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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 30, pp. 15068 - 15073
Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin... 
EVOLUTIONARY ORIGIN | MULTIDISCIPLINARY SCIENCES | cartilage | TRANSCRIPTION | bone | SPECIFICATION | MODEL | GLIAL-CELLS | glia | MESENCHYMAL STEM-CELLS | Schwann cell precursors | NEURONS | DIFFERENTIATION | NEURAL CREST | mesenchymal cells | EXPRESSION | Chromaffin Cells - cytology | Chondrocytes - cytology | Nerve Tissue - metabolism | Nerve Tissue - cytology | Embryo, Mammalian | Multipotent Stem Cells - metabolism | Melanocytes - metabolism | Neurons - cytology | Neural Stem Cells - cytology | Zebrafish - embryology | Schwann Cells - cytology | Neural Crest - metabolism | Neuroglia - cytology | Nerve Tissue - embryology | Melanocytes - cytology | Bone and Bones - metabolism | Mesenchymal Stem Cells - cytology | Myelin Proteolipid Protein - metabolism | Cell Differentiation | Neurons - metabolism | Mesenchymal Stem Cells - metabolism | Cell Lineage - genetics | Chondrocytes - metabolism | Bone and Bones - cytology | Biomarkers - metabolism | Nerve Fibers - metabolism | Gene Expression | Neural Crest - cytology | Osteocytes - metabolism | SOXE Transcription Factors - metabolism | Osteocytes - cytology | Neural Crest - growth & development | Schwann Cells - metabolism | Embryonic Development | Zebrafish - genetics | Chromaffin Cells - metabolism | Animals | Multipotent Stem Cells - cytology | Myelin Proteolipid Protein - genetics | Zebrafish - metabolism | Embryo, Nonmammalian | Neuroglia - metabolism | Mice | Bone and Bones - embryology | Neural Stem Cells - metabolism | SOXE Transcription Factors - genetics | Embryonic development | Animal models | Mesenchyme | Osteocytes | Zebrafish | Nervous system | Melanocytes | Glial cells | Cell differentiation | Population genetics | Fibers | Embryonic growth stage | Chromaffin cells | Craniofacial growth | Embryogenesis | Biomedical materials | Evolutionary conservation | Precursors | Chondrocytes | Biocompatibility | Skeleton | Parasympathetic nervous system | Biological Sciences
Journal Article
Circulation research, ISSN 1524-4571, 2009, Volume 104, Issue 6, pp. 733 - 741
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. To develop appropriate prevention and/or therapeutic strategies for... 
Vascular calcification | Smooth muscle cells | Genetic fate mapping | Lineage reprogramming | Runx2/Cbfa1 | WALL | CARDIAC & CARDIOVASCULAR SYSTEMS | vascular calcification | ATHEROSCLEROSIS | lineage reprogramming | genetic fate mapping | CARTILAGE | smooth muscle cells | IN-VITRO | DEFICIENT | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | MATRIX-GLA-PROTEIN | HEMATOLOGY | EXPRESSION | Calcinosis - genetics | Vascular Diseases - pathology | Homeodomain Proteins - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Arteries - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Mice, Mutant Strains | Bone Morphogenetic Protein 2 - metabolism | Calcinosis - metabolism | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | SOX9 Transcription Factor - metabolism | Bone Morphogenetic Protein 2 - genetics | Chondrocytes - pathology | RNA, Messenger - genetics | Vascular Diseases - genetics | Arteries - pathology | Transcription Factors - genetics | Down-Regulation - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Proteins - genetics | Transcription Factors - metabolism | Animals | Proteins - metabolism | Sp7 Transcription Factor | Stem Cells - pathology | Wnt3 Protein | Mice | Calcinosis - pathology | Vascular Diseases - metabolism | Wnt3A Protein | Cell Dedifferentiation - genetics | SOX9 Transcription Factor - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Cbfa1 | Runx2
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0188398
Epithelial and stromal stem cells are required to maintain corneal transparency. The aim of the study was to develop a new method to isolate and grow both... 
PROGENITOR CELLS | THERAPY | NEURAL CREST DERIVATIVES | MULTIDISCIPLINARY SCIENCES | CULTURE-CONDITIONS | TISSUE | NICHE | PAX6 | EXPRESSION | TRANSPLANTATION | Cell Proliferation | Humans | Adipocytes - drug effects | Spheroids, Cellular - cytology | PAX6 Transcription Factor - genetics | Limbus Corneae - drug effects | Corneal Stroma - cytology | Polycomb Repressive Complex 1 - genetics | Limbus Corneae - metabolism | Epithelium, Corneal - drug effects | Cell Differentiation | Neurons - metabolism | Culture Media - chemistry | Neoplasm Proteins - genetics | Fibroblasts - metabolism | Biomarkers - metabolism | Corneal Stroma - drug effects | SOX9 Transcription Factor - metabolism | Gene Expression | Corneal Stroma - metabolism | Spheroids, Cellular - metabolism | Keratinocytes - drug effects | Keratinocytes - metabolism | Fibroblasts - drug effects | Fibroblasts - cytology | Chondrocytes - cytology | Epithelial Cells - metabolism | Epithelium, Corneal - cytology | Polycomb Repressive Complex 1 - metabolism | Epithelial Cells - drug effects | Adipocytes - cytology | Neurons - cytology | Stem Cells - cytology | Neoplasm Proteins - metabolism | Stem Cells - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Chondrocytes - drug effects | Nestin - genetics | Spheroids, Cellular - drug effects | Epithelial Cells - cytology | Neurons - drug effects | Chondrocytes - metabolism | PAX6 Transcription Factor - metabolism | Keratinocytes - cytology | Cell Separation - methods | Nestin - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Adipocytes - metabolism | Culture Media - pharmacology | Epithelium, Corneal - metabolism | Stem Cells - drug effects | Primary Cell Culture | Limbus Corneae - cytology | SOX9 Transcription Factor - genetics | Physiological aspects | Cornea | Genetic aspects | Research | Stem cells | Vimentin | Bioengineering | Cell culture | Nestin | Transparency | Media (culture) | Transplants & implants | Sox9 protein | Osteocytes | Adipocytes | Scraping | Biomedical materials | Epidermal growth factor | Fibroblasts | Biocompatibility | Chondrogenesis | Explants | Second harmonic generation | Colonies | Fibrils | Forming | Collagenase | Sox10 protein | Studies | Pax6 protein | Microscopy | Biopsy | Collagen | Chondrocytes | Differentiation | Methods | Life Sciences | Cellular Biology
Journal Article
Matrix biology, ISSN 0945-053X, 2018, Volume 70, pp. 102 - 122
Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous health condition that affects millions of people world-wide, and causes... 
Animal models | SM/J | LG/J | Intervertebral disc degeneration | Matrix degradation | Nucleus pulposus | Hypertrophy | LOW-BACK-PAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INBRED STRAINS | BONE MICROSTRUCTURE | MECHANICAL-PROPERTIES | LUMBAR | AGGRECAN | CELL BIOLOGY | NUCLEUS PULPOSUS CELLS | ARTICULAR-CARTILAGE | MICE | EXPRESSION | Annulus Fibrosus - metabolism | Humans | Alkaline Phosphatase - metabolism | Pyrophosphatases - genetics | Extracellular Matrix - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Wnt Proteins - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - pathology | Collagen Type X - metabolism | Wnt Proteins - genetics | Annulus Fibrosus - pathology | Cell Death | Female | Chondrocytes - metabolism | Disease Models, Animal | Intervertebral Disc Degeneration - genetics | Chondrocytes - pathology | Alkaline Phosphatase - genetics | Phosphoric Diester Hydrolases - metabolism | Nucleus Pulposus - metabolism | Signal Transduction | Glycosaminoglycans - metabolism | Matrix Metalloproteinase 13 - genetics | Gene Expression Regulation | Nucleus Pulposus - pathology | Collagen Type X - genetics | Mice, Transgenic | Phosphoric Diester Hydrolases - genetics | Aggrecans - metabolism | Aggrecans - genetics | Matrix Metalloproteinase 13 - metabolism | Pyrophosphatases - metabolism | Animals | Connective Tissue Growth Factor - genetics | Mice | Extracellular Matrix - pathology | Connective Tissue Growth Factor - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Homeostasis - genetics | Physiological aspects | Endothelial growth factors | Cell death | Collagen | Analysis | Cells | intervertebral disc degeneration | matrix degradation | hypertrophy | nucleus pulposus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 5, pp. 1875 - 1880
Here we examined the involvement of Notch signaling in the endochondral ossification process, which is crucial for osteoarthritis (OA) development.... 
Cartilage | Knee joint | Articular cartilage | Chondrocytes | Ligands | Bones | Mice | Skeletal development | Gene expression regulation | Osteoarthritis | Cartilage degradation | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | skeletal development | BONE-DEVELOPMENT | LIGANDS | ARTICULAR-CARTILAGE | PATHWAY | GROWTH | cartilage degradation | DIFFERENTIATION | RECEPTORS | EXPRESSION | REVEALS | Cartilage - pathology | Homeodomain Proteins - metabolism | Humans | Cartilage - drug effects | Collagen Type II - metabolism | Knee Joint - pathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Serrate-Jagged Proteins | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Jagged-1 Protein | SOX9 Transcription Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Membrane Proteins - genetics | Osteoarthritis - metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Cell Line, Tumor | HeLa Cells | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Receptor, Notch2 - antagonists & inhibitors | Receptor, Notch2 - genetics | Chondrocytes - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - metabolism | Chondrocytes - metabolism | Calcium-Binding Proteins - metabolism | Knee Joint - metabolism | Cell Line | Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism | Osteoarthritis - prevention & control | Dipeptides - pharmacology | Knee Joint - drug effects | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Receptor, Notch1 - metabolism | Cartilage - metabolism | Collagen Type II - genetics | Homeodomain Proteins - genetics | Osteoarthritis - genetics | Animals | Fluorescent Antibody Technique | SOX9 Transcription Factor - genetics | Osteogenesis | Endochondral ossification | Physiological aspects | Development and progression | Cellular signal transduction | Health aspects | Membrane proteins | Biological Sciences
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2011, Volume 15, Issue 3, pp. 635 - 646
Tumour‐associated fibroblasts (TAFs) are part of the tumour stroma, providing functional and structural support for tumour progression and development. The... 
tumour‐associated fibroblasts (TAFs) | cytokines | tumour stroma | pluripotency | growth factors | mesenchymal stem cells (MSCs) | Tumour stroma | Mesenchymal stem cells (MSCs) | Tumour-associated fibroblasts (TAFs) | Cytokines | Growth factors | Pluripotency | MEDICINE, RESEARCH & EXPERIMENTAL | BONE-MARROW | PROLIFERATION | INTERMEDIATE FILAMENTS | CANCER | DELIVERY | BETA | CELL BIOLOGY | tumour-associated fibroblasts (TAFs) | VEHICLES | NK CELLS | MARROW STROMAL CELLS | Tumor Necrosis Factor-alpha - metabolism | Chondrocytes - cytology | Cell Proliferation | Vimentin - metabolism | Humans | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Adipocytes - cytology | Vascular Endothelial Growth Factor A - metabolism | Fibroblasts - ultrastructure | Mesenchymal Stromal Cells - cytology | Mesenchymal Stromal Cells - ultrastructure | Hyaluronan Receptors - metabolism | Interleukin-10 - metabolism | Female | Cell Differentiation | Osteoblasts - cytology | HLA-DR Antigens - metabolism | Chondrocytes - metabolism | Fibroblasts - metabolism | Cell Line | Interleukin-1 - metabolism | Microscopy, Electron, Transmission | Bone Marrow Cells - cytology | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Fibroblasts - pathology | Muscle, Smooth - chemistry | Bone Marrow Cells - ultrastructure | Integrin beta1 - metabolism | Breast Neoplasms - pathology | Adipocytes - metabolism | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | Lysosomes | Smooth muscle | Biology | Leukocytes | Adipocytes | CD29 antigen | Cell surface | Osteoblasts | Proteins | Genotype & phenotype | CD90 antigen | Biomedical materials | Filaments | Actin | CD44 antigen | Bone marrow | Fibroblasts | Extracellular matrix | CD73 antigen | Autocrine signalling | Chondrogenesis | Vascular endothelial growth factor | Antigens | Phenotypes | Intermediate filaments | Muscles | Cell differentiation | Analogies | Osteoblastogenesis | Stem cells | Chondrocytes | Cytoskeleton | Chemokines | Tumors | Cancer
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | COLLAGEN | RHEUMATOLOGY | DIFFERENTIATED PHENOTYPE | HYPERTROPHY | IN-VITRO | SYNOVIAL FIBROBLASTS | HUMAN OSTEOARTHRITIC CARTILAGE | SIGNALING PATHWAY | beta-Catenin | ARTICULAR CHONDROCYTES | ORTHOPEDICS | KNEE OSTEOARTHRITIS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2005, Volume 174, Issue 8, pp. 5016 - 5023
Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU) deposited in synovium and articular cartilage initiate joint inflammation... 
REGULATED KINASE | ACTIVATION | RECEPTOR 2 | PROTEIN | PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | TRANSCRIPTION | IMMUNOLOGY | EXPRESSION | INTERLEUKIN-8 | CUTTING EDGE | Protein Kinases - metabolism | Calcium Pyrophosphate - toxicity | Toll-Like Receptor 2 | Membrane Glycoproteins - metabolism | Chondrocytes - immunology | Humans | Calcium Pyrophosphate - metabolism | DNA, Complementary - genetics | Chondrocalcinosis - immunology | Interleukin-1 Receptor-Associated Kinases | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Receptors, Cell Surface - antagonists & inhibitors | Chondrocytes - drug effects | Toll-Like Receptors | Membrane Glycoproteins - antagonists & inhibitors | Cattle | Base Sequence | Antigens, Differentiation - metabolism | Gout - immunology | Chondrocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Nitric Oxide - biosynthesis | Gene Expression | Uric Acid - metabolism | Signal Transduction | Uric Acid - toxicity | RNA, Messenger - genetics | Cells, Cultured | Crystallization | Receptors, Cell Surface - metabolism | Myeloid Differentiation Factor 88 | I-kappa B Kinase | Immunity, Innate | Gout - etiology | Membrane Glycoproteins - genetics | Proto-Oncogene Proteins c-akt | Adaptor Proteins, Signal Transducing | Gout - metabolism | Animals | Models, Biological | Chondrocalcinosis - etiology | TNF Receptor-Associated Factor 6 - metabolism | Chondrocalcinosis - metabolism | Receptors, Immunologic - metabolism | rac1 GTP-Binding Protein - metabolism | Receptors, Cell Surface - genetics
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 23, Issue 12, pp. 2288 - 2296
Summary Objective Hypoxia-inducible factor-2α (HIF-2α) transcriptionally upregulates Nampt in articular chondrocytes. NAMPT, which exhibits nicotinamide... 
Rheumatology | NAD+ biosynthesis | Hypoxia-inducible factor (HIF) | Sirtuin | Osteoarthritis | Chondrocytes | NAD | biosynthesis | APOPTOSIS | RHEUMATOLOGY | SIRTUINS | NAD(+) biosynthesis | SIRT1 | CARTILAGE | NUCLEUS PULPOSUS CELLS | METABOLISM | BIOLOGY | GROWTH | STRESS | ORTHOPEDICS | EXPRESSION | Sirtuin 1 - metabolism | Up-Regulation | Arthritis, Experimental - genetics | Immunoprecipitation | Matrix Metalloproteinase 12 - genetics | RNA, Messenger - metabolism | Sirtuin 1 - genetics | Arthritis, Experimental - metabolism | Sirtuin 2 - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Nicotinamide Phosphoribosyltransferase - metabolism | Cartilage, Articular - metabolism | Sirtuins - genetics | Cytokines - genetics | Chondrocytes - metabolism | NAD - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Matrix Metalloproteinase 13 - metabolism | Sirtuin 2 - genetics | Nicotinamide Phosphoribosyltransferase - genetics | Animals | Osteoarthritis, Knee - genetics | Mice | Matrix Metalloproteinase 3 - genetics | Sirtuins - metabolism | Osteoarthritis, Knee - metabolism
Journal Article