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Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 41, pp. 28284 - 28298
Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is composed of the following repeating trisaccharide unit: ->... 
RESIDUAL DIPOLAR COUPLINGS | FREE-RADICAL DEPOLYMERIZATION | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LEWIS-X | HUMAN-LEUKOCYTE ELASTASE | P-SELECTIN | ANTICOAGULANT ACTIVITIES | HEPARAN-SULFATE | MOLECULAR-DYNAMICS SIMULATIONS | STICHOPUS-JAPONICUS | Leukocyte Elastase - metabolism | Sea Cucumbers - chemistry | Chondroitin Sulfates - metabolism | P-Selectin - metabolism | Hydrogen Peroxide | Proteinase Inhibitory Proteins, Secretory - metabolism | Molecular Sequence Data | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Iron | Proteinase Inhibitory Proteins, Secretory - chemistry | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Leukocyte Elastase - antagonists & inhibitors | Leukocyte Disorders - metabolism | P-Selectin - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | L-Selectin - metabolism | Immune System Diseases - metabolism | Peritonitis - pathology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Immune System Diseases - pathology | Neutrophils - metabolism | Neutrophil Infiltration - drug effects | Neutrophils - pathology | Oxidation-Reduction | Neutrophils - drug effects | Peritonitis - metabolism | Models, Molecular | Chondroitin Sulfates - isolation & purification | Immune System Diseases - drug therapy | Leukocyte Disorders - pathology | Proteinase Inhibitory Proteins, Secretory - isolation & purification | Chondroitin Sulfates - pharmacology | Chondroitin Sulfates - chemistry | Leukocyte Disorders - drug therapy | Proteinase Inhibitory Proteins, Secretory - pharmacology | Animals | L-Selectin - chemistry | Mice | Peritonitis - drug therapy | Carbohydrate Conformation | Index Medicus | Carbohydrate-binding Protein | Selectin | Molecular Dynamics | Glycosaminoglycan | Glycobiology and Extracellular Matrices | Inflammation | Microarray | GAG | Carbohydrate Structure | Nuclear Magnetic Resonance (NMR)
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 33, pp. 13582 - 13587
Sulfate-reducing bacteria (SRB) colonize the guts of ~50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing, RNA-Seq, plus... 
Datasets | Ammonia | Microbiota | Polysaccharides | Gnotobiotics | Diet | Hydrogen | Humans | Mice | Sulfates | Hydrogen sulfide | Hydrogenotrophs | Artificial human gut microbiota/microbiome | Microbial foodwebs | Determinants of microbial fitness | hydrogenotrophs | CHONDROITIN SULFATE | RAT | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | COLON | SULFIDE | microbial foodwebs | hydrogen sulfide | FATTY-ACID OXIDATION | ANAEROBIC-BACTERIA | BACTEROIDES-THETAIOTAOMICRON | DESULFOVIBRIO-VULGARIS HILDENBOROUGH | artificial human gut microbiota/microbiome | determinants of microbial fitness | CONTINUOUS-CULTURE | Hydrogen Sulfide - metabolism | Chondroitin Sulfates - metabolism | Gas Chromatography-Mass Spectrometry | Species Specificity | Gastrointestinal Tract - microbiology | Bromodeoxyuridine | Chondroitin Sulfates - pharmacology | DNA Primers - genetics | Desulfovibrio - genetics | Sequence Analysis, DNA | Genetic Vectors - genetics | Chondroitin Sulfates - administration & dosage | Feces - microbiology | Animals | Mutagenesis | Desulfovibrio - drug effects | Desulfovibrio - metabolism | Mass Spectrometry | DNA Transposable Elements - genetics | Dietary Supplements | Desulfovibrio - growth & development | Physiological aspects | Sulfate-reducing bacteria | Genetic aspects | Research | Bacterial genetics | Microbial metabolism | Bacteria | Genomes | Metabolism | Digestive system | Mass spectrometry | Index Medicus | Biological Sciences | artificial human gut microbiota | microbiome
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 257 - 269
Fucosylated chondroitin sulfate (FCS), a structurally unusual glycosaminoglycan, has distinct anticoagulant properties, and is an especially strong inhibitor... 
Anticoagulant | Factor Xase inhibitor | Structure–activity relationship | Antithrombotic | Fucosylated chondroitin sulfate | Structureeactivity relationship | PHYSICOCHEMICAL CHARACTERISTICS | STICHOPUS-JAPONICUS SELENKA | FUCOSE BRANCHES | CHEMISTRY, MEDICINAL | FACTOR-IXA | THROMBIN | BLOOD PLATELETS | POLYSACCHARIDE ACCOUNT | SEA-CUCUMBER | Structure-activity relationship | MOLECULAR-WEIGHT HEPARINS | DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN | Fibrinolytic Agents - chemistry | Humans | Molecular Conformation | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Anticoagulants - chemical synthesis | Dose-Response Relationship, Drug | Cysteine Endopeptidases - metabolism | Anticoagulants - chemistry | Enzyme Inhibitors - chemistry | Fibrinolytic Agents - chemical synthesis | Enzyme Inhibitors - pharmacology | Rats | Chondroitin Sulfates - pharmacology | Chondroitin Sulfates - chemistry | Mice, Inbred Strains | Rats, Sprague-Dawley | Fibrinolytic Agents - pharmacology | Animals | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Factor XII - antagonists & inhibitors | Factor XII - metabolism | Mice | Thrombosis - drug therapy | Chondroitin Sulfates - chemical synthesis | Anticoagulants (Medicine) | Sulfates | Analysis | Chondroitin | Medical examination | Prothrombin | Thrombin | Blood | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2007, Volume 282, Issue 20, pp. 14984 - 14991
Heparin is an excellent inhibitor of P- and L-selectin binding to the carbohydrate determinant, sialyl Lewisx. As a consequence of its anti-selectin activity,... 
CARCINOMA MUCINS | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | P-SELECTIN | LUNG COLONIZATION | CELL-ADHESION | COLON | HEPARIN | CANCER | PLATELET-AGGREGATING ACTIVITIES | Sea Cucumbers - chemistry | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | P-Selectin - metabolism | Lung Neoplasms - metabolism | Pneumonia - pathology | Heparin - therapeutic use | Lung Neoplasms - pathology | Thioglycolates - toxicity | L-Selectin - metabolism | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Peritonitis - pathology | Neoplasm Metastasis | Adenocarcinoma - metabolism | Lung Neoplasms - secondary | Pneumonia - chemically induced | Heparin - pharmacology | Neutrophil Infiltration - drug effects | Disease Models, Animal | Lipopolysaccharides - toxicity | Peritonitis - metabolism | Anticoagulants - therapeutic use | Chondroitin Sulfates - pharmacology | Peritonitis - chemically induced | Chondroitin Sulfates - chemistry | Cell Adhesion - drug effects | Chondroitin Sulfates - therapeutic use | Adenocarcinoma - drug therapy | Animals | Pneumonia - drug therapy | Partial Thromboplastin Time | Anticoagulants - pharmacology | Mice | Neoplasms, Experimental - metabolism | Peritonitis - drug therapy | Carbohydrate Conformation | Pneumonia - metabolism | Neoplasms, Experimental - drug therapy | Index Medicus
Journal Article
Materials Science & Engineering C, ISSN 0928-4931, 02/2017, Volume 71, pp. 67 - 74
Journal Article