINE METABOLISM | INDUCED OXIDATIVE STRESS | TOXICOLOGY | RISK-ASSESSMENT | RANA-RIDIBUNDA | Glutathione Peroxidase - metabolism | Environmental Monitoring | Glutathione - metabolism | Glutathione Reductase - metabolism | Skin - metabolism | Liver - metabolism | Glutathione Transferase - metabolism | Rivers | Water Pollutants, Chemical - analysis | Catalase - metabolism | Sulfhydryl Compounds - metabolism | Animals | Water Pollutants, Chemical - toxicity | Metals, Heavy - toxicity | Metals, Heavy - analysis | Ranidae - metabolism | Cholinesterases - metabolism | Oxidative Stress - drug effects | Muscles - metabolism | Serbia | Superoxide Dismutase - metabolism | Pollution | Glutathione transferase | Liver | Physiological aspects | Environmental aspects | Superoxide | Skin | Heavy metals | Index Medicus
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Loading RightsEcotoxicology, ISSN 0963-9292, 2/2008, Volume 17, Issue 2, pp. 93 - 101
Fish-eating birds can be exposed to levels of dietary methylmercury (MeHg) known or suspected to adversely affect normal behavior and reproduction, but little...
Environment, general | Neurochemistry | Ecotoxicology | Loon | Methylmercury | Environment | Ecology | Selenium | Mercury | Eagle | Environmental Management | mercury | neurochemistry | MINK MUSTELA-VISON | LUTRA-CANADENSIS | CEREBRAL-CORTEX | methylmercury | loon | ENVIRONMENTAL SCIENCES | selenium | PINCHI LAKE REGION | BRITISH-COLUMBIA | eagle | ECOLOGY | TOXICOLOGY | WILD RIVER OTTERS | RECEPTOR-BINDING | REPRODUCTION | EXPOSURE | Fishes - metabolism | Methylmercury Compounds - metabolism | Species Specificity | Receptors, N-Methyl-D-Aspartate - metabolism | Brain - enzymology | Receptors, Muscarinic - metabolism | Mercury - metabolism | Brain - metabolism | Tissue Distribution | Liver - drug effects | Biotransformation | Eagles - metabolism | Dealkylation | Liver - metabolism | Brain - drug effects | Food Chain | Mercury - toxicity | Water Pollutants, Chemical - metabolism | Animals | Selenium - metabolism | Water Pollutants, Chemical - toxicity | Methylmercury Compounds - toxicity | Birds - metabolism | Cholinesterases - metabolism | Monoamine Oxidase - metabolism | Selenium compounds | Environmental aspects | Physiological aspects | Methyl aspartate
Environment, general | Neurochemistry | Ecotoxicology | Loon | Methylmercury | Environment | Ecology | Selenium | Mercury | Eagle | Environmental Management | mercury | neurochemistry | MINK MUSTELA-VISON | LUTRA-CANADENSIS | CEREBRAL-CORTEX | methylmercury | loon | ENVIRONMENTAL SCIENCES | selenium | PINCHI LAKE REGION | BRITISH-COLUMBIA | eagle | ECOLOGY | TOXICOLOGY | WILD RIVER OTTERS | RECEPTOR-BINDING | REPRODUCTION | EXPOSURE | Fishes - metabolism | Methylmercury Compounds - metabolism | Species Specificity | Receptors, N-Methyl-D-Aspartate - metabolism | Brain - enzymology | Receptors, Muscarinic - metabolism | Mercury - metabolism | Brain - metabolism | Tissue Distribution | Liver - drug effects | Biotransformation | Eagles - metabolism | Dealkylation | Liver - metabolism | Brain - drug effects | Food Chain | Mercury - toxicity | Water Pollutants, Chemical - metabolism | Animals | Selenium - metabolism | Water Pollutants, Chemical - toxicity | Methylmercury Compounds - toxicity | Birds - metabolism | Cholinesterases - metabolism | Monoamine Oxidase - metabolism | Selenium compounds | Environmental aspects | Physiological aspects | Methyl aspartate
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Loading RightsEuropean Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 623, Issue 1, pp. 14 - 21
We have recently demonstrated that bis(7)-Cognitin, a promising multifunctional anti-Alzheimer s dimer, can remarkably reduce the generation of amyloid β...
Bis-Cognitin | Amyloid β peptide | α-Secretase | Protein kinase C | BACE-1 | BETA-SECRETASE | INDUCED NEURONAL APOPTOSIS | D-ASPARTATE RECEPTORS | AMYLOID-PRECURSOR-PROTEIN | HUPERZINE-A | alpha-Secretase | PKC ACTIVATION | DISEASE | PHARMACOLOGY & PHARMACY | Amyloid beta peptide | MULTIPLE-TARGETS | BIS-TACRINE | ACETYLCHOLINESTERASE INHIBITORS | Enzyme Activators - pharmacology | Amyloid Precursor Protein Secretases - genetics | AMP-Activated Protein Kinases - metabolism | Humans | Enzyme Activators - metabolism | Receptors, Muscarinic - metabolism | Aspartic Acid Endopeptidases - genetics | Dose-Response Relationship, Drug | Tacrine - pharmacology | Protein Isoforms - metabolism | Cholinesterase Inhibitors - metabolism | Protein Kinase C - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Phorbol Esters - pharmacology | Neurons - metabolism | Neurons - drug effects | Tacrine - analogs & derivatives | Muscarinic Antagonists - metabolism | Receptors, Muscarinic - genetics | Tacrine - metabolism | Peptide Fragments - metabolism | Cells, Cultured | Mutant Proteins - genetics | Alzheimer Disease - drug therapy | Rats | Mutant Proteins - metabolism | Protein Kinase C - antagonists & inhibitors | Amyloid Precursor Protein Secretases - metabolism | Phorbol Esters - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Cholinesterase Inhibitors - pharmacology | Aspartic Acid Endopeptidases - metabolism | Neurons - enzymology | Cell Line, Tumor | Mice | Protein Isoforms - genetics
Bis-Cognitin | Amyloid β peptide | α-Secretase | Protein kinase C | BACE-1 | BETA-SECRETASE | INDUCED NEURONAL APOPTOSIS | D-ASPARTATE RECEPTORS | AMYLOID-PRECURSOR-PROTEIN | HUPERZINE-A | alpha-Secretase | PKC ACTIVATION | DISEASE | PHARMACOLOGY & PHARMACY | Amyloid beta peptide | MULTIPLE-TARGETS | BIS-TACRINE | ACETYLCHOLINESTERASE INHIBITORS | Enzyme Activators - pharmacology | Amyloid Precursor Protein Secretases - genetics | AMP-Activated Protein Kinases - metabolism | Humans | Enzyme Activators - metabolism | Receptors, Muscarinic - metabolism | Aspartic Acid Endopeptidases - genetics | Dose-Response Relationship, Drug | Tacrine - pharmacology | Protein Isoforms - metabolism | Cholinesterase Inhibitors - metabolism | Protein Kinase C - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Phorbol Esters - pharmacology | Neurons - metabolism | Neurons - drug effects | Tacrine - analogs & derivatives | Muscarinic Antagonists - metabolism | Receptors, Muscarinic - genetics | Tacrine - metabolism | Peptide Fragments - metabolism | Cells, Cultured | Mutant Proteins - genetics | Alzheimer Disease - drug therapy | Rats | Mutant Proteins - metabolism | Protein Kinase C - antagonists & inhibitors | Amyloid Precursor Protein Secretases - metabolism | Phorbol Esters - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Cholinesterase Inhibitors - pharmacology | Aspartic Acid Endopeptidases - metabolism | Neurons - enzymology | Cell Line, Tumor | Mice | Protein Isoforms - genetics
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Loading RightsChemistry and Biodiversity, ISSN 1612-1872, 2008, Volume 5, Issue 12, pp. 2465 - 2578
This review is part of a series of review articles on the metabolism of drugs and other xenobiotics published in Chemistry & Biodiversity. After a thorough...
FLAVIN-CONTAINING MONOOXYGENASE-3 | CATECHOL-O-METHYLTRANSFERASE | HUMAN CYTOSOLIC SULFOTRANSFERASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-SERUM CHOLINESTERASE | AFRICAN-AMERICAN SUBJECTS | HISTAMINE N-METHYLTRANSFERASE | HUMAN CYTOCHROME-P450 ENZYMES | CHEMISTRY, MULTIDISCIPLINARY | SINGLE-NUCLEOTIDE POLYMORPHISMS | COMMON GENETIC POLYMORPHISMS | THIOPURINE-S-METHYLTRANSFERASE | Species Specificity | Oxidoreductases - genetics | Humans | Rats | Genotype | Oxidoreductases - chemistry | Polymorphism, Genetic | Cytochrome P-450 Enzyme System - chemistry | Pharmaceutical Preparations - metabolism | Animals | Enzymes - genetics | Pharmaceutical Preparations - chemistry | Sex Factors | Cytochrome P-450 Enzyme System - genetics | Mice | Mutation | Pharmacokinetics | Enzymes - metabolism
FLAVIN-CONTAINING MONOOXYGENASE-3 | CATECHOL-O-METHYLTRANSFERASE | HUMAN CYTOSOLIC SULFOTRANSFERASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN-SERUM CHOLINESTERASE | AFRICAN-AMERICAN SUBJECTS | HISTAMINE N-METHYLTRANSFERASE | HUMAN CYTOCHROME-P450 ENZYMES | CHEMISTRY, MULTIDISCIPLINARY | SINGLE-NUCLEOTIDE POLYMORPHISMS | COMMON GENETIC POLYMORPHISMS | THIOPURINE-S-METHYLTRANSFERASE | Species Specificity | Oxidoreductases - genetics | Humans | Rats | Genotype | Oxidoreductases - chemistry | Polymorphism, Genetic | Cytochrome P-450 Enzyme System - chemistry | Pharmaceutical Preparations - metabolism | Animals | Enzymes - genetics | Pharmaceutical Preparations - chemistry | Sex Factors | Cytochrome P-450 Enzyme System - genetics | Mice | Mutation | Pharmacokinetics | Enzymes - metabolism
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