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Nature Neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 703 - 712
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict... 
RETINAL GANGLION-CELLS | NEURITE GROWTH | AXON REGENERATION | OPTIC-NERVE REGENERATION | SPINAL-CORD-INJURY | TYROSINE-PHOSPHATASE-SIGMA | CORTICOSPINAL TRACT REGENERATION | NOGO RECEPTOR | OLIGODENDROCYTE-MYELIN GLYCOPROTEIN | FUNCTIONAL RECEPTOR | NEUROSCIENCES | Protein Binding - genetics | Embryo, Mammalian | Humans | Myelin Proteins - deficiency | Nerve Regeneration - physiology | Myelin-Associated Glycoprotein - genetics | Myelin-Associated Glycoprotein - metabolism | Ganglia, Spinal - cytology | Dose-Response Relationship, Drug | Tubulin - metabolism | Transfection | GPI-Linked Proteins - deficiency | Receptor-Like Protein Tyrosine Phosphatases, Class 4 - pharmacology | Protein Binding - drug effects | Optic Nerve Injuries - metabolism | Neurons - metabolism | Nogo Receptor 1 | Neurons - drug effects | Receptors, Tumor Necrosis Factor - genetics | Animals, Newborn | Receptors, Tumor Necrosis Factor - metabolism | Gene Expression Regulation - genetics | Cells, Cultured | Chondroitin Sulfate Proteoglycans - metabolism | Gene Expression Regulation - physiology | Rats | Receptors, Cell Surface - metabolism | Mutation - genetics | Myelin Proteins - genetics | GPI-Linked Proteins - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Central Nervous System - cytology | Receptors, Cell Surface - deficiency | Mice | Myelin Proteins - metabolism | GPI-Linked Proteins - genetics | Receptors, Cell Surface - genetics | Neuroplasticity | Physiological aspects | Proteoglycans | Research | Chondroitin | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 09/2012, Volume 72, Issue 3, pp. 419 - 432
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, pp. e0189164 - e0189164
Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair... 
PROMOTES FUNCTIONAL RECOVERY | ACTIVATION | PLEIOTROPHIN | MULTIPLE-SCLEROSIS | MULTIDISCIPLINARY SCIENCES | DEMYELINATED LESIONS | REMYELINATION | EXTRACELLULAR-MATRIX | ASTROCYTES | RECEPTOR-TYPE-Z | ZETA/RPTP-BETA | Dosage and administration | Research | Cell differentiation | Neuroglia | Chondroitin | Protamine sulfate | Index Medicus
Journal Article
The Journal of neuroscience : the official journal of the Society for Neuroscience, ISSN 1529-2401, 04/2014, Volume 34, Issue 14, pp. 4822 - 36
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2012, Volume 109, Issue 23, pp. 9155 - 9160
Physical and chemical constraints imposed by the periinfarct glial scar may contribute to the limited clinical improvement often observed after ischemie brain... 
Glypicans | Neurites | Scars | Spinal cord | Neurons | Astrocytes | Central nervous system | Antibodies | Strokes | Behavioral neuroscience | Astrogliosis | Glia | Astrocyte | GLIAL SCAR | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | astrogliosis | DELAYED TREATMENT | glia | NEURITE OUTGROWTH | NEURAL STEM/PROGENITOR CELLS | ADULT-RAT | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | astrocyte | INHIBITORY MOLECULES | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Chondroitin ABC Lyase - administration & dosage | Rats | Glypicans - administration & dosage | Psychomotor Performance - drug effects | Stroke - drug therapy | Glial Fibrillary Acidic Protein - immunology | Chondroitin ABC Lyase - pharmacology | Neurocan - therapeutic use | Rats, Sprague-Dawley | Blotting, Western | Stroke - enzymology | Glypicans - therapeutic use | Microtubule-Associated Proteins - immunology | Chondroitin ABC Lyase - therapeutic use | Animals | Fibroblast Growth Factor 2 - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Neurocan - administration & dosage | Glypicans - pharmacology | Neurites - drug effects | Neurocan - pharmacology | Infusions, Intra-Arterial | Stroke (Disease) | Physiological aspects | Proteoglycans | Research | Patient outcomes | Neuroglia | Proteins | Brain damage | Stroke | Ischemia | Gene expression | Rodents | Index Medicus | Biological Sciences
Journal Article
by Zhong, J and Lan, C and Zhang, C and Yang, Y and Chen, WX and Zhang, KY and Zhao, HL and Fang, XY and Li, HH and Tan, L and Wang, P and Ge, HF and Hu, R and Feng, H
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 07/2019, Volume 120, Issue 7, pp. 11008 - 11021
Neural stem/progenitor cells (NSPCs) are a promising candidate for the cell-replacement therapy after central nervous system (CNS) injury. However, the short... 
neural stem | FUNCTIONAL RECOVERY | MATRIX | PROGENITORS | STEM-CELLS | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | progenitor cells | RECEPTOR | CELL BIOLOGY | PTP-SIGMA | alpha-actinin4 | chondroitin sulfate proteoglycan | protein tyrosine phosphatase receptor sigma | IN-VIVO | migration | NEUROGENESIS | DIFFERENTIATION
Journal Article
Matrix Biology, ISSN 0945-053X, 08/2013, Volume 32, Issue 6, pp. 352 - 363
Perineuronal nets (PNNs) are extracellular matrix structures consisting of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, link proteins and tenascin-R... 
Critical period plasticity | CSPG receptor | Perineuronal net | Mouse visual cortex | Parvalbumin interneuron | RAT CEREBRAL-CORTEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRITICAL PERIOD | PARVALBUMIN-CONTAINING NEURONS | TENASCIN-R | LATERAL GENICULATE-NUCLEUS | CELL BIOLOGY | EXTRACELLULAR-MATRIX | POSTNATAL-DEVELOPMENT | MONOCULAR DEPRIVATION | GABAERGIC NEURONS | N-ACETYLGALACTOSAMINE | Immunohistochemistry | Darkness | Visual Cortex - growth & development | Extracellular Matrix Proteins - biosynthesis | Extracellular Matrix - metabolism | Parvalbumins - metabolism | Male | Neurons - cytology | Neurogenesis - genetics | Extracellular Matrix - genetics | Gene Expression Regulation, Developmental | Hyaluronic Acid - biosynthesis | Parvalbumins - genetics | Female | Neurons - metabolism | Nogo Proteins | Plant Lectins - chemistry | Aggrecans - biosynthesis | Chondroitin Sulfate Proteoglycans - biosynthesis | Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics | Animals, Newborn | Receptors, N-Acetylglucosamine - chemistry | Signal Transduction | Visual Cortex - cytology | Mice, Inbred C57BL | Proteoglycans - biosynthesis | Myelin Proteins - genetics | Tenascin - biosynthesis | Extracellular Matrix - ultrastructure | Animals | Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism | Mice | Visual Cortex - metabolism | Myelin Proteins - metabolism | Extracellular Matrix - pathology | Lectins | Fluorescence | GABA | Hyaluronic acid | Sulfates | Chondroitin | Protein binding | Index Medicus
Journal Article
PLoS Medicine, ISSN 1549-1277, 08/2008, Volume 5, Issue 8, pp. 1262 - 1277
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 02/2018, Volume 96, Issue 2, pp. 222 - 233
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous... 
ALS | CSPG | PTPσ | reactive astrocyte | LAR | SOD1 | AXON GROWTH-INHIBITORS | SECRETASE-MEDIATED CLEAVAGE | PTP sigma | NEUROSCIENCES | INTRATHECAL DELIVERY | PROMOTES FUNCTIONAL RECOVERY | PTP-SIGMA | CNS INJURY | REACTIVE ASTROCYTES | SPINAL-CORD-INJURY | CENTRAL-NERVOUS-SYSTEM | PROTEIN-TYROSINE-PHOSPHATASE | Rats, Transgenic | Gene Expression Regulation - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Chondroitin Sulfate Proteoglycans - metabolism | Rats | Mutation - genetics | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | Analysis of Variance | Spinal Cord - pathology | Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism | Adenomatous Polyposis Coli Protein - metabolism | Statistics, Nonparametric | Superoxide Dismutase-1 - genetics | Female | Astrocytes - metabolism | Disease Models, Animal | Tyrosine | Medical research | Nervous system diseases | Phosphatases | Medicine, Experimental | Amyotrophic lateral sclerosis | Genetic engineering | Superoxide | Sulfates | Chondroitin | Central nervous system | Transgenic | Superoxide dismutase | Sclerosis | Receptors | Rodents | Extracellular matrix | Horns | Motor neurons | Proteoglycans | Neurons | Astrocytes | Gene expression | Zinc | White blood cells | Regeneration | Gliosis | Chondroitin sulfate | Sulfate | Aberration | Immunofluorescence | Protein-tyrosine-phosphatase | Index Medicus
Journal Article