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International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 1842
As in humans, osteoarthritis (OA) causes considerable economic loss to the equine industry. New hopes for cartilage repair have emerged with the... 
Col1a1 | Chondrocyte | Tissue engineering | Dedifferentiation | Hypoxia | Matrix-associated autologous chondrocyte implantation (MACI) | HtrA1 | BMP-2 | Equine model | Type II collagen | SiRNA | CARTILAGE REPAIR | OSTEOARTHRITIC CHONDROCYTES | matrix-associated autologous chondrocyte implantation (MACI) | hypoxia | tissue engineering | BONE MORPHOGENETIC PROTEIN-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERINE-PROTEASE HTRA1 | dedifferentiation | siRNA | COLLAGEN SPONGE SCAFFOLDS | HUMAN ARTICULAR CHONDROCYTES | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | CHONDROGENIC EXPRESSION | type II collagen | equine model | chondrocyte | II COLLAGEN | TERM-FOLLOW-UP | Bone Morphogenetic Protein 2 - pharmacology | RNA, Small Interfering - genetics | Chondrocytes - cytology | Collagen Type I - metabolism | Cartilage, Articular - cytology | Collagen Type III - metabolism | Extracellular Matrix - metabolism | Cell Differentiation - genetics | Chondrocytes - drug effects | Phenotype | Animals | RNA Interference | Cartilage, Articular - metabolism | Cell Differentiation - drug effects | Bone Morphogenetic Protein 2 - metabolism | Biomarkers | Horses | Cell Culture Techniques | Cell Hypoxia - genetics | Chondrocytes - metabolism | Tissue Engineering | Medical research | Cell culture | Therapy | Collagen (type I) | Bone morphogenetic protein 2 | RNA-mediated interference | Interference | Clinical trials | Implantation | Data processing | Ribonucleic acid--RNA | Cartilage | Biomedical materials | Collagen | Chondrocytes | Autologous chondrocyte implantation | Extracellular matrix | Biocompatibility | Osteoarthritis | Three dimensional models | Cartilage diseases | Life Sciences
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2010, Volume 402, Issue 1, pp. 23 - 29
The MAPK/ERK pathway is involved in IL-1b-induced cyclooxygenase (COX-2) expression and prostaglandin E2 (PGE2) production; two factors that play important... 
Chondrocytes
Journal Article
Central European Journal of Immunology, ISSN 1426-3912, 2018, Volume 43, Issue 2, pp. 209 - 219
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6082, pp. 717 - 721
Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that... 
Cartilage | Molecules | REPORTS | Chondrocytes | Collagens | Stem cells | Lead | Arthritis | Chondrogenesis | Osteoarthritis | Vehicles | PATHOGENESIS | GENE | ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | FILAMIN | OSTEOARTHRITIS | BONE | TRANSCRIPTION FACTOR | EXPRESSION | CHONDROGENESIS | CHONDROCYTE DIFFERENTIATION | Anilides - therapeutic use | Chondrocytes - cytology | Phthalic Acids - chemistry | Humans | Anilides - chemistry | Structure-Activity Relationship | Osteoarthritis - drug therapy | Osteoarthritis - physiopathology | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cell Nucleus - metabolism | Chondrocytes - physiology | Cattle | Microfilament Proteins - metabolism | Osteoarthritis - pathology | Phthalic Acids - pharmacology | Contractile Proteins - metabolism | Chondrocytes - metabolism | Mesenchymal Stromal Cells - physiology | Core Binding Factor beta Subunit - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | Phthalic Acids - therapeutic use | Core Binding Factor Alpha 2 Subunit - metabolism | Cartilage, Articular - cytology | Filamins | Phthalic Acids - administration & dosage | Regeneration | Animals | High-Throughput Screening Assays | Anilides - administration & dosage | Small Molecule Libraries | Anilides - pharmacology | Mice | Care and treatment | Physiological aspects | Transplantation | Methods | Molecular biology | Biomedical materials | Effectiveness | Breakdown | Biocompatibility | Articular | Adults
Journal Article
Journal Article
Development (Cambridge), ISSN 0950-1991, 01/2017, Volume 144, Issue 2, pp. 221 - 234
Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature to... 
Pluripotency programs | Fracture repair | Endochondral ossification | Chondrocyte transformation | OSTEOBLAST DIFFERENTIATION | MARROW | DEVELOPMENTAL BIOLOGY | SIGNALING CENTER | MESENCHYMAL STEM-CELLS | CHONDROCYTE DIFFERENTIATION | CRE ACTIVITY | OCT4 EXPRESSION | IN-VIVO | HYPERTROPHIC CHONDROCYTES | SOX9 | Human Umbilical Vein Endothelial Cells | Bony Callus - growth & development | Chondrocytes - cytology | Osteogenesis - physiology | Humans | Male | Cell Transdifferentiation - genetics | Chondrocytes - physiology | Cartilage - cytology | Fracture Healing - physiology | Cartilage - physiology | Osteoblasts - cytology | Bone and Bones - cytology | Bone and Bones - physiology | Neovascularization, Physiologic - genetics | Mice, Inbred C57BL | Osteoblasts - physiology | Pluripotent Stem Cells - physiology | Cells, Cultured | Up-Regulation - genetics | Mice, Knockout | Chondrogenesis - physiology | Neovascularization, Physiologic - physiology | Animals | Mice | Fracture Healing - genetics | Bony Callus - metabolism | Callus | Transformation | Therapeutic applications | Oct-4 protein | Cell division | Bone healing | Osteoblasts | Endothelial cells | Ossification | Cartilage | Growth plate | Regeneration | Fractures | Molecular modelling | Rodents | Chondrocytes | Bone (endochondral) | Pluripotency | Hypertrophy | Apoptosis | Stem Cells and Regeneration
Journal Article
International Journal of Artificial Organs, ISSN 0391-3988, 08/2011, Volume 34, Issue 8, pp. 690 - 691
Objectives: The degeneration of the nucleus pulposus (NP) is one major reason for low back pain. One possible method of treatment is cell-based therapy with... 
Chondrocytes
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 658 - 10
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 2011, Volume 7, Issue 1, pp. 234 - 243
Journal Article
Biomaterials, ISSN 0142-9612, 02/2014, Volume 35, Issue 7, pp. 2207 - 2217
We developed an injectable hydrogel system to evaluate the effect of hydrogel stiffness on chondrocyte cellular functions in a three-dimensional (3D)... 
Cartilage | Injectable | Chondrocyte | Stiffness | Hydrogel
Journal Article
European Cells and Materials, ISSN 1473-2262, 2015, Volume 30, pp. 200 - 209
Joint injury often leads to post-traumatic osteoarthritis (PTOA). Acute injury responses to trauma induce production of pro-inflammatory cytokines and... 
CDK9 | Cartilage | Flavopiridol | Inflammatory cytokines | Chondrocytes | CYTOKINES | MATERIALS SCIENCE, BIOMATERIALS | chondrocytes | ENGINEERING, BIOMEDICAL | cartilage | TRANSCRIPTION | inflammatory cytokines | COMPRESSION | ANTERIOR CRUCIATE LIGAMENT | DEGENERATION | CELL & TISSUE ENGINEERING | OSTEOARTHRITIC CARTILAGE | IMPACT | POSTTRAUMATIC OSTEOARTHRITIS | GENE-EXPRESSION | ARTICULAR CHONDROCYTES | Chondrocytes - pathology | Inflammation - pathology | Apoptosis - drug effects | Extracellular Matrix - drug effects | RNA, Messenger - genetics | Extracellular Matrix - metabolism | Stress, Mechanical | Apoptosis - genetics | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | RNA, Messenger - metabolism | Cartilage, Articular - pathology | Chondrocytes - drug effects | Animals | Cartilage, Articular - metabolism | Cattle | Inflammation - genetics | Cyclin-Dependent Kinase 9 - metabolism | Protein Kinase Inhibitors - pharmacology | Cartilage, Articular - drug effects | Chondrocytes - metabolism | to the subsequent induction of chondrocyte apoptosis and cartilage matrix deterioration. Thus | we determined the effects of CDK9 inhibition in suppressing the injury response in mechanically-injured cartilage explants. Bovine cartilage explants were injured by a single compressive load of 30 % strain at 100 %/s | we measured the mRNA expression of pro-inflammatory cytokines | and chondrocyte viability and apoptosis by TUNEL staining. For long-term outcome | and by determining the mechanical properties with instantaneous and relaxation moduli. Our data showed CDK9 inhibitor markedly reduced injury-induced inflammatory cytokine and catabolic gene expression. CDK9 inhibitor also attenuated chondrocyte apoptosis and reduced cartilage matrix degradation. Lastly | and apoptotic genes by RT-PCR | and then treated with the CDK9 inhibitor Flavopiridol. To assess acute injury responses | catabolic enzymes | acute injury responses | cartilage matrix degradation was assessed by soluble glycosaminoglycan release | the mechanical properties of the injured explants were preserved by CDK9 inhibitor. Our results provide a temporal profile connecting the chain of events from mechanical impact | and thus it is an attractive target for limiting the injury response. Here | which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiting step for transcriptional activation of injury response genes is controlled by cyclin-dependent kinase 9 (CDK9)
Journal Article
The American Journal of Sports Medicine, ISSN 0363-5465, 02/2008, Volume 36, Issue 2, pp. 235 - 246
Journal Article
PLoS ONE, 08/2013, Volume 8, Issue 8
Multiple osteochondromas (MO) is an inherited skeletal disorder, and the molecular mechanism of MO remains elusive. Exome sequencing has high chromosomal... 
Chondrocytes
Journal Article